{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T21:32:11Z","timestamp":1772832731396,"version":"3.50.1"},"reference-count":90,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T00:00:00Z","timestamp":1676678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"FCT\/MCTES, Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["MTS\/SAS\/0077\/2020"],"award-info":[{"award-number":["MTS\/SAS\/0077\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"FCT\/MCTES, Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"FCT\/MCTES, Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["UIDP\/50006\/2020"],"award-info":[{"award-number":["UIDP\/50006\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"FCT\/MCTES, Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["LA\/P\/0008\/2020"],"award-info":[{"award-number":["LA\/P\/0008\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Park of Montesinho","award":["MTS\/SAS\/0077\/2020"],"award-info":[{"award-number":["MTS\/SAS\/0077\/2020"]}]},{"name":"Natural Park of Montesinho","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"Natural Park of Montesinho","award":["UIDP\/50006\/2020"],"award-info":[{"award-number":["UIDP\/50006\/2020"]}]},{"name":"Natural Park of Montesinho","award":["LA\/P\/0008\/2020"],"award-info":[{"award-number":["LA\/P\/0008\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Separations"],"abstract":"<jats:p>Environmental pollution is a crucial problem in our society, having nowadays a better understanding of its consequences, which include the increase of contaminant cocktails present in the environment. The contamination of honeybees can occur through their interaction with the nearby environment. Therefore, if honeybees are previously contaminated, there is a possibility of contamination of their products, such as honey as natural, or minimally processed, product, resulting from the honeybees\u2019 activity. Considering that honey is a highly consumed product, it is extremely necessary to control its quality and safety, including evaluating the presence and quantification of contaminants, which should follow monitoring studies and the legislation established by the European Union. This work aims to review the literature of different contaminants reported on honey, including pesticides, persistent organic pollutants, polycyclic aromatic hydrocarbons, and pharmaceuticals, focusing on the reports using the QuEChERS technique for the extraction. Furthermore, reports of microplastics on honey samples were also discussed. Despite the existence of several methods that identify and quantify these contaminants, few methods have been reported to operate with different groups of contaminants simultaneously. The development of methods with this characteristic (while being fast, low cost, and with a lower impact on the environment), monitoring studies to identify the risks, and an update on legislation are priority actions and future perspectives to follow.<\/jats:p>","DOI":"10.3390\/separations10020142","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T02:02:09Z","timestamp":1676858529000},"page":"142","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Contaminant Cocktails of High Concern in Honey: Challenges, QuEChERS Extraction and Levels"],"prefix":"10.3390","volume":"10","author":[{"given":"Mariana","family":"Lamas","sequence":"first","affiliation":[{"name":"REQUIMTE\/LAQV, Instituto Superior de Engenharia do Porto, Instituto Polit\u00e9cnico do Porto, 4249-015 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8803-0041","authenticated-orcid":false,"given":"Francisca","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Instituto Superior de Engenharia do Porto, Instituto Polit\u00e9cnico do Porto, 4249-015 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3209-3366","authenticated-orcid":false,"given":"Maria Helena","family":"Amaral","sequence":"additional","affiliation":[{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, MEDTECH, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3924-776X","authenticated-orcid":false,"given":"Cristina","family":"Delerue-Matos","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Instituto Superior de Engenharia do Porto, Instituto Polit\u00e9cnico do Porto, 4249-015 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3979-7523","authenticated-orcid":false,"given":"Virg\u00ednia Cruz","family":"Fernandes","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, Instituto Superior de Engenharia do Porto, Instituto Polit\u00e9cnico do Porto, 4249-015 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,18]]},"reference":[{"key":"ref_1","unstructured":"European Commission (2022, November 04). About Pollinators. Available online: https:\/\/wikis.ec.europa.eu\/display\/EUPKH\/About+pollinators."},{"key":"ref_2","first-page":"583","article-title":"The Honey as a Bioindicator of the Environment","volume":"24","author":"Sager","year":"2017","journal-title":"Ecol. Chem. Eng. S"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1080\/02757540.2020.1770737","article-title":"Monitoring of honey contamination with polycyclic aromatic hydrocarbons in Herzegovina region","volume":"36","author":"Kazazic","year":"2020","journal-title":"Chem. Ecol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1139\/er-2017-0029","article-title":"The use of honeybees and honey as environmental bioindicators for metals and radionuclides: A review","volume":"25","year":"2017","journal-title":"Environ. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1051\/apido:2005027","article-title":"Honey as a bioindicator for environmental pollution with SO2","volume":"36","author":"Ponikvar","year":"2005","journal-title":"Apidologie"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1007\/s00244-007-9126-x","article-title":"Bee honey as an environmental bioindicator of pesticides\u2019 occurrence in six agricultural areas of Greece","volume":"55","author":"Balayiannis","year":"2008","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"ref_7","first-page":"12","article-title":"Organochlorine pesticide residues in Uganda\u2019s honey as a bioindicator of environmental contamination and reproductive health implications to consumers","volume":"214","author":"Nyanzi","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_8","unstructured":"European Union (2022, October 16). Regulation (EC) No 396\/2005 of the European Parliament and of the Council of 23 February 2005 on Maximum Residue Levels of Pesticides in or on Food and Feed of Plant and Animal Origin and Amending Council Directive 91\/414\/EEC. Available online: https:\/\/eur-lex.europa.eu\/legal-content\/EN\/TXT\/?uri=CELEX%3A32005R0396."},{"key":"ref_9","first-page":"e06491","article-title":"The 2019 European Union report on pesticide residues in food","volume":"19","author":"Cabrera","year":"2021","journal-title":"Efsa J."},{"key":"ref_10","unstructured":"European Union (2022, September 10). Commission Recommendation of 3 March 2014 on the Monitoring of Traces of Brominated Flame Retardants in Food. Available online: https:\/\/eur-lex.europa.eu\/legal-content\/EN\/TXT\/?uri=CELEX%3A32014H0118&qid=1676587691936."},{"key":"ref_11","unstructured":"European Union (2022, September 10). Commission Regulation (EC) No 1881\/2006 of 19 December 2006 Setting Maximum Levels for Certain Contaminants in Foodstuff. Available online: https:\/\/eur-lex.europa.eu\/legal-content\/EN\/TXT\/?uri=CELEX%3A32006R1881&qid=1676587516415."},{"key":"ref_12","first-page":"33","article-title":"Composition and properties of Apis mellifera honey: A review","volume":"57","author":"Sancho","year":"2018","journal-title":"J. Apic. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/1541-4337.12182","article-title":"Physicochemical Properties, Minerals, Trace Elements, and Heavy Metals in Honey of Different Origins: A Comprehensive Review","volume":"15","author":"Solayman","year":"2016","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.foodchem.2015.09.051","article-title":"Honey: Chemical composition, stability and authenticity","volume":"196","author":"Gauche","year":"2016","journal-title":"Food Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.mex.2016.05.005","article-title":"Efficiency of QuEChERS approach for determining 52 pesticide residues in honey and honey bees","volume":"3","author":"Calatayud","year":"2016","journal-title":"MethodsX"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1093\/chrsci\/49.9.715","article-title":"Determination of Pesticides in Fruit and Fruit Juices by Chromatographic Methods. An Overview","volume":"49","author":"Fernandes","year":"2011","journal-title":"J. Chromatogr. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s00216-013-7457-1","article-title":"Challenges and new directions in analytical sample preparation","volume":"406","author":"Gjelstad","year":"2014","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"109141","DOI":"10.1016\/j.foodres.2020.109141","article-title":"Review of pesticide residue analysis in fruits and vegetables. Pre-treatment, extraction and detection techniques","volume":"133","author":"Narenderan","year":"2020","journal-title":"Food Res. Int."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.talanta.2015.11.045","article-title":"Pesticides in honey: A review on chromatographic analytical methods","volume":"149","author":"Fernandes","year":"2016","journal-title":"Talanta"},{"key":"ref_20","first-page":"809","article-title":"Accelerated solvent extraction by using an \u2018in-line\u2019 clean-up approach for multiresidue analysis of pesticides in organic honey","volume":"34","author":"Chiesa","year":"2017","journal-title":"Food Addit. Contam. Part A-Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/jaoac\/86.2.412","article-title":"Fast and easy multiresidue method employing acetonitrile extraction\/partitioning and \u201cdispersive solid-phase extraction\u201d for the determination of pesticide residues in produce","volume":"86","author":"Anastassiades","year":"2003","journal-title":"J. AOAC Int."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aca.2019.02.036","article-title":"QuEChERS\u2014Fundamentals, relevant improvements, applications and future trends","volume":"1070","author":"Perestrelo","year":"2019","journal-title":"Anal. Chim. Acta"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Serban Moldoveanu, V.D. (2015). Modern Sample Preparation for Chromatography, Elsevier.","DOI":"10.1016\/B978-0-444-54319-6.00002-5"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1515\/intox-2016-0012","article-title":"Organochlorine pesticides, their toxic effects on living organisms and their fate in the environment","volume":"9","author":"Jayaraj","year":"2016","journal-title":"Interdiscip. Toxicol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Tudi, M., Daniel Ruan, H., Wang, L., Lyu, J., Sadler, R., Connell, D., Chu, C., and Phung, D.T. (2021). Agriculture Development, Pesticide Application and Its Impact on the Environment. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18031112"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev-environ-120920-111015","article-title":"Agrochemicals, Environment, and Human Health","volume":"47","author":"Devi","year":"2022","journal-title":"Annu. Rev. Environ. Resour."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ejar.2020.08.007","article-title":"Pesticides pollution: Classifications, human health impact, extraction and treatment techniques","volume":"46","author":"Hassaan","year":"2020","journal-title":"Egypt J. Aquatic Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"134612","DOI":"10.1016\/j.scitotenv.2019.134612","article-title":"Pesticides in the urban environment: A potential threat that knocks at the door","volume":"711","author":"Venkateswarlu","year":"2020","journal-title":"Sci. Total Environ."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Serrano-Medina, A., Ugalde-Lizarraga, A., Bojorquez-Cuevas, M.S., Garnica-Ruiz, J., Gonzalez-Corral, M.A., Garcia-Ledezma, A., Pineda-Garcia, G., and Cornejo-Bravo, J.M. (2019). Neuropsychiatric Disorders in Farmers Associated with Organophosphorus Pesticide Exposure in a Rural Village of Northwest Mexico. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16050689"},{"key":"ref_30","unstructured":"European Commission (2022, September 29). Pesticides and Bees. Available online: https:\/\/food.ec.europa.eu\/animals\/live-animal-movements\/honey-bees\/pesticides-and-bees_en."},{"key":"ref_31","unstructured":"Butler, D. (2022, September 29). Scientists Hail European Ban on Bee-Harming Pesticides. Available online: https:\/\/www.nature.com\/articles\/d41586-018-04987-4."},{"key":"ref_32","unstructured":"European Commission (2022, September 29). Neonicotinoids. Available online: https:\/\/food.ec.europa.eu\/plants\/pesticides\/approval-active-substances\/renewal-approval\/neonicotinoids_en."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1590\/1413-70542018421021117","article-title":"LC-MS\/MS analysis of neonicotinoid insecticides: Residue findings in chilean honeys","volume":"42","author":"Bridi","year":"2018","journal-title":"Cienc. Agrotec."},{"key":"ref_34","unstructured":"European Comission (2022, October 16). Analytical Quality Control and Method Validation Procedures for Pesticide Residues Analysis in Food and Feed 2022, 57. Available online: https:\/\/www.eurl-pesticides.eu\/docs\/public\/tmplt_article.asp?CntID=727."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"21826","DOI":"10.1007\/s11356-021-17196-w","article-title":"Simultaneous detection of ten kinds of insecticide residues in honey and pollen using UPLC-MS\/MS with graphene and carbon nanotubes as adsorption and purification materials","volume":"29","author":"Pang","year":"2022","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Almeida, M.O., Oloris, S.C.S., Faria, V.H.E., Ribeiro, M.C.M., Cantini, D.M., and Soto-Blanco, B. (2020). Optimization of Method for Pesticide Detection in Honey by Using Liquid and Gas Chromatography Coupled with Mass Spectrometric Detection. Foods, 9.","DOI":"10.3390\/foods9101368"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1080\/00218839.2016.1143693","article-title":"Validation and monitoring of pesticide residues in honey using QuEChERS and gas chromatographic analysis","volume":"54","author":"Nadaf","year":"2015","journal-title":"J. Apic. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1080\/19476337.2021.1901785","article-title":"Analysis of insecticide residues in honey by liquid chromatography tandem mass spectrometry using QuEChERS optimized by the Plackett Burman design","volume":"19","author":"Souza","year":"2021","journal-title":"Cyta-J. Food"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Ligor, M., Bukowska, M., Ratiu, I.A., Gadzala-Kopciuch, R., and Buszewski, B. (2020). Determination of Neonicotinoids in Honey Samples Originated from Poland and Other World Countries. Molecules, 25.","DOI":"10.3390\/molecules25245817"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.envpol.2019.02.004","article-title":"Ultra-trace level determination of neonicotinoids in honey as a tool for assessing environmental contamination","volume":"247","author":"Kammoun","year":"2019","journal-title":"Environ. Pollut."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"34005","DOI":"10.1007\/s11356-018-3312-4","article-title":"Pesticide residues in Indian raw honeys, an indicator of environmental pollution","volume":"25","author":"Kumar","year":"2018","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_42","first-page":"1573","article-title":"Determining Pesticide Residues in Honey and their Potential Risk to Consumers","volume":"23","author":"Eissa","year":"2014","journal-title":"Pol. J. Environ. Stud."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.foodchem.2016.05.036","article-title":"Multiclass method for pesticides quantification in honey by means of modified QuEChERS and UHPLC-MS\/MS","volume":"211","author":"Tette","year":"2016","journal-title":"Food Chem."},{"key":"ref_44","first-page":"10","article-title":"Multiresidue Determination of Pesticide Residues in Honey by Modified QuEChERS Method and Gas Chromatography with Electron Capture Detection","volume":"25","author":"Orso","year":"2014","journal-title":"J. Braz. Chem. Soc."},{"key":"ref_45","first-page":"97","article-title":"Simple and rapid method of analysis for determination of pesticide residues in honey using dispersive solid phase extraction and GC determination","volume":"5","author":"Barakat","year":"2007","journal-title":"J. Food Agric. Environ."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"5157","DOI":"10.1007\/s00216-017-0463-y","article-title":"A multiresidue method for the analysis of 90 pesticides, 16 PAHs, and 22 PCBs in honey using QuEChERS-SPME","volume":"409","author":"Fajloun","year":"2017","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_47","unstructured":"International Agency for Research on Cancer (2022, November 12). Agents Classified by the IARC Monographs. Available online: https:\/\/monographs.iarc.who.int\/agents-classified-by-the-iarc\/."},{"key":"ref_48","unstructured":"European Commission (2022, November 12). EU Pesticides Database. Available online: https:\/\/food.ec.europa.eu\/plants\/pesticides\/eu-pesticides-database_en."},{"key":"ref_49","unstructured":"International Agency for Research on Cancer (2022, November 12). Monographs Available. Available online: https:\/\/monographs.iarc.who.int\/monographs-available\/."},{"key":"ref_50","unstructured":"UN Environment Programme (2022, December 26). What Are POPs?. Available online: http:\/\/chm.pops.int\/TheConvention\/ThePOPs\/tabid\/673\/Default.aspx."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.teac.2019.e00063","article-title":"Review of the QuEChERS method for the analysis of organic pollutants: Persistent organic pollutants, polycyclic aromatic hydrocarbons, and pharmaceuticals","volume":"22","author":"Kim","year":"2019","journal-title":"Trends Environ. Anal. Chem."},{"key":"ref_52","unstructured":"UN Environment Programme (2022, December 26). All POPs Listed in the Stockholm Convention. Available online: http:\/\/chm.pops.int\/TheConvention\/ThePOPs\/AllPOPs\/tabid\/2509\/Default.aspx."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.envpol.2007.06.051","article-title":"Global fate of POPs: Current and future research directions","volume":"150","author":"Lohmann","year":"2007","journal-title":"Environ. Pollut."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1007\/s00267-017-0896-2","article-title":"Polycyclic Aromatic Hydrocarbons: A Critical Review of Environmental Occurrence and Bioremediation","volume":"60","author":"Alegbeleye","year":"2017","journal-title":"Environ. Manag."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Kosek, K., and Ruman, M. (2021). Arctic Freshwater Environment Altered by the Accumulation of Commonly Determined and Potentially New POPs. Water, 13.","DOI":"10.3390\/w13131739"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Othman, N., Ismail, Z., Selamat, M.I., Sheikh Abdul Kadir, S.H., and Shibraumalisi, N.A. (2022). A Review of Polychlorinated Biphenyls (PCBs) Pollution in the Air: Where and How Much Are We Exposed to?. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph192113923"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Hens, B., and Hens, L. (2017). Persistent Threats by Persistent Pollutants: Chemical Nature, Concerns and Future Policy Regarding PCBs-What Are We Heading For?. Toxics, 6.","DOI":"10.3390\/toxics6010001"},{"key":"ref_58","unstructured":"International Agency for Research on Cancer (2023, February 10). IARC Monographs Volume 107: Polychlorinated Biphenyls and Polybrominated Biphenyls. Available online: https:\/\/www.iarc.who.int\/news-events\/iarc-monographs-volume-107-polychlorinated-biphenyls-and-polybrominated-biphenyls\/."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Kim, Y.A., Park, J.B., Woo, M.S., Lee, S.Y., Kim, H.Y., and Yoo, Y.H. (2019). Persistent Organic Pollutant-Mediated Insulin Resistance. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16030448"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"124901","DOI":"10.1016\/j.chemosphere.2019.124901","article-title":"The influence of polyphenols on metabolic disorders caused by compounds released from plastics\u2014Review","volume":"240","author":"Zwierello","year":"2020","journal-title":"Chemosphere"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3389\/fpubh.2020.00014","article-title":"Environmental and Health Impacts of Air Pollution: A Review","volume":"8","author":"Manisalidis","year":"2020","journal-title":"Front. Public Health"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1080\/10643389.2020.1738854","article-title":"Emission sources and full spectrum of health impacts of black carbon associated polycyclic aromatic hydrocarbons (PAHs) in urban environment: A review","volume":"51","author":"Ali","year":"2021","journal-title":"Crit. Rev. Environ. Sci. Technol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1080\/19393210.2019.1569727","article-title":"PAHs in different honeys from Serbia","volume":"12","author":"Petrovic","year":"2019","journal-title":"Food Addit. Contam. Part B-Surveill."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1080\/19440049.2020.1865578","article-title":"Contamination of polychlorinated biphenyls in honey from the Brazilian state of Rio Grande do Sul","volume":"38","author":"Vareli","year":"2021","journal-title":"Food Addit. Contam. Part A-Chem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.microc.2015.02.008","article-title":"Method development for the determination of PFOA and PFOS in honey based on the dispersive Solid Phase Extraction (d-SPE) with micro-UHPLC-MS\/MS system","volume":"121","author":"Surma","year":"2015","journal-title":"Microchem. J."},{"key":"ref_66","first-page":"9","article-title":"Determination of 16 PAHs and 22 PCBs in honey samples originated from different region of Lebanon and used as environmental biomonitors sentinel","volume":"54","author":"Fajloun","year":"2019","journal-title":"J. Environ. Sci. Health Part A-Toxic\/Hazard. Subst. Environ. Eng."},{"key":"ref_67","unstructured":"European Union (2022, October 16). Commission Regulation (EU) No 1259\/2011 of 2 December 2011 Amending Regulation (EC) No 1881\/2006 as Regards Maximum Levels for Dioxins, Dioxin-Like PCBs and Non Dioxin-Like PCBs in Foodstuffs. Available online: https:\/\/eur-lex.europa.eu\/legal-content\/EN\/TXT\/?uri=CELEX%3A32011R1259&qid=1676587373985."},{"key":"ref_68","unstructured":"European Union (2022, October 16). Commission Regulation (EU) 2020\/1255 of 7 September 2020 Amending Regulation (EC) No 1881\/2006 as Regards Maximum Levels of Polycyclic Aromatic Hydrocarbons (PAHs) in Traditionally Smoked Meat and Smoked Meat Products and Traditionally Smoked Fish and Smoked Fishery Products and Establishing a Maximum Level of PAHs in Powders of Food of Plant Origin Used for the Preparation of Beverages. Available online: https:\/\/eur-lex.europa.eu\/legal-content\/EN\/TXT\/?uri=CELEX%3A32020R1255."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.foodchem.2016.11.026","article-title":"Development and validation of a multiclass method for the quantification of veterinary drug residues in honey and royal jelly by liquid chromatography-tandem mass spectrometry","volume":"221","author":"Jin","year":"2017","journal-title":"Food Chem."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jfca.2021.104120","article-title":"Multiresidue analysis of 15 antibiotics in honey using modified QuEChERS and high performance liquid chromatography-tandem mass spectrometry","volume":"103","author":"Xu","year":"2021","journal-title":"J. Food Compos. Anal."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1080\/19440049.2021.1881621","article-title":"Validation of two UHPLC-MS\/MS methods for fast and reliable determination of quinolone residues in honey","volume":"38","author":"Emir","year":"2021","journal-title":"Food Addit. Contam. Part A-Chem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1155\/2018\/4271385","article-title":"Simultaneous Determination of Nitroimidazoles and Quinolones in Honey by Modified QuEChERS and LC-MS\/MS Analysis","volume":"2018","author":"Lei","year":"2018","journal-title":"Int. J. Anal. Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.talanta.2012.02.011","article-title":"Determination of quinolones of veterinary use in bee products by ultra-high performance liquid chromatography-tandem mass spectrometry using a QuEChERS extraction procedure","volume":"93","year":"2012","journal-title":"Talanta"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.foodchem.2019.01.003","article-title":"Determination of neonicotinoids and 199 other pesticide residues in honey by liquid and gas chromatography coupled with tandem mass spectrometry","volume":"282","author":"Gawel","year":"2019","journal-title":"Food Chem."},{"key":"ref_75","unstructured":"European Union (2022, October 16). Commission Regulation (EU) No 37\/2010 of 22 December 2009 on Pharmacologically Active Substances and Their Classification Regarding Maximum Residue Limits in Foodstuffs of Animal Origin. Available online: https:\/\/eur-lex.europa.eu\/legal-content\/EN\/TXT\/?uri=CELEX%3A32010R0037&qid=1676587318550."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.watres.2017.11.011","article-title":"Analysis of microplastics in water by micro-Raman spectroscopy: Release of plastic particles from different packaging into mineral water","volume":"129","author":"Schymanski","year":"2018","journal-title":"Water Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"124357","DOI":"10.1016\/j.jhazmat.2020.124357","article-title":"Environmental source, fate, and toxicity of microplastics","volume":"407","author":"Wang","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s13181-018-0661-9","article-title":"Microplastics and Human Health: Our Great Future to Think About Now","volume":"14","author":"Kontrick","year":"2018","journal-title":"J. Med. Toxicol."},{"key":"ref_79","unstructured":"Plastics Europe (2022, December 26). Plastics\u2014the Facts 2022. Available online: https:\/\/plasticseurope.org\/knowledge-hub\/plastics-the-facts-2022\/."},{"key":"ref_80","unstructured":"Plastics Europe (2022, December 26). Plastics\u2014the Facts 2021. Available online: https:\/\/plasticseurope.org\/knowledge-hub\/plastics-the-facts-2021\/."},{"key":"ref_81","unstructured":"Plastics Europe (2022, December 26). Plastics\u2014the Facts 2020. Available online: https:\/\/plasticseurope.org\/knowledge-hub\/plastics-the-facts-2020\/."},{"key":"ref_82","unstructured":"Plastics Europe (2022, December 26). Plastics\u2014the Facts 2019. Available online: https:\/\/plasticseurope.org\/knowledge-hub\/plastics-the-facts-2019\/."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.marpolbul.2018.11.022","article-title":"Microplastics: Finding a consensus on the definition","volume":"138","author":"Frias","year":"2019","journal-title":"Mar. Pollut. Bull."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.envpol.2018.01.024","article-title":"Current opinion: What is a nanoplastic?","volume":"235","author":"Gigault","year":"2018","journal-title":"Environ. Pollut."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1515\/pjfns-2015-0025","article-title":"Origin of Synthetic Particles in Honeys","volume":"65","author":"Liebezeit","year":"2015","journal-title":"Pol. J. Food Nutr. Sci."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Silva, G.C., Madrid, F.G.M., Hernandez, D., Pincheira, G., Peralta, A.K., Gavilan, M.U., Vergara-Carmona, V., and Fuentes-Penailillo, F. (2021). Microplastics and Their Effect in Horticultural Crops: Food Safety and Plant Stress. Agronomy, 11.","DOI":"10.3390\/agronomy11081528"},{"key":"ref_87","first-page":"7","article-title":"Micro- and nano-plastics in edible fruit and vegetables. The first diet risks assessment for the general population","volume":"187","author":"Conti","year":"2020","journal-title":"Environ. Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1080\/19440049.2013.843025","article-title":"Non-pollen particulates in honey and sugar","volume":"30","author":"Liebezeit","year":"2013","journal-title":"Food Addit. Contam. Part A-Chem. Anal. Control. Expo. Risk Assess."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Diaz-Basantes, M.F., Conesa, J.A., and Fullana, A. (2020). Microplastics in Honey, Beer, Milk and Refreshments in Ecuador as Emerging Contaminants. Sustainability, 12.","DOI":"10.3390\/su12145514"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"144481","DOI":"10.1016\/j.scitotenv.2020.144481","article-title":"Honeybees as active samplers for microplastics","volume":"767","author":"Edo","year":"2021","journal-title":"Sci. Total Environ."}],"container-title":["Separations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2297-8739\/10\/2\/142\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:36:08Z","timestamp":1760121368000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2297-8739\/10\/2\/142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,18]]},"references-count":90,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["separations10020142"],"URL":"https:\/\/doi.org\/10.3390\/separations10020142","relation":{},"ISSN":["2297-8739"],"issn-type":[{"value":"2297-8739","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,18]]}}}