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Acoustofluidic devices offer advantages such as low energy consumption, high throughput, and label-free operation, making them suitable for particle manipulation tasks including pumping, mixing, sorting, and separation. In this review, we provide an overview and discussion of recent advancements in SAW-based microfluidic devices for micro- and nanoparticle manipulation. Through a thorough investigation of the literature, we explore interdigitated transducer designs, materials, fabrication techniques, microfluidic channel properties, and SAW operational modes of acoustofluidic devices. SAW-based actuators are mainly based on lithium niobate piezoelectric transducers, with a plethora of wavelengths, microfluidic dimensions, and transducer configurations, applied for different fluid manipulation methods: mixing, sorting, and separation. We observed the accuracy of particle sorting across different size ranges and discussed different alternative device configurations to enhance sensitivity. Additionally, the collected data show the successful implementation of SAW devices in real-world applications in medical diagnostics and environmental monitoring. By critically analyzing different approaches, we identified common trends, challenges, and potential areas for improvement in SAW-based microfluidics. Furthermore, we discuss the current state-of-the-art and opportunities for further research and development in this field.<\/jats:p>","DOI":"10.3390\/s25051577","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T07:47:37Z","timestamp":1741074457000},"page":"1577","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A Review of SAW-Based Micro- and Nanoparticle Manipulation in Microfluidics"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1448-1779","authenticated-orcid":false,"given":"D\u00e9bora","family":"Amorim","sequence":"first","affiliation":[{"name":"Microelectromechanical Systems Research Unit (CMEMS), School of Engineering, Campus de Azur\u00e9m, University of Minho, 4800-058 Guimar\u00e3es, Portugal"},{"name":"INL\u2014International Iberian Nanotechnology Laboratory, 4715-330 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2945-9267","authenticated-orcid":false,"given":"Patr\u00edcia C.","family":"Sousa","sequence":"additional","affiliation":[{"name":"INL\u2014International Iberian Nanotechnology Laboratory, 4715-330 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9005-9599","authenticated-orcid":false,"given":"Carlos","family":"Abreu","sequence":"additional","affiliation":[{"name":"Microelectromechanical Systems Research Unit (CMEMS), School of Engineering, Campus de Azur\u00e9m, University of Minho, 4800-058 Guimar\u00e3es, Portugal"},{"name":"LABBELS\u2014Associate Laboratory, 4800-122 Braga, Portugal"},{"name":"ADiT-Lab\u2014Instituto Polit\u00e9cnico de Viana do Castelo, 4900-367 Viana do Castelo, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8962-0710","authenticated-orcid":false,"given":"Susana O.","family":"Catarino","sequence":"additional","affiliation":[{"name":"Microelectromechanical Systems Research Unit (CMEMS), School of Engineering, Campus de Azur\u00e9m, University of Minho, 4800-058 Guimar\u00e3es, Portugal"},{"name":"LABBELS\u2014Associate Laboratory, 4800-122 Braga, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1007\/s12551-023-01112-2","article-title":"A review of acoustofluidic separation of bioparticles","volume":"15","author":"Hossein","year":"2023","journal-title":"Biophys. 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