{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T10:58:41Z","timestamp":1776077921390,"version":"3.50.1"},"reference-count":106,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2018,1,20]],"date-time":"2018-01-20T00:00:00Z","timestamp":1516406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>Picocyanobacteria are extremely important organisms in the world\u2019s oceans and freshwater ecosystems. They play an essential role in primary production and their domination in phytoplankton biomass is common in both oligotrophic and eutrophic waters. Their role is expected to become even more relevant with the effect of climate change. However, this group of photoautotrophic organisms still remains insufficiently recognized. Only a few works have focused in detail on the occurrence of massive blooms of picocyanobacteria, their toxicity and allelopathic activity. Filling the gap in our knowledge about the mechanisms involved in the proliferation of these organisms could provide a better understanding of aquatic environments. In this review, we gathered and described recent information about allelopathic activity of picocyanobacteria and occurrence of their massive blooms in many aquatic ecosystems. We also examined the relationships between climate change and representative picocyanobacterial genera from freshwater, brackish and marine ecosystems. This work emphasizes the importance of studying the smallest picoplanktonic fractions of cyanobacteria.<\/jats:p>","DOI":"10.3390\/toxins10010048","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T04:51:13Z","timestamp":1516596673000},"page":"48","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Allelopathic and Bloom-Forming Picocyanobacteria in a Changing World"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3147-6605","authenticated-orcid":false,"given":"Sylwia","family":"\u015aliwi\u0144ska-Wilczewska","sequence":"first","affiliation":[{"name":"Institute of Oceanography, Faculty of Oceanography and Geography, University of Gdansk, Av. Pilsudskiego 46, 81-378 Gdynia, Poland"}]},{"given":"Jakub","family":"Maculewicz","sequence":"additional","affiliation":[{"name":"Institute of Oceanography, Faculty of Oceanography and Geography, University of Gdansk, Av. Pilsudskiego 46, 81-378 Gdynia, Poland"}]},{"given":"Aldo","family":"Barreiro Felpeto","sequence":"additional","affiliation":[{"name":"Interdisciplinary Center of Marine and Environmental Research\u2013CIMAR\/CIIMAR, University of Porto, Av. General Norton de Matos s\/n, 4450-208 Matosinhos, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6092-887X","authenticated-orcid":false,"given":"Adam","family":"Lata\u0142a","sequence":"additional","affiliation":[{"name":"Institute of Oceanography, Faculty of Oceanography and Geography, University of Gdansk, Av. Pilsudskiego 46, 81-378 Gdynia, Poland"}]}],"member":"1968","published-online":{"date-parts":[[2018,1,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.4081\/jlimnol.2010.257","article-title":"Single cells and microcolonies of freshwater picocyanobacteria: A common ecology","volume":"69","author":"Callieri","year":"2010","journal-title":"J. Limnol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s10750-012-1278-7","article-title":"Occurrence of cyanobacteria and cyanotoxin in the Southern Baltic Proper. Filamentous cyanobacteria versus single-celled picocyanobacteria","volume":"701","author":"Sutryk","year":"2013","journal-title":"Hydrobiologia"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1126\/science.aaj1751","article-title":"A plankton bloom shifts as the ocean warms","volume":"354","author":"Worden","year":"2016","journal-title":"Science"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"9824","DOI":"10.1073\/pnas.1307701110","article-title":"Present and future global distributions of the marine Cyanobacteria Prochlorococcus and Synechococcus","volume":"110","author":"Flombaum","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"765","DOI":"10.4319\/lo.1988.33.4_part_2.0765","article-title":"Phototrophic picoplankton: An overview from marine and freshwater ecosystems","volume":"33","author":"Stockner","year":"1988","journal-title":"Limnol. Oceanogr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1139\/f86-184","article-title":"Phosphate uptake rates of phytoplankton assemblages grown at different dilution rates in semi-continuous culture","volume":"43","author":"Suttle","year":"1986","journal-title":"Can. J. Fish Aquat. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"6281","DOI":"10.1128\/jb.176.20.6281-6285.1994","article-title":"Reciprocal light-dark transcriptional control of nif and rbc expression and light-dependent posttranslational control of nitrogenase activity in Synechococcus sp. strain RF-1","volume":"176","author":"Chow","year":"1994","journal-title":"J. Bacteriol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1126\/science.1133471","article-title":"Small phytoplankton and carbon export from the surface ocean","volume":"315","author":"Richardson","year":"2007","journal-title":"Science"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4081\/jlimnol.2002.1","article-title":"Freshwater autotrophic picoplankton: A review","volume":"61","author":"Callieri","year":"2002","journal-title":"J. Limnol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Meriluoto, J., Spoof, L., and Codd, G.A. (2017). Picocyanobacteria. Handbook on Cyanobacterial Monitoring and Cyanotoxin Analysis, John Wiley & Sons, Ltd.","DOI":"10.1002\/9781119068761"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jmarsys.2012.09.006","article-title":"Ecology and trophic preference of picoplankton and nanoplankton in the Gulf of Mannar and the Palk Bay, southeast coast of India","volume":"111\u2013112","author":"Jyothibabu","year":"2013","journal-title":"J. Mar. Syst."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Motwani, N.H., and Gorokhova, E. (2013). Mesozooplankton grazing on picocyanobacteria in the Baltic Sea as inferred from molecular diet analysis. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0079230"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1023\/B:HYDR.0000033096.14267.43","article-title":"Bloom of picocyanobacteria in the Venice lagoon during summer-autumn 2001: Ecological sequences","volume":"523","author":"Sorokin","year":"2004","journal-title":"Hydrobiologia"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.5194\/hess-18-1073-2014","article-title":"Dynamics of auto- and heterotrophic picoplankton and associated viruses in Lake Geneva","volume":"18","author":"Parvathi","year":"2014","journal-title":"Hydrol. Earth. Syst. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1093\/plankt\/fbn059","article-title":"Dynamics of phosphorus in the Venice lagoon during a picocyanobacteria bloom","volume":"30","author":"Sorokin","year":"2008","journal-title":"J. Plankton Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1099\/mic.0.2008\/019836-0","article-title":"Picocyanobacterial community structure of freshwater lakes and the Baltic Sea revealed by phylogenetic analyses and clade-specificquantitative PCR","volume":"154","author":"Handley","year":"2008","journal-title":"Microbiology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1038\/nclimate2722","article-title":"Impact of ocean acidification on the structure of future phytoplankton communities","volume":"5","author":"Dutkiewicz","year":"2015","journal-title":"Nat. Clim. Chang."},{"key":"ref_18","unstructured":"Beardall, J. (2008). Blooms of Synechococcus: An Analysis of the Problem Worldwide and Possible Causative Factors in Relation to Nuisance Blooms in the Gippsland Lakes, Monash University."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.hal.2011.10.027","article-title":"The rise of harmful cyanobacteria blooms: The potential roles of eutrophication and climate change","volume":"14","author":"Davis","year":"2012","journal-title":"Harmful Algae"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Brutemark, A., Vandelannoote, A., Engstr\u00f6m-\u00d6st, J., and Suikkanen, S. (2015). A less saline Baltic Sea promotes cyanobacterial growth, hampers intracellular microcystin production and leads to strain-specific differences in allelopathy. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0128904"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1126\/science.1155398","article-title":"Blooms like it hot","volume":"320","author":"Paerl","year":"2008","journal-title":"Science"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s11099-014-0024-y","article-title":"Effects of light intensity and temperature on the photosynthetic irradiance response curves and chlorophyll fluorescence in three picocyanobacterial strains of Synechococcus","volume":"52","year":"2014","journal-title":"Photosynthetica"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.0022-3646.1996.00549.x","article-title":"Changes in photosynthesis in response to combined irradiance and temperature stress in cyanobacterial surface waterblooms","volume":"32","author":"Ibelings","year":"1996","journal-title":"J. Phycol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"179","DOI":"10.2216\/i0031-8884-9-2-179.1","article-title":"The survival of axenic cultures of marine planktonic algae from prolonged exposure to darkness at 20 \u00b0C","volume":"9","author":"Antia","year":"1970","journal-title":"Phycologia"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/BF02011452","article-title":"Effects of temperature on the darkness survival of marine microplanktonic algae","volume":"3","author":"Antia","year":"1976","journal-title":"Microb. Ecol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/0198-0149(87)90001-X","article-title":"Effect of irradiances up to 2000 \u03bcE m\u22122 s\u22121 on marine Synechococcus WH7803-I. Growth, pigmentation and cell composition","volume":"34","author":"Kana","year":"1987","journal-title":"Deep Sea Res. Part I"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1016\/j.csr.2003.06.001","article-title":"BASIC: Baltic Sea cyanobacteria. An investigation of the structure and dynamics of water blooms of cyanobacteria in the Baltic Sea\u2014Responses to a changing environment","volume":"23","author":"Stal","year":"2003","journal-title":"Cont. Shelf Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/iroh.201501819","article-title":"Allelopathic activity of the picocyanobacterium Synechococcus sp. under varied light, temperature and salinity conditions","volume":"101","author":"Pniewski","year":"2016","journal-title":"Int. Rev. Hydrobiol."},{"key":"ref_29","first-page":"241","article-title":"Allelopathic interactions between Synechococcus sp. and Nodularia spumigena under different light conditions","volume":"37","author":"Pniewski","year":"2016","journal-title":"Allelopath. J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1093\/plankt\/fbh038","article-title":"Phytoplankton and zooplankton seasonal dynamics in a subtropical estuary: Importance of cyanobacteria","volume":"26","author":"Murrell","year":"2004","journal-title":"J. Plankton Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1093\/plankt\/fbi061","article-title":"Phytoplankton seasonal dynamics in a Mediterranean coastal lagoon: Emphasis on the picoeukaryote community","volume":"27","author":"Bec","year":"2005","journal-title":"J. Plankton Res."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Hudnell, K.H. (2008). Global warming and cyanobacterial harmful algal booms. Cyanobacterial Harmful Algal Blooms: State of the Science and Research Needs, Springer. Advances in Experimental Medicine and Biology.","DOI":"10.1007\/978-0-387-75865-7"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1758-2229.2008.00004.x","article-title":"Climate change: A catalyst for global expansion of harmful cyanobacterial blooms","volume":"1","author":"Paerl","year":"2009","journal-title":"Eviron. Microb. Rep."},{"key":"ref_34","unstructured":"Houghton, J.T., Ding, Y., Griggs, D.J., Noguer, M., Van der Lin-den, P.J., Dai, X., Maskell, K., and Johnson, C.A. (2001). Climate Change 2001: The Scientific Basis, Cambridge University Press."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3354\/meps116259","article-title":"Comparative physiology of Synechococcus and Prochlorococcus: Influence of light and temperature on growth, pigments, fluorescence and absorptive properties","volume":"116","author":"Moore","year":"1995","journal-title":"Mar. Ecol. Prog. Ser."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ecss.2016.05.014","article-title":"First mesocosm experiments to study the impacts of ocean acidification on plankton communities in the NW Mediterranean Sea (MedSeA project)","volume":"186","author":"Gazeau","year":"2017","journal-title":"Estuar. Coast. Shelf Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3389\/fmicb.2012.00213","article-title":"Diversity and distribution of marine Synechococcus: Multiple gene phylogenies for consensus classification and development of qPCR assays for sensitive measurement of clades in the ocean","volume":"3","author":"Ahlgren","year":"2012","journal-title":"Front. Microbiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1461-0248.2007.01026.x","article-title":"Colourful coexistence of red and green picocyanobacteria in lakes and seas","volume":"10","author":"Stomp","year":"2007","journal-title":"Ecol. Lett."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1462-2920.2007.01442.x","article-title":"Diversity and phylogeny of Baltic Sea picocyanobacteria inferred from their ITS and phycobiliprotein operons","volume":"10","author":"Haverkamp","year":"2008","journal-title":"Environ. Microbiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/ismej.2008.118","article-title":"Colorful microdiversity of Synechococcus strains (picocyanobacteria) isolated from the Baltic Sea","volume":"3","author":"Haverkamp","year":"2009","journal-title":"ISME J."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1111\/j.1529-8817.2006.00282.x","article-title":"Comparative molecular evolution of newly discovered picocyanobacterial strains reveals a phylogenetically informative variable region of beta-phycoerythrin","volume":"42","author":"Everroad","year":"2006","journal-title":"J. Phycol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"V\u00f6r\u00f6s, L., Callieri, C., Katalin, V., and Bertoni, R. (1998). Freshwater picocyanobacteria along a trophic gradient and light quality range. Phytoplankton and Trophic Gradients, Springer.","DOI":"10.1007\/978-94-017-2668-9_10"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0076-6879(88)67004-2","article-title":"Isolation and purification of cyanobacteria","volume":"167","author":"Rippka","year":"1988","journal-title":"Methods Enzymol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1038\/ismej.2014.35","article-title":"Picocyanobacteria containing a novel pigment gene cluster dominate the brackish water Baltic Sea","volume":"8","author":"Larsson","year":"2014","journal-title":"ISME J."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"12030","DOI":"10.1073\/pnas.1306260110","article-title":"Role of a Microcin-C-like biosynthetic gene cluster in allelopathic interactions in marine Synechococcus","volume":"110","author":"Brahamsha","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature03044","article-title":"Adaptive divergence in pigment composition promotes phytoplankton biodiversity","volume":"432","author":"Stomp","year":"2004","journal-title":"Nature"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1146\/annurev-marine-120308-081121","article-title":"Progress in understanding harmful algal blooms: Paradigm shifts and new technologies for research, monitoring and management","volume":"4","author":"Anderson","year":"2012","journal-title":"Annu. Rev. Mar. Sci."},{"key":"ref_48","unstructured":"Whitton, B., and Potts, M. (2000). Picoplankton and other non-bloom forming cyanobacteria in lakes. The Ecology of Cyanobacteria: Their Diversity in Time and Space, Kluwer Academic Publishers."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s10872-010-0033-9","article-title":"Features of the Comacchio ecosystem transformed during persistent bloom of picocyanobacteria","volume":"66","author":"Sorokin","year":"2010","journal-title":"J. Oceanogr."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3354\/meps073269","article-title":"Picoplanktonic algae in the northern Baltic Sea: Seasonal dynamics and flagellate grazing","volume":"73","author":"Kuosa","year":"1991","journal-title":"Mar. Ecol. Prog. Ser."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0924-7963(99)00092-5","article-title":"Pigments, size and distribution of Synechococcus spp. in the Black Sea","volume":"24","author":"Uysal","year":"2000","journal-title":"J. Mar. Syst."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s10452-009-9269-0","article-title":"Winter bloom of picoeukaryotes in Hungarian shallow turbid soda pans and the role of light and temperature","volume":"43","author":"Somogyi","year":"2009","journal-title":"Aquat. Ecol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Wong, Y.S., and Tam, N.F.Y. (1998). Dynamics of picoplankton and microplankton flora in the experimental wastewater stabilisation ponds in the arid region of Marrakech, Morocco and Cyanobacteria effect on Escherichia coli and Vibrio cholerae survival. Wastewater Treatment with Algae, Springer-Verlag\/Landes Bioscience.","DOI":"10.1007\/978-3-662-10863-5"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"179","DOI":"10.2166\/wst.2000.0637","article-title":"Harmful cyanobacterial toxic blooms in waste stabilisation ponds","volume":"42","author":"Oudra","year":"2000","journal-title":"Water Sci. Technol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"695","DOI":"10.4319\/lo.2000.45.3.0695","article-title":"Spatial and temporal variability of picocyanobacteria Synechococcus sp. in San Francisco Bay","volume":"45","author":"Ning","year":"2000","journal-title":"Limnol. Oceanogr."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3354\/ame035185","article-title":"Phytoplankton community structure and productivity along the axis of the Mississippi River plume in oligotrophic Gulf of Mexico waters","volume":"35","author":"Wawrik","year":"2004","journal-title":"Aquat. Microb. Ecol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.4319\/lo.1999.44.4.1166","article-title":"Blooms of the picoplanktonic cyanobacterium Synechococcus in Florida Bay, a subtropical inner-shelf lagoon","volume":"14","author":"Phlips","year":"1999","journal-title":"Limnol. Oceanogr."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s10533-009-9329-5","article-title":"Nitrogen dynamics at the sediment\u2013water interface in shallow, sub-tropical Florida Bay: Why denitrification efficiency may decrease with increased eutrophication","volume":"95","author":"Gardner","year":"2009","journal-title":"Biogeochemistry"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/plankt\/19.1.113","article-title":"Production of Oikopleura dioica (Appendicularia) following a picoplankton \u2018bloom\u2019 in a eutrophic coastal area","volume":"19","author":"Nakamura","year":"1997","journal-title":"J. Plankton Res."},{"key":"ref_60","first-page":"1879","article-title":"Picocyanobacteria single forms aggregated and microcolonies","volume":"27","author":"Passoni","year":"2000","journal-title":"Verh. Internat. Verein Limnol."},{"key":"ref_61","first-page":"119","article-title":"Taxonomic and species delineation of picoplanktonic cyanoprocaryotes","volume":"83","year":"1996","journal-title":"Algol. Stud."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jembe.2017.07.008","article-title":"Allelopathic activity of the picocyanobacterium Synechococcus sp. on filamentous cyanobacteria","volume":"496","author":"Maculewicz","year":"2017","journal-title":"J. Exp. Mar. Biol. Ecol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.ecohyd.2017.05.001","article-title":"First record of allelopathic activity of the picocyanobacterium Synechococcus sp. on a natural plankton community","volume":"17","author":"Maculewicz","year":"2017","journal-title":"Ecohydrol. Hydrobiol."},{"key":"ref_64","first-page":"85","article-title":"Characterization of phycotoxins produced by cyanobacteria","volume":"35","year":"2006","journal-title":"Oceanol. Hydrobiol. Stud."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.3390\/md11082751","article-title":"Hepatotoxic seafood poisoning (HSP) due to microcystins: A threat from the ocean?","volume":"11","author":"Vareli","year":"2013","journal-title":"Mar. Drugs"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.3390\/md8051650","article-title":"On the chemistry, toxicology and genetics of the cyanobacterial toxins, microcystin, nodularin, saxitoxin and cylindrospermopsin","volume":"8","author":"Pearson","year":"2010","journal-title":"Mar. Drugs"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1039\/c2np00075j","article-title":"The chemical ecology of cyanobacteria","volume":"29","author":"Engene","year":"2012","journal-title":"Nat. Prod. Rep."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10408444.2015.1137865","article-title":"Risk to human health associated with the environmental occurrence of cyanobacterial neurotoxic alkaloids anatoxins and saxitoxins","volume":"46","author":"Testai","year":"2016","journal-title":"Crit. Rev. Toxicol."},{"key":"ref_69","unstructured":"Carmichael, W.W. (1981). Preliminary tests of toxicity of Synechocystis sp. growth on wastewater medium. The Water Environment: Algal Toxins and Health, Plenum Press."},{"key":"ref_70","unstructured":"Mitsui, A., Rosner, D., Goodman, A., Reyes-Vasquez, G., Kusumi, T., Kodama, T., and Nomoto, K. (1987, January 10\u201314). Hemolytic toxins in a marine cyanobacterium Synechococcus sp.. Proceedings of the International Red Tide Symposium, Takamatsu, Japan."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/(SICI)1522-7278(199902)14:1<31::AID-TOX6>3.0.CO;2-B","article-title":"First report of microcystin production by picoplanktonic cyanobacteria isolated from a northeast Brazilian drinking water supply","volume":"14","author":"Domingos","year":"1999","journal-title":"Environ. Toxicol."},{"key":"ref_72","first-page":"95","article-title":"Microcystin production and toxicity of picocyanobacteria as a risk factor for drinking water treatment plants","volume":"92","year":"1999","journal-title":"Algol. Stud."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1746-1448-2-5","article-title":"Cyanobacteria toxins in the Salton Sea","volume":"2","author":"Carmichael","year":"2006","journal-title":"Saline Syst."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1007\/s00248-009-9540-x","article-title":"Cyanotoxins from black band disease of corals and from other coral reef environments","volume":"58","author":"Gantar","year":"2009","journal-title":"Microb. Ecol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.toxicon.2005.06.010","article-title":"Toxicity of culturable cyanobacteria strains isolated from the Portuguese coast","volume":"46","author":"Martins","year":"2005","journal-title":"Toxicon"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s10750-009-9728-6","article-title":"Morphological and molecular characterization of cyanobacteria from a Brazilian facultative wastewater stabilization pond and evaluation of microcystin production","volume":"627","author":"Furtado","year":"2009","journal-title":"Hydrobiologia"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/tox.10029","article-title":"Detection and quantification of microcystins from cyanobacteria strains isolated from reservoirs and ponds in Morocco","volume":"17","author":"Oudra","year":"2002","journal-title":"Environ. Toxicol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.hal.2011.12.005","article-title":"Microcystin producing cyanobacterial communities in Amvrakikos Gulf (Mediterranean Sea, NW Greece) and toxin accumulation in mussels (Mytilus galloprovincialis)","volume":"15","author":"Vareli","year":"2012","journal-title":"Harmful Algae"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.3390\/md13031497","article-title":"Toxic Picoplanktonic Cyanobacteria-Review","volume":"13","author":"Jakubowska","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"5074","DOI":"10.1073\/pnas.0501526102","article-title":"Diverse taxa of cyanobacteria produce \u03b2-N-methylamino-l-alanine, a neurotoxic amino acid","volume":"102","author":"Cox","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1007\/s00726-011-1057-1","article-title":"The non-protein amino acid \u03b2-N-methylamino-l-alanine in Portuguese cyanobacterial isolates","volume":"42","author":"Cianca","year":"2012","journal-title":"Amino Acids"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"13380","DOI":"10.1073\/pnas.2235808100","article-title":"Biomagnification of cyanobacterial neurotoxins and neurodegenerative disease among the Chamorro people of Guam","volume":"100","author":"Cox","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Graham, J.L., Loftin, K.A., Ziegler, A.C., and Meyer, M.T. (2008). Guidelines for Design and Sampling for Cyanobacterial Toxin and Taste-and-Odor Studies in Lakes and Reservoirs.","DOI":"10.3133\/sir20085038"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Bradley, P.M. (2013). Environmental factors that influence cyanobacteria and geosmin occurrence in reservoirs. Current Perspectives in Contaminant Hydrology and Water Resources Sustainability, Tech Online.","DOI":"10.5772\/47884"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"5499","DOI":"10.1128\/JB.00121-09","article-title":"Structure of compositionally simple lipopolysaccharide from marine Synechococcus","volume":"191","author":"Snyder","year":"2009","journal-title":"J. Bacteriol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/BF00427195","article-title":"Characterization of the lipopolysaccharides from eight strains of the cyanobacterium Synechococcus","volume":"127","author":"Schmidt","year":"1980","journal-title":"Arch. Microbiol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/BF00427196","article-title":"Lipopolysaccharides in four strains of the unicellular cyanobacterium Synechocystis","volume":"127","author":"Schmidt","year":"1980","journal-title":"Arch. Microbiol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0166-445X(02)00010-3","article-title":"Effects of enteric bacterial and cyanobacterial lipopolysaccharides and of microcystin-LR, on glutathione S-transferase activities in zebra fish (Danio rerio)","volume":"60","author":"Best","year":"2002","journal-title":"Aquat. Toxicol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0005-2760(93)90079-O","article-title":"Thioic O-acid ester in sulfolipid isolated from freshwater picoplankton cyanobacterium, Synechococcus sp.","volume":"1169","author":"Kunimitsu","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3390\/md204154","article-title":"Isolation of araguspongine M, a new stereoisomer of an araguspongine\/xestospongin alkaloid and dopamine from the marine sponge Neopetrosia exigua collected in Palau","volume":"2","author":"Liu","year":"2004","journal-title":"Mar. Drugs"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.4319\/lo.2005.50.6.1918","article-title":"Structure of synechobactins, new siderophores of the marine cyanobacterium Synechococcus sp. PCC 7002","volume":"50","author":"Ito","year":"2005","journal-title":"Limnol. Oceanogr."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"6899","DOI":"10.1073\/pnas.1103014108","article-title":"Fatty acid production in genetically modified cyanobacteria","volume":"108","author":"Liu","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1529-8817.2007.00333.x","article-title":"Does allelopathy contribute to Cylindrospermopsis raciborskii (cyanobacteria) bloom occurrence and geographic expansion?","volume":"43","author":"Figueredo","year":"2007","journal-title":"J. Phycol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ecss.2015.07.038","article-title":"The influence of extracellular compounds produced by selected Baltic cyanobacteria, diatoms and dinoflagellates on growth of green algae Chlorella vulgaris","volume":"167","author":"Kosakowska","year":"2015","journal-title":"Estuar. Coast. Shelf. Sci."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Allen, J.L., Ten-Hage, L., and Leflaive, J. (2017). Regulation of Fatty Acid Production and Release in Benthic Algae: Could Parallel Allelopathy Be Explained with Plant Defence Theories?. Microb. Ecol.","DOI":"10.1007\/s00248-017-1082-z"},{"key":"ref_96","unstructured":"Barreiro, A., Roy, S., and Vasconcelos, V.M. (2017). Allelopathy prevents competitive exclusion and promotes phytoplankton biodiversity. Oikos."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.3389\/fmicb.2017.01495","article-title":"Cyanobacterial Allelochemicals But Not Cyanobacterial Cells Markedly Reduce Microbial Community Diversity","volume":"8","author":"Dias","year":"2017","journal-title":"Front. Microbiol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.marenvres.2017.09.016","article-title":"Allelopathic effects of diatom filtrates on the toxic benthic dinoflagellate Ostreopsis cf. ovata","volume":"131","author":"Pichierri","year":"2017","journal-title":"Mar. Environ. Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.hal.2016.11.010","article-title":"Allelopathic effects of Microcystis aeruginosa on green algae and a diatom: Evidence from exudates addition and co-culturing","volume":"61","author":"Wang","year":"2017","journal-title":"Harmful Algae"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/md6010001","article-title":"Antimicrobial and cytotoxic assessment of marine cyanobacteria\u2014Synechocystis and Synechococcus","volume":"6","author":"Martins","year":"2008","journal-title":"Mar. Drugs"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3390\/md12010098","article-title":"Exploring bioactive properties of marine cyanobacteria isolated from the Portuguese coast: High potential as a source of anticancer compounds","volume":"12","author":"Costa","year":"2014","journal-title":"Mar. Drugs"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.micres.2004.09.001","article-title":"Factors affecting antimicrobial activity of Synechococcus leopoliensis","volume":"159","author":"Noaman","year":"2004","journal-title":"Microbiol. Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.toxicon.2007.06.020","article-title":"Toxicity assess\u00adment of crude and partially purified extracts of marine Synechocystis and Synechococcus cyanobacterial strains in marine invertebrates","volume":"50","author":"Martins","year":"2007","journal-title":"Toxicon"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.3390\/md8061908","article-title":"Are known cyanotoxins involved in the toxicity of picoplanktonic and filamentous north atlantic marine cyanobacteria?","volume":"8","author":"Martins","year":"2010","journal-title":"Mar. Drugs"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1080\/15287394.2014.991466","article-title":"Picocyanobacteria from a clade of marine cyanobium revealed bioactive potential against microalgae, bacteria and marine invertebrates","volume":"78","author":"Costa","year":"2015","journal-title":"Toxicol. Environ. Health Part A"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/conphys\/cou020","article-title":"Exposure to bloom-like concentrations of two marine Synechococcus cyanobacteria (strains CC9311 and CC9902) differentially alters fish behaviour","volume":"2","author":"Hamilton","year":"2014","journal-title":"Conserv. Physiol."}],"container-title":["Toxins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6651\/10\/1\/48\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T14:51:58Z","timestamp":1760194318000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6651\/10\/1\/48"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,20]]},"references-count":106,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,1]]}},"alternative-id":["toxins10010048"],"URL":"https:\/\/doi.org\/10.3390\/toxins10010048","relation":{},"ISSN":["2072-6651"],"issn-type":[{"value":"2072-6651","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,20]]}}}