{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T22:03:53Z","timestamp":1776895433025,"version":"3.51.2"},"reference-count":22,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"COMPETE2020\/FEDER","award":["POCI-01-0247-FEDER-017875"],"award-info":[{"award-number":["POCI-01-0247-FEDER-017875"]}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/130203\/2017"],"award-info":[{"award-number":["SFRH\/BD\/130203\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>Surfaces with antimicrobial properties are gaining notoriety as an efficient method to avoid surface contamination. Self-disinfecting paints are a promising strategy towards cleaner indoor environments by preventing the colonization of walls with microorganisms. However, its widespread use needs an appropriate toxicological safety evaluation due to the potential for biological disturbance associated to its biocidal activity. In this work, the cyto- and genotoxic assessment of two self-disinfecting paints containing the antimicrobial substances triclosan (TCS) and isoborneol (ISB) is performed. HaCaT and A549 cell lines models were selected for the in vitro assessment. To evaluate the cytotoxicity, tests by direct contact and on extracts obtained from leaching were performed following ISO 10993, whereas the genotoxicity was assessed by comet assay and cytokinesis-block micronucleus (CBMN) assay. The results showed low levels of cyto- and genotoxicity under the models and conditions tested, indicating that these substances have commercial potential.<\/jats:p>","DOI":"10.3390\/toxics10020058","type":"journal-article","created":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T04:49:51Z","timestamp":1643258991000},"page":"58","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["In Vitro Cyto- and Genotoxicity Assessment of Antibacterial Paints with Triclosan and Isoborneol"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0285-6972","authenticated-orcid":false,"given":"Micaela","family":"Querido","sequence":"first","affiliation":[{"name":"Environmental Health Department, National Institute of Health, 4000-055 Porto, Portugal"},{"name":"EPIUnit, Institute of Public Health, University of Porto, 4050-600 Porto, Portugal"},{"name":"Laboratory for Integrative and Translational Research in Population Health (ITR), 4050-600 Porto, Portugal"},{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, University of Porto, 4050-313 Porto, Portugal"}]},{"given":"Fernanda","family":"Ros\u00e1rio","sequence":"additional","affiliation":[{"name":"Environmental Health Department, National Institute of Health, 4000-055 Porto, Portugal"},{"name":"EPIUnit, Institute of Public Health, University of Porto, 4050-600 Porto, Portugal"},{"name":"Laboratory for Integrative and Translational Research in Population Health (ITR), 4050-600 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5357-6167","authenticated-orcid":false,"given":"Maria","family":"Bessa","sequence":"additional","affiliation":[{"name":"Environmental Health Department, National Institute of Health, 4000-055 Porto, Portugal"},{"name":"EPIUnit, Institute of Public Health, University of Porto, 4050-600 Porto, Portugal"},{"name":"Laboratory for Integrative and Translational Research in Population Health (ITR), 4050-600 Porto, Portugal"},{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, University of Porto, 4050-313 Porto, Portugal"}]},{"given":"Francisca","family":"Mendes","sequence":"additional","affiliation":[{"name":"Environmental Health Department, National Institute of Health, 4000-055 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4802-7881","authenticated-orcid":false,"given":"Jos\u00e9","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Environmental Health Department, National Institute of Health, 4000-055 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8693-5250","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Environmental Health Department, National Institute of Health, 4000-055 Porto, Portugal"},{"name":"EPIUnit, Institute of Public Health, University of Porto, 4050-600 Porto, Portugal"},{"name":"Laboratory for Integrative and Translational Research in Population Health (ITR), 4050-600 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2146-1223","authenticated-orcid":false,"given":"Cristiana","family":"Pereira","sequence":"additional","affiliation":[{"name":"Environmental Health Department, National Institute of Health, 4000-055 Porto, Portugal"},{"name":"EPIUnit, Institute of Public Health, University of Porto, 4050-600 Porto, Portugal"},{"name":"Laboratory for Integrative and Translational Research in Population Health (ITR), 4050-600 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/lam.13127","article-title":"Biofilm Contamination of High-Touched Surfaces in Intensive Care Units: Epidemiology and Potential Impacts","volume":"68","author":"Costa","year":"2019","journal-title":"Lett. 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