{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T04:37:05Z","timestamp":1772080625441,"version":"3.50.1"},"reference-count":66,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T00:00:00Z","timestamp":1598227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER- 028425"],"award-info":[{"award-number":["POCI-01-0145-FEDER- 028425"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sustainability"],"abstract":"<jats:p>Ultraviolet (UV) filters are present in a broad range of personal hygiene products, which may be transported via aquatic environments and domestic wastewaters due to inefficient treating station sewage removal and direct human contact. The aim of the present study was to evaluate the potential effects of a UV filter, in particular benzophenone-3 (BP3) (also known as oxybenzone) on the mussel species Mytilus galloprovincialis. Mussels were exposed to this organic substance for 96 h in environmentally relevant concentrations (10, 100, and 1000 ng\/L). After exposure, biomarkers related with the mussels\u2019 metabolism and oxidative stress were evaluated. The results revealed significantly higher activity of electron transport system and energy reserves (glycogen and protein (PROT)) at the intermediate concentration of 100 ng\/L, suggesting that at lower concentrations mussels\u2019 metabolism was not activated due to low stress. Conversely, at the highest concentration (1000 ng\/L), mussels were no longer able to continue to increase their metabolic activity. Higher metabolic capacity was accompanied by increased PROT content associated with increased enzyme production to activate their antioxidant system. Nevertheless, at the highest concentration, cellular damage occurred as a consequence of ineffective activation of antioxidant and biotransformation enzymes. The results of the present study address uncertainties that are fundamental to the environmental risk assessment and management of these economically important near-shore bivalves and other marine species. Although an acute exposure was performed, alterations observed indicate the negative impacts of BP3 towards marine bivalves, which could be enhanced after longer exposure periods or if mussels are simultaneously exposed to other stressors (e.g., other pollutants or climate change related factors). The present study may thus contribute to the definition of fundamental knowledge for the establishment of appropriate regulatory guidelines and practices that ensure the preservation and sustainability of biological resources, allowing for prediction and mitigation of the impacts from these compounds.<\/jats:p>","DOI":"10.3390\/su12176852","type":"journal-article","created":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T10:37:32Z","timestamp":1598265452000},"page":"6852","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Impacts of UV Filters in Mytilus galloprovincialis: Preliminary Data on the Acute Effects Induced by Environmentally Relevant Concentrations"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4352-0068","authenticated-orcid":false,"given":"Diana","family":"Bordalo","sequence":"first","affiliation":[{"name":"Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"given":"Carla","family":"Leite","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal"},{"name":"Centre for Environmental and Marine Studies (CESAM), University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"given":"\u00c2ngela","family":"Almeida","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal"},{"name":"Centre for Environmental and Marine Studies (CESAM), University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0879-9470","authenticated-orcid":false,"given":"Amadeu M. V. M.","family":"Soares","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal"},{"name":"Centre for Environmental and Marine Studies (CESAM), University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"given":"Carlo","family":"Pretti","sequence":"additional","affiliation":[{"name":"Interuniversity Consortium of Marine Biology of Leghorn \u201cG. Bacci\u201d, 57128 Livorno, Italy"},{"name":"Department of Veterinary Sciences, University of Pisa, 56122 San Piero a Grado, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4900-3897","authenticated-orcid":false,"given":"Rosa","family":"Freitas","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal"},{"name":"Centre for Environmental and Marine Studies (CESAM), University of Aveiro, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1365-2133.2011.10298.x","article-title":"Sunscreen use: Controversies, challenges and regulatory aspects","volume":"165","author":"Beitner","year":"2011","journal-title":"Br. J. Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1159\/000064535","article-title":"Photocarcinogenesis: UVA vs. UVB Radiation","volume":"15","year":"2002","journal-title":"Ski. Pharmacol. Appl. Ski. Physiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1021\/ac202903d","article-title":"Environmental mass spectrometry: Emerging contaminants and current issues","volume":"84","author":"Richardson","year":"2012","journal-title":"Anal. Chem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1021\/es040055r","article-title":"Occurrence of some organic UV filters in wastewater, in surface waters, and in fish from Swiss lakes","volume":"39","author":"Balmer","year":"2005","journal-title":"Environ. Sci. Technol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"CIR (Cosmetic Ingredient Review) (2005). Annual Review of Cosmetic Ingredient Safety Assessments-2002\/20031. Int. J. Toxicol., 24, 1\u2013102.","DOI":"10.1080\/10915810590918625"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.aquatox.2008.08.018","article-title":"Estrogenic activity and reproductive effects of the UV-filter oxybenzone (2-hydroxy-4-methoxyphenyl-methanone) in fish","volume":"90","author":"Coronado","year":"2008","journal-title":"Aquat. Toxicol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"392A","DOI":"10.1021\/es040639t","article-title":"Scrutinizing Pharmaceuticals and personal care products in wastewater treatment","volume":"38","author":"Ternes","year":"2004","journal-title":"Environ. Sci. Technol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1289\/ehp.11269","article-title":"Concentrations of the sunscreen agent benzophenone-3 in residents of the United States: National Health and Nutrition Examination Survey 2003\u20132004","volume":"116","author":"Calafat","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.envpol.2019.05.133","article-title":"Environmental risks associated with contaminants of legacy and emerging concern at European aquaculture areas","volume":"252","author":"Aminot","year":"2019","journal-title":"Environ. Pollut."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"125887","DOI":"10.1016\/j.chemosphere.2020.125887","article-title":"Annual release of selected UV filters via effluent from wastewater treatment plants in Australia","volume":"247","author":"Verhagen","year":"2020","journal-title":"Chemosphere"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.envint.2015.10.004","article-title":"A review of organic UV-filters in wastewater treatment plants","volume":"86","author":"Ramos","year":"2016","journal-title":"Environ. Int."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jaad.2018.06.033","article-title":"Review of environmental effects of oxybenzone and other sunscreen active ingredients","volume":"80","author":"Schneider","year":"2019","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.chemosphere.2004.01.012","article-title":"Occurrence of UV filter compounds from sunscreens in surface waters: Regional mass balance in two Swiss lakes","volume":"55","author":"Poiger","year":"2004","journal-title":"Chemosphere"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.chroma.2003.10.114","article-title":"Determination of residues of UV filters in natural waters by solid-phase extraction coupled to liquid chromatography-photodiode array detection and gas chromatography-mass spectrometry","volume":"1026","author":"Giokas","year":"2004","journal-title":"J. Chromatogr. A"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.envint.2014.05.015","article-title":"Occurrences, toxicities, and ecological risks of benzophenone-3, a common component of organic sunscreen products: A mini-review","volume":"70","author":"Kim","year":"2014","journal-title":"Environ. Int."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0021-9673(01)00866-4","article-title":"Determination of the UV filters worldwide authorised in sunscreens by high-performance liquid chromatography: Use of cyclodextrins as mobile phase modifier","volume":"921","author":"Chisvert","year":"2001","journal-title":"J. Chromatogr. A"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.envint.2015.03.012","article-title":"Environmental occurrence and risk of organic UV filters and stabilizers in multiple matrices in Norway","volume":"80","author":"Langford","year":"2015","journal-title":"Environ. Int."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Tovar-S\u00e1nchez, A., S\u00e1nchez-Quiles, D., Basterretxea, G., Bened\u00e9, J.L., Chisvert, A., Salvador, A., Moreno-Garrido, I., and Blasco, J. (2013). Sunscreen Products as Emerging Pollutants to Coastal Waters. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0065451"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Juliano, C., and Magrini, G.A. (2017). Cosmetic ingredients as emerging pollutants of environmental and health concern. A mini-review. Cosmetics, 4.","DOI":"10.3390\/cosmetics4020011"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1504\/IJEP.2000.002311","article-title":"Development of biomarkers to detect the effects of organic pollution on aquatic invertebrates: Recent molecular, genotoxic, cellular and immunological studies on the common mussel (Mytilus edulis L.) and other mytilids","volume":"13","author":"Livingstone","year":"2000","journal-title":"Int. J. Environ. Pollut."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.oceano.2015.07.004","article-title":"Seasonal assessment of biological indices, bioaccumulation and bioavailability of heavy metals in mussels Mytilus galloprovincialis from Algerian west coast, applied to environmental monitoring","volume":"57","author":"Boutiba","year":"2015","journal-title":"Oceanologia"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.chemosphere.2017.09.144","article-title":"Bioaccumulation of UV filters in Mytilus galloprovincialis mussel","volume":"190","author":"Rodil","year":"2018","journal-title":"Chemosphere"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.chroma.2017.06.039","article-title":"Simultaneous determination of UV-filters and estrogens in aquatic invertebrates by modified quick, easy, cheap, effective, rugged, and safe extraction and liquid chromatography tandem mass spectrometry","volume":"1509","author":"He","year":"2017","journal-title":"J. Chromatogr. A"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1016\/j.scitotenv.2018.10.021","article-title":"Occurrence of antibiotics, estrogenic hormones, and UV-filters in water, sediment, and oyster tissue from the Chesapeake Bay","volume":"650","author":"He","year":"2019","journal-title":"Sci. Total Environ."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1289\/ehp.10966","article-title":"Sunscreens cause coral bleaching by promoting viral infections","volume":"116","author":"Danovaro","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ecoenv.2015.05.017","article-title":"Hepatic oxidative stress biomarker responses in freshwater fish Carassius auratus exposed to four benzophenone UV filters","volume":"119","author":"Liu","year":"2015","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.aquatox.2014.07.004","article-title":"Effects of benzophenone-3 exposure on endocrine disruptionand reproduction of Japanese medaka (Oryzias latipes)\u2014A two generation exposure study","volume":"155","author":"Kim","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"139102","DOI":"10.1016\/j.scitotenv.2020.139102","article-title":"Effects of the UV filter, oxybenzone, adsorbed to microplastics in the clam Scrobicularia plana","volume":"733","author":"Mestre","year":"2020","journal-title":"Sci. Total Environ."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"105295","DOI":"10.1016\/j.aquatox.2019.105295","article-title":"The toxicological effects of oxybenzone, an active ingredient in sun cream personal care products, on prokaryotic alga Arthrospira sp. and eukaryotic alga Chlorella sp.","volume":"216","author":"Zhong","year":"2019","journal-title":"Aquat. Toxicol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"105293","DOI":"10.1016\/j.aquatox.2019.105293","article-title":"Acute exposure to environmentally relevant concentrations of benzophenone-3 induced genotoxicity in Poecilia reticulata","volume":"216","author":"Almeida","year":"2019","journal-title":"Aquat. Toxicol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.chemosphere.2013.10.053","article-title":"Ecotoxicological evaluation of four UV filters using marine organisms from different trophic levels Isochrysis galbana, Mytilus galloprovincialis, Paracentrotus lividus, and Siriella armata","volume":"104","author":"Paredes","year":"2014","journal-title":"Chemosphere"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.4319\/lo.1975.20.5.0849","article-title":"Respiration and the respiratory electron transport in marine zooplankton","volume":"20","author":"King","year":"1975","journal-title":"Limnol. Oceanogr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1023\/A:1008228517955","article-title":"The use of biomarkers in Daphnia magna toxicity testing. IV. Cellular energy allocation: A new methodology to assess the energy budget of toxicant-stressed Daphnia populations","volume":"6","author":"Janssen","year":"1997","journal-title":"J. Aquat. Ecosyst. Stress Recovery"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0021-9258(18)73134-7","article-title":"The biuret reaction in the determination of serum proteins I. A study of the conditions necessary for the production of a stable color which bears a quantitative relationship to the protein concentration","volume":"135","author":"Robinson","year":"1940","journal-title":"J. Biol. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1021\/ac60111a017","article-title":"Calorimetric method for determination of sugars and related substances","volume":"28","author":"Dubois","year":"1956","journal-title":"Anal. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0003-2697(88)90554-4","article-title":"A spectrophotometric method for determination of catalase activity in small tissue samples","volume":"174","author":"Johansson","year":"1988","journal-title":"Anal. Biochem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.aquatox.2014.05.029","article-title":"Physiological and biochemical responses of the polychaete Diopatra neapolitana to organic matter enrichment","volume":"155","author":"Carregosa","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"ref_38","first-page":"158","article-title":"Studies on the quantitative and qualitative characterization of erythrocyte glutathione-peroxidase","volume":"70","author":"Paglia","year":"1967","journal-title":"J. Lab. Clin. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione S-transferases. The first enzymatic step in mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"J. Biol. Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0076-6879(78)52032-6","article-title":"Microsomal lipid peroxidation","volume":"52","author":"Buege","year":"1978","journal-title":"Methods Enzymol."},{"key":"ref_41","unstructured":"Anderson, M.J., Gorley, R.N., and Clarke, K.R. (2008). PERMANOVA+ for PRIMER: Guide to Software and Statistical Methods, PRIMER-E."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1046\/j.1365-2125.1999.00056.x","article-title":"Absorption of sunscreens across human skin: An evaluation of commercial products for children and adults","volume":"48","author":"Jiang","year":"1999","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.0022-202X.2004.22725.x","article-title":"Systemic absorption of the sunscreens benzophenone-3, octyl-methoxycinnamate, and 3-(4-methyl-benzylidene) camphor after whole-body topical application and reproductive hormone levels in humans","volume":"123","author":"Janjua","year":"2004","journal-title":"J. Investig. Dermatol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1126\/science.1138275","article-title":"Food Web-Specific Biomagnification of Persistent Organic Pollutants","volume":"317","author":"Kelly","year":"2007","journal-title":"Science"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/jat.2550150207","article-title":"Pharmacokinetics of benzophenone-3 after oral exposure in male rats","volume":"15","author":"Kadry","year":"1995","journal-title":"J. Appl. Toxicol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.tox.2008.02.009","article-title":"Toxicokinetics and metabolisms of benzophenone-type UV filters in rats","volume":"248","author":"Jeon","year":"2008","journal-title":"Toxicology"},{"key":"ref_47","first-page":"788","article-title":"Metabolism of benzophenone-3 in Rats","volume":"21","author":"Okereke","year":"1993","journal-title":"Drug Metab. Dispos."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"12532","DOI":"10.1021\/es4032908","article-title":"Characteristic Profiles of Benzonphenone-3 and its Derivatives in Urine of Children and Adults from the United States and China","volume":"47","author":"Wang","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0009-2797(01)00293-9","article-title":"Metabolism of 2-hydroxy-4-methoxybenzophenone in isolated rat hepatocytes and xenoestrogenic effects of its metabolites on MCF-7 human breast cancer cells","volume":"139","author":"Nakagawa","year":"2002","journal-title":"Chem.-Biol. Interact."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s00244-015-0227-7","article-title":"Toxicopathological effects of the sunscreen UV filter, oxybenzone (benzophenone-3), on coral planulae and cultured primary cells and its environmental contamination in Hawaii and the U.S. Virgin Islands","volume":"70","author":"Downs","year":"2016","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"114857","DOI":"10.1016\/j.envpol.2020.114857","article-title":"Toxic effects and transcriptome analyses of zebrafish (Danio rerio) larvae exposed to benzophenones","volume":"265","author":"Meng","year":"2020","journal-title":"Environ. Pollut."},{"key":"ref_52","first-page":"11","article-title":"Hypoxia, hyperoxia and exposure to potassium dichromate or fenitrothion alter the energy metabolism in Chironomus riparius Mg. (Diptera: Chironomidae larvae)","volume":"130","author":"Choi","year":"2001","journal-title":"Comp. Biochem. Physiol. Part C"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1023\/A:1017582119098","article-title":"Seasonal changes in the respiratory electron transport system (ETS) and respiration rate of the zebra mussel, Dreissena polymorpha in Saginaw Bay, Lake Huron","volume":"448","author":"Fanslow","year":"2001","journal-title":"Hydrobiologia"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41514-017-0013-z","article-title":"How does hormesis impact biology, toxicology, and medicine?","volume":"3","author":"Calabrese","year":"2017","journal-title":"NPJ Aging Mech. Dis."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.aquaculture.2005.07.008","article-title":"Seasonal changes in carbohydrate metabolism and its relationship with summer mortality of Pacific oyster Crassostrea gigas (Thunberg) in Marennes\u2013Ol\u00e9ron bay (France)","volume":"252","author":"Patrick","year":"2006","journal-title":"Aquaculture"},{"key":"ref_56","first-page":"441","article-title":"Biochemical composition of the parasitic amphipod Hyperia galba in relation to age and starvation","volume":"161","author":"Dittrich","year":"1991","journal-title":"J. Comp. Physiol. BBiochem. Syst. Environ. Physiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.ecoenv.2017.09.051","article-title":"Biochemical responses and accumulation patterns of Mytilus galloprovincialis exposed to thermal stress and Arsenic contamination","volume":"147","author":"Coppola","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/S0891-5849(00)00224-0","article-title":"Oxidative stress and cell cycle checkpoint function","volume":"28","author":"Shackelford","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.marenvres.2013.07.006","article-title":"Oxidative pathways of chemical toxicity and oxidative stress biomarkers in marine organisms","volume":"93","author":"Regoli","year":"2014","journal-title":"Mar. Environ. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.envpol.2008.10.019","article-title":"Contamination assessment of a coastal lagoon (Ria de Aveiro, Portugal) using defence and damage biochemical indicators in gill of Liza aurata\u2013An integrated biomarker approach","volume":"157","author":"Oliveira","year":"2009","journal-title":"Environ. Pollut."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.aquatox.2014.08.002","article-title":"Presence of the pharmaceutical drug carbamazepine in coastal systems: Effects on bivalves","volume":"156","author":"Almeida","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"4236","DOI":"10.1016\/j.jece.2018.06.032","article-title":"Toxicity effects of silver nanoparticles on the freshwater bivalve Corbicula fluminea","volume":"6","author":"Liu","year":"2018","journal-title":"J. Environ. Chem. Eng."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"117104","DOI":"10.1016\/j.saa.2019.05.009","article-title":"Molecular mechanism of CAT and SOD activity change under MPA-CdTe quantum dots induced oxidative stress in the mouse primary hepatocytes","volume":"220","author":"Hao","year":"2019","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_64","first-page":"287","article-title":"First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid","volume":"54","author":"Ighodaro","year":"2017","journal-title":"Alex. J. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3600001","article-title":"Structure, function and evolution of glutathione transferases: Implications for classification of non-mammalian members of an ancient enzyme superfamily","volume":"360","author":"Sheenan","year":"2001","journal-title":"Biochem. J."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ecoenv.2017.05.005","article-title":"Toxicity of organic UV-filters to the aquatic midge Chironomus riparius","volume":"143","author":"Campos","year":"2017","journal-title":"Ecotoxicol. Environ. Saf."}],"container-title":["Sustainability"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2071-1050\/12\/17\/6852\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:05:37Z","timestamp":1760177137000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2071-1050\/12\/17\/6852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,24]]},"references-count":66,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2020,9]]}},"alternative-id":["su12176852"],"URL":"https:\/\/doi.org\/10.3390\/su12176852","relation":{},"ISSN":["2071-1050"],"issn-type":[{"value":"2071-1050","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,24]]}}}