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Tecnologia","doi-asserted-by":"publisher","award":["CEECINST\/00098\/2018"],"award-info":[{"award-number":["CEECINST\/00098\/2018"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>Portugal mainland and Atlantic archipelagos (Madeira and Azores) provide a wide array of coastal ecosystems with varying typology and degrees of human pressure, which shape the microbial communities thriving in these habitats, leading to the development of microbial resistance traits. The samples collected on the Portuguese northeast Atlantic coast waters show an unequivocal prevalence of Bacteria over Archaea with a high prevalence of Proteobacteria, Cyanobacteria, Bacteroidetes and Actinobacteria. Several taxa, such as the Vibrio genus, showed significant correlations with anthropogenic pollution. These anthropogenic pressures, along with the differences in species diversity among the surveyed sites, lead to observed differences in the presence and resistance-related sequences\u2019 abundance (set of all metal and antibiotic resistant genes and their precursors in pathogenic and non-pathogenic bacteria). Gene ontology terms such as antibiotic resistance, redox regulation and oxidative stress response were prevalent. A higher number of significant correlations were found between the abundance of resistance-related sequences and pollution, inorganic pressures and density of nearby population centres when compared to the number of significant correlations between taxa abundance at different phylogenetic levels and the same environmental traits. This points towards predominance of the environmental conditions over the sequence abundance rather than the taxa abundance. Our data suggest that the whole resistome profile can provide more relevant or integrative answers in terms of anthropogenic disturbance of the environment, either as a whole or grouped in gene ontology groups, appearing as a promising tool for impact assessment studies which, due to the ubiquity of the sequences across microbes, can be surveyed independently of the taxa present in the samples.<\/jats:p>","DOI":"10.3390\/toxics10100613","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T05:08:02Z","timestamp":1665983282000},"page":"613","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Unravelling the Portuguese Coastal and Transitional Waters\u2019 Microbial Resistome as a Biomarker of Differential Anthropogenic Impact"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1914-7435","authenticated-orcid":false,"given":"Bernardo","family":"Duarte","sequence":"first","affiliation":[{"name":"MARE\u2014Marine and Environmental Sciences Centre and ARNET\u2014Aquatic Research Infrastructure Network Associated Laboratory, Faculdade de Ci\u00eancias da Universidade de Lisboa, Campo Grande, 1749-016 Lisbon, Portugal"},{"name":"Departamento de Biologia Vegetal, Faculdade de Ci\u00eancias da Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8156-7700","authenticated-orcid":false,"given":"Andreia","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Departamento de Biologia Vegetal, Faculdade de Ci\u00eancias da Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal"},{"name":"BioISI\u2014Biosystems and Integrative Sciences Institute, Plant Functional Genomics Group, Departamento de Biologia Vegetal, Faculdade de Ci\u00eancias da Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2355-9638","authenticated-orcid":false,"given":"Patr\u00edcio","family":"Ramalhosa","sequence":"additional","affiliation":[{"name":"MARE\u2014Marine and Environmental Sciences Centre and ARNET\u2014Aquatic Research Infrastructure Network Associated Laboratory, Ag\u00eancia Regional para o Desenvolvimento da Investiga\u00e7\u00e3o Tecnologia e Inova\u00e7\u00e3o (ARDITI), Edif\u00edcio Madeira Tecnopolo Piso 0, Caminho da Penteada, 9020-105 Funchal, Portugal"},{"name":"OOM\u2014Oceanic Observatory of Madeira, Ag\u00eancia Regional para o Desenvolvimento da Investiga\u00e7\u00e3o Tecnologia e Inova\u00e7\u00e3o (ARDITI), Edif\u00edcio Madeira Tecnopolo Piso 0, Caminho da Penteada, 9020-105 Funchal, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2143-6535","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Canning-Clode","sequence":"additional","affiliation":[{"name":"MARE\u2014Marine and Environmental Sciences Centre and ARNET\u2014Aquatic Research Infrastructure Network Associated Laboratory, Ag\u00eancia Regional para o Desenvolvimento da Investiga\u00e7\u00e3o Tecnologia e Inova\u00e7\u00e3o (ARDITI), Edif\u00edcio Madeira Tecnopolo Piso 0, Caminho da Penteada, 9020-105 Funchal, Portugal"},{"name":"Smithsonian Environmental Research Center, 647 Contees Wharf Road, Edgewater, MD 21037, USA"}]},{"given":"Isabel","family":"Ca\u00e7ador","sequence":"additional","affiliation":[{"name":"MARE\u2014Marine and Environmental Sciences Centre and ARNET\u2014Aquatic Research Infrastructure Network Associated Laboratory, Faculdade de Ci\u00eancias da Universidade de Lisboa, Campo Grande, 1749-016 Lisbon, Portugal"},{"name":"Departamento de Biologia Vegetal, Faculdade de Ci\u00eancias da Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6374-1194","authenticated-orcid":false,"given":"Vanessa F.","family":"Fonseca","sequence":"additional","affiliation":[{"name":"MARE\u2014Marine and Environmental Sciences Centre and ARNET\u2014Aquatic Research Infrastructure Network Associated Laboratory, Faculdade de Ci\u00eancias da Universidade de Lisboa, Campo Grande, 1749-016 Lisbon, Portugal"},{"name":"Departamento de Biologia Animal, Faculdade de Ci\u00eancias da Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"733","DOI":"10.3389\/fmars.2021.658434","article-title":"Applying Limnological Feature-Based Machine Learning Techniques to Chemical State Classification in Marine Transitional Systems","volume":"8","author":"Concepcion","year":"2021","journal-title":"Front. 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