{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T06:47:31Z","timestamp":1771051651220,"version":"3.50.1"},"reference-count":199,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T00:00:00Z","timestamp":1457395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC IMI-MIC 1142 2012"],"award-info":[{"award-number":["PTDC IMI-MIC 1142 2012"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BPD\/94204\/2013"],"award-info":[{"award-number":["SFRH\/BPD\/94204\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["IF\/00899\/2013"],"award-info":[{"award-number":["IF\/00899\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Many viruses exploit specific arms of the endomembrane system. The unique composition of each arm prompts the development of remarkably specific interactions between viruses and sub-organelles. This review focuses on the viral\u2013host interactions occurring on the endocytic recycling compartment (ERC), and mediated by its regulatory Ras-related in brain (Rab) GTPase Rab11. This protein regulates trafficking from the ERC and the trans-Golgi network to the plasma membrane. Such transport comprises intricate networks of proteins\/lipids operating sequentially from the membrane of origin up to the cell surface. Rab11 is also emerging as a critical factor in an increasing number of infections by major animal viruses, including pathogens that provoke human disease. Understanding the interplay between the ERC and viruses is a milestone in human health. Rab11 has been associated with several steps of the viral lifecycles by unclear processes that use sophisticated diversified host machinery. For this reason, we first explore the state-of-the-art on processes regulating membrane composition and trafficking. Subsequently, this review outlines viral interactions with the ERC, highlighting current knowledge on viral-host binding partners. Finally, using examples from the few mechanistic studies available we emphasize how ERC functions are adjusted during infection to remodel cytoskeleton dynamics, innate immunity and membrane composition.<\/jats:p>","DOI":"10.3390\/v8030064","type":"journal-article","created":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T10:14:25Z","timestamp":1457432065000},"page":"64","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Recycling Endosomes and Viral Infection"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1005-2651","authenticated-orcid":false,"given":"S\u00edlvia","family":"Vale-Costa","sequence":"first","affiliation":[{"name":"Cell Biology of Viral Infection Lab, Instituto Gulbenkian de Ci\u00eancia, Rua da Quinta Grande, 6, 2780-156 Oeiras, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4129-6659","authenticated-orcid":false,"given":"Maria","family":"Amorim","sequence":"additional","affiliation":[{"name":"Cell Biology of Viral Infection Lab, Instituto Gulbenkian de Ci\u00eancia, Rua da Quinta Grande, 6, 2780-156 Oeiras, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2016,3,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.virol.2015.02.029","article-title":"Ultrastructure of the replication sites of positive-strand RNA viruses","volume":"479\u2013480","author":"Harak","year":"2015","journal-title":"Virology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nrmicro1890","article-title":"Modification of intracellular membrane structures for virus replication","volume":"6","author":"Miller","year":"2008","journal-title":"Nat. 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