{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T12:03:01Z","timestamp":1769169781720,"version":"3.49.0"},"reference-count":20,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T00:00:00Z","timestamp":1679270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Pfizer Portugal","award":["42420671"],"award-info":[{"award-number":["42420671"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Background: Patients with immune-mediated inflammatory diseases (IMIDs) treated with immunomodulatory therapy present an increased susceptibility to infections. Vaccination is a crucial element in the management of IMID patients; however, rates remain suboptimal. This study intended to clarify the adherence to prescribed vaccines. Materials and methods: This prospective cohort study included 262 consecutive adults with inflammatory bowel disease and rheumatological diseases who underwent an infectious diseases evaluation before initiating or switching immunosuppressive\/biological therapy. Vaccine prescription and adherence were assessed during an infectious diseases (ID) consultation using a real-world multidisciplinary clinical project. Results: At baseline, less than 5% had all their vaccines up-to-date. More than 650 vaccines were prescribed to 250 (95.4%) patients. The most prescribed were pneumococcal and influenza vaccines, followed by hepatitis A and B vaccines. Adherence to each of the vaccines ranged from 69.1\u201387.3%. Complete adherence to vaccines occurred in 151 (60.4%) patients, while 190 (76%) got at least two-thirds of them. Twenty patients (8%) did not adhere to any of the vaccines. No significant differences were found in the adherence rates of patients with different sociodemographic and health-related determinants. Conclusions: ID physicians can play a role in the process of increasing vaccine prescription and adherence. However, more data on patients\u2019 beliefs and vaccine hesitancy, along with mobilization of all health care professionals and adequate local interventions, shall be considered to improve vaccine adherence.<\/jats:p>","DOI":"10.3390\/vaccines11030703","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T05:46:42Z","timestamp":1679291202000},"page":"703","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Adherence to Vaccines in Adult Patients with Immune-Mediated Inflammatory Diseases: A Two-Year Prospective Portuguese Cohort Study"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6464-7063","authenticated-orcid":false,"given":"Candida","family":"Abreu","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, S\u00e3o Jo\u00e3o Hospital Center, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"},{"name":"Department of Medicine, Faculty of Medicine, University of Porto, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"},{"name":"Instituto de Inova\u00e7\u00e3o e Investiga\u00e7\u00e3o em Sa\u00fade (I3S), Rua Alfredo Allen 208, 4200-135 Porto, Portugal"},{"name":"Instituto Nacional de Engenharia Biom\u00e9dica (INEB), Rua do Campo Alegre 823, 4150-177 Porto, Portugal"}]},{"given":"Antonio","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, S\u00e3o Jo\u00e3o Hospital Center, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"},{"name":"Department of Medicine, Faculty of Medicine, University of Porto, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"}]},{"given":"Fernando","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, S\u00e3o Jo\u00e3o Hospital Center, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"},{"name":"Department of Medicine, Faculty of Medicine, University of Porto, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"}]},{"given":"Gabriela","family":"Canelas","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, S\u00e3o Jo\u00e3o Hospital Center, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"},{"name":"Department of Medicine, Faculty of Medicine, University of Porto, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"}]},{"given":"Lucia","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, S\u00e3o Jo\u00e3o Hospital Center, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"},{"name":"Department of Medicine, Faculty of Medicine, University of Porto, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"}]},{"given":"Stefano","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, S\u00e3o Jo\u00e3o Hospital Center, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"},{"name":"Department of Medicine, Faculty of Medicine, University of Porto, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"}]},{"given":"Antonio","family":"Sarmento","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, S\u00e3o Jo\u00e3o Hospital Center, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"},{"name":"Department of Medicine, Faculty of Medicine, University of Porto, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"},{"name":"Instituto de Inova\u00e7\u00e3o e Investiga\u00e7\u00e3o em Sa\u00fade (I3S), Rua Alfredo Allen 208, 4200-135 Porto, Portugal"},{"name":"Instituto Nacional de Engenharia Biom\u00e9dica (INEB), Rua do Campo Alegre 823, 4150-177 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2634-9668","authenticated-orcid":false,"given":"Fernando","family":"Magro","sequence":"additional","affiliation":[{"name":"Unit of Pharmacology and Therapeutics, Department of Biomedicine, Faculty of Medicine, University of Porto, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"},{"name":"Department of Gastroenterology, S\u00e3o Jo\u00e3o Hospital Center, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"},{"name":"Clinical Pharmacology Unit, S\u00e3o Jo\u00e3o Hospital Center, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1007\/s11938-018-0200-4","article-title":"Update on Vaccinating the Patient with Inflammatory Bowel Disease","volume":"16","author":"Coukos","year":"2018","journal-title":"Curr. Treat. Options Gastroenterol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1136\/annrheumdis-2019-215882","article-title":"2019 update of EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases","volume":"79","author":"Furer","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ajg.2016.537","article-title":"ACG Clinical Guideline: Preventive Care in Inflammatory Bowel Disease","volume":"112","author":"Farraye","year":"2017","journal-title":"Am. J. Gastroenterol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1093\/ecco-jcc\/jjab052","article-title":"ECCO Guidelines on the Prevention, Diagnosis, and Management of Infections in Inflammatory Bowel Disease","volume":"15","author":"Kucharzik","year":"2021","journal-title":"J. Crohns Coliti"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"374","DOI":"10.7326\/M20-8080","article-title":"Recommended Adult Immunization Schedule, United States, 2021","volume":"174","author":"Freedman","year":"2021","journal-title":"Ann. Intern. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1097\/01.MIB.0000437737.68841.87","article-title":"Immunization Rates and Vaccine Beliefs Among Patients with Inflammatory Bowel Disease: An opportunity for improvement","volume":"20","author":"Wasan","year":"2014","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00296-016-3608-y","article-title":"Low vaccination rates among patients with rheumatoid arthritis in a German outpatient clinic","volume":"37","author":"Krasselt","year":"2017","journal-title":"Rheumatol. Int."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/ecco-jcc\/jjv064","article-title":"Vaccination in Inflammatory Bowel Disease Patients: Attitudes, Knowledge, and Uptake","volume":"9","author":"Malhi","year":"2015","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_9","first-page":"CD008983","article-title":"Influenza vaccines in immunosuppressed adults with cancer","volume":"2","author":"Bitterman","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e2016044","DOI":"10.4084\/mjhid.2016.044","article-title":"Influenza and pneumococcal vaccination in hematological malignancies: A systematic review of efficacy, effectiveness and safety","volume":"8","author":"Mannocci","year":"2016","journal-title":"Mediterr. J. Hematol. Infect. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.mayocp.2019.02.024","article-title":"Vaccination of Adults in General Medical Practice","volume":"95","author":"Hunter","year":"2020","journal-title":"Mayo Clin. Proc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1093\/ibd\/izab247","article-title":"Interventions to Improve Adherence to Preventive Care in Inflammatory Bowel Disease: A Systematic Review","volume":"28","author":"Yu","year":"2022","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1007\/s10067-019-04430-7","article-title":"Interventions to improve vaccine acceptance among rheumatoid arthritis patients: A systematic review","volume":"38","author":"Colmegna","year":"2019","journal-title":"Clin. Rheumatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/apt.15057","article-title":"Vaccination for influenza and pneumococcus in patients with gastrointestinal cancer or inflammatory bowel disease: A prospective cohort study of methods for improving coverage","volume":"49","author":"Sitte","year":"2019","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s10067-020-05059-7","article-title":"Understanding factors associated with vaccine uptake and vaccine hesitancy in patients with rheumatoid arthritis: A scoping literature review","volume":"40","author":"Boucher","year":"2021","journal-title":"Clin. Rheumatol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Aw, J., Seng, J.J.B., Seah, S.S.Y., and Low, L.L. (2021). COVID-19 Vaccine Hesitancy\u2014A Scoping Review of Literature in High-Income Countries. Vaccines, 9.","DOI":"10.3390\/vaccines9080900"},{"key":"ref_17","unstructured":"Centers for Disease Control and Prevention (2021, July 27). Standards for Adult Immunization Practice, Available online: www.cdc.gov\/vaccines\/hcp\/adults\/for-practice\/standards\/index.html."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"6681","DOI":"10.1016\/j.vaccine.2016.11.015","article-title":"Vaccination of special populations: Protecting the vulnerable","volume":"34","author":"Doherty","year":"2016","journal-title":"Vaccine"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.vaccine.2020.12.014","article-title":"Assessing the impact of shared decision making processes on influenza vaccination rates in adult patients in outpatient care: A systematic review and meta-analysis","volume":"39","author":"Sanftenberg","year":"2021","journal-title":"Vaccine"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.dld.2017.09.002","article-title":"Screening, prophylaxis and counselling before the start of biological therapies: A practical approach focused on IBD patients","volume":"49","author":"Abreu","year":"2017","journal-title":"Dig. Liver Dis."}],"container-title":["Vaccines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-393X\/11\/3\/703\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:59:03Z","timestamp":1760122743000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-393X\/11\/3\/703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,20]]},"references-count":20,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["vaccines11030703"],"URL":"https:\/\/doi.org\/10.3390\/vaccines11030703","relation":{},"ISSN":["2076-393X"],"issn-type":[{"value":"2076-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,20]]}}}