{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:57:01Z","timestamp":1771660621003,"version":"3.50.1"},"reference-count":33,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["(grant number 213589\/Z\/18\/Z)"],"award-info":[{"award-number":["(grant number 213589\/Z\/18\/Z)"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006506","name":"Minist\u00e9rio da Sa\u00fade","doi-asserted-by":"publisher","award":["Long-term surveillance platform for Zika and microcephaly under the Unified Health System"],"award-info":[{"award-number":["Long-term surveillance platform for Zika and microcephaly under the Unified Health System"]}],"id":[{"id":"10.13039\/501100006506","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Background: The clinical manifestations of microcephaly\/congenital Zika syndrome (microcephaly\/CZS) have harmful consequences on the child\u2019s health, increasing vulnerability to childhood morbidity and mortality. This study analyzes the case fatality rate and child\u2013maternal characteristics of cases and deaths related to microcephaly\/CZS in Brazil, 2015\u20132017. Methods: Population-based study developed by linkage of three information systems. We estimate frequencies of cases, deaths, case fatality rate related to microcephaly\/CZS according to child and maternal characteristics and causes of death. Multivariate logistic regression models were applied. Results: The microcephaly\/CZS case fatality rate was 10% (95% CI 9.2\u201310.7). Death related to microcephaly\/CZS was associated to moderate (OR = 2.15; 95% CI 1.63\u20132.83), and very low birth weight (OR = 3.77; 95% CI 2.20\u20136.46); late preterm births (OR = 1.65; 95% CI 1.21\u20132.23), Apgar &lt; 7 at 1st (OR = 5.98; 95% CI 4.46\u20138.02) and 5th minutes (OR = 4.13; 95% CI 2.78\u20136.13), among others. Conclusions: A high microcephaly\/CZS case fatality rate and important factors associated with deaths related to this syndrome were observed. These results can alert health teams to these problems and increase awareness about the factors that may be associated with worse outcomes.<\/jats:p>","DOI":"10.3390\/v12111228","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T21:21:00Z","timestamp":1604006460000},"page":"1228","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Case Fatality Rate Related to Microcephaly Congenital Zika Syndrome and Associated Factors: A Nationwide Retrospective Study in Brazil \u2020"],"prefix":"10.3390","volume":"12","author":[{"given":"Maria Concei\u00e7\u00e3o","family":"N. Costa","sequence":"first","affiliation":[{"name":"Center of Data and Knowledge Integration for Health (CIDACS), Gon\u00e7alo Moniz Institute, Oswaldo Cruz Foundation, Salvador 41745-715, Bahia, Brazil"},{"name":"Collective Health Institute, Federal University of Bahia, Salvador 40110-040, Bahia, Brazil"}]},{"given":"Luciana Lobato","family":"Cardim","sequence":"additional","affiliation":[{"name":"Center of Data and Knowledge Integration for Health (CIDACS), Gon\u00e7alo Moniz Institute, Oswaldo Cruz Foundation, Salvador 41745-715, Bahia, Brazil"}]},{"given":"Maria Gloria","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Center of Data and Knowledge Integration for Health (CIDACS), Gon\u00e7alo Moniz Institute, Oswaldo Cruz Foundation, Salvador 41745-715, Bahia, Brazil"},{"name":"Collective Health Institute, Federal University of Bahia, Salvador 40110-040, Bahia, Brazil"}]},{"given":"Mauricio L.","family":"Barreto","sequence":"additional","affiliation":[{"name":"Center of Data and Knowledge Integration for Health (CIDACS), Gon\u00e7alo Moniz Institute, Oswaldo Cruz Foundation, Salvador 41745-715, Bahia, Brazil"},{"name":"Collective Health Institute, Federal University of Bahia, Salvador 40110-040, Bahia, Brazil"}]},{"given":"Rita de Cassia Oliveira de","family":"Carvalho-Sauer","sequence":"additional","affiliation":[{"name":"Collective Health Institute, Federal University of Bahia, Salvador 40110-040, Bahia, Brazil"},{"name":"East Regional Health Center of the State Health Secretariat of Bahia, Santo Antonio de Jesus 44570-550, Bahia, Brazil"}]},{"given":"Florisneide R.","family":"Barreto","sequence":"additional","affiliation":[{"name":"Center of Data and Knowledge Integration for Health (CIDACS), Gon\u00e7alo Moniz Institute, Oswaldo Cruz Foundation, Salvador 41745-715, Bahia, Brazil"}]},{"given":"Martha Suely Itaparica","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Center of Data and Knowledge Integration for Health (CIDACS), Gon\u00e7alo Moniz Institute, Oswaldo Cruz Foundation, Salvador 41745-715, Bahia, Brazil"},{"name":"Municipal Health Secretariat of Salvador 40.010-010, Bahia, Brazil"}]},{"given":"Wanderson K.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Center of Data and Knowledge Integration for Health (CIDACS), Gon\u00e7alo Moniz Institute, Oswaldo Cruz Foundation, Salvador 41745-715, Bahia, Brazil"},{"name":"Ministry of Defense Hospital das Armed Forces, Technical Directorate of Education and Research, Brasilia 70675-731, Brazil"}]},{"given":"Giovanny V. A.","family":"Fran\u00e7a","sequence":"additional","affiliation":[{"name":"Secretariat of Health Surveillance, Ministry of Health, Brasilia 70070-040, Brazil"}]},{"given":"Eduardo Hage","family":"Carmo","sequence":"additional","affiliation":[{"name":"Center of Data and Knowledge Integration for Health (CIDACS), Gon\u00e7alo Moniz Institute, Oswaldo Cruz Foundation, Salvador 41745-715, Bahia, Brazil"}]},{"given":"Roberto F. S","family":"Andrade","sequence":"additional","affiliation":[{"name":"Center of Data and Knowledge Integration for Health (CIDACS), Gon\u00e7alo Moniz Institute, Oswaldo Cruz Foundation, Salvador 41745-715, Bahia, Brazil"},{"name":"Physics Institute, Federal University of Bahia, Salvador 40210-340, Bahia, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1594-2311","authenticated-orcid":false,"given":"Moreno S.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Center of Data and Knowledge Integration for Health (CIDACS), Gon\u00e7alo Moniz Institute, Oswaldo Cruz Foundation, Salvador 41745-715, Bahia, Brazil"}]},{"given":"Rafael V.","family":"Veiga","sequence":"additional","affiliation":[{"name":"Center of Data and Knowledge Integration for Health (CIDACS), Gon\u00e7alo Moniz Institute, Oswaldo Cruz Foundation, Salvador 41745-715, Bahia, Brazil"}]},{"given":"Juliane F.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Center of Data and Knowledge Integration for Health (CIDACS), Gon\u00e7alo Moniz Institute, Oswaldo Cruz Foundation, Salvador 41745-715, Bahia, Brazil"}]},{"given":"Qeren H. R. F.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Gon\u00e7alo Moniz Institute, Oswaldo Cruz Foundation, Salvador 40296-710, Bahia, Brazil"}]},{"given":"Larissa C.","family":"Costa","sequence":"additional","affiliation":[{"name":"Center of Data and Knowledge Integration for Health (CIDACS), Gon\u00e7alo Moniz Institute, Oswaldo Cruz Foundation, Salvador 41745-715, Bahia, Brazil"}]},{"given":"Giovanini E.","family":"Coelho","sequence":"additional","affiliation":[{"name":"Pan-American Health Organization\/World Health Organization, Department of Communicable Diseases and Environmental Determinants of Health, Neglected, Tropical and Vector-Borne Diseases, Washington, WA 20037, USA"}]},{"given":"Enny S.","family":"Paixao","sequence":"additional","affiliation":[{"name":"Center of Data and Knowledge Integration for Health (CIDACS), Gon\u00e7alo Moniz Institute, Oswaldo Cruz Foundation, Salvador 41745-715, Bahia, Brazil"},{"name":"London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"601","DOI":"10.2105\/AJPH.2016.303113","article-title":"The Epidemic of Zika Virus\u2013Related Microcephaly in Brazil: Detection, Control, Etiology, and Future Scenarios","volume":"106","author":"Teixeira","year":"2016","journal-title":"Am. 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