{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T18:43:54Z","timestamp":1775069034034,"version":"3.50.1"},"reference-count":32,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T00:00:00Z","timestamp":1626912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Coordena\u00e7\u00e3o Aperfei\u00e7oamento de Pessoal de Nivel Superior (CAPES) and Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Sergipe (FAPITEC)","award":["88887.159533\/2017-00"],"award-info":[{"award-number":["88887.159533\/2017-00"]}]},{"name":"Portuguese Science and Technology Foundation (FCT\/MCT) and European Funds (PRODER\/COMPETE)","award":["UIDB\/04469\/2020"],"award-info":[{"award-number":["UIDB\/04469\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxics"],"abstract":"<jats:p>Multi-Walled Carbon Nanotubes (MWCNT) have been functionalized with rutin through three steps (i. reaction step; ii. purification step; iii. drying step) and their physicochemical properties investigated with respect to morphological structure, thermal analysis, Fourier Transform Infrared Spectroscopy (FTIR), and cytotoxicity. The molecular docking suggested the rutin-functionalized MWCNT occurred by hydrogen bonds, which was confirmed by FTIR assays, corroborating the results obtained by thermal analyses. A tubular shape, arranged in a three-dimensional structure, could be observed. Mild cytotoxicity observed in 3T3 fibroblasts suggested a dose\u2013effect relationship after exposure. These findings suggest the formation of aggregates of filamentous structures on the cells favoring the cell penetration.<\/jats:p>","DOI":"10.3390\/toxics9080173","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T22:37:14Z","timestamp":1626993434000},"page":"173","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Rutin-Functionalized Multi-Walled Carbon Nanotubes: Molecular Docking, Physicochemistry and Cytotoxicity in Fibroblasts"],"prefix":"10.3390","volume":"9","author":[{"given":"Conrado","family":"Neto","sequence":"first","affiliation":[{"name":"Institute of Technology and Research (ITP), University of Tiradentes (UNIT), Av. Murilo Dantas, 300, Aracaju 49010-390, Brazil"}]},{"given":"Felipe","family":"Lima","sequence":"additional","affiliation":[{"name":"Institute of Technology and Research (ITP), University of Tiradentes (UNIT), Av. Murilo Dantas, 300, Aracaju 49010-390, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6341-9365","authenticated-orcid":false,"given":"Renata","family":"Morais","sequence":"additional","affiliation":[{"name":"Institute of Technology and Research (ITP), University of Tiradentes (UNIT), Av. Murilo Dantas, 300, Aracaju 49010-390, Brazil"}]},{"given":"Lucas","family":"de Andrade","sequence":"additional","affiliation":[{"name":"Institute of Technology and Research (ITP), University of Tiradentes (UNIT), Av. Murilo Dantas, 300, Aracaju 49010-390, Brazil"}]},{"given":"Renata","family":"de Lima","sequence":"additional","affiliation":[{"name":"School of Bioprocess Engineering and Biotechnology, Sorocaba University, Rodovia Raposo Tavares km 92, Sorocaba 18023-000, S\u00e3o Paulo, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3618-8415","authenticated-orcid":false,"given":"Marco","family":"Chaud","sequence":"additional","affiliation":[{"name":"School of Bioprocess Engineering and Biotechnology, Sorocaba University, Rodovia Raposo Tavares km 92, Sorocaba 18023-000, S\u00e3o Paulo, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3524-6900","authenticated-orcid":false,"given":"Matheus","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Chemistry, CICECO\u2014Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"given":"Ricardo","family":"de Albuquerque J\u00fanior","sequence":"additional","affiliation":[{"name":"Institute of Technology and Research (ITP), University of Tiradentes (UNIT), Av. 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