{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:41:08Z","timestamp":1760218868354,"version":"build-2065373602"},"reference-count":31,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2014,7,14]],"date-time":"2014-07-14T00:00:00Z","timestamp":1405296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Rabbit hemorrhagic disease is caused by a calicivirus, rabbit hemorrhagic disease virus (RHDV), which is responsible for high mortality in domestic and wild European rabbits (Oryctolagus cuniculus). RHDV strains were sequenced from wild European rabbits (Oryctolagus cuniculus algirus) collected in the Azorean island of Pico, Portugal. Phylogenetic analyses showed that the Pico RHDV strains diverge from all of the others described so far, but cluster with the genogroups 1\u20135 (G1\u2013G5). The genetic distance between the Pico RHDV sequences and each G1, G2 and G3\u2013G5 genogroup (~0.08) is compatible with an RHDV introduction at least 17 years ago. Our results show that in Pico, RHDV is the outcome of an independent evolution from the original RHDV strain that appeared in its European rabbit population. These are the first sequences of RHDV obtained in the subspecies O. c. algirus, outside of its original region, the Iberian Peninsula. Furthermore, we discuss the risk of rabbit translocations from the Azores to the Iberian Peninsula, where the rabbit wild populations are suffering high mortalities.<\/jats:p>","DOI":"10.3390\/v6072698","type":"journal-article","created":{"date-parts":[[2014,7,14]],"date-time":"2014-07-14T11:33:53Z","timestamp":1405337633000},"page":"2698-2707","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Rabbit Hemorrhagic Disease Virus Detected in Pico, Azores, Portugal, Revealed a Unique Endemic Strain with More Than 17 Years of Independent Evolution"],"prefix":"10.3390","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6055-8298","authenticated-orcid":false,"given":"Pedro","family":"Esteves","sequence":"first","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos, InBIO Laborat\u00f3rio Associado (CIBIO), Vair\u00e3o, 4485-661, Portugal"},{"name":"Departamento de Biologia, Faculdade de Ci\u00eancias da Universidade do Porto, Porto, 4169-007, Portugal"},{"name":"Instituto de Investiga\u00e7\u00e3o e Forma\u00e7\u00e3o Avan\u00e7ada em Ci\u00eancias e Tecnologias da Sa\u00fade (CESPU), Gandra, 4585-116, Portugal"}]},{"given":"Ana","family":"Lopes","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos, InBIO Laborat\u00f3rio Associado (CIBIO), Vair\u00e3o, 4485-661, Portugal"},{"name":"Departamento de Biologia, Faculdade de Ci\u00eancias da Universidade do Porto, Porto, 4169-007, Portugal"},{"name":"INSERM, UMR892, Universit\u00e9 de Nantes, Nantes, 44007, France"}]},{"given":"Maria","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos, InBIO Laborat\u00f3rio Associado (CIBIO), Vair\u00e3o, 4485-661, Portugal"}]},{"given":"Ana","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos, InBIO Laborat\u00f3rio Associado (CIBIO), Vair\u00e3o, 4485-661, Portugal"},{"name":"Departamento de Biologia, Faculdade de Ci\u00eancias da Universidade do Porto, Porto, 4169-007, Portugal"},{"name":"SaBio\u2014IREC (CSIC-UCLM-JCCM), Ciudad Real, 13071, Spain"}]},{"given":"David","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos, InBIO Laborat\u00f3rio Associado (CIBIO), Vair\u00e3o, 4485-661, Portugal"},{"name":"Departamento de Biologia, Faculdade de Ci\u00eancias da Universidade do Porto, Porto, 4169-007, Portugal"}]},{"given":"Joana","family":"Abrantes","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos, InBIO Laborat\u00f3rio Associado (CIBIO), Vair\u00e3o, 4485-661, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2014,7,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1297-9716-43-12","article-title":"Rabbit haemorrhagic disease (RHD) and rabbit haemorrhagic disease virus (RHDV): A review","volume":"43","author":"Abrantes","year":"2012","journal-title":"Vet. 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