{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T06:29:39Z","timestamp":1775802579411,"version":"3.50.1"},"reference-count":65,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES)","award":["2022.01991.PTDC"],"award-info":[{"award-number":["2022.01991.PTDC"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","award":["2022.01991.PTDC"],"award-info":[{"award-number":["2022.01991.PTDC"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Distrito Federal (FAPDF)","award":["2022.01991.PTDC"],"award-info":[{"award-number":["2022.01991.PTDC"]}]},{"name":"Funda\u00e7\u00e3o de Apoio ao Desenvolvimento do Ensino, Ci\u00eancia e Tecnologia do Estado de Mato Grosso do Sul (FUNDECT)","award":["2022.01991.PTDC"],"award-info":[{"award-number":["2022.01991.PTDC"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia\u2014Minist\u00e9rio da Ci\u00eancia, Tecnologia e Ensino Superior (FCT-MCTES, Portugal)","award":["2022.01991.PTDC"],"award-info":[{"award-number":["2022.01991.PTDC"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Human alphaherpesvirus 1 (HSV-1) is a significantly widespread viral pathogen causing recurrent infections that are currently incurable despite available treatment protocols. Studies have highlighted the potential of antimicrobial peptides sourced from Vespula lewisii venom, particularly those belonging to the mastoparan family, as effective against HSV-1. This study aimed to demonstrate the antiviral properties of mastoparans, including mastoparan-L [I5, R8], mastoparan-MO, and [I5, R8] mastoparan, against HSV-1. Initially, Vero cell viability was assessed in the presence of these peptides, followed by the determination of antiviral activity, mechanism of action, and dose-response curves through plaque assays. Structural analyses via circular dichroism and nuclear magnetic resonance were conducted, along with evaluating membrane fluidity changes induced by [I5, R8] mastoparan using fluorescence-labeled lipid vesicles. Cytotoxic assays revealed high cell viability (&gt;80%) at concentrations of 200 \u00b5g\/mL for mastoparan-L and mastoparan-MO and 50 \u00b5g\/mL for [I5, R8] mastoparan. Mastoparan-MO and [I5, R8] mastoparan exhibited over 80% HSV-1 inhibition, with up to 99% viral replication inhibition, particularly in the early infection stages. Structural analysis indicated an \u03b1-helical structure for [I5, R8] mastoparan, suggesting effective viral particle disruption before cell attachment. Mastoparans present promising prospects for HSV-1 infection control, although further investigation into their mechanisms is warranted.<\/jats:p>","DOI":"10.3390\/v16060948","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T06:47:30Z","timestamp":1718174850000},"page":"948","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Antiviral Activities of Mastoparan-L-Derived Peptides against Human Alphaherpesvirus 1"],"prefix":"10.3390","volume":"16","author":[{"given":"Liana Costa Pereira","family":"Vilas Boas","sequence":"first","affiliation":[{"name":"P\u00f3s-Gradua\u00e7\u00e3o em Patologia Molecular, Campus Darcy Ribeiro, Universidade de Bras\u00edlia, Bras\u00edlia 70910-900, DF, Brazil"},{"name":"Centro de An\u00e1lises Bioqu\u00edmicas e Prote\u00f4micas, P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Gen\u00f4micas e Biotecnologia, Universidade Cat\u00f3lica de Bras\u00edlia, Bras\u00edlia 70790-760, DF, Brazil"}]},{"given":"Danieli Fernanda","family":"Buccini","sequence":"additional","affiliation":[{"name":"Centro de An\u00e1lises Bioqu\u00edmicas e Prote\u00f4micas, P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Gen\u00f4micas e Biotecnologia, Universidade Cat\u00f3lica de Bras\u00edlia, Bras\u00edlia 70790-760, DF, Brazil"},{"name":"P\u00f3s-Gradua\u00e7\u00e3o em Biotecnologia, Universidade Cat\u00f3lica Dom Bosco, Campo Grande 79117-900, MS, Brazil"}]},{"given":"Rhayfa Lorrayne Ara\u00fajo","family":"Berlanda","sequence":"additional","affiliation":[{"name":"P\u00f3s-Gradua\u00e7\u00e3o em Patologia Molecular, Campus Darcy Ribeiro, Universidade de Bras\u00edlia, Bras\u00edlia 70910-900, DF, Brazil"},{"name":"Centro de An\u00e1lises Bioqu\u00edmicas e Prote\u00f4micas, P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Gen\u00f4micas e Biotecnologia, Universidade Cat\u00f3lica de Bras\u00edlia, Bras\u00edlia 70790-760, DF, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1854-8907","authenticated-orcid":false,"given":"Bruno de Paula Oliveira","family":"Santos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Resson\u00e2ncia Magn\u00e9tica Nuclear, Instituto de Qu\u00edmica, Universidade Federal de Goi\u00e1s, Goi\u00e2nia 74690-900, GO, Brazil"}]},{"given":"Mariana Rocha","family":"Maximiano","sequence":"additional","affiliation":[{"name":"Centro de An\u00e1lises Bioqu\u00edmicas e Prote\u00f4micas, P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Gen\u00f4micas e Biotecnologia, Universidade Cat\u00f3lica de Bras\u00edlia, Bras\u00edlia 70790-760, DF, Brazil"},{"name":"P\u00f3s-Gradua\u00e7\u00e3o em Biotecnologia, Universidade Cat\u00f3lica Dom Bosco, Campo Grande 79117-900, MS, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9985-2980","authenticated-orcid":false,"given":"Luciano Morais","family":"Li\u00e3o","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Resson\u00e2ncia Magn\u00e9tica Nuclear, Instituto de Qu\u00edmica, Universidade Federal de Goi\u00e1s, Goi\u00e2nia 74690-900, GO, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2903-4282","authenticated-orcid":false,"given":"S\u00f3nia","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0580-0475","authenticated-orcid":false,"given":"Nuno C.","family":"Santos","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9546-0525","authenticated-orcid":false,"given":"Oct\u00e1vio Luiz","family":"Franco","sequence":"additional","affiliation":[{"name":"P\u00f3s-Gradua\u00e7\u00e3o em Patologia Molecular, Campus Darcy Ribeiro, Universidade de Bras\u00edlia, Bras\u00edlia 70910-900, DF, Brazil"},{"name":"Centro de An\u00e1lises Bioqu\u00edmicas e Prote\u00f4micas, P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Gen\u00f4micas e Biotecnologia, Universidade Cat\u00f3lica de Bras\u00edlia, Bras\u00edlia 70790-760, DF, Brazil"},{"name":"P\u00f3s-Gradua\u00e7\u00e3o em Biotecnologia, Universidade Cat\u00f3lica Dom Bosco, Campo Grande 79117-900, MS, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s12223-016-0482-7","article-title":"Herpesvirus: An Underestimated Virus","volume":"62","author":"Rechenchoski","year":"2017","journal-title":"Folia Microbiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev-micro-092412-155654","article-title":"An Inquiry into the Molecular Basis of HSV Latency and Reactivation","volume":"67","author":"Roizman","year":"2013","journal-title":"Annu. 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