{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:25:32Z","timestamp":1760232332705,"version":"build-2065373602"},"reference-count":129,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Portuguese Foundation for Science and Technology","award":["UIDB\/04033\/2020 (CITAB)","PT2020","CNPq 301964\/2019-0 Chamada 06\/2019","Chamada CNPq n 01\/2019","PT18 RT 3786"],"award-info":[{"award-number":["UIDB\/04033\/2020 (CITAB)","PT2020","CNPq 301964\/2019-0 Chamada 06\/2019","Chamada CNPq n 01\/2019","PT18 RT 3786"]}]},{"name":"FCT\/MEC","award":["UIDB\/04033\/2020 (CITAB)","PT2020","CNPq 301964\/2019-0 Chamada 06\/2019","Chamada CNPq n 01\/2019","PT18 RT 3786"],"award-info":[{"award-number":["UIDB\/04033\/2020 (CITAB)","PT2020","CNPq 301964\/2019-0 Chamada 06\/2019","Chamada CNPq n 01\/2019","PT18 RT 3786"]}]},{"name":"Coordena\u00e7\u00e3o Aperfei\u00e7oamento de Pessoal de Nivel Superior (CAPES), Funda\u00e7\u00e3o de \u00c1mparo \u00e0 Pesquisa do Estado de Sergipe (FAPITEC) (PROCESSO: 88887.159533\/2017-00 extra\u00e7\u00e3o, encapsula\u00e7\u00e3o e caracteriza\u00e7\u00e3o de bioativos para o interesse biotecnologico) and Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","award":["UIDB\/04033\/2020 (CITAB)","PT2020","CNPq 301964\/2019-0 Chamada 06\/2019","Chamada CNPq n 01\/2019","PT18 RT 3786"],"award-info":[{"award-number":["UIDB\/04033\/2020 (CITAB)","PT2020","CNPq 301964\/2019-0 Chamada 06\/2019","Chamada CNPq n 01\/2019","PT18 RT 3786"]}]},{"DOI":"10.13039\/501100011011","name":"Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["UIDB\/04033\/2020 (CITAB)","PT2020","CNPq 301964\/2019-0 Chamada 06\/2019","Chamada CNPq n 01\/2019","PT18 RT 3786"],"award-info":[{"award-number":["UIDB\/04033\/2020 (CITAB)","PT2020","CNPq 301964\/2019-0 Chamada 06\/2019","Chamada CNPq n 01\/2019","PT18 RT 3786"]}],"id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Technologies"],"abstract":"<jats:p>This paper presents a comprehensive review of the main types of vaccines approaching production technology, regulatory parameters, and the quality control of vaccines. Bioinformatic tools and computational strategies have been used in the research and development of new pharmaceutical products, reducing the time between supposed pharmaceutical product candidates (R&amp;D steps) and final products (to be marketed). In fact, in the reverse vaccinology field, in silico studies can be very useful in identifying possible vaccine targets from databases. In addition, in some cases (subunit or RNA\/ DNA vaccines), the in silico approach permits: (I) the evaluation of protein immunogenicity through the prediction of epitopes, (II) the potential adverse effects of antigens through the projection of similarity to host proteins, (III) toxicity and (IV) allergenicity, contributing to obtaining safe, effective, stable, and economical vaccines for existing and emerging infectious pathogens. Additionally, the rapid growth of emerging infectious diseases in recent years should be considered a driving force for developing and implementing new vaccines and reassessing vaccine schedules in companion animals, food animals, and wildlife disease control. Comprehensive and well-planned vaccination schedules are effective strategies to prevent and treat infectious diseases.<\/jats:p>","DOI":"10.3390\/technologies10050109","type":"journal-article","created":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T11:53:55Z","timestamp":1666612435000},"page":"109","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Production Technologies, Regulatory Parameters, and Quality Control of Vaccine Vectors for Veterinary Use"],"prefix":"10.3390","volume":"10","author":[{"given":"Raquel de M.","family":"Barbosa","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Federal University of Rio Grande do Norte, R. Gen. Gustavo Cordeiro de Faria, S\/N\u2014Petr\u00f3polis, Natal 59012-570, Brazil"},{"name":"Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Granada, Campus of Cartuja s\/n, 18071 Granada, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7524-9914","authenticated-orcid":false,"given":"Am\u00e9lia M.","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Biology and Environment, School of Life Sciences and Environment, University of Tr\u00e1s-os-Montes and Alto Douro (UTAD), 5001-801 Vila Real, Portugal"},{"name":"Centre for Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Tr\u00e1s-os-Montes and Alto Douro UTAD, 5001-801 Vila Real, Portugal"}]},{"given":"Classius F. da","family":"Silva","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Exatas e da Terra, Universidade Federal de S\u00e3o Paulo, Rua Arthur Riedel, 275 Diadema, S\u00e3o Paulo 09972-270, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0357-4144","authenticated-orcid":false,"given":"Juliana C.","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Laboratory of Nanotechnology and Nanomedicine (LNMED), Institute of Technology and Research (ITP), Av. Murilo Dantas, 300, Aracaju 49010-390, Brazil"},{"name":"Industrial Biotechnology Program, University of Tiradentes (UNIT), Av. Murilo Dantas 300, Aracaju 49032-490, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6527-6612","authenticated-orcid":false,"given":"Patricia","family":"Severino","sequence":"additional","affiliation":[{"name":"Laboratory of Nanotechnology and Nanomedicine (LNMED), Institute of Technology and Research (ITP), Av. Murilo Dantas, 300, Aracaju 49010-390, Brazil"},{"name":"Industrial Biotechnology Program, University of Tiradentes (UNIT), Av. Murilo Dantas 300, Aracaju 49032-490, Brazil"}]},{"given":"Lyghia M. A.","family":"Meirelles","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Federal University of Rio Grande do Norte, R. Gen. Gustavo Cordeiro de Faria, S\/N\u2014Petr\u00f3polis, Natal 59012-570, Brazil"}]},{"given":"Arnobio A. da","family":"Silva-Junior","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Federal University of Rio Grande do Norte, R. Gen. Gustavo Cordeiro de Faria, S\/N\u2014Petr\u00f3polis, Natal 59012-570, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2219-3566","authenticated-orcid":false,"given":"C\u00e9sar","family":"Viseras","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Granada, Campus of Cartuja s\/n, 18071 Granada, Spain"}]},{"given":"Joel","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, No. 228, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9737-6017","authenticated-orcid":false,"given":"Eliana B.","family":"Souto","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, No. 228, 4050-313 Porto, Portugal"},{"name":"REQUIMTE\/UCIBIO, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, No. 228, 4050-313 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,21]]},"reference":[{"unstructured":"Fine, A.H. 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