{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:19:55Z","timestamp":1760059195093,"version":"build-2065373602"},"reference-count":34,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Universidade do Porto, Funda\u00e7\u00e3o Amadeu Dias"},{"name":"Santander Universidades"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Trigeminal somatosensory-evoked potentials (TSEPs) provide valuable insight into neural responses to oral stimuli. This study investigates TSEP recording methods and their impact on interpreting results in clinical settings to improve the development process of neurostimulation-based therapies. The experiments and results presented here aim at identifying appropriate stimulation characteristics to design an active dental prosthesis capable of contributing to restoring the lost neurosensitive connection between the teeth and the brain. Two methods of TSEP acquisition, traditional and occluded, were used, each conducted by a different volunteer. Traditional TSEP acquisition involves stimulation at different sites with varying parameters to achieve a control base. In contrast, occluded TSEPs examine responses acquired under low- and high-force bite conditions to assess the influence of periodontal mechanoreceptors and muscle activation on measurements. Traditional TSEPs demonstrated methodological feasibility with satisfactory results despite a limited subject pool. However, occluded TSEPs presented challenges in interpreting results, with responses deviating from expected norms, particularly under high force conditions, due to the simultaneous occurrence of stimulation and dental occlusion. While traditional TSEPs highlight methodological feasibility, the occluded approach highlights complexities in outcome interpretation and urges caution in clinical application. Previously unreported results were achieved, which underscores the importance of conducting further research with larger sample sizes and refined protocols in order to strengthen the reliability and validity of TSEP assessments.<\/jats:p>","DOI":"10.3390\/s25113355","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T05:52:52Z","timestamp":1748325172000},"page":"3355","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Assessment of the Sensory Function in the Maxillofacial Region: A Dual-Case Pilot Study"],"prefix":"10.3390","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5947-3983","authenticated-orcid":false,"given":"Jo\u00e3o Maia","family":"Aguiar","sequence":"first","affiliation":[{"name":"INESC TEC\u2014INESC Technology and Science, 4200-465 Porto, Portugal"},{"name":"Faculdade de Engenharia, Universidade do Porto, 4200-465 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9160-9158","authenticated-orcid":false,"given":"Jos\u00e9","family":"Machado da Silva","sequence":"additional","affiliation":[{"name":"INESC TEC\u2014INESC Technology and Science, 4200-465 Porto, Portugal"},{"name":"Faculdade de Engenharia, Universidade do Porto, 4200-465 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2759-0384","authenticated-orcid":false,"given":"Carlos","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Faculdade de Engenharia, Universidade do Porto, 4200-465 Porto, Portugal"},{"name":"LAETA\/INEGI, Institute of Science and Innovation in Mechanical and Industrial Engineering, 4200-465 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3323-9117","authenticated-orcid":false,"given":"Jorge","family":"Marinho","sequence":"additional","affiliation":[{"name":"Instituto Portugu\u00eas de Oncologia do Porto FG, EPE (IPO-Porto), 4200-072 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"key":"ref_1","first-page":"ZE21","article-title":"Oral health and quality of life: Current concepts","volume":"11","author":"Baiju","year":"2017","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1111\/j.1365-2842.2012.02340.x","article-title":"From brain to bridge: Masticatory function and dental implants","volume":"39","author":"Trulsson","year":"2012","journal-title":"J. Oral Rehabil."},{"key":"ref_3","unstructured":"Johnsen, S.E. (2005). Human Periodontal Mechanoreceptors: Functional Properties and Role in Jaw Motor Control, Karolinska Institutet."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1365-2842.2006.01623.x","article-title":"Mechanisms of oral somatosensory and motor functions and their clinical correlates","volume":"33","author":"Sessle","year":"2006","journal-title":"J. Oral Rehabil."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e0701","DOI":"10.1097\/MD.0000000000010701","article-title":"Relationship between foot posture and dental malocclusions in children aged 6 to 9 years: A cross-sectional study","volume":"97","year":"2018","journal-title":"Medicine"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"15090","DOI":"10.18632\/oncotarget.23850","article-title":"Tooth loss and cancer risk: A dose - response meta analysis of prospective cohort studies","volume":"9","author":"Shi","year":"2018","journal-title":"Oncotarget"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Fang, W.L., Jiang, M.J., Gu, B.B., Wei, Y.M., Fan, S.N., Liao, W., Zheng, Y.Q., Liao, S.W., Xiong, Y., and Li, Y. (2018). Tooth loss as a risk factor for dementia: Systematic review and meta-analysis of 21 observational studies. BMC Psychiatry, 18.","DOI":"10.1186\/s12888-018-1927-0"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1365-2842.2006.01629.x","article-title":"Sensory-motor function of human periodontal mechanoreceptors","volume":"33","author":"Trulsson","year":"2006","journal-title":"J. Oral Rehabil."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1093\/eurpub\/ckad160.1134","article-title":"The Global Impact of Edentulism: A Systematic Review","volume":"33","author":"Hunter","year":"2023","journal-title":"Eur. J. Public Health"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Misch, C.E. (2014). Dental Implant Prosthetics-E-Book, Elsevier Health Sciences.","DOI":"10.1016\/B978-0-323-07845-0.00016-6"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0022-3913(03)00212-9","article-title":"Clinical complications with implants and implant prostheses","volume":"90","author":"Goodacre","year":"2003","journal-title":"J. Prosthet. Dent."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3109\/00016357409026342","article-title":"Studies on function and dysfunction of the masticatory system: IV. Age and sex distribution of symptoms of dysfunction of the masticatory system in Lapps in the north of Finland","volume":"32","author":"Helkimo","year":"1974","journal-title":"Acta Odontol. Scand."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"da Silva, J.M., Cerrone, I., Mal\u00e1gon, D., Marinho, J., Mundy, S., Gaspar, J., and Mendes, J.G. (2020, January 18\u201320). A Smart Dental Prosthesis to Restore Dental Proprioceptivity. Proceedings of the 2020 XXXV Conference on Design of Circuits and Integrated Systems (DCIS), Madrid, Spain.","DOI":"10.1109\/DCIS51330.2020.9268653"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1590\/S1678-77572008000300002","article-title":"Dealing with dental implant failures","volume":"16","author":"Levin","year":"2008","journal-title":"J. Appl. Oral Sci."},{"key":"ref_15","first-page":"423","article-title":"Success or failure of dental implants? A literature review with treatment considerations","volume":"53","author":"Porter","year":"2005","journal-title":"Gen. Dent."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1743-0003-10-60","article-title":"Biofeedback in rehabilitation","volume":"10","author":"Giggins","year":"2013","journal-title":"J. Neuroeng. Rehabil."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Toledo-Peral, C.L., Vega-Mart\u00ednez, G., Mercado-Guti\u00e9rrez, J.A., Rodr\u00edguez-Reyes, G., Vera-Hern\u00e1ndez, A., Leija-Salas, L., and Guti\u00e9rrez-Mart\u00ednez, J. (2022). Virtual\/Augmented Reality for Rehabilitation Applications Using Electromyography as Control\/Biofeedback: Systematic Literature Review. Electronics, 11.","DOI":"10.3390\/electronics11142271"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s40136-023-00451-8","article-title":"The Evolution of Swallowing Rehabilitation and Emergence of Biofeedback Modalities","volume":"11","author":"Huckabee","year":"2023","journal-title":"Curr. Otorhinolaryngol. Rep."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Vieira, M.d.A., Oliveira-Souza, A.I.S.d., Hahn, G., B\u00e4hr, L., Armijo-Olivo, S., and Ferreira, A.P.d.L. (2023). Effectiveness of Biofeedback in Individuals with Awake Bruxism Compared to Other Types of Treatment: A Systematic Review. Int. J. Environ. Res. Public Health, 20.","DOI":"10.3390\/ijerph20021558"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Florjanski, W., Malysa, A., Orzeszek, S., Smardz, J., Olchowy, A., Paradowska-Stolarz, A., and Wieckiewicz, M. (2019). Evaluation of Biofeedback Usefulness in Masticatory Muscle Activity Management\u2014A Systematic Review. J. Clin. Med., 8.","DOI":"10.3390\/jcm8060766"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.joms.2005.12.005","article-title":"Somatosensory evoked potentials of inferior alveolar nerve","volume":"64","author":"Arcuri","year":"2006","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/S0901-5027(87)80076-0","article-title":"Trigeminal somatosensory evoked potentials: A review of the literature as applicable to oral dysaesthesias","volume":"16","author":"Bennett","year":"1987","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Waldman, H.J. (2007). Evoked potential testing. Pain Management, Elsevier.","DOI":"10.1016\/B978-0-7216-0334-6.50021-2"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/j.clinph.2008.03.016","article-title":"Recommendations for the clinical use of somatosensory-evoked potentials","volume":"119","author":"Cruccu","year":"2008","journal-title":"Clin. Neurophysiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/0266-4356(87)90070-2","article-title":"Applications of trigeminal somatosensory evoked potentials (TSEPs) in oral and maxillofacial surgery","volume":"25","author":"Barker","year":"1987","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1177\/155005948301400204","article-title":"Cortical evoked potentials in response to trigeminus nerve stimulation in humans","volume":"14","author":"Badr","year":"1983","journal-title":"Clin. Electroencephalogr."},{"key":"ref_27","first-page":"81","article-title":"Trigeminal somatosensory evoked potential in inferior alveolar nerve damage assessment","volume":"36","author":"Wang","year":"2011","journal-title":"J. Brain Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S1567-4231(09)70100-5","article-title":"Diseases of cranial nerves and brainstem","volume":"Volume 7","author":"Cruccu","year":"2006","journal-title":"Handbook of Clinical Neurophysiology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"817","DOI":"10.33588\/rn.27159.98179","article-title":"Somatosensory trigeminal evoked potentials after gingival stimulation of the mental nerve. Normal values","volume":"27","author":"Villanueva","year":"1998","journal-title":"Rev. De Neurol."},{"key":"ref_30","first-page":"63","article-title":"Somatosensory evoked potentials following trigeminal nerve stimulation in trigeminal neuralgia","volume":"9","author":"Petruch","year":"1981","journal-title":"Ann. Neurol. Off. J. Am. Neurol. Assoc. Child Neurol. Soc."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.jns.2014.10.025","article-title":"Somatosensory evoked magnetic fields following tongue and hard palate stimulation on the preferred chewing side","volume":"347","author":"Maezawa","year":"2014","journal-title":"J. Neurol. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0004-9514(14)60582-1","article-title":"Functional electrical stimulation of the extremities in the neurological patient: A review","volume":"33","author":"Singer","year":"1987","journal-title":"Aust. J. Physiother."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.snb.2005.03.121","article-title":"Ag\/AgCl microelectrodes with improved stability for microfluidics","volume":"114","author":"Polk","year":"2006","journal-title":"Sens. Actuators B Chem."},{"key":"ref_34","unstructured":"American Dental Association (1999). Current Dental Terminology, American Dental Association. [3rd ed.]."}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/25\/11\/3355\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:40:59Z","timestamp":1760031659000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/25\/11\/3355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,26]]},"references-count":34,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["s25113355"],"URL":"https:\/\/doi.org\/10.3390\/s25113355","relation":{},"ISSN":["1424-8220"],"issn-type":[{"type":"electronic","value":"1424-8220"}],"subject":[],"published":{"date-parts":[[2025,5,26]]}}}