{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:10:23Z","timestamp":1760145023708,"version":"build-2065373602"},"reference-count":43,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Comunidad of Madrid and European funding from FSE and FEDER programs","award":["S2018\/BAA-4393","AVANSECAL-II-CM","UIDB\/00674\/2020","UIDP\/00674\/2020","M1420-01-0145-FEDER-000005","M14-20 M1420-01-0145-FEDER-000008"],"award-info":[{"award-number":["S2018\/BAA-4393","AVANSECAL-II-CM","UIDB\/00674\/2020","UIDP\/00674\/2020","M1420-01-0145-FEDER-000005","M14-20 M1420-01-0145-FEDER-000008"]}]},{"name":"FCT-Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["S2018\/BAA-4393","AVANSECAL-II-CM","UIDB\/00674\/2020","UIDP\/00674\/2020","M1420-01-0145-FEDER-000005","M14-20 M1420-01-0145-FEDER-000008"],"award-info":[{"award-number":["S2018\/BAA-4393","AVANSECAL-II-CM","UIDB\/00674\/2020","UIDP\/00674\/2020","M1420-01-0145-FEDER-000005","M14-20 M1420-01-0145-FEDER-000008"]}]},{"name":"Programmatic Fund","award":["S2018\/BAA-4393","AVANSECAL-II-CM","UIDB\/00674\/2020","UIDP\/00674\/2020","M1420-01-0145-FEDER-000005","M14-20 M1420-01-0145-FEDER-000008"],"award-info":[{"award-number":["S2018\/BAA-4393","AVANSECAL-II-CM","UIDB\/00674\/2020","UIDP\/00674\/2020","M1420-01-0145-FEDER-000005","M14-20 M1420-01-0145-FEDER-000008"]}]},{"name":"ARDITI\u2014Ag\u00eancia Regional para o Desenvolvimento da Investiga\u00e7\u00e3o Tecnologia e Inova\u00e7\u00e3o","award":["S2018\/BAA-4393","AVANSECAL-II-CM","UIDB\/00674\/2020","UIDP\/00674\/2020","M1420-01-0145-FEDER-000005","M14-20 M1420-01-0145-FEDER-000008"],"award-info":[{"award-number":["S2018\/BAA-4393","AVANSECAL-II-CM","UIDB\/00674\/2020","UIDP\/00674\/2020","M1420-01-0145-FEDER-000005","M14-20 M1420-01-0145-FEDER-000008"]}]},{"name":"PROEQUIPRAM program","award":["S2018\/BAA-4393","AVANSECAL-II-CM","UIDB\/00674\/2020","UIDP\/00674\/2020","M1420-01-0145-FEDER-000005","M14-20 M1420-01-0145-FEDER-000008"],"award-info":[{"award-number":["S2018\/BAA-4393","AVANSECAL-II-CM","UIDB\/00674\/2020","UIDP\/00674\/2020","M1420-01-0145-FEDER-000005","M14-20 M1420-01-0145-FEDER-000008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Separations"],"abstract":"<jats:p>Culinary aromatic herbs (CAHs), used worldwide for culinary and industrial purposes, are recognized for their wide range of beneficial health effects including antimicrobial, antioxidant, anti-hyperlipidemic, anti-inflammatory, anti-type 2 diabetes mellitus, antitumorigenic and anticarcinogenic, and anti-hypertensive properties, in addition to glucose- and cholesterol-lowering activities as well as properties that affect mental health and cognition via their phytochemical constituents, such as polyphenols (flavonoids and non-flavonoids), sulfur- and nitrogen-containing compounds, alkaloids, minerals, and vitamins. Moreover, the volatile organic metabolites (VOMs) found in CAHs offer unique analytical biosignatures linked to their sensory qualities and organoleptic characteristics. This study aimed to establish the volatilomic pattern of CAHs commonly used in Europe and in the Mediterranean region, oregano (Origanum vulgare L.) and two savory species: savory (Satureja hortensis L.) and lemon savory (Satureja montana L. var. citriodora). The volatilomic pattern of CAHs was established using headspace solid-phase microextraction (HS-SPME) followed by gas chromatography\u2013mass spectrometry (GC-MS) determination. This is a powerful strategy to unravel the potential health benefits related to the most important VOMs identified in each aromatic herb. This comprehensive understanding will aid in establishing the authenticity of these herbs, while also safeguarding against possible fraudulent activities and adulterations. A total of 112 VOMs from different chemical families were identified. Terpenoids amounted to the major chemical family in the investigated aromatic herbs accounting for 96.0, 95.1, and 79.7% of the total volatile composition for savory, lemon savory, and oregano, respectively. Apart from contributing to flavor profiles, certain identified VOMs also possess bioactive properties, opening interesting avenues for potential application in the food, pharmaceutical, and cosmetic sectors. The volatilomic pattern combined with unsupervised principal component analysis facilitated the differentiation of the aromatic herbs under investigation, revealing the most related VOMs in each sample, which can be used as markers for the authentication of these valuable aromatic herbs, such as caryophyllene oxide (103), camphene (6), p-cymene (23), and borneol (74), among others. In addition, some VOMs have a high influence on the aromatic herb\u2019s bioactive potential, helping to prevent certain diseases including cancer, inflammatory-related diseases, diabetes, and cardiovascular diseases.<\/jats:p>","DOI":"10.3390\/separations11060181","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T08:49:03Z","timestamp":1718009343000},"page":"181","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterization of the Volatilomic Fingerprint of Culinary Aromatic Herbs: A Comparative Study Based on Chemometric Analysis"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7315-2713","authenticated-orcid":false,"given":"Sergio","family":"Izcara","sequence":"first","affiliation":[{"name":"Departamento de Tecnolog\u00eda Qu\u00edmica y Ambiental, Escuela Superior de Ciencias Experimentales y Tecnolog\u00eda (E.S.C.E.T.), Universidad Rey Juan Carlos, c\/Tulip\u00e1n s\/n, M\u00f3stoles, 28933 Madrid, Spain"},{"name":"CQM\u2014Centro de Qu\u00edmica da Madeira, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7223-1022","authenticated-orcid":false,"given":"Rosa","family":"Perestrelo","sequence":"additional","affiliation":[{"name":"CQM\u2014Centro de Qu\u00edmica da Madeira, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6448-2385","authenticated-orcid":false,"given":"Sonia","family":"Morante-Zarcero","sequence":"additional","affiliation":[{"name":"Departamento de Tecnolog\u00eda Qu\u00edmica y Ambiental, Escuela Superior de Ciencias Experimentales y Tecnolog\u00eda (E.S.C.E.T.), Universidad Rey Juan Carlos, c\/Tulip\u00e1n s\/n, M\u00f3stoles, 28933 Madrid, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2091-6772","authenticated-orcid":false,"given":"Isabel","family":"Sierra","sequence":"additional","affiliation":[{"name":"Departamento de Tecnolog\u00eda Qu\u00edmica y Ambiental, Escuela Superior de Ciencias Experimentales y Tecnolog\u00eda (E.S.C.E.T.), Universidad Rey Juan Carlos, c\/Tulip\u00e1n s\/n, M\u00f3stoles, 28933 Madrid, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1965-3151","authenticated-orcid":false,"given":"Jos\u00e9","family":"Sousa C\u00e2mara","sequence":"additional","affiliation":[{"name":"CQM\u2014Centro de Qu\u00edmica da Madeira, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal"},{"name":"Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias Exatas e Engenharia, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6701","DOI":"10.2174\/1381612823666161123094235","article-title":"Functional Foods for Health: The Interrelated Antioxidant and Anti-Inflammatory Role of Fruits, Vegetables, Herbs, Spices and Cocoa in Humans","volume":"22","author":"Serafini","year":"2017","journal-title":"Curr. Pharm. Des."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"4202","DOI":"10.1021\/acs.jafc.2c00010","article-title":"Elderberry (Sambucus Nigra L.): Bioactive Compounds, Health Functions, and Applications","volume":"70","author":"Liu","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.foodchem.2016.08.111","article-title":"Spices in the Management of Diabetes Mellitus","volume":"217","author":"Bi","year":"2017","journal-title":"Food Chem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"19183","DOI":"10.3390\/ijms151019183","article-title":"Culinary Herbs and Spices: Their Bioactive Properties, the Contribution of Polyphenols and the Challenges in Deducing Their True Health Benefits","volume":"15","author":"Opara","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1080\/10408398.2011.574802","article-title":"Recent Advances in Biologically Active Compounds in Herbs and Spices: A Review of the Most Effective Antioxidant and Anti-Inflammatory Active Principles","volume":"53","author":"Motilva","year":"2013","journal-title":"Crit. Rev. Food Sci. Nutr."},{"doi-asserted-by":"crossref","unstructured":"Yashin, A., Yashin, Y., Xia, X., and Nemzer, B. (2017). Antioxidant Activity of Spices and Their Impact on Human Health: A Review. Antioxidants, 6.","key":"ref_6","DOI":"10.3390\/antiox6030070"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"353","DOI":"10.17306\/J.AFS.2016.4.34","article-title":"The Industrial Potential of Herbs and Spices\u2014A Mini Review","volume":"15","author":"Leja","year":"2016","journal-title":"Acta Sci. Pol. Technol. Aliment."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"127773","DOI":"10.1016\/j.foodchem.2020.127773","article-title":"Phytochemical and Pharmacological Review of Cinnamomum Verum J. Presl-a Versatile Spice Used in Food and Nutrition","volume":"338","author":"Singh","year":"2021","journal-title":"Food Chem."},{"doi-asserted-by":"crossref","unstructured":"Cozzolino, R., Stocchero, M., Perestrelo, R., and C\u00e2mara, J.S. (2022). Comprehensive evaluation of the volatomic fingerprint of saffron from Campania towards its authenticity and quality. Foods, 11.","key":"ref_9","DOI":"10.3390\/foods11030366"},{"doi-asserted-by":"crossref","unstructured":"Izcara, S., Perestrelo, R., Morante-Zarcero, S., Sierra, I., and C\u00e2mara, J.S. (2022). Spices volatilomic fingerprinting\u2014A comprehensive approach to explore its authentication and bioactive properties. Molecules, 27.","key":"ref_10","DOI":"10.3390\/molecules27196403"},{"doi-asserted-by":"crossref","unstructured":"Izcara, S., Casado, N., Morante-Zarcero, S., and Sierra, I. (2020). A Miniaturized QuEChERS Method Combined with Ultrahigh Liquid Chromatography Coupled to Tandem Mass Spectrometry for the Analysis of Pyrrolizidine Alkaloids in Oregano Samples. Foods, 9.","key":"ref_11","DOI":"10.3390\/foods9091319"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/20014091076695","article-title":"An Overview of Analytical Chemistry of Phenolic Compounds in Foods","volume":"31","author":"Escarpa","year":"2001","journal-title":"Crit. Rev. Anal. Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1016\/j.foodchem.2010.12.026","article-title":"A Critical Review of Methods for Characterisation of Polyphenolic Compounds in Fruits and Vegetables","volume":"126","author":"Ignat","year":"2011","journal-title":"Food Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1134\/S1061934808110026","article-title":"Chromatographic and Electrophoretic Methods for Determining Polyphenol Compounds","volume":"63","author":"Kartsova","year":"2008","journal-title":"J. Anal. Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.3390\/molecules18022328","article-title":"Techniques for Analysis of Plant Phenolic Compounds","volume":"18","author":"Khoddami","year":"2013","journal-title":"Molecules"},{"doi-asserted-by":"crossref","unstructured":"Andrade, C., Perestrelo, R., and C\u00e2mara, J.S. (2022). Valorization of Spent Coffee Grounds as a Natural Source of Bioactive Compounds for Several Industrial Applications-A Volatilomic Approach. Foods, 11.","key":"ref_16","DOI":"10.3390\/foods11121731"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.foodchem.2017.10.049","article-title":"Exploring a Volatomic-Based Strategy for a Fingerprinting Approach of Vaccinium Padifolium L. Berries at Different Ripening Stages","volume":"245","author":"Figueira","year":"2018","journal-title":"Food Chem."},{"doi-asserted-by":"crossref","unstructured":"Aguiar, J., Gon\u00e7alves, J.L., Alves, V.L., and C\u00e2mara, J.S. (2021). Relationship between Volatile Composition and Bioactive Potential of Vegetables and Fruits of Regular Consumption\u2014An Integrative Approach. Molecules, 26.","key":"ref_18","DOI":"10.3390\/molecules26123653"},{"doi-asserted-by":"crossref","unstructured":"Figueira, J.A., Porto-Figueira, P., Pereira, J.A.M., and C\u00e2mara, J.S. (2020). Tangerines Cultivated on Madeira Island\u2014A High Throughput Natural Source of Bioactive Compounds. Foods, 9.","key":"ref_19","DOI":"10.3390\/foods9101470"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"109550","DOI":"10.1016\/j.foodres.2020.109550","article-title":"Geographical Differentiation of Apple Ciders Based on Volatile Fingerprint","volume":"137","author":"Sousa","year":"2020","journal-title":"Food Res. Int."},{"doi-asserted-by":"crossref","unstructured":"Izcara, S., Perestrelo, R., Morante-Zarcero, S., Sierra, I., and C\u00e2mara, J.S. (2022). Volatilomic Fingerprinting from Edible Flowers. Unravelling Some Impact Compounds behind Its Attractiveness. Food Biosci., 50.","key":"ref_21","DOI":"10.1016\/j.fbio.2022.102188"},{"doi-asserted-by":"crossref","unstructured":"Perestrelo, R., Silva, C., C\u00e2mara, J.S., Maria, R., Perestrelo, S., and C\u00e2mara, J.S. (2019). Madeira Wine Volatile Profile. A Platform to Establish Madeira Wine Aroma Descriptors. Molecules, 24.","key":"ref_22","DOI":"10.3390\/molecules24173028"},{"unstructured":"Acree, T., and Arn, H. (2019, February 14). Flavornet Home Page. Available online: http:\/\/www.flavornet.org\/.","key":"ref_23"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"W388","DOI":"10.1093\/nar\/gkab382","article-title":"MetaboAnalyst 5.0: Narrowing the Gap between Raw Spectra and Functional Insights","volume":"49","author":"Pang","year":"2021","journal-title":"Nucleic Acids Res."},{"doi-asserted-by":"crossref","unstructured":"Li, C., Zha, W., Li, W., Wang, J., and You, A. (2023). Advances in the Biosynthesis of Terpenoids and Their Ecological Functions in Plant Resistance. Int. J. Mol. Sci., 24.","key":"ref_25","DOI":"10.3390\/ijms241411561"},{"doi-asserted-by":"crossref","unstructured":"Kamran, S., Sinniah, A., Abdulghani, M.A.M., and Alshawsh, M.A. (2022). Therapeutic Potential of Certain Terpenoids as Anticancer Agents: A Scoping Review. Cancers, 14.","key":"ref_26","DOI":"10.3390\/cancers14051100"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s10787-021-00918-4","article-title":"Phenols and Terpenoids: Natural Products as Inhibitors of NLRP3 Inflammasome in Cardiovascular Diseases","volume":"30","author":"Hua","year":"2022","journal-title":"Inflammopharmacology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s40200-021-00943-8","article-title":"Flavonoids, Alkaloids and Terpenoids: A New Hope for the Treatment of Diabetes Mellitus","volume":"21","author":"Singh","year":"2022","journal-title":"J. Diabetes Metab. Disord."},{"doi-asserted-by":"crossref","unstructured":"Kim, T., Song, B., Cho, K.S., and Lee, I.S. (2020). Therapeutic Potential of Volatile Terpenes and Terpenoids from Forests for Inflammatory Diseases. Int. J. Mol. Sci., 21.","key":"ref_29","DOI":"10.3390\/ijms21062187"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"97","DOI":"10.5487\/TR.2017.33.2.097","article-title":"Terpenes from Forests and Human Health","volume":"33","author":"Cho","year":"2017","journal-title":"Toxicol. Res."},{"doi-asserted-by":"crossref","unstructured":"Tousif, M.I., Nazir, M., Riaz, N., Saleem, M., Tauseef, S., Azam, S.M., Arfan Yawer, M., and Zengin, G. (2023). Terpenoids as Human Neutrophil Elastase (HNE) Inhibitors: A Comprehensive Review of Natural Anti-Inflammatory Isoprenoids. ChemBioChem, 24.","key":"ref_31","DOI":"10.1002\/cbic.202300346"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"380","DOI":"10.3389\/fphar.2017.00380","article-title":"Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development","volume":"8","author":"Javed","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"9243","DOI":"10.1016\/j.arabjc.2020.11.009","article-title":"Thymol Bioactivity: A Review Focusing on Practical Applications","volume":"13","author":"Escobar","year":"2020","journal-title":"Arab. J. Chem."},{"doi-asserted-by":"crossref","unstructured":"Zinno, P., Guantario, B., Lombardi, G., Ranaldi, G., Finamore, A., Allegra, S., Mammano, M.M., Fascella, G., Raffo, A., and Roselli, M. (2023). Chemical Composition and Biological Activities of Essential Oils from Origanum Vulgare Genotypes Belonging to the Carvacrol and Thymol Chemotypes. Plants, 12.","key":"ref_34","DOI":"10.3390\/plants12061344"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"6803","DOI":"10.1021\/acs.jafc.3c06461","article-title":"Thymol as a Potential Neuroprotective Agent: Mechanisms, Efficacy, and Future Prospects","volume":"72","author":"Peng","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2147\/IJN.S444815","article-title":"Targeted Delivery of Geraniol via Hyaluronic Acid-Conjugation Enhances Its Anti-Tumor Activity Against Prostate Cancer","volume":"19","author":"Yu","year":"2024","journal-title":"Int. J. Nanomed."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1080\/10412905.2020.1745697","article-title":"Antimicrobial Activity of Geraniol: An Integrative Review","volume":"32","author":"Moraes","year":"2020","journal-title":"J. Essent. Oil Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"20220319","DOI":"10.1515\/chem-2022-0319","article-title":"Physicochemical and Biological Properties of Carvacrol","volume":"21","author":"Gandova","year":"2023","journal-title":"Open Chem."},{"doi-asserted-by":"crossref","unstructured":"M\u0105czka, W., Twardawska, M., Grabarczyk, M., and Wi\u0144ska, K. (2023). Carvacrol\u2014A Natural Phenolic Compound with Antimicrobial Properties. Antibiotics, 12.","key":"ref_39","DOI":"10.3390\/antibiotics12050824"},{"doi-asserted-by":"crossref","unstructured":"Khan, F., Pandey, P., and Maqsood, R.U.T.K. (2022). Anticancer Effects of Carvacrol in In Vitro and In Vivo Models: A Comprehensive Review. Biointerface Res. Appl. Chem., 13.","key":"ref_40","DOI":"10.33263\/BRIAC133.290"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"31826","DOI":"10.1021\/acsomega.3c03337","article-title":"Carvacrol-Fabricated Chitosan Nanoparticle Synergistic Potential with Topoisomerase Inhibitors on Breast and Cervical Cancer Cells","volume":"8","author":"Akhlaq","year":"2023","journal-title":"ACS Omega"},{"doi-asserted-by":"crossref","unstructured":"Doghish, A., Shehabeldine, A., El-Mahdy, H., Hassanin, M., Al-Askar, A., Marey, S., AbdElgawad, H., and Hashem, A. (2023). Thymus Vulgaris Oil Nanoemulsion: Synthesis, Characterization, Antimicrobial and Anticancer Activities. Molecules, 28.","key":"ref_42","DOI":"10.3390\/molecules28196910"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"101379","DOI":"10.1016\/j.scp.2023.101379","article-title":"From Residue to Resource: The Recovery of High-Added Values Compounds through an Integral Green Valorization of Citrus Residual Biomass","volume":"37","author":"Lamine","year":"2024","journal-title":"Sustain. Chem. Pharm."}],"container-title":["Separations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2297-8739\/11\/6\/181\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:56:24Z","timestamp":1760108184000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2297-8739\/11\/6\/181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,10]]},"references-count":43,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["separations11060181"],"URL":"https:\/\/doi.org\/10.3390\/separations11060181","relation":{},"ISSN":["2297-8739"],"issn-type":[{"type":"electronic","value":"2297-8739"}],"subject":[],"published":{"date-parts":[[2024,6,10]]}}}