{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T21:35:59Z","timestamp":1772055359064,"version":"3.50.1"},"reference-count":16,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T00:00:00Z","timestamp":1604361600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04565\/2020"],"award-info":[{"award-number":["UIDB\/04565\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008679","name":"University of C\u00f3rdoba","doi-asserted-by":"publisher","award":["MOD.4.2 P.P.2017 AGR164 AGR256"],"award-info":[{"award-number":["MOD.4.2 P.P.2017 AGR164 AGR256"]}],"id":[{"id":"10.13039\/501100008679","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vaccines"],"abstract":"<jats:p>Despite the outstanding technological advances achieved in the last few decades, infectious diseases remain a major societal challenge. From the variolation carried out in ancient China during the 15th century to the more advanced RNA and DNA vaccines presently available, vaccines have been proven as highly effective therapeutic tools to combat various infectious diseases. Vaccine research and development is now empowered with recent advances in Omics sciences and the developments of powerful bioinformatics tools. This Special Issue has gathered a total of nine original papers, including seven research papers and two reviews, illustrating the use of Omics data and bioinformatics in the research, design and development of vaccines against pathogens and cancer. The integration of knowledge from Omics and Bioinformatics will certainly boost vaccine research and development, leading to novel therapeutic tools against new and old pathogens and cancer in the near future.<\/jats:p>","DOI":"10.3390\/vaccines8040653","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T20:00:29Z","timestamp":1604433629000},"page":"653","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Omics and Bioinformatics Approaches to Identify Novel Antigens for Vaccine Investigation and Development"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8850-274X","authenticated-orcid":false,"given":"Jorge H.","family":"Leit\u00e3o","sequence":"first","affiliation":[{"name":"iBB\u2014Institute for Bioengineering and Biosciences, and Bioengineering Department, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1049-001 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8744-7045","authenticated-orcid":false,"given":"Manuel J.","family":"Rodr\u00edguez-Ortega","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of C\u00f3rdoba, Campus de Excelencia Internacional CeiA3, 14071 C\u00f3rdoba, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,3]]},"reference":[{"key":"ref_1","unstructured":"(2020, October 19). COVID-19 Data Repository by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University. Available online: https:\/\/github.com\/CSSEGISandData\/COVID-19."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Mukherjee, S., Tworowski, D., Detroja, R., Mukherjee, S.B., and Frenkel-Morgenstern, M. (2020). Immunoinformatics and Structural Analysis for Identification of Immunodominant Epitopes in SARS-CoV-2 as Potential Vaccine Targets. Vaccines, 8.","DOI":"10.3390\/vaccines8020290"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1099\/ijsem.0.002293","article-title":"Burkholderia puraquae sp. nov., a novel species of the Burkholderia cepacia complex isolated from hospital settings and agricultural soils","volume":"68","author":"Martina","year":"2018","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Sousa, S., Seixas, A., and Leit\u00e3o, J.H. (2018). Postgenomic Approaches and Bioinformatics Tools to Advance the Development of Vaccines against Bacteria of the Burkholderia cepacia Complex. Vaccines, 6.","DOI":"10.3390\/vaccines6020034"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Sousa, S.A., Seixas, A.M., Mandal, M., Rodr\u00edguez-Ortega, M.J., and Leit\u00e3o, J.H. (2020). Characterization of the Burkholderia cenocepacia J2315 Surface-Exposed Immunoproteome. Vaccines, 8.","DOI":"10.3390\/vaccines8030509"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nbt1179","article-title":"Characterization and identification of vaccine candidate proteins through analysis of the group A Streptococcus surface proteome","volume":"24","author":"Norais","year":"2006","journal-title":"Nat. Biotechnol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Gal\u00e1n-Rela\u00f1o, \u00c1., G\u00f3mez-Gasc\u00f3n, L., Rodr\u00edguez-Franco, A., Luque, I., Huerta, B., Tarradas, C., and Rodr\u00edguez-Ortega, M.J. (2020). Search of Potential Vaccine Candidates against Trueperella pyogenes Infections through Proteomic and Bioinformatic Analysis. Vaccines, 8.","DOI":"10.3390\/vaccines8020314"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Rzewuska, M., Kwiecie\u0144, E., Chrobak-Chmiel, D., Kizerwetter-\u015awida, M., Stefa\u0144ska, I., and Giery\u0144ska, M. (2019). Pathogenicity and Virulence of Trueperella pyogenes: A Review. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20112737"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Prados de la Torre, E., Rodr\u00edguez-Franco, A., and Rodr\u00edguez-Ortega, M.J. (2020). Proteomic and Bioinformatic Analysis of Streptococcus suis Human Isolates: Combined Prediction of Potential Vaccine Candidates. Vaccines, 8.","DOI":"10.3390\/vaccines8020188"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Kerdsin, A., Takeuchi, D., Nuangmek, A., Akeda, Y., Gottschalk, M., and Oishi, K. (2020). Genotypic Comparison between Streptococcus suis Isolated from Pigs and Humans in Thailand. Pathogens, 9.","DOI":"10.3390\/pathogens9010050"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Costa, J.P., Pinheiro, M.J.F., Sousa, S.A., Botelho do Rego, A.M., Marques, F., Oliveira, M.C., Leit\u00e3o, J.H., Mira, N.P., and NN Carvalho, M.F. (2019). Antimicrobial Activity of Silver Camphorimine Complexes against Candida Strains. Antibiotics, 8.","DOI":"10.3390\/antibiotics8030144"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Buldain, I., Pellon, A., Zaldibar, B., Antoran, A., Martin-Souto, L., Aparicio-Fernandez, L., Areitio, M., Mayayo, E., Rementeria, A., and Hernando, F.L. (2019). Study of Humoral Responses against Lomentospora\/Scedosporium spp. and Aspergillus fumigatus to Identify L. prolificans Antigens of Interest for Diagnosis and Treatment. Vaccines, 7.","DOI":"10.3390\/vaccines7040212"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Zhu, T., McClure, R., Harrison, O.B., Genco, C., and Massari, P. (2019). Integrated Bioinformatic Analyses and Immune Characterization of New Neisseria gonorrhoeae Vaccine Antigens Expressed during Natural Mucosal Infection. Vaccines, 7.","DOI":"10.3390\/vaccines7040153"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Dar, H.A., Zaheer, T., Shehroz, M., Ullah, N., Naz, K., Muhammad, S.A., Zhang, T., and Ali, A. (2019). 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