{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T20:28:12Z","timestamp":1770841692650,"version":"3.50.1"},"reference-count":45,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Portuguese Foundation for Science and Technology, I.P.","award":["UIDB\/04045\/2020"],"award-info":[{"award-number":["UIDB\/04045\/2020"]}]},{"name":"Portuguese Foundation for Science and Technology, I.P.","award":["UIDP\/04748\/2020"],"award-info":[{"award-number":["UIDP\/04748\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sports"],"abstract":"<jats:p>Alzheimer\u2019s disease is a type of dementia that progressively affects memory, thinking, and behavior. It can interfere with daily activities and lead to a decline in cognitive abilities over time. Exercise-based interventions can complement Alzheimer\u2019s disease treatment. Exercise is a valuable tool in all healthcare settings and has shown promise as an effective cognitive improvement intervention for people with cognitive impairments. This systematic review and meta-analysis aimed to analyze the effect of physical exercise on the QoL of subjects with Alzheimer\u2019s disease. A search was performed with the help of the electronic databases PubMed and Web of Science. Randomized controlled trials with exercise-based interventions were selected. Four studies met the inclusion criteria, which included interventions based on exercise. The effects were summarized using standardized mean differences (95% confidence intervals) using random-effect models. The results showed that exercise had no significant effect on the QoL of subjects with Alzheimer. Thus, the effect of exercise interventions on the QoL of patients with Alzheimer\u2019s disease is not conclusive. More research is needed about this topic and the way in which the QoL is assessed; the necessity to conduct an objective way to assess the QoL in this population is mandatory.<\/jats:p>","DOI":"10.3390\/sports11080149","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T10:11:22Z","timestamp":1691662282000},"page":"149","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of Exercise on Quality of Life in Subjects with Alzheimer\u2019s Disease: Systematic Review with Meta-Analysis of Randomized Clinical Trials"],"prefix":"10.3390","volume":"11","author":[{"given":"Mariana","family":"Mendes","sequence":"first","affiliation":[{"name":"Sport Sciences School of Rio Maior, Polytechnic of Santar\u00e9m (ESDRM), 2040-413 Rio Maior, Portugal"}]},{"given":"\u00c9rica","family":"Correia","sequence":"additional","affiliation":[{"name":"Sport Sciences School of Rio Maior, Polytechnic of Santar\u00e9m (ESDRM), 2040-413 Rio Maior, Portugal"}]},{"given":"Anabela","family":"Vitorino","sequence":"additional","affiliation":[{"name":"Sport Sciences School of Rio Maior, Polytechnic of Santar\u00e9m (ESDRM), 2040-413 Rio Maior, Portugal"},{"name":"Research Center in Sports Sciences, Health Sciences and Human Development (CIDESD), 5001-801 Vila Real, Portugal"},{"name":"Life Quality Research Center (CIEQV), 2040-413 Rio Maior, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7125-0865","authenticated-orcid":false,"given":"Jos\u00e9","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Sport Sciences School of Rio Maior, Polytechnic of Santar\u00e9m (ESDRM), 2040-413 Rio Maior, Portugal"},{"name":"Life Quality Research Center (CIEQV), 2040-413 Rio Maior, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8156-3291","authenticated-orcid":false,"given":"Lu\u00eds","family":"Cid","sequence":"additional","affiliation":[{"name":"Sport Sciences School of Rio Maior, Polytechnic of Santar\u00e9m (ESDRM), 2040-413 Rio Maior, Portugal"},{"name":"Research Center in Sports Sciences, Health Sciences and Human Development (CIDESD), 5001-801 Vila Real, Portugal"},{"name":"Life Quality Research Center (CIEQV), 2040-413 Rio Maior, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9875-6986","authenticated-orcid":false,"given":"Teresa","family":"Bento","sequence":"additional","affiliation":[{"name":"Sport Sciences School of Rio Maior, Polytechnic of Santar\u00e9m (ESDRM), 2040-413 Rio Maior, Portugal"},{"name":"Research Center in Sports Sciences, Health Sciences and Human Development (CIDESD), 5001-801 Vila Real, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5485-9430","authenticated-orcid":false,"given":"Raul","family":"Antunes","sequence":"additional","affiliation":[{"name":"Life Quality Research Center (CIEQV), 2040-413 Rio Maior, Portugal"},{"name":"ESECS, Polytechnic of Leiria, 2411-901 Leiria, Portugal"},{"name":"Center for Innovative Care and Health Technology (ciTechCare), Polytechnic of Leiria, 2411-901 Leiria, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7179-6814","authenticated-orcid":false,"given":"Diogo","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Research Center in Sports Sciences, Health Sciences and Human Development (CIDESD), 5001-801 Vila Real, Portugal"},{"name":"Life Quality Research Center (CIEQV), 2040-413 Rio Maior, Portugal"},{"name":"ESECS, Polytechnic of Leiria, 2411-901 Leiria, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8529-5546","authenticated-orcid":false,"given":"Nuno","family":"Couto","sequence":"additional","affiliation":[{"name":"Sport Sciences School of Rio Maior, Polytechnic of Santar\u00e9m (ESDRM), 2040-413 Rio Maior, Portugal"},{"name":"Research Center in Sports Sciences, Health Sciences and Human Development (CIDESD), 5001-801 Vila Real, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Alzheimer\u2019s Association (2018). Alzheimer\u2019s Disease Facts and Figures. Alzheimer\u2019s Dement., 14, 367\u2013429.","DOI":"10.1016\/j.jalz.2018.02.001"},{"key":"ref_2","unstructured":"WebMD (2022, December 27). Alzheimers. Available online: https:\/\/www.webmd.com\/alzheimers\/default.htm."},{"key":"ref_3","unstructured":"World Health Organization (2017). Global Action Plan on the Public Health Response to Dementia 2017\u20132025, World Health Organization."},{"key":"ref_4","unstructured":"Dire\u00e7\u00e3o Geral da Sa\u00fade (2015). Programa Nacional para a Promo\u00e7\u00e3o da Alimenta\u00e7\u00e3o Saud\u00e1vel, Dire\u00e7\u00e3o Geral da Sa\u00fade."},{"key":"ref_5","unstructured":"International, A.D., Wimo, A., Ali, G.-C., Guerchet, M., Prince, M., Prina, M., and Wu, Y.-T. (2015). World Alzheimer Report 2015: The Global Impact of Dementia: An Analysis of Prevalence, Incidence, Cost and Trends, Alzheimer\u2019s Disease International (ADI)."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s12264-019-00340-5","article-title":"Activation of the Brain to Postpone Dementia: A Concept Originating from Postmortem Human Brain Studies","volume":"35","author":"Zhu","year":"2019","journal-title":"Neurosci. Bull."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Alzheimer\u2019s Association (2022). Alzheimer\u2019s Disease Facts and Figures. Alzheimer\u2019s Dement., 18, 700\u2013789.","DOI":"10.1002\/alz.12638"},{"key":"ref_8","unstructured":"Georges, J., Bintener, C., and Miller, O. (2022, December 27). Dementia in Europe Yearbook 2019: Estimating the Prevalence of Dementia in Europe, Alzheimer Europe. Available online: https:\/\/www.alzheimer-europe.org\/resources\/publications\/dementia-europe-yearbook-2019-estimating-prevalence-dementia-europe."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/1467-9280.t01-1-01430","article-title":"Fitness Effects on the Cognitive Function of Older Adults: A Meta-Analytic Study","volume":"14","author":"Colcombe","year":"2003","journal-title":"Psychol. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1177\/153331750301800409","article-title":"The Effect of a Multisensory Exercise Program on Engagement, Behavior, and Selected Physiological Indexes in Persons with Dementia","volume":"18","author":"Heyn","year":"2003","journal-title":"Am. J. Alzheimers Dis. Other Demen."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1016\/j.apmr.2004.03.019","article-title":"The Effects of Exercise Training on Elderly Persons with Cognitive Impairment and Dementia: A Meta-Analysis","volume":"85","author":"Heyn","year":"2004","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/BF02982674","article-title":"Endurance and Strength Training Outcomes on Cognitively Impaired and Cognitively Intact Older Adults: A Meta-Analysis","volume":"12","author":"Heyn","year":"2008","journal-title":"J. Nutr. Health Aging"},{"key":"ref_13","unstructured":"World Health Organization (2022). Global Status Report on Physical Activity 2022, World Health Organization."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1159\/000491818","article-title":"Effects of Physical Activity in Nursing Home Residents with Dementia: A Randomized Controlled Trial","volume":"46","author":"Henskens","year":"2018","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"ref_15","unstructured":"WHO (2022, December 27). Whoqol\u2014Measuring Quality Of Life|The World Health Organization. Available online: https:\/\/www.who.int\/tools\/whoqol."},{"key":"ref_16","first-page":"601","article-title":"Effectiveness of Physical Exercise on Alzheimer\u2019s disease. A Systematic Review","volume":"9","year":"2022","journal-title":"J. Prev. Alzheimers Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1177\/0733464817693374","article-title":"Exercise and Quality of Life in Dementia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","volume":"38","author":"Ojagbemi","year":"2019","journal-title":"J. Appl. Gerontol."},{"key":"ref_18","first-page":"1593","article-title":"Physical activity can improve cognition in patients with Alzheimer\u2019s disease: A systematic review and meta-analysis of randomized controlled trials","volume":"13","author":"Du","year":"2018","journal-title":"Clin. Inter."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Jia, R.X., Liang, J.H., Xu, Y., and Wang, Y.Q. (2019). Effects of physical activity and exercise on the cognitive function of patients with Alzheimer disease: A meta-analysis. BMC Geriatr., 19.","DOI":"10.1186\/s12877-019-1175-2"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"560461","DOI":"10.3389\/fpsyg.2020.560461","article-title":"Physical activity for executive function and activities of daily living in AD patients: A systematic review and meta-analysis","volume":"11","author":"Zhu","year":"2020","journal-title":"Front. Psychol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"101479","DOI":"10.1016\/j.arr.2021.101479","article-title":"Exercise interventions in Alzheimer\u2019s disease: A systematic review and meta-analysis of randomized controlled trials","volume":"72","author":"Valenzuela","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s11556-019-0234-1","article-title":"Effect of 9 Weeks Continuous vs. Interval Aerobic Training on Plasma BDNF Levels, Aerobic Fitness, Cognitive Capacity and Quality of Life among Seniors with Mild to Moderate Alzheimer\u2019s Disease: A Randomized Controlled Trial","volume":"17","author":"Enette","year":"2020","journal-title":"Eur. Rev. Aging Phys. Act."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3233\/JAD-150817","article-title":"Moderate-to-High Intensity Physical Exercise in Patients with Alzheimer\u2019s Disease: A Randomized Controlled Trial","volume":"50","author":"Hoffmann","year":"2015","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 Statement: An Updated Guideline for Reporting Systematic Reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders, DSM-5; American Psychiatric Publishing. [5th ed.].","DOI":"10.1176\/appi.books.9780890425596"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"l4898","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: A revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","article-title":"Te Cochrane Collaboration\u2019s tool for assessing risk of bias in randomised trials","volume":"343","author":"Higgins","year":"2011","journal-title":"BMJ"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"k1675","DOI":"10.1136\/bmj.k1675","article-title":"Dementia And Physical Activity (Dapa) Trial of Moderate to High Intensity Exercise Training for People with Dementia: Randomised Controlled Trial","volume":"361","author":"Lamb","year":"2018","journal-title":"BMJ"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.2174\/1871527315666151111123319","article-title":"The Effects of Aerobic Exercise on Cognitive Function of Alzheimer\u2019s Disease Patients","volume":"14","author":"Yang","year":"2015","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ijnurstu.2019.02.019","article-title":"Effects of a Moderate-Intensity Aerobic Exercise Programme on the Cognitive Function and Quality of Life of Community-Dwelling Elderly People with Mild Cognitive Impairment: A Randomised Controlled Trial","volume":"93","author":"Song","year":"2019","journal-title":"Int. J. Nurs. Stud."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1001\/jamainternmed.2013.359","article-title":"Effects of the Finnish Alzheimer Disease Exercise Trial (FINALEX): A Randomized Controlled Trial","volume":"173","author":"Laakkonen","year":"2013","journal-title":"JAMA Intern. Med."},{"key":"ref_33","first-page":"1045","article-title":"Aerobic exercise improves quality of life, psychological well-being and systemic inflammation in subjects with Alzheimer\u2019s disease","volume":"16","year":"2016","journal-title":"Afr. Health Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3389\/fnins.2020.00131","article-title":"Relationship between Exercise and Alzheimer\u2019s Disease: A Narrative Literature Review","volume":"14","author":"Meng","year":"2020","journal-title":"Front. Neurosci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1007\/s12603-021-1665-8","article-title":"International Exercise Recommendations in Older Adults (ICFSR): Expert Consensus Guidelines","volume":"25","author":"Izquierdo","year":"2021","journal-title":"J. Nutr. Health Aging"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"927128","DOI":"10.3389\/fpsyt.2022.927128","article-title":"Effect of Physical Exercise on Cognitive Function of Alzheimer\u2019s Disease Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trial","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Psychiatry"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1097\/00002093-199404000-00015","article-title":"Quality of Life in Alzheimer Disease","volume":"8","author":"Lawton","year":"1994","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1159\/000079196","article-title":"A Model for Quality of Life Measures in Patients with Dementia: Lawton\u2019s next Step","volume":"18","author":"Jonker","year":"2004","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1007\/s11136-005-5416-9","article-title":"How Are Quality of Life Ratings Made? Toward a Model of Quality of Life in People with Dementia","volume":"15","author":"Bennett","year":"2006","journal-title":"Qual. Life Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1192\/bjp.bp.104.007658","article-title":"Quality of Life of People with Dementia in Residential Care Homes","volume":"188","author":"Hoe","year":"2006","journal-title":"Br. J. Psychiatry"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1046\/j.1532-5415.2001.49210.x","article-title":"The Relationship between Caregivers\u2019 Global Ratings of Alzheimer\u2019s Disease Patients\u2019 Quality of Life, Disease Severity, and the Caregiving Experience","volume":"49","author":"Karlawish","year":"2001","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1097\/00006842-200205000-00016","article-title":"Assessing Quality of Life in Older Adults with Cognitive Impairment","volume":"64","author":"Logsdon","year":"2002","journal-title":"Psychosom. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/00019442-200405000-00006","article-title":"What Explains Differences between Dementia Patients\u2019 and Their Caregivers\u2019 Ratings of Patients\u2019 Quality of Life?","volume":"12","author":"Sands","year":"2004","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/gps.1075","article-title":"Patient versus Informant Perspectives of Quality of Life in Mild Cognitive Impairment and Alzheimer\u2019s Disease","volume":"19","author":"Ready","year":"2004","journal-title":"Int. J. Geriat. Psychiatry"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/00002093-200310000-00002","article-title":"Whose Quality of Life Is It Anyway? The Validity and Reliability of the Quality of Life-Alzheimer\u2019s Disease (Qol-Ad) Scale","volume":"17","author":"Thorgrimsen","year":"2003","journal-title":"Alzheimer Dis. Assoc. Disord."}],"container-title":["Sports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4663\/11\/8\/149\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:29:59Z","timestamp":1760128199000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4663\/11\/8\/149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,9]]},"references-count":45,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2023,8]]}},"alternative-id":["sports11080149"],"URL":"https:\/\/doi.org\/10.3390\/sports11080149","relation":{},"ISSN":["2075-4663"],"issn-type":[{"value":"2075-4663","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,9]]}}}