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To pursue this goal, the modulation of the lipid profile of black soldier fly larvae (Hermetia illucens) has received great attention. While its nutritional profile can shift with diet, the ability to modulate its lipidome is yet to be understood. The present work provides an overview of the lipid modulation of H. illucens larvae through its diet, aiming to produce a more suitable ingredient for marine aquafeeds. Marine-based substrates significantly improve the lipid profile of H. illucens larvae, namely its omega-3 fatty acids profile. An improvement of approximately 40% can be achieved using fish discards. Substantial levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), two essential fatty acids for marine fish and shrimp species, were recorded in H. illucens larvae fed on fish discards and coffee silverskin with Schyzochytrium sp. Unfortunately, these improvements are still deeply connected to marine-based bioresources, some still being too costly for use at an industrial scale (e.g., microalgae). New approaches using solutions from the biotechnology toolbox will be decisive to make H. illucens larvae a feasible alternative ingredient for marine aquafeeds without having to rely on marine bioresources.<\/jats:p>","DOI":"10.3390\/su14116472","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T02:30:06Z","timestamp":1653964206000},"page":"6472","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Improving the Lipid Profile of Black Soldier Fly (Hermetia illucens) Larvae for Marine Aquafeeds: Current State of Knowledge"],"prefix":"10.3390","volume":"14","author":[{"given":"Daniela P.","family":"Rodrigues","sequence":"first","affiliation":[{"name":"ECOMARE, CESAM\u2014Centre for Environmental and Marine Studies, Department of Biology, University of Aveiro, Santiago University Campus, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5422-1090","authenticated-orcid":false,"given":"Olga M. C. C.","family":"Ameixa","sequence":"additional","affiliation":[{"name":"ECOMARE, CESAM\u2014Centre for Environmental and Marine Studies, Department of Biology, University of Aveiro, Santiago University Campus, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1122-4726","authenticated-orcid":false,"given":"Jos\u00e9 Antonio","family":"V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Group of Recycling and Valorisation of Waste Materials (REVAL), Marine Research Institute (IIM-CSIC), C\/Eduardo Cabello, 6, 36208 Vigo, Galicia, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1670-9335","authenticated-orcid":false,"given":"Ricardo","family":"Calado","sequence":"additional","affiliation":[{"name":"ECOMARE, CESAM\u2014Centre for Environmental and Marine Studies, Department of Biology, University of Aveiro, Santiago University Campus, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,25]]},"reference":[{"key":"ref_1","first-page":"267","article-title":"Ecosystem services provided by the little things that run the world","volume":"5","author":"Ameixa","year":"2018","journal-title":"Sel. 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