{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T07:09:04Z","timestamp":1774076944736,"version":"3.50.1"},"reference-count":34,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF21OC0067235"],"award-info":[{"award-number":["NNF21OC0067235"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["LONG-COVID-EXP-CM"],"award-info":[{"award-number":["LONG-COVID-EXP-CM"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006541","name":"Fondo Europeo De Desarrollo Regional\u2014Recursos REACT-UE del Programa Operativo de Madrid 2014\u20132020, en la l\u00ednea de actuaci\u00f3n de proyectos de I+D+i en materia de respuesta a COVID 19","doi-asserted-by":"publisher","award":["NNF21OC0067235"],"award-info":[{"award-number":["NNF21OC0067235"]}],"id":[{"id":"10.13039\/501100006541","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006541","name":"Fondo Europeo De Desarrollo Regional\u2014Recursos REACT-UE del Programa Operativo de Madrid 2014\u20132020, en la l\u00ednea de actuaci\u00f3n de proyectos de I+D+i en materia de respuesta a COVID 19","doi-asserted-by":"publisher","award":["LONG-COVID-EXP-CM"],"award-info":[{"award-number":["LONG-COVID-EXP-CM"]}],"id":[{"id":"10.13039\/501100006541","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>The aim of this study was to investigate the effects of administrating Remdesivir at the acute COVID-19 phase on developing post-COVID symptoms in previously hospitalized COVID-19 survivors by controlling factors such as age, sex, body mass index, and vaccination status. A case-control study was performed. Hospitalized COVID-19 survivors who had received intravenous Remdesivir during the acute phase (n = 216) were matched by age, sex, body mass index, and vaccination status with survivors who did not receive antiviral treatment (n = 216). Participants were asked to self-report the presence of any post-COVID symptom (defined as a symptom that started no later than three months after infection) and whether the symptom persisted at the time of study (mean: 18.4, SD: 0.8 months). Anxiety levels (HADS-A), depressive symptoms (HADS-D), sleep quality (PSQI), and severity\/disability (FIC) were also compared. The multivariate analysis revealed that administration of Remdesivir at the acute COVID-19 phase was a protective factor for long-term COVID development (OR0.401, 95%CI 0.256\u20130.628) and specifically for the following post-COVID symptoms: fatigue (OR0.399, 95%CI 0.270\u20130.590), pain (OR0.368, 95% CI 0.248\u20130.548), dyspnea at rest (OR0.580, 95%CI 0.361\u20130.933), concentration loss (OR0.368, 95%CI 0.151\u20130.901), memory loss (OR0.399, 95%CI 0.270\u20130.590), hair loss (OR0.103, 95%CI 0.052\u20130.207), and skin rashes (OR0.037, 95%CI 0.005\u20130.278). This study supports the potential protective role of intravenous administration of Remdesivir during the COVID-19 acute phase for long-lasting post-COVID symptoms in previously hospitalized COVID-19 survivors.<\/jats:p>","DOI":"10.3390\/v16060947","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T06:47:30Z","timestamp":1718174850000},"page":"947","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Is Antiviral Treatment with Remdesivir at the Acute Phase of SARS-CoV-2 Infection Effective for Decreasing the Risk of Long-Lasting Post-COVID Symptoms?"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3772-9690","authenticated-orcid":false,"given":"C\u00e9sar","family":"Fern\u00e1ndez-de-las-Pe\u00f1as","sequence":"first","affiliation":[{"name":"Department of Physical Therapy, Occupational Therapy, Physical Medicine and Rehabilitation, Universidad Rey Juan Carlos, 28922 Madrid, Spain"},{"name":"Center for Neuroplasticity and Pain (CNAP), Sensory-Motor Interaction (SMI), Department of Health Science and Technology, Faculty of Medicine, Aalborg University, DK 9220 Aalborg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anabel","family":"Franco-Moreno","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Universitario Infanta Leonor-Virgen de la Torre, 28031 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1538-3043","authenticated-orcid":false,"given":"Mar\u00eda","family":"Ruiz-Ruig\u00f3mez","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Universitario Doce de Octubre, 28041 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estibaliz","family":"Arrieta-Ortubay","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Universitario Doce de Octubre, 28041 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4212-7419","authenticated-orcid":false,"given":"Pablo","family":"Ryan-Murua","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Universitario Infanta Leonor-Virgen de la Torre, 28031 Madrid, Spain"},{"name":"CIBER de Enfermedades Infecciosas (CIBERINFEC), Instituto de Investigaci\u00f3n Carlos III (ISCIIII), 28220 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Lumbreras-Bermejo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Universitario Doce de Octubre, 28041 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0748-2594","authenticated-orcid":false,"given":"Pablo","family":"del-Valle-Loarte","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Universitario Severo Ochoa, 28911 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0104-1029","authenticated-orcid":false,"given":"Oscar J.","family":"Pellicer-Valero","sequence":"additional","affiliation":[{"name":"Image Processing Laboratory (IPL), Universitat de Val\u00e8ncia, Parc Cient\u00edfic, Paterna, 46980 Val\u00e8ncia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1331-129X","authenticated-orcid":false,"given":"Rocco","family":"Giordano","sequence":"additional","affiliation":[{"name":"Center for Neuroplasticity and Pain (CNAP), Sensory-Motor Interaction (SMI), Department of Health Science and Technology, Faculty of Medicine, Aalborg University, DK 9220 Aalborg, Denmark"},{"name":"Department of Oral and Maxillofacial Surgery, Aalborg University Hospital, DK 9100 Aalborg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Arendt-Nielsen","sequence":"additional","affiliation":[{"name":"Center for Neuroplasticity and Pain (CNAP), Sensory-Motor Interaction (SMI), Department of Health Science and Technology, Faculty of Medicine, Aalborg University, DK 9220 Aalborg, Denmark"},{"name":"Department of Gastroenterology & Hepatology, Mech-Sense, Clinical Institute, Aalborg University Hospital, DK 9100 Aalborg, Denmark"},{"name":"Steno Diabetes Center North Denmark, Clinical Institute, Aalborg University Hospital, DK 9100 Aalborg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Mart\u00edn-Garrido","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Virgen del Roc\u00edo, 41012 Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8860-6837","authenticated-orcid":false,"given":"Juan","family":"Torres-Macho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Universitario Infanta Leonor-Virgen de la Torre, 28031 Madrid, Spain"},{"name":"Department of Medicine, School of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.2147\/CLEP.S422386","article-title":"Efficacy and safety of novel oral antivirals in hospitalized COVID-19 patients: A network meta-analysis of randomized clinical trials","volume":"15","author":"Liu","year":"2023","journal-title":"Clin. Epidemiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1007\/s43440-022-00388-7","article-title":"Oral antiviral treatments for COVID-19: Opportunities and challenges","volume":"74","author":"Rahmah","year":"2022","journal-title":"Pharmacol. Rep."},{"key":"ref_3","unstructured":"(2023, July 15). Coronavirus Disease (COVID-19) Pandemic. Available online: https:\/\/www.who.int\/emergencies\/diseases\/novel-coronavirus-2019."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"105768","DOI":"10.1016\/j.antiviral.2023.105768","article-title":"Efficacy and safety of antiviral treatments for symptomatic COVID-19 outpatients: Systematic review and network meta-analysis","volume":"221","author":"Zur","year":"2024","journal-title":"Antivir. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/cpt.2603","article-title":"Innovative Randomized phase i study and dosing regimen selection to accelerate and inform pivotal COVID-19 trial of Nirmatrelvir","volume":"112","author":"Singh","year":"2022","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref_6","unstructured":"(2024, April 01). Ritonavir-Boosted Nirmatrelvir (Paxlovid), Available online: https:\/\/www.covid19treatmentguidelines.nih.gov\/therapies\/antivirals-including-antibody-products\/ritonavir-boosted-nirmatrelvir--paxlovid-\/."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e00162-20","DOI":"10.1128\/CMR.00162-20","article-title":"Remdesivir against COVID-19 and other viral diseases","volume":"34","author":"Malin","year":"2021","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_8","unstructured":"(2024, April 01). Remdesivir, Available online: https:\/\/www.covid19treatmentguidelines.nih.gov\/therapies\/antivirals-including-antibody-products\/remdesivir\/."},{"key":"ref_9","first-page":"36","article-title":"Long COVID: Complications, underlying mechanisms, and treatment strategies","volume":"7","author":"Zadeh","year":"2023","journal-title":"Arch. Microbiol. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s15010-021-01696-5","article-title":"Long COVID: Current definition","volume":"50","year":"2022","journal-title":"Infection"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e102","DOI":"10.1016\/S1473-3099(21)00703-9","article-title":"A clinical case definition of post-COVID-19 condition by a Delphi consensus","volume":"22","author":"Soriano","year":"2022","journal-title":"Lancet Infect. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1093\/infdis\/jiac136","article-title":"Global prevalence of post COVID-19 condition or long COVID: A meta-analysis and systematic review","volume":"226","author":"Chen","year":"2022","journal-title":"J. Infect. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Han, Q., Zheng, B., Daines, L., and Sheikh, A. (2022). Long-term sequelae of COVID-19: A systematic review and meta-analysis of one-year follow-up studies on post-COVID symptoms. Pathogens, 11.","DOI":"10.3390\/pathogens11020269"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jinf.2023.12.004","article-title":"Persistence of post-COVID symptoms in the general population two years after SARS-CoV-2 infection: A systematic review and meta-analysis","volume":"88","author":"Notarte","year":"2024","journal-title":"J. Infect."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e28852","DOI":"10.1002\/jmv.28852","article-title":"A systematic review and meta-analysis of long-term sequelae of COVID-19 2-year after SARS-CoV-2 infection: A call to action for neurological, physical, and psychological sciences","volume":"95","author":"Rahmati","year":"2023","journal-title":"J. Med. Virol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1007\/s10787-023-01204-1","article-title":"Long COVID and possible preventive options","volume":"31","author":"Gyires","year":"2023","journal-title":"Inflammopharmacology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s15010-023-02154-0","article-title":"Is antiviral treatment at the acute phase of COVID-19 effective for decreasing the risk of long-COVID? A systematic review","volume":"52","author":"Catahay","year":"2024","journal-title":"Infection"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1093\/qjmed\/hcab297","article-title":"Risk factors and incidence of long-COVID syndrome in hospitalized patients: Does remdesivir have a protective effect?","volume":"114","author":"Boglione","year":"2022","journal-title":"QJM"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Badenes Bonet, D., Caguana V\u00e9lez, O.A., Duran Jord\u00e0, X., Comas Serrano, M., Posso Rivera, M., Admetll\u00f3, M., Herranz Blasco, A., Cuadrado Godia, E., Marco Navarro, E., and Martin Ezquerra, G. (2023). Treatment of COVID-19 during the acute phase in hospitalized patients decreases post-acute sequelae of COVID-19. J. Clin. Med., 12.","DOI":"10.3390\/jcm12124158"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"6152","DOI":"10.1038\/s41467-022-33825-5","article-title":"Effect of remdesivir post hospitalization for COVID-19 infection from the randomized SOLIDARITY Finland trial","volume":"13","author":"Nevalainen","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e229","DOI":"10.2196\/jmir.2818","article-title":"Telephone versus internet administration of self-report measures of social anxiety, depressive symptoms, and insomnia: Psychometric evaluation of a method to reduce the impact of missing data","volume":"15","author":"Hedman","year":"2013","journal-title":"J. Med. Internet Res."},{"key":"ref_22","unstructured":"Herrmann-Lingen, C., Buss, U., and Snaith, R.P. (2011). Hospital Anxiety and Depression Scale\u2014Deutsche Version (HADS-D), Verlag Hans Huber."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez-de-las-Pe\u00f1as, C., Rodr\u00edguez-Jim\u00e9nez, J., Palacios-Ce\u00f1a, M., de-la-Llave-Rinc\u00f3n, A.I., Fuensalida-Novo, S., Florencio, L.L., Ambite-Quesada, S., Ortega-Santiago, R., Arias-Bur\u00eda, J.L., and Liew, B.X.W. (2022). Psychometric properties of the Hospital Anxiety and Depression Scale (HADS) in previously hospitalized COVID-19 patients. Int. J. Environ. Res. Public. Health, 19.","DOI":"10.3390\/ijerph19159273"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Olss\u00f8n, I., Mykletun, A., and Dahl, A.A. (2005). The Hospital Anxiety and Depression Rating Scale: A cross-sectional study of psychometrics and case findings abilities in general practice. BMC Psychiatry, 5.","DOI":"10.1186\/1471-244X-5-46"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","article-title":"The Pittsburgh Sleep Quality Index: A new instrument for psychiatric practice and research","volume":"28","author":"Buysse","year":"1989","journal-title":"Psychiatry Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s11136-005-1463-5","article-title":"The validity and reliability of the functional impairment checklist (FIC) in the evaluation of functional consequences of severe acute respiratory distress syndrome (SARS)","volume":"15","author":"Lam","year":"2006","journal-title":"Qual. Life Res."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez-de-las-Pe\u00f1as, C., Palacios-Ce\u00f1a, M., Rodr\u00edguez-Jim\u00e9nez, J., de-la-Llave-Rinc\u00f3n, A.I., Fuensalida-Novo, S., Cigar\u00e1n-M\u00e9ndez, M., Florencio, L.L., Ambite-Quesada, S., Ortega-Santiago, R., and Pardo-Hern\u00e1ndez, A. (2022). Psychometric properties of the Functional Impairment Checklist (FIC) as a disease-specific patient-reported outcome measure (PROM) in previously hospitalized COVID-19 survivors with long-COVID. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph191811460"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"750378","DOI":"10.3389\/fmed.2021.750378","article-title":"More than 100 persistent symptoms of SARS-CoV-2 (Long COVID): A scoping review","volume":"8","author":"Hayes","year":"2021","journal-title":"Front. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e28750","DOI":"10.1002\/jmv.28750","article-title":"Efficacy of nirmatrelvir and ritonavir for post-acute COVID-19 sequelae beyond 3 months of SARS-CoV-2 infection","volume":"95","author":"Chuang","year":"2023","journal-title":"J. Med. Virol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1001\/jamainternmed.2023.0743","article-title":"Association of treatment with Nirmatrelvir and the risk of post-COVID-19 condition","volume":"183","author":"Xie","year":"2023","journal-title":"JAMA Intern. Med."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Geng, L.N., Bonilla, H., Hedlin, H., Jacobson, K.B., Tian, L., Jagannathan, P., Yang, P.C., Subramanian, A.K., Liang, J.W., and Shen, S. (2024). Nirmatrelvir-Ritonavir and symptoms in adults with post-acute sequelae of SARS-CoV-2 infection: The STOP-PASC Randomized Clinical Trial. JAMA Intern. Med., e242007.","DOI":"10.1001\/jamainternmed.2024.2007"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Wang, H., Wei, Y., Hung, C.T., Lin, G., Jiang, X., Li, C., Jia, K.M., Yam, C.H.K., Chow, T.Y., and Ho, J.Y. (2024). Association of nirmatrelvir-ritonavir with post-acute sequelae and mortality in patients admitted to hospital with COVID-19: A retrospective cohort study. Lancet Infect. Dis.","DOI":"10.1016\/S1473-3099(24)00217-2"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.7326\/M23-1394","article-title":"Effectiveness of Nirmatrelvir-Ritonavir against the development of post-COVID-19 conditions among U.S. Veterans: A Target Trial Emulation","volume":"176","author":"Ioannou","year":"2023","journal-title":"Ann. Intern. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1093\/cid\/ciab352","article-title":"Development and validation of the long COVID symptom and impact tools, a set of patient-reported instruments constructed from patients\u2019 lived experience","volume":"74","author":"Tran","year":"2022","journal-title":"Clin. Infect. Dis."}],"container-title":["Viruses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4915\/16\/6\/947\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:57:16Z","timestamp":1760108236000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4915\/16\/6\/947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,12]]},"references-count":34,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["v16060947"],"URL":"https:\/\/doi.org\/10.3390\/v16060947","relation":{},"ISSN":["1999-4915"],"issn-type":[{"value":"1999-4915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,12]]}}}