{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:17:57Z","timestamp":1777587477372,"version":"3.51.4"},"reference-count":140,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/00674\/2020"],"award-info":[{"award-number":["UIDB\/00674\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDP\/00674\/2020"],"award-info":[{"award-number":["UIDP\/00674\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ARDITI-Ag\u00eancia Regional para o Desenvolvimento da Investiga\u00e7\u00e3o Tecnologia e Inova\u00e7\u00e3o","award":["M1420-01-0145-FEDER-000005"],"award-info":[{"award-number":["M1420-01-0145-FEDER-000005"]}]},{"name":"PROEQUIPRAM","award":["M14-20 M1420-01-0145-FEDER-000008"],"award-info":[{"award-number":["M14-20 M1420-01-0145-FEDER-000008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Separations"],"abstract":"<jats:p>Some chemical substances have the potential to enter the coastal and marine environment and cause adverse effects on ecosystems, biodiversity and human health. For a large majority of them, their fate and effects are poorly understood as well as their use still unregulated. Finding effective and sustainable strategies for the identification of these emerging and\/or anthropogenic contaminants that might cause polluting effects in marine environments to mitigate their adverse effects, is of utmost importance and a great challenge for managers, regulators and researchers. In this review we will evaluate the impact of emerging contaminants (ECs) on marine coastal zones namely in their ecosystems and biodiversity, highlighting the potential risks of organic pollutants, pharmaceuticals and personal care products. Emerging microextraction techniques and high-resolution analytical platforms used in isolation, identification and quantification of ECs will be also reviewed.<\/jats:p>","DOI":"10.3390\/separations8070095","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T12:03:27Z","timestamp":1625141007000},"page":"95","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Emerging Contaminants in Seafront Zones. Environmental Impact and Analytical Approaches"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1965-3151","authenticated-orcid":false,"given":"Jos\u00e9 S.","family":"C\u00e2mara","sequence":"first","affiliation":[{"name":"CQM\u2014Centro de Qu\u00edmica da Madeira, Campus Universit\u00e1rio da Penteada, 9020-105 Funchal, Portugal"},{"name":"Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias Exatas e Engenharia, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9872-5293","authenticated-orcid":false,"given":"Sarah","family":"Montesdeoca-Esponda","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Estudios Ambientales y Recursos Naturales (i-UNAT), Universidad de Las Palmas de Gran Canaria, 35017 Las Palmas de Gran Canaria, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4350-0526","authenticated-orcid":false,"given":"Jorge","family":"Freitas","sequence":"additional","affiliation":[{"name":"CQM\u2014Centro de Qu\u00edmica da Madeira, Campus Universit\u00e1rio da Penteada, 9020-105 Funchal, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9189-9589","authenticated-orcid":false,"given":"Rayco","family":"Guedes-Alonso","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Estudios Ambientales y Recursos Naturales (i-UNAT), Universidad de Las Palmas de Gran Canaria, 35017 Las Palmas de Gran Canaria, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3003-3607","authenticated-orcid":false,"given":"Zoraida","family":"Sosa-Ferrera","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Estudios Ambientales y Recursos Naturales (i-UNAT), Universidad de Las Palmas de Gran Canaria, 35017 Las Palmas de Gran Canaria, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7223-1022","authenticated-orcid":false,"given":"Rosa","family":"Perestrelo","sequence":"additional","affiliation":[{"name":"CQM\u2014Centro de Qu\u00edmica da Madeira, Campus Universit\u00e1rio da Penteada, 9020-105 Funchal, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,1]]},"reference":[{"key":"ref_1","unstructured":"United Nations (2021, March 15). The Ocean Conference\u2014Fact Sheet Package, New York, NY, USA. Available online: https:\/\/sustainabledevelopment.un.org\/content\/documents\/Ocean_Factsheet_People.pdf."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Mora, C., Tittensor, D.P., Adl, S., Simpson, A.G.B., and Worm, B. (2011). How many species are there on earth and in the ocean?. PLoS Biol., 9.","DOI":"10.1371\/journal.pbio.1001127"},{"key":"ref_3","unstructured":"Creel, L. (2003). Ripple Effects: Population and Coastal Regions, Population Reference Bureau."},{"key":"ref_4","first-page":"287","article-title":"Pollution of Sea Water and Marine Sediments in Coastal Areas","volume":"9","author":"Berne","year":"1980","journal-title":"Ambio"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"4645","DOI":"10.1021\/ac9008012","article-title":"Water analysis: Emerging contaminants and current issues","volume":"81","author":"Richardson","year":"2009","journal-title":"Anal. Chem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.ijheh.2011.08.002","article-title":"Emerging pollutants in wastewater: A review of the literature","volume":"214","author":"Deblonde","year":"2011","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.nbt.2014.01.001","article-title":"Emerging pollutants in the environment: Present and future challenges in biomonitoring, ecological risks and bioremediation","volume":"32","author":"Gavrilescu","year":"2015","journal-title":"N. Biotechnol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.iswcr.2015.03.002","article-title":"Emerging pollutants in the environment: A challenge for water resource management","volume":"3","author":"Geissen","year":"2015","journal-title":"Int. Soil Water Conserv. Res."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"K\u00fcster, A., and Adler, N. (2014). Pharmaceuticals in the environment: Scientific evidence of risks and its regulation. Philos. Trans. R. Soc. B Biol. Sci., 369.","DOI":"10.1098\/rstb.2013.0587"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1289\/ehp.1104477","article-title":"Pharmaceuticals and personal care products in the environment: What are the big questions?","volume":"120","author":"Boxall","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.emcon.2016.12.004","article-title":"Pharmaceuticals and personal care products (PPCPs) in the freshwater aquatic environment","volume":"3","author":"Ebele","year":"2017","journal-title":"Emerg. Contam."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.marpolbul.2005.06.034","article-title":"Emerging chemicals of concern: Pharmaceuticals and personal care products (PPCPs) in Asia, with particular reference to Southern China","volume":"50","author":"Richardson","year":"2005","journal-title":"Mar. Pollut. Bull."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.envpol.2013.08.005","article-title":"Sources, factors, mechanisms and possible solutions to pollutants in marine ecosystems","volume":"182","author":"Mostofa","year":"2013","journal-title":"Environ. Pollut."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.2175\/106143016X14696400495695","article-title":"Effects of pollution on marine organisms","volume":"88","author":"Mearns","year":"2016","journal-title":"Water Environ. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"142644","DOI":"10.1016\/j.scitotenv.2020.142644","article-title":"Pharmaceuticals in the marine environment: What are the present challenges in their monitoring?","volume":"766","author":"Branchet","year":"2021","journal-title":"Sci. Total Environ."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.marpol.2012.05.016","article-title":"On the environmental effectiveness of the EU marine strategy framework directive","volume":"38","author":"Bertram","year":"2013","journal-title":"Mar. Policy"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1080\/00908320903285463","article-title":"The European Union and the Marine Strategy Framework Directive: Continuing the development of European ocean use management","volume":"41","author":"Juda","year":"2010","journal-title":"Ocean Dev. Int. Law"},{"key":"ref_18","first-page":"197","article-title":"The emerging contaminants in the context of the EU water framework directive","volume":"46","author":"Carere","year":"2016","journal-title":"Handb. Environ. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12302-020-00312-x","article-title":"Chemicals of emerging concern in marine specimens of the German Environmental Specimen Bank","volume":"32","author":"Fliedner","year":"2020","journal-title":"Environ. Sci. Eur."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.marpolbul.2013.06.012","article-title":"Evaluating legacy contaminants and emerging chemicals in marine environments using adverse outcome pathways and biological effects-directed analysis","volume":"74","author":"Hutchinson","year":"2013","journal-title":"Mar. Pollut. Bull."},{"key":"ref_21","first-page":"79","article-title":"Effects of emerging contaminants on biodiversity, community structure, and adaptation of river biota","volume":"46","author":"Kuzmanovic","year":"2016","journal-title":"Handb. Environ. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.envpol.2017.07.082","article-title":"Contaminants of emerging concern in the open sea waters of the Western Mediterranean","volume":"229","author":"Kohoutek","year":"2017","journal-title":"Environ. Pollut."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.marpolbul.2016.06.090","article-title":"Fate, behaviour and weathering of priority HNS in the marine environment: An online tool","volume":"111","author":"Cunha","year":"2016","journal-title":"Mar. Pollut. Bull."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.marpolbul.2016.06.091","article-title":"Chemical contaminants entering the marine environment from sea-based sources: A review with a focus on European seas","volume":"112","author":"Tornero","year":"2016","journal-title":"Mar. Pollut. Bull."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1752-153X-8-15","article-title":"A review of what is an emerging contaminant","volume":"8","author":"Desrosiers","year":"2014","journal-title":"Chem. Cent. J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.marpolbul.2018.11.060","article-title":"Legacy and emerging pollutants in the Gulf of Gda\u0144sk (southern Baltic Sea)\u2014Loads and distribution revisited","volume":"139","author":"Zaborska","year":"2019","journal-title":"Mar. Pollut. Bull."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.marpolbul.2013.12.045","article-title":"Der Emerging organic contaminants in coastal waters: Anthropogenic impact, environmental release and ecological risk","volume":"85","author":"Jiang","year":"2014","journal-title":"Mar. Pollut. Bull."},{"key":"ref_28","first-page":"121","article-title":"Bioaccumulation of emerging contaminants in aquatic biota: Patterns of pharmaceuticals in mediterranean river networks","volume":"46","author":"Huerta","year":"2016","journal-title":"Handb. Environ. Chem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fmars.2016.00024","article-title":"Antibiotics as CECs: An overview of the hazards posed by antibiotics and antibiotic resistance","volume":"3","author":"Scott","year":"2016","journal-title":"Front. Mar. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3389\/fmars.2017.00415","article-title":"Pharmaceuticals and personal care products in municipal wastewater and the marine receiving environment near Victoria Canada","volume":"4","author":"Krogh","year":"2017","journal-title":"Front. Mar. Sci."},{"key":"ref_31","first-page":"1","article-title":"Emerging contaminants effect on aquatic ecosystem: Human health risks","volume":"19","author":"Srikanth","year":"2019","journal-title":"Agric. Res. Technol. Open Access J."},{"key":"ref_32","first-page":"40","article-title":"Plastic marine debris: Sources, distribution and impacts on coastal and ocean biodiversity","volume":"3","author":"Pawar","year":"2016","journal-title":"PENCIL Publ. Biol. Sci. Oceanogr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.marenvres.2018.05.001","article-title":"Pharmaceuticals in the aquatic environments: Evidence of emerged threat and future challenges for marine organisms","volume":"140","author":"Mezzelani","year":"2018","journal-title":"Mar. Environ. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.chemosphere.2011.07.015","article-title":"Aquaculture effects on environmental and public welfare\u2014The case of Mediterranean mariculture","volume":"85","author":"Grigorakis","year":"2011","journal-title":"Chemosphere"},{"key":"ref_35","unstructured":"UNESCO (2017). Pharmaceuticals in the Aquatic Environment of the Baltic Sea Region\u2014A Status Report, UNESCO."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.ecolecon.2006.10.022","article-title":"The coasts of our world: Ecological, economic and social importance","volume":"63","author":"Intralawan","year":"2007","journal-title":"Ecol. Econ."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"20130572","DOI":"10.1098\/rstb.2013.0572","article-title":"Sources, impacts and trends of pharmaceuticals in the marine and coastal environment","volume":"369","author":"Gaw","year":"2014","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"ref_38","unstructured":"(2021, May 05). Quintiles IMS Global Medicines Use in 2020: Outlook and Implications. Available online: https:\/\/pt.slideshare.net\/IMSHealth1\/global-medicines-use-in-2020-outlook-and-implications."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.envpol.2012.04.024","article-title":"Biological effects of environmentally relevant concentrations of the pharmaceutical Triclosan in the marine mussel Perna perna (Linnaeus, 1758)","volume":"168","author":"Cortez","year":"2012","journal-title":"Environ. Pollut."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1139\/er-2018-0054","article-title":"Pharmaceuticals in the marine environment: A review","volume":"27","author":"Ojemaye","year":"2019","journal-title":"Environ. Rev."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/ics.12030","article-title":"Commonly used UV filter toxicity on biological functions: Review of last decade studies","volume":"35","author":"Gilbert","year":"2013","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/ics.12165","article-title":"Photoprotection in changing times\u2014UV filter efficacy and safety, sensitization processes and regulatory aspects","volume":"37","author":"Stiefel","year":"2015","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"392A","DOI":"10.1021\/es040639t","article-title":"Scrutinizing pharmaceuticals and personal care products in wastewater treatment","volume":"38","author":"Ternes","year":"2004","journal-title":"Environ. Sci. Technol."},{"key":"ref_44","first-page":"1082","article-title":"Research progress and challenge of synthetic musks: From personal care, environment pollution to human health","volume":"29","author":"Gao","year":"2017","journal-title":"Prog. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/ieam.73","article-title":"Integrated risk assessment of household chemicals and consumer products: Addressing concerns about triclosan","volume":"6","author":"Mackay","year":"2010","journal-title":"Integr. Environ. Assess. Manag."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s00216-006-0728-3","article-title":"Analytical methods for the determination of persistent ingredients of personal care products in environmental matrices","volume":"386","author":"Peck","year":"2006","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Ojemaye, C.Y., and Petrik, L. (2021). Pharmaceuticals and personal care product in the marine environment around False Bay, Cape Town, South Africa: Occurrence and risk assessment study. Environ. Toxicol. Chem.","DOI":"10.1002\/etc.5053"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/j.chemosphere.2010.11.018","article-title":"A review of personal care products in the aquatic environment: Environmental concentrations and toxicity","volume":"82","author":"Brausch","year":"2011","journal-title":"Chemosphere"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.envpol.2015.09.039","article-title":"Toxic heritage: Maternal transfer of pyrethroid insecticides and sunscreen agents in dolphins from Brazil","volume":"207","author":"Alonso","year":"2015","journal-title":"Environ. Pollut."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3511","DOI":"10.1016\/j.chroma.2011.04.006","article-title":"Multiresidue analytical method for the determination of antimicrobials, preservatives, benzotriazole UV stabilizers, flame retardants and plasticizers in fish using ultra high performance liquid chromatography coupled with tandem mass spectrometry","volume":"1218","author":"Kim","year":"2011","journal-title":"J. Chromatogr. A"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.scitotenv.2017.03.044","article-title":"Significance of metabolites in the environmental risk assessment of pharmaceuticals consumed by human","volume":"592","author":"Han","year":"2017","journal-title":"Sci. Total Environ."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Tovar-S\u00e1nchez, A., S\u00e1nchez-Quiles, D., Basterretxea, G., Bened\u00e9, J.L., Chisvert, A., Salvador, A., Moreno-Garrido, I., and Blasco, J. (2013). Sunscreen products as emerging pollutants to coastal waters. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0065451"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"110449","DOI":"10.1016\/j.ecoenv.2020.110449","article-title":"Comparative metal accumulation and toxicogenetic damage induction in three neotropical fish species with distinct foraging habits and feeding preferences","volume":"195","author":"Lacerda","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1007\/s00216-012-6067-7","article-title":"An overview of UV-absorbing compounds (organic UV filters) in aquatic biota","volume":"404","year":"2012","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"143720","DOI":"10.1016\/j.scitotenv.2020.143720","article-title":"Understanding the occurrence and distribution of emerging pollutants and endocrine disruptors in sensitive coastal South Florida Ecosystems","volume":"757","author":"Ng","year":"2021","journal-title":"Sci. Total Environ."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"125028","DOI":"10.1016\/j.jhazmat.2020.125028","article-title":"The antineoplastic drugs cyclophosphamide and cisplatin in the aquatic environment\u2014Review","volume":"412","author":"Azeiteiro","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"26772","DOI":"10.1007\/s11356-020-12046-7","article-title":"Effects of paracetamol on the polychaete Hediste diversicolor: Occurrence of oxidative stress, cyclooxygenase inhibition and behavioural alterations","volume":"28","author":"Nogueira","year":"2021","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"342","DOI":"10.2174\/1874070701610010342","article-title":"Antibiotic resistant bacteria in the environment as bio-indicators of pollution","volume":"10","author":"Paulson","year":"2016","journal-title":"Open Biotechnol. J."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Smaldone, G., Marrone, R., Cappiello, S., Martin, G.A., Oliva, G., Cortesi, M.L., and Anastasio, A. (2014). Occurrence of antibiotic resistance in bacteria isolated from seawater organisms caught in Campania Region: Preliminary study. BMC Vet. Res.","DOI":"10.1186\/1746-6148-10-161"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.envres.2015.11.026","article-title":"Single and joint ecotoxicity data estimation of organic UV filters and nanomaterials toward selected aquatic organisms. Urban groundwater risk assessment","volume":"145","year":"2016","journal-title":"Environ. Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.envpol.2011.12.014","article-title":"Ecotoxicological effect characterisation of widely used organic UV filters","volume":"163","author":"Kaiser","year":"2012","journal-title":"Environ. Pollut."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1016\/j.scitotenv.2018.10.148","article-title":"Comparative toxicities of four benzophenone ultraviolet filters to two life stages of two coral species","volume":"651","author":"He","year":"2019","journal-title":"Sci. Total Environ."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13671-020-00284-4","article-title":"Sunscreen safety: A review of recent studies on humans and the environment","volume":"9","author":"Adler","year":"2020","journal-title":"Curr. Dermatol. Rep."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Merola, C., Lucon-Xiccato, T., Bertolucci, C., and Perugini, M. (2021). Behavioural effects of early-life exposure to parabens in zebrafish larvae. J. Appl. Toxicol.","DOI":"10.1002\/jat.4171"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"106269","DOI":"10.1016\/j.envint.2020.106269","article-title":"Environmental pharmaceuticals and climate change: The case study of carbamazepine in M. galloprovincialis under ocean acidification scenario","volume":"146","author":"Mezzelani","year":"2021","journal-title":"Environ. Int."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Sadutto, D., Andreu, V., Ilo, T., Akkanen, J., and Pic\u00f3, Y. (2021). Pharmaceuticals and personal care products in a Mediterranean coastal wetland: Impact of anthropogenic and spatial factors and environmental risk assessment. Environ. Pollut., 271.","DOI":"10.1016\/j.envpol.2020.116353"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0378-4274(03)00257-1","article-title":"Probabilistic hazard assessment of environmentally occurring pharmaceuticals toxicity to fish, daphnids and algae by ECOSAR screening","volume":"144","author":"Sanderson","year":"2003","journal-title":"Toxicol. Lett."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.scitotenv.2017.08.279","article-title":"Occurrence, distribution and environmental risk of pharmaceutically active compounds (PhACs) in coastal and ocean waters from the Gulf of Cadiz (SW Spain)","volume":"612","year":"2018","journal-title":"Sci. Total Environ."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.scitotenv.2014.11.097","article-title":"Assessment of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawaters of North of Portugal: Occurrence and environmental risk","volume":"508","author":"Santos","year":"2015","journal-title":"Sci. Total Environ."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.fsi.2020.12.013","article-title":"Immunity and inflammatory responses in gilthead sea bream (Sparus aurata L.) exposed to sub-lethal mixture of carbamazepine, cadmium chloride and polybrominated diphenyl ether","volume":"111","author":"Manuguerra","year":"2021","journal-title":"Fish Shellfish Immunol."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"\u015awiacka, K., Michnowska, A., Maculewicz, J., Caban, M., and Smolarz, K. (2021). Toxic effects of NSAIDs in non-target species: A review from the perspective of the aquatic environment. Environ. Pollut., 273.","DOI":"10.1016\/j.envpol.2020.115891"},{"key":"ref_72","unstructured":"(2021, June 01). European Commission Technical Guidance Documentin support of Commission Directive93\/67\/EEC on Risk Assessment for new notifieds ubstances, Commission Regulation (EC) No1488\/94 on Risk Assessment for existing substances, Directive 98\/8\/EC of the Euro. Available online: https:\/\/echa.europa.eu\/documents\/10162\/16960216\/tgdpart2_2ed_en.pdf."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.jhazmat.2014.10.023","article-title":"Is there a risk for the aquatic environment due to the existence of emerging organic contaminants in treated domestic wastewater? Greece as a case-study","volume":"283","author":"Thomaidi","year":"2015","journal-title":"J. Hazard. Mater."},{"key":"ref_74","unstructured":"European Medicines Agency (2021, March 01). Environmental Risk Assessment of Medicinal Products for Human Use. Available online: https:\/\/www.ema.europa.eu\/en\/documents\/scientific-guideline\/guideline-environmental-risk-assessment-medicinal-products-human-use-first-version_en.pdf."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1016\/j.jhazmat.2010.12.037","article-title":"GC-MS analysis and ecotoxicological risk assessment of triclosan, carbamazepine and parabens in Indian rivers","volume":"186","author":"Ramaswamy","year":"2011","journal-title":"J. Hazard. Mater."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.envpol.2017.09.046","article-title":"Environmental risk assessment of triclosan and ibuprofen in marine sediments using individual and sub-individual endpoints","volume":"232","author":"Pusceddu","year":"2018","journal-title":"Environ. Pollut."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1007\/s10646-008-0209-x","article-title":"Hazard assessment of commonly used agricultural antibiotics on aquatic ecosystems","volume":"17","author":"Park","year":"2008","journal-title":"Ecotoxicology"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jhazmat.2016.02.030","article-title":"Ecological risk assessment associated to the removal of endocrine-disrupting parabens and benzophenone-4 in wastewater treatment","volume":"310","year":"2016","journal-title":"J. Hazard. Mater."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Zhou, L., Fan, D., Yin, W., Gu, W., Wang, Z., Liu, J., Xu, Y., Shi, L., Liu, M., and Ji, G. (2021). Comparison of seven in silico tools for evaluating of daphnia and fish acute toxicity: Case study on Chinese priority controlled chemicals and new chemicals. BMC Bioinform., 22.","DOI":"10.1186\/s12859-020-03903-w"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"11384","DOI":"10.1007\/s11356-020-11320-y","article-title":"Occurrence and risk assessment of pharmaceuticals and cocaine around the coastal submarine sewage outfall in Guaruj\u00e1, S\u00e3o Paulo State, Brazil","volume":"28","author":"Roveri","year":"2021","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"110810","DOI":"10.1016\/j.marpolbul.2019.110810","article-title":"Antibiotics in coastal water and sediments of the East China Sea: Distribution, ecological risk assessment and indicators screening","volume":"151","author":"Li","year":"2020","journal-title":"Mar. Pollut. Bull."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.scitotenv.2012.08.036","article-title":"Risk assessment on the presence of pharmaceuticals in sediments, soils and waters of the Pego-Oliva Marshlands (Valencia, eastern Spain)","volume":"440","author":"Andreu","year":"2012","journal-title":"Sci. Total Environ."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"12022","DOI":"10.1007\/s11356-018-1386-7","article-title":"Occurrence and assessment of the risk of ultraviolet filters and light stabilizers in Victorian estuaries","volume":"25","author":"Allinson","year":"2018","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.jenvman.2018.12.079","article-title":"Monitoring and environmental risk assessment of benzotriazole UV stabilizers in the sewage and coastal environment of Gran Canaria (Canary Islands, Spain)","volume":"233","year":"2019","journal-title":"J. Environ. Manag."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"135057","DOI":"10.1016\/j.scitotenv.2019.135057","article-title":"Priority and emerging micropollutants distribution from coastal to continental slope sediments: A case study of Capbreton Submarine Canyon (North Atlantic Ocean)","volume":"703","author":"Azaroff","year":"2020","journal-title":"Sci. Total Environ."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"32196","DOI":"10.1007\/s11356-018-3185-6","article-title":"The impact of propranolol, 17\u03b1-ethinylestradiol, and gemfibrozil on early life stages of marine organisms: Effects and risk assessment","volume":"25","author":"Capolupo","year":"2018","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.envint.2009.09.002","article-title":"Removal of pharmaceuticals during wastewater treatment and environmental risk assessment using hazard indexes","volume":"36","author":"Gros","year":"2010","journal-title":"Environ. Int."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"6663","DOI":"10.1007\/s10661-014-3881-8","article-title":"Occurrence of pharmaceuticals in urban wastewater of north Indian cities and risk assessment","volume":"186","author":"Singh","year":"2014","journal-title":"Environ. Monit. Assess."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.scitotenv.2016.03.063","article-title":"A first screening and risk assessment of pharmaceuticals and additives in personal care products in waste water, sludge, recipient water and sediment from Faroe Islands, Iceland and Greenland","volume":"562","author":"Huber","year":"2016","journal-title":"Sci. Total Environ."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.trac.2016.05.023","article-title":"Current sample preparation methodologies for analysis of emerging pollutants in different environmental matrices","volume":"82","author":"Dimpe","year":"2016","journal-title":"Trends Anal. Chem."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Sadutto, D., and Pic\u00f3, Y. (2020). Sample preparation to determine pharmaceutical and personal care products in an all-water matrix: Solid phase extraction. Molecules, 25.","DOI":"10.3390\/molecules25215204"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"130161","DOI":"10.1016\/j.chemosphere.2021.130161","article-title":"Screening of pharmaceuticals in coastal waters of the southern coast of Viti Levu in Fiji, South Pacific","volume":"276","author":"Dehm","year":"2021","journal-title":"Chemosphere"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"144642","DOI":"10.1016\/j.scitotenv.2020.144642","article-title":"Fate of antibiotics in engineered wastewater systems and receiving water environment: A case study on the coast of Hangzhou Bay, China","volume":"769","author":"Bao","year":"2021","journal-title":"Sci. Total Environ."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chroma.2004.10.110","article-title":"Liquid chromatography-tandem mass spectrometry for the analysis of pharmaceutical residues in environmental samples: A review","volume":"1067","author":"Hernando","year":"2005","journal-title":"J. Chromatogr. A"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ecss.2011.09.009","article-title":"Pharmaceuticals, alkylphenols and pesticides in Mediterranean coastal waters: Results from a pilot survey using passive samplers","volume":"114","author":"Munaron","year":"2012","journal-title":"Estuar. Coast. Shelf Sci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.scitotenv.2016.01.051","article-title":"Occurrence of pharmaceuticals and cocaine in a Brazilian coastal zone","volume":"548\u2013549","author":"Pereira","year":"2016","journal-title":"Sci. Total Environ."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.scitotenv.2013.12.123","article-title":"A year-long study of the spatial occurrence and relative distribution of pharmaceutical residues in sewage effluent, receiving marine waters and marine bivalves","volume":"476\u2013477","author":"McEneff","year":"2014","journal-title":"Sci. Total Environ."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"6709","DOI":"10.1016\/j.watres.2011.10.004","article-title":"Reconnaissance of selected PPCP compounds in Costa Rican surface waters","volume":"45","author":"Spongberg","year":"2011","journal-title":"Water Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1007\/s10646-009-0416-0","article-title":"Occurrence and distribution of steroids, hormones and selected pharmaceuticals in South Florida coastal environments","volume":"19","author":"Singh","year":"2010","journal-title":"Ecotoxicology"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"105633","DOI":"10.1016\/j.microc.2020.105633","article-title":"Ultrasound-assisted dispersive liquid-liquid microextraction for determination of enrofloxacin in surface waters","volume":"160","author":"Dias","year":"2021","journal-title":"Microchem. J."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.jhazmat.2011.03.092","article-title":"Occurrence and phase distribution of selected pharmaceuticals in the Yangtze Estuary and its coastal zone","volume":"190","author":"Yang","year":"2011","journal-title":"J. Hazard. Mater."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.envres.2015.02.016","article-title":"Seasonal distribution of pharmaceuticals in marine water and sediment from a mediterranean coastal lagoon (SE Spain)","volume":"138","author":"Gros","year":"2015","journal-title":"Environ. Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"145057","DOI":"10.1016\/j.scitotenv.2021.145057","article-title":"Emerging contaminants detected in aquaculture sites in Java, Indonesia","volume":"773","author":"Hidayati","year":"2021","journal-title":"Sci. Total Environ."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.envpol.2013.06.028","article-title":"Occurrence and distribution of pharmaceutically active and endocrine disrupting compounds in Singapore\u2019s marine environment: Influence of hydrodynamics and physical-chemical properties","volume":"182","author":"Bayen","year":"2013","journal-title":"Environ. Pollut."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.2134\/jeq2009.0189","article-title":"Occurrence of herbicides and pharmaceutical and personal care products in surface water and groundwater around Liberty Bay, Puget Sound, Washington","volume":"39","author":"Dougherty","year":"2010","journal-title":"J. Environ. Qual."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.envres.2014.10.019","article-title":"Personal care products and steroid hormones in the Antarctic coastal environment associated with two Antarctic research stations, McMurdo Station and Scott Base","volume":"136","author":"Emnet","year":"2015","journal-title":"Environ. Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.marpolbul.2014.06.024","article-title":"Polar organic micropollutants in the coastal environment of different marine systems","volume":"85","author":"Voutsa","year":"2014","journal-title":"Mar. Pollut. Bull."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.talanta.2014.11.071","article-title":"Determination of eight pharmaceuticals in an aqueous sample using automated derivatization solid-phase microextraction combined with gas chromatography-mass spectrometry","volume":"136","author":"Huang","year":"2015","journal-title":"Talanta"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"461171","DOI":"10.1016\/j.chroma.2020.461171","article-title":"A polymeric solid-phase microextraction fiber for the detection of pharmaceuticals in water samples","volume":"1623","author":"Wang","year":"2020","journal-title":"J. Chromatogr. A"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00216-017-0763-2","article-title":"Simultaneous determination of 41 multiclass organic pollutants in environmental waters by means of polyethersulfone microextraction followed by liquid chromatography\u2013tandem mass spectrometry","volume":"410","author":"Mijangos","year":"2018","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"4771","DOI":"10.1016\/j.chroma.2010.05.047","article-title":"Determination of hydroxylated benzophenone UV filters in sea water samples by dispersive liquid-liquid microextraction followed by gas chromatography-mass spectrometry","volume":"1217","author":"Tarazona","year":"2010","journal-title":"J. Chromatogr. A"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.aca.2013.12.033","article-title":"Determination of UV filters in both soluble and particulate fractions of seawaters by dispersive liquid-liquid microextraction followed by gas chromatography-mass spectrometry","volume":"812","author":"Chisvert","year":"2014","journal-title":"Anal. Chim. Acta"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.chroma.2019.01.013","article-title":"Simultaneous determination of synthetic musks and UV-filters in water matrices by dispersive liquid-liquid microextraction followed by gas chromatography tandem mass-spectrometry","volume":"1590","author":"Ramos","year":"2019","journal-title":"J. Chromatogr. A"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"9818","DOI":"10.1007\/s11356-020-07599-6","article-title":"An environmentally friendly strategy for determining organic ultraviolet filters in seawater using liquid-phase microextraction with liquid chromatography\u2013tandem mass spectrometry","volume":"27","author":"Ku","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s00216-012-5906-x","article-title":"On-line solid-phase extraction coupled to ultra-performance liquid chromatography with tandem mass spectrometry detection for the determination of benzotriazole UV stabilizers in coastal marine and wastewater samples","volume":"403","year":"2012","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chroma.2013.08.007","article-title":"Determination of trace levels of benzophenone-type ultra-violet filters in real matrices by bar adsorptive micro-extraction using selective sorbent phases","volume":"1311","author":"Almeida","year":"2013","journal-title":"J. Chromatogr. A"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1002\/jssc.201300191","article-title":"Development of a sensitive determination method for benzotriazole UV stabilizers in enviromental water samples with stir bar sorption extraction and liquid desorption prior to ultra-high performance liquid chromatography with tandem mass spectrometry","volume":"36","year":"2013","journal-title":"J. Sep. Sci."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.microc.2015.09.023","article-title":"Ultrasound-assisted emulsification microextraction followed by gas chromatography-mass spectrometry and gas chromatography-tandem mass spectrometry for the analysis of UV filters in water","volume":"124","author":"Vila","year":"2016","journal-title":"Microchem. J."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.chemosphere.2016.08.102","article-title":"Rapid monitoring of residual UV-stabilizers in seawater samples from beaches using fabric phase sorptive extraction and UHPLC-MS\/MS","volume":"164","author":"Kabir","year":"2016","journal-title":"Chemosphere"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.chroma.2018.06.016","article-title":"Development and optimization of a solid-phase microextraction gas chromatography\u2013tandem mass spectrometry methodology to analyse ultraviolet filters in beach sand","volume":"1564","author":"Vila","year":"2018","journal-title":"J. Chromatogr. A"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"10895","DOI":"10.1021\/es402574k","article-title":"Parabens in sediment and sewage sludge from the United States, Japan, and Korea: Spatial distribution and temporal trends","volume":"47","author":"Liao","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1002\/etc.2003","article-title":"Organic contaminants of emerging concern in sediments and flatfish collected near outfalls discharging treated wastewater effluent to the Southern California Bight","volume":"31","author":"Maruya","year":"2012","journal-title":"Environ. Toxicol. Chem."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1007\/s11368-014-0884-6","article-title":"Occurrence of pharmaceutical and personal care products (PPCPs) in marine sediments in the Todos os Santos Bay and the north coast of Salvador, Bahia, Brazil","volume":"14","author":"Beretta","year":"2014","journal-title":"J. Soils Sediments"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.envint.2013.01.009","article-title":"Method validation and reconnaissance of pharmaceuticals, personal care products, and alkylphenols in surface waters, sediments, and mussels in an urban estuary","volume":"54","author":"Klosterhaus","year":"2013","journal-title":"Environ. Int."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.scitotenv.2018.12.222","article-title":"Pharmaceuticals and personal care products in water, sediments, aquatic organisms, and fish feeds in the Pearl River Delta: Occurrence, distribution, potential sources, and health risk assessment","volume":"659","author":"Xie","year":"2019","journal-title":"Sci. Total Environ."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/etc.2281","article-title":"Quantification of pharmaceuticals, personal care products, and perfluoroalkyl substances in the marine sediments of Puget Sound, Washington, USA. Environ","volume":"32","author":"Long","year":"2013","journal-title":"Toxicol. Chem."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.marpolbul.2016.06.105","article-title":"Pharmaceutically active compounds and endocrine disrupting chemicals in water, sediments and mollusks in mangrove ecosystems from Singapore","volume":"109","author":"Bayen","year":"2016","journal-title":"Mar. Pollut. Bull."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.marpolbul.2014.01.022","article-title":"Occurrence, distribution and partitioning of nonionic surfactants and pharmaceuticals in the urbanized Long Island Sound Estuary (NY)","volume":"85","author":"Petrovic","year":"2014","journal-title":"Mar. Pollut. Bull."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.scitotenv.2013.08.039","article-title":"A survey of emerging contaminants in the estuarine receiving environment around Auckland, New Zealand","volume":"468\u2013469","author":"Stewart","year":"2014","journal-title":"Sci. Total Environ."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/bmc.1621","article-title":"Combination of microwave-assisted micellar extraction with liquid chromatography tandem mass spectrometry for the determination of fluoroquinolone antibiotics in coastal marine sediments and sewage sludges samples","volume":"26","year":"2012","journal-title":"Biomed. Chromatogr."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/jssc.201200664","article-title":"Microwave-assisted extraction combined with on-line solid phase extraction followed by ultra-high-performance liquid chromatography with tandem mass spectrometric determination of benzotriazole UV stabilizers in marine sediments and sewage sludges","volume":"36","year":"2013","journal-title":"J. Sep. Sci."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"De la Guardia, M., and Armenta, S. (2011). Greening Sample Treatments, Elsevier.","DOI":"10.1016\/B978-0-444-53709-6.00005-7"},{"key":"ref_133","unstructured":"Kataoka, H. (2019). Pharmaceutical analysis. Sample preparation. Encyclopedia of Analytical Science, Elsevier."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jhazmat.2018.09.047","article-title":"Development and application of retention time prediction models in the suspect and non-target screening of emerging contaminants","volume":"363","author":"Aalizadeh","year":"2019","journal-title":"J. Hazard. Mater."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"105708","DOI":"10.1016\/j.envint.2020.105708","article-title":"Retrospective screening of high-resolution mass spectrometry archived digital samples can improve environmental risk assessment of emerging contaminants: A case study on antifungal azoles","volume":"139","author":"Creusot","year":"2020","journal-title":"Environ. Int."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"6237","DOI":"10.1007\/s00216-015-8681-7","article-title":"Non-target screening with high-resolution mass spectrometry: Critical review using a collaborative trial on water analysis","volume":"407","author":"Schymanski","year":"2015","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1021\/es5002105","article-title":"Identifying small molecules via high resolution mass spectrometry: Communicating confidence","volume":"48","author":"Schymanski","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.chemosphere.2016.09.077","article-title":"Analysis of emerging contaminants in water and solid samples using high resolution mass spectrometry with a Q Exactive orbital ion trap and estrogenic activity with YES-assay","volume":"166","author":"Chappuis","year":"2017","journal-title":"Chemosphere"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.chroma.2015.04.052","article-title":"Micro-solid-phase extraction of organochlorine pesticides using porous metal-organic framework MIL-101 as sorbent","volume":"1401","author":"Huang","year":"2015","journal-title":"J. Chromatogr. A"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.talanta.2017.07.091","article-title":"Trace determination of volatile polycyclic aromatic hydrocarbons in natural waters by magnetic ionic liquid-based stir bar dispersive liquid microextraction","volume":"176","author":"Anderson","year":"2018","journal-title":"Talanta"}],"container-title":["Separations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2297-8739\/8\/7\/95\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:24:39Z","timestamp":1760163879000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2297-8739\/8\/7\/95"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,1]]},"references-count":140,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,7]]}},"alternative-id":["separations8070095"],"URL":"https:\/\/doi.org\/10.3390\/separations8070095","relation":{},"ISSN":["2297-8739"],"issn-type":[{"value":"2297-8739","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,1]]}}}