{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:29:44Z","timestamp":1772252984755,"version":"3.50.1"},"reference-count":37,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T00:00:00Z","timestamp":1653350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>(1) Background: tuberculosis (TB) is considered one of the leading causes of death worldwide by a single infectious agent. This study aimed to identify hotspots of people diagnosed with tuberculosis and abusive use of alcohol, tobacco, and other drugs in communities through a geospatial intelligence application; (2) Methods: an ecological study with a spatio-temporal approach. We considered tuberculosis cases diagnosed and registered in the Notifiable Diseases Information System, which presented information on alcoholism, smoking, and drug abuse. Spatial Variations in Temporal Trends (SVTT) and scan statistics were applied for the identification of Hotspots; (3) Results: between the study period, about 29,499 cases of tuberculosis were reported. When we applied the SVTT for alcoholism, three Hotspots were detected, one of which was protective (RR: 0.08\u2013CI95%: 0.02\u20130.32) and two at risk (RR: 1.42\u2013CI95%: 1.11\u20131.73; RR: 1.39\u2013CI95%: 1.28\u20131.50). Regarding smoking, two risk clusters were identified (RR: 1.15\u2013CI95%: 1.01\u20131.30; RR: 1.68\u2013CI95%: 1.54\u20131.83). For other drugs, a risk cluster was found (RR: 1.13\u2013CI95%: 0.99\u20131.29) and two protections (RR: 0.70\u2013CI95%: 0.63\u20130.77; RR: 0.76\u2013CI95%: 0.65\u20130.89); (4) Conclusion: it was evidenced that in the communities being studied, there exists a problem of TB with drug addiction. The disordered use of these substances may harm a person\u2019s brain and behavior and lead to an inability to continue their treatment, putting the community at further risk for TB.<\/jats:p>","DOI":"10.3390\/tropicalmed7060082","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T05:12:27Z","timestamp":1653455547000},"page":"82","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Identifying Hotspots of People Diagnosed of Tuberculosis with Addiction to Alcohol, Tobacco, and Other Drugs through a Geospatial Intelligence Application in Communities from Southern Brazil"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4045-3584","authenticated-orcid":false,"given":"Alessandro Rolim","family":"Scholze","sequence":"first","affiliation":[{"name":"Department of Maternal-Infant and Public Health Nursing, Ribeir\u00e3o Preto College of Nursing, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 05403-000, Sao Paulo, Brazil"}]},{"given":"Felipe Mendes","family":"Delpino","sequence":"additional","affiliation":[{"name":"Department of Maternal-Infant and Public Health Nursing, Ribeir\u00e3o Preto College of Nursing, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 05403-000, Sao Paulo, Brazil"}]},{"given":"Luana Seles","family":"Alves","sequence":"additional","affiliation":[{"name":"Department of Maternal-Infant and Public Health Nursing, Ribeir\u00e3o Preto College of Nursing, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 05403-000, Sao Paulo, Brazil"}]},{"given":"Josilene D\u00e1lia","family":"Alves","sequence":"additional","affiliation":[{"name":"Institute of Biological Sciences and Health, Federal University of Mato Grosso, Barra do Gar\u00e7as 78600-000, Mato Grosso, Brazil"}]},{"given":"Tha\u00eds Zamboni","family":"Berra","sequence":"additional","affiliation":[{"name":"Department of Maternal-Infant and Public Health Nursing, Ribeir\u00e3o Preto College of Nursing, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 05403-000, Sao Paulo, Brazil"}]},{"given":"Ant\u00f4nio Carlos Vieira","family":"Ramos","sequence":"additional","affiliation":[{"name":"Department of Maternal-Infant and Public Health Nursing, Ribeir\u00e3o Preto College of Nursing, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 05403-000, Sao Paulo, Brazil"}]},{"given":"Miguel","family":"Fuentealba-Torres","sequence":"additional","affiliation":[{"name":"Nursing Department, Faculdade de Enfermagem e Obstetr\u00edcia, Universidad de los Andes, Santiago 12455, Chile"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1406-4585","authenticated-orcid":false,"given":"In\u00eas","family":"Fronteira","sequence":"additional","affiliation":[{"name":"Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, 1349-008 Lisbon, Portugal"}]},{"given":"Ricardo Alexandre","family":"Arc\u00eancio","sequence":"additional","affiliation":[{"name":"Department of Maternal-Infant and Public Health Nursing, Ribeir\u00e3o Preto College of Nursing, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 05403-000, Sao Paulo, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Thomas, B.E., Thiruvengadam, K., Gupta, A., Kadam, D., Ovung, S., Sivakumar, S., Shivakumar, S.V.B.Y., Paradkar, M., Gupte, N., and Suryavanshi, N. (2019). Smoking, alcohol use disorder and tuberculosis treatment outcomes: A dual co-morbidity burden that cannot be ignored. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0220507"},{"key":"ref_2","unstructured":"World Health Organization (WHO) (2020). Global Tuberculosis Report, WHO. Available online: https:\/\/www.who.int\/publications\/i\/item\/9789240001503."},{"key":"ref_3","unstructured":"Ministry of Health (2021, July 11). Health Surveillance Department. Epidemiological Bulletin. Tuberculosis. Brazil, Available online: https:\/\/www.gov.br\/saude\/pt-br\/media\/pdf\/2021\/marco\/24\/boletim-tuberculose-2021_24.03."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1590\/1413-81232018231.25242015","article-title":"Tend\u00eancia da mortalidade por tuberculose no estado do Paran\u00e1, Brasil\u20141998 a 2012","volume":"23","author":"Cecilio","year":"2018","journal-title":"Cienc. Saude Colet."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Reis-Santos, B., Shete, P., Bertolde, A.I., Sales, C.M., Sanchez, M.N., Arakaki-Sanchez, D., Andrade, K.B., Gomes, M.G.M., Boccia, D., and Lienhardt, C. (2019). Tuberculosis in Brazil and cash transfer programs: A longitudinal database study of the effect of cash transfer on cure rates. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0212617"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.gaceta.2019.01.004","article-title":"Magnitud de los determinantes sociales en el riesgo de mortalidad por tuberculosis en el Centro-Oeste de Brasil","volume":"34","author":"Alves","year":"2019","journal-title":"Gac. Sanit."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Shimeles, E., Enquselassie, F., Aseffa, A., Tilahun, M., Mekonen, A., Wondimagegn, G., and Hailu, T. (2019). Risk factors for tuberculosis: A case\u2014Control study in Addis Ababa, Ethiopia. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0214235"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"5639","DOI":"10.1038\/s41598-020-62667-8","article-title":"Drug misuse, tobacco smoking, alcohol and other social determinants of tuberculosis in UK-born adults in England: A community-based case-control study","volume":"10","author":"Rodrigues","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Myers, B., Bouton, T.C., Ragan, E.J., White, L.F., McIlleron, H., Theron, D., Parry, C.D.H., Horsburgh, C.R., Warren, R.M., and Jacobson, K.R. (2018). Impact of alcohol consumption on tuberculosis treatment outcomes: A prospective longitudinal cohort study protocol. BMC Infect. Dis., 18.","DOI":"10.1186\/s12879-018-3396-y"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/tmi.13409","article-title":"Determinants of multidrug-resistant tuberculosis in S\u00e3o Paulo\u2014Brazil: A multilevel Bayesian analysis of factors associated with individual, community and access to health services","volume":"25","author":"Arroyo","year":"2020","journal-title":"Trop. Med. Int. Health"},{"key":"ref_11","unstructured":"(2021, July 11). Methodological Guideline: Synthesis of Evidence for Policies, Available online: https:\/\/bvsms.saude.gov.br\/bvs\/publicacoes\/diretriz_sintese_evidencias_politicas.pdf."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1002\/sim.4780140809","article-title":"Spatial disease clusters: Detection and inference","volume":"14","author":"Kulldorff","year":"1995","journal-title":"Stat. Med."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Chen, J., Qiu, Y., Yang, R., Li, L., Hou, J., Lu, K., and Xu, L. (2019). The characteristics of spatial-temporal distribution and cluster of tuberculosis in Yunnan Province, China, 2005\u20132018. BMC Public Health, 19.","DOI":"10.1186\/s12889-019-7993-5"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1590\/S1982-21702012000400006","article-title":"Detec\u00e7\u00e3o de agrupamentos espa\u00e7o-temporais para identifica\u00e7\u00e3o de \u00e1reas de risco de homic\u00eddios por arma branca em Jo\u00e3o Pessoa, PB","volume":"18","author":"Lucena","year":"2012","journal-title":"Brazil. Bol. Ci\u00eanc. Geod."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1002\/sim.6143","article-title":"Relative risk estimates from spatial and space-time scan statistics: Are they biased?","volume":"33","author":"Prates","year":"2014","journal-title":"Stat. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1177\/0962280213485312","article-title":"Detection of spatial variations in temporal trends with a quadratic function","volume":"25","author":"Moraga","year":"2016","journal-title":"Stat. Methods Med. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e3343","DOI":"10.1590\/1518-8345.3223.3343","article-title":"Tuberculosis associated with the living conditions in an endemic municipality in the North of Brazil","volume":"28","author":"Nogueira","year":"2020","journal-title":"Rev. Latino-Am. Enferm."},{"key":"ref_18","unstructured":"Wagner, M.B., and Callegari-Jacques, S.M. (1998). Association measures in epidemiological studies: Relative risk and odds ratio. J. Pediatr., 247\u2013251. Available online: http:\/\/bases.bireme.br\/cgi-bin\/wxislind.exe\/iah\/online\/?IsisScript=iah\/iah.xis&src=google&base=LILACS&lang=p&nextAction=lnk&exprSearch=220088&indexSearch=ID."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e00025618","DOI":"10.1590\/0102-311x00025618","article-title":"Do drinking problems in the past affect current consumption?","volume":"35","author":"Reis","year":"2019","journal-title":"Cad. Sa\u00fade P\u00fablica."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ijid.2018.05.004","article-title":"Prevalence of and risk factors associated with latent tuberculosis in Singapore: A cross-sectional survey","volume":"72","author":"Yap","year":"2018","journal-title":"Int. J. Infect. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s15010-016-0963-2","article-title":"Risk for latent and active tuberculosis in Germany","volume":"45","author":"Herzmann","year":"2016","journal-title":"Infection"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Desissa, F., Workineh, T., and Beyene, T. (2018). Risk factors for the occurrence of multidrug-resistant tuberculosis among patients undergoing multidrug-resistant tuberculosis treatment in East Shoa, Ethiopia. BMC Public Health, 18.","DOI":"10.1186\/s12889-018-5371-3"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Navya, N., Jeyashree, K., Madhukeshwar, A.K., Anand, T., Nirgude, A.S., Nayarmoole, B.M., and Isaakidis, P. (2019). Are they there yet? Linkage of patients with tuberculosis to services for tobacco cessation and alcohol abuse\u2014A mixed methods study from Karnataka, India. BMC Health Serv. Res., 19.","DOI":"10.1186\/s12913-019-3913-8"},{"key":"ref_24","first-page":"e19093","article-title":"Psychoactive substance use in patients with tuberculosis: Treatment adherence and interface with Brief Interventions","volume":"serV","author":"Abreu","year":"2020","journal-title":"Rev. Enf. Ref."},{"key":"ref_25","first-page":"1","article-title":"Prevalence and associated factors for alcohol use disorder among tuberculosis patients: A systematic review and meta-analysis study","volume":"16","author":"Necho","year":"2021","journal-title":"Subst. Abus. Treat. Prev. Policy"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1590\/s1806-37562017000000443","article-title":"Risk factors for tuberculosis: Diabetes, smoking, alcohol use, and the use of other drugs","volume":"44","author":"Silva","year":"2018","journal-title":"J. Bras. Pneumol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/01902148.2018.1444824","article-title":"Tuberculosis and cigarette smoke exposure: An update ofin vitroandin vivostudies","volume":"44","author":"Hernandez","year":"2018","journal-title":"Exp. Lung Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1017\/gheg.2020.1","article-title":"Tobacco smoking as a risk factor for tuberculous pleural effusion: A case-control study","volume":"5","author":"Tewatia","year":"2020","journal-title":"Glob. Health Epidemiol. Genom."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e20180359","DOI":"10.1590\/1806-3713\/e20180359","article-title":"Smoking and pulmonary tuberculosis treatment failure: A case-control study","volume":"45","author":"Aguilar","year":"2019","journal-title":"J. Bras. Pneumol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.4103\/jfmpc.jfmpc_373_20","article-title":"Tobacco use and nicotine dependence among newly diagnosed pulmonary tuberculosis patients in Ballabgarh tuberculosis unit, Haryana","volume":"9","author":"Kumar","year":"2020","journal-title":"J. Fam. Med. Prim. Care"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"67","DOI":"10.18332\/tid\/125195","article-title":"A narrative review of facilitators and barriers to smoking cessation and tobacco-dependence treatment in patients with tuberculosis in low- and middle-income countries","volume":"18","author":"Zvolska","year":"2020","journal-title":"Tob. Induc. Dis."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Burusie, A., Enquesilassie, F., Addissie, A., Dessalegn, B., and Lamaro, T. (2020). Effect of smoking on tuberculosis treatment outcomes: A systematic review and meta-analysis. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0239333"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Rutebemberwa, E., Nyamurungi, K., Joshi, S., Olando, Y., Mamudu, H.M., and Pack, R.P. (2021). Health workers\u2019 perceptions on where and how to integrate tobacco use cessation services into tuberculosis treatment; a qualitative exploratory study in Uganda. BMC Public Health, 21.","DOI":"10.1186\/s12889-021-11502-4"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1093\/aje\/kwy081","article-title":"Contribution of Smoking to Tuberculosis Incidence and Mortality in High-Tuberculosis-Burden Countries","volume":"187","author":"Amere","year":"2018","journal-title":"Am. J. Epidemiol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Soboka, M., Tolessa, O., Tesfaye, M., Adorjan, K., Krahl, W., Tesfaye, E., Yitayih, Y., Strobl, R., and Grill, E. (2020). Magnitude and predictors of khat use among patients with tuberculosis in Southwest Ethiopia: A longitudinal study. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0236154"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"ofab548","DOI":"10.1093\/ofid\/ofab548","article-title":"Alarming Tuberculosis Rate Among People Who Inject Drugs in Vietnam","volume":"9","author":"Nagot","year":"2021","journal-title":"Open Forum Infect. Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ijtb.2016.11.009","article-title":"Smoking and alcohol consumption: Risk factors for pulmonary tuberculosis among the tribal community in central India","volume":"64","author":"Rao","year":"2017","journal-title":"Indian J. Tuberc."}],"container-title":["Tropical Medicine and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2414-6366\/7\/6\/82\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:17:23Z","timestamp":1760138243000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2414-6366\/7\/6\/82"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,24]]},"references-count":37,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,6]]}},"alternative-id":["tropicalmed7060082"],"URL":"https:\/\/doi.org\/10.3390\/tropicalmed7060082","relation":{"has-preprint":[{"id-type":"doi","id":"10.20944\/preprints202204.0010.v1","asserted-by":"object"}]},"ISSN":["2414-6366"],"issn-type":[{"value":"2414-6366","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,24]]}}}