{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T11:53:42Z","timestamp":1777118022893,"version":"3.51.4"},"reference-count":50,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["UID\/QUI\/UI0313\/2019"],"award-info":[{"award-number":["UID\/QUI\/UI0313\/2019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>The formation of complexes of the drug 5-fluorouracil (5-FU) with \u03b2-cyclodextrin (\u03b2-CD) and sodium dodecyl sulphate (SDS) was studied through experimental measurements of the ternary mutual diffusion coefficients (D11, D22, D12, and D21) for the systems {5-FU (component 1) + \u03b2-CD (component 2) + water} and {5-FU (component 1) + SDS (component 2) + water} at 298.15 K and at concentrations up to 0.05 mol dm\u22123 by using the Taylor dispersion method, with the objective of removing this polluting drug from the residual systems in which it was present. The results found showed that a coupled diffusion of 5-FU occurred with both \u03b2-CD and SDS, as indicated by the nonzero values of the cross-diffusion coefficients, D12 and D21, as a consequence of the complex formation between 5-FU and the \u03b2-CD or SDS species. That is, 5-FU was solubilized (encapsulated) by both carriers, although to a greater extent with SDS (K = 20.0 (\u00b10.5) mol\u22121 dm3) than with \u03b2-CD (K = 10.0 (\u00b10.5) mol\u22121 dm3). Values of 0.107 and 0.190 were determined for the maximum fraction of 5-FU solubilized with \u03b2-CD and SDS (at concentrations above its CMC), respectively. This meant that SDS was more efficient at encapsulating and thus removing the 5-FU drug.<\/jats:p>","DOI":"10.3390\/toxics10060300","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T21:43:42Z","timestamp":1654119822000},"page":"300","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Complexation of 5-Fluorouracil with \u03b2-Cyclodextrin and Sodium Dodecyl Sulfate: A Useful Tool for Encapsulating and Removing This Polluting Drug"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2912-0028","authenticated-orcid":false,"given":"Ana","family":"Cabral","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Department of Chemistry, CQC, Institute of Molecular Sciences, University of Coimbra, 3004-535 Coimbra, Portugal"}]},{"given":"Ana","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Department of Chemistry, CQC, Institute of Molecular Sciences, University of Coimbra, 3004-535 Coimbra, Portugal"}]},{"given":"Neuza","family":"Joaquim","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal"}]},{"given":"Francisco","family":"Veiga","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2005-8990","authenticated-orcid":false,"given":"Sara","family":"Sofio","sequence":"additional","affiliation":[{"name":"Department of Chemistry, CQC, Institute of Molecular Sciences, University of Coimbra, 3004-535 Coimbra, Portugal"}]},{"given":"Isabel","family":"Paiva","sequence":"additional","affiliation":[{"name":"Centre of Geography and Spatial Planning, Department of Geography and Tourism, University of Coimbra, 3004-530 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9736-3999","authenticated-orcid":false,"given":"Miguel","family":"Esteso","sequence":"additional","affiliation":[{"name":"Universidad Cat\u00f3lica de \u00c1vila, Calle los Canteros s\/n, 05005 \u00c1vila, Spain"},{"name":"U.D. Qu\u00edmica F\u00edsica, Universidad de Alcal\u00e1, 28805 Alcal\u00e1 de Henares, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9787-0843","authenticated-orcid":false,"given":"M.","family":"Rodrigo","sequence":"additional","affiliation":[{"name":"U.D. Qu\u00edmica F\u00edsica, Universidad de Alcal\u00e1, 28805 Alcal\u00e1 de Henares, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4612-7686","authenticated-orcid":false,"given":"Artur","family":"Valente","sequence":"additional","affiliation":[{"name":"Department of Chemistry, CQC, Institute of Molecular Sciences, University of Coimbra, 3004-535 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3005-1963","authenticated-orcid":false,"given":"Ana","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Chemistry, CQC, Institute of Molecular Sciences, University of Coimbra, 3004-535 Coimbra, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1634\/theoncologist.7-4-288","article-title":"Clinical Studies of Three Oral Prodrugs of 5-Fluorouracil (Capecitabine, UFT, S-1): A Review","volume":"7","author":"Martino","year":"2002","journal-title":"Oncologist"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1016\/j.bmcl.2012.03.031","article-title":"Development of hydrocortisone succinic acid\/and 5-fluorouracil\/chitosan microcapsules for oral and topical drug deliveries","volume":"22","author":"Lam","year":"2012","journal-title":"Bioorg. 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