{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:30:18Z","timestamp":1772253018239,"version":"3.50.1"},"reference-count":50,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:00:00Z","timestamp":1662681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Brazilian National Council for Scientific and Technological Development","award":["306041\/2021-9"],"award-info":[{"award-number":["306041\/2021-9"]}]},{"name":"Brazilian National Council for Scientific and Technological Development","award":["305842\/2017-0"],"award-info":[{"award-number":["305842\/2017-0"]}]},{"name":"Brazilian National Council for Scientific and Technological Development","award":["313423\/2019-9"],"award-info":[{"award-number":["313423\/2019-9"]}]},{"name":"Brazilian National Council for Scientific and Technological Development","award":["305291\/2018-1"],"award-info":[{"award-number":["305291\/2018-1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Several vaccines against COVID-19 are now available, based on different techniques and made by different laboratories spread around the world. With the roll out of the vaccination process in an advanced stage in many countries, the reduced risk of hospitalization due to the Omicron variant relative to the Delta variant infection, despite the higher transmission risk of Omicron, may lead to a misinterpretation of the results, as infection by Omicron is associated with a significant reduction in severe outcomes and shorter hospitalization time than the Delta variant. We compared the in-hospital mortality due to the Omicron (Jan\u2013Mar 2022) with Gamma (Jan 2021) and Delta (Oct\u2013Dec 2021) variants of patients in the Brazilian public health system. This study also discusses the decrease in booster vaccine effectiveness in patients hospitalized due to the Omicron variant compared with the Delta variant. Without a remodeling of vaccines for new variants, booster doses may be necessary with a shorter time interval.<\/jats:p>","DOI":"10.3390\/vaccines10091504","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T04:54:41Z","timestamp":1662699281000},"page":"1504","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Retrospective Cohort Study of COVID-19 in Patients of the Brazilian Public Health System with SARS-CoV-2 Omicron Variant Infection"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5598-2679","authenticated-orcid":false,"given":"Thiago B.","family":"Murari","sequence":"first","affiliation":[{"name":"Modelagem Computacional, University Center SENAI\/CIMATEC, Salvador 41650-010, BA, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4405-1582","authenticated-orcid":false,"given":"Larissa Moraes dos Santos","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Modelagem Computacional, University Center SENAI\/CIMATEC, Salvador 41650-010, BA, Brazil"},{"name":"SENAI Institute of Innovation (ISI) in Health Advanced Systems, University Center SENAI\/CIMATEC, Salvador 41650-010, BA, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7476-9267","authenticated-orcid":false,"given":"Hernane B. de B.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Modelagem Computacional, University Center SENAI\/CIMATEC, Salvador 41650-010, BA, Brazil"},{"name":"Departamento de Ci\u00eancias Exatas e da Terra, Universidade do Estado da Bahia, Salvador 41150-000, BA, Brazil"}]},{"given":"Alo\u00edsio S.","family":"Nascimento Filho","sequence":"additional","affiliation":[{"name":"Modelagem Computacional, University Center SENAI\/CIMATEC, Salvador 41650-010, BA, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8402-6416","authenticated-orcid":false,"given":"Hugo","family":"Saba","sequence":"additional","affiliation":[{"name":"Modelagem Computacional, University Center SENAI\/CIMATEC, Salvador 41650-010, BA, Brazil"},{"name":"Departamento de Ci\u00eancias Exatas e da Terra, Universidade do Estado da Bahia, Salvador 41150-000, BA, Brazil"}]},{"given":"Fulvio A.","family":"Scorza","sequence":"additional","affiliation":[{"name":"Disciplina de Neuroci\u00eancia, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo (EPM\/UNIFESP), S\u00e3o Paulo 04021-001, SP, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4893-338X","authenticated-orcid":false,"given":"Ant\u00f4nio-Carlos","family":"G. de Almeida","sequence":"additional","affiliation":[{"name":"Departamento de Engenharia de Biossistemas, Universidade Federal de S\u00e3o Jo\u00e3o del-Rei (UFSJ), S\u00e3o Jo\u00e3o del-Rei 36307-352, MG, Brazil"}]},{"given":"Ethel L. N.","family":"Maciel","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Epidemiologia, Universidade Federal do Esp\u00edrito Santo, Vit\u00f3ria 29075-910, ES, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4707-5945","authenticated-orcid":false,"given":"Jos\u00e9 F. F.","family":"Mendes","sequence":"additional","affiliation":[{"name":"Departamento de F\u00edsica and I3N, Universidade de Aveiro, 3880 Aveiro, Portugal"}]},{"given":"Tarc\u00edsio M.","family":"Rocha Filho","sequence":"additional","affiliation":[{"name":"International Center for Condensed Matter Physics and Instituto de F\u00edsica, Universidade de Bras\u00edlia, Bras\u00edlia 70910-900, DF, Brazil"}]},{"given":"John R.","family":"David","sequence":"additional","affiliation":[{"name":"Faculty of Public Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA"},{"name":"Department of Immunology and Infectious Diseases, Harvard Medical School, Boston, MA 02115, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2861-5061","authenticated-orcid":false,"given":"Roberto","family":"Badar\u00f3","sequence":"additional","affiliation":[{"name":"Modelagem Computacional, University Center SENAI\/CIMATEC, Salvador 41650-010, BA, Brazil"},{"name":"SENAI Institute of Innovation (ISI) in Health Advanced Systems, University Center SENAI\/CIMATEC, Salvador 41650-010, BA, Brazil"}]},{"given":"Bruna Aparecida Souza","family":"Machado","sequence":"additional","affiliation":[{"name":"Modelagem Computacional, University Center SENAI\/CIMATEC, Salvador 41650-010, BA, Brazil"},{"name":"SENAI Institute of Innovation (ISI) in Health Advanced Systems, University Center SENAI\/CIMATEC, Salvador 41650-010, BA, Brazil"}]},{"given":"Marcelo A.","family":"Moret","sequence":"additional","affiliation":[{"name":"Modelagem Computacional, University Center SENAI\/CIMATEC, Salvador 41650-010, BA, Brazil"},{"name":"Departamento de Ci\u00eancias Exatas e da Terra, Universidade do Estado da Bahia, Salvador 41150-000, BA, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,9]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2020, September 09). 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