{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:09:01Z","timestamp":1777424941802,"version":"3.51.4"},"reference-count":49,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Portuguese Foundation for Science and Technology (FCT)","award":["UIDB\/00276\/2020"],"award-info":[{"award-number":["UIDB\/00276\/2020"]}]},{"name":"Portuguese Foundation for Science and Technology (FCT)","award":["LA\/P\/0059\/2020"],"award-info":[{"award-number":["LA\/P\/0059\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>The study aimed to investigate the impact of noise levels in the hospital environment on the stress experienced by hospitalized cats undergoing elective ovariohysterectomy surgery. A total of 33 domestic female cats were included in the study, divided into four groups: a control group (CG) and three experimental groups based on ward noise levels: G1 (Quiet, &lt;60 dB), G2 (Medium, between 60 and 85 dB), and G3 (Noisy, &gt;85 dB). Behavioral assessments, respiratory rate (RR), and plasma cortisol levels ([Cort]p) were measured as indicators of stress. A composite measure of stress, termed the final stress value (FSV), was calculated by summing scores across various behavioral categories. Data collection occurred at three time points: immediately following surgery (T1), and at 2 h (T2) and 3 h (T3) post-surgery. FSV and RR were assessed at all three time points (T1, T2, and T3), while [Cort]p levels were measured at T1 and T3. The study observed that the median values of FSV, RR, and [Cort]p tended to increase with both higher noise levels and longer exposure durations to noise. Significant differences in RR were found between group pairs G1G2 at T1 (|D| = 0.63 &lt; cut-off = 0.98), and G2G3 at T2 (|D| = 0.69 &lt; cut-off = 0.97). Regarding [Cort]p, significant differences were noted between the CGG1 group pair at T0 (p &lt; 0.01), and T3 (p = 0.03). Furthermore, an excellent Spearman correlation coefficient (rho = 0.91) was found between FSV and RR, indicating that RR can serve as an effective tool for assessing stress levels in cats. The findings of this study provide valuable insights into the welfare of cats in a hospital environment and support the scientific validity of existing recommendations aimed at improving their well-being. Specifically, the study underscores the importance of minimizing noise levels in hospitals as a means to reduce stress in cats. This conclusion aligns with existing guidelines and recommendations for enhancing the welfare of hospitalized cats.<\/jats:p>","DOI":"10.3390\/vetsci11040173","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T03:56:13Z","timestamp":1713153373000},"page":"173","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Influence of Noise Level on the Stress Response of Hospitalized Cats"],"prefix":"10.3390","volume":"11","author":[{"given":"Marisa","family":"Gir\u00e3o","sequence":"first","affiliation":[{"name":"Department of Clinics\u2014Surgery, Faculty of Veterinary Medicine, University of Lisbon (FMV-ULisboa), 1300 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3733-3223","authenticated-orcid":false,"given":"George","family":"Stilwell","sequence":"additional","affiliation":[{"name":"Department of Clinics\u2014Surgery, Faculty of Veterinary Medicine, University of Lisbon (FMV-ULisboa), 1300 Lisbon, Portugal"},{"name":"Centre for Interdisciplinary Research in Animal Health (CIISA), University of Lisbon (FMV-ULisboa), 1300 Lisbon, Portugal"},{"name":"Associate Laboratory for Animal and Veterinary Sciences (AL4AnimalS), 1300 Lisbon, Portugal"}]},{"given":"Pedro","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Anjos of Assis Veterinary Medicine Centre (CMVAA), 2830 Barreiro, Portugal"},{"name":"Faculty of American Laser Study Club\u2014ALSC, Altamonte Springs, FL 32714, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6784-2806","authenticated-orcid":false,"given":"L. Miguel","family":"Carreira","sequence":"additional","affiliation":[{"name":"Department of Clinics\u2014Surgery, Faculty of Veterinary Medicine, University of Lisbon (FMV-ULisboa), 1300 Lisbon, Portugal"},{"name":"Centre for Interdisciplinary Research in Animal Health (CIISA), University of Lisbon (FMV-ULisboa), 1300 Lisbon, Portugal"},{"name":"Associate Laboratory for Animal and Veterinary Sciences (AL4AnimalS), 1300 Lisbon, Portugal"},{"name":"Anjos of Assis Veterinary Medicine Centre (CMVAA), 2830 Barreiro, Portugal"},{"name":"Faculty of American Laser Study Club\u2014ALSC, Altamonte Springs, FL 32714, USA"},{"name":"Private Human Dentistry (PHD), 1200 Lisbon, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,12]]},"reference":[{"key":"ref_1","unstructured":"Bayer HealthCare (2024, March 13). Bayer Veterinary Care Usage Study III: Feline Findings. Available online: http:\/\/www.bayerdvm.com\/show.aspx\/news-release-bvcus-iii-feline-findings."},{"key":"ref_2","unstructured":"Overall, K.L. (2013). Manual of Clinical Behavioral Medicine for Dogs and Cats, Elsevier Mosby."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Rodan, I., and Heath, S. (2016). Feline Behavioral Health and Welfare, Elsevier.","DOI":"10.1016\/B978-1-4557-7401-2.00002-7"},{"key":"ref_4","unstructured":"Beaver, B.V. (2003). Feline Behavior: A Guide for Veterinarians, Elsevier. [2nd ed.]."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nrn849","article-title":"The stressed hippocampus, synaptic plasticity and lost memories","volume":"3","author":"Kim","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/978-1-4020-3227-1_2","article-title":"The assessment of welfare","volume":"Volume 3","author":"Rochlitz","year":"2007","journal-title":"The Welfare of Cats"},{"key":"ref_7","first-page":"95","article-title":"Evolutionary origins and functions of the stress response system","volume":"Volume 1","author":"Fink","year":"2016","journal-title":"Stress: Concepts, Cognition, Emotion and Behavior\u2014Handbook of Stress"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Rodan, I., and Heath, S. (2016). Feline Behavioral Health and Welfare, Elsevier.","DOI":"10.1016\/B978-1-4557-7401-2.00002-7"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.jfms.2011.03.012","article-title":"AAFP and ISFM feline-friendly handling guidelines","volume":"13","author":"Rodan","year":"2011","journal-title":"J. Feline Med. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.applanim.2014.10.005","article-title":"Comparison of stress exhibited by cats examined in a clinic versus a home setting","volume":"173","author":"Nibblett","year":"2015","journal-title":"Appl. Anim. Behav. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.applanim.2014.08.006","article-title":"Environmental factors that affect the behavior and welfare of domestic cats (Felis silvestris catus) housed in cages","volume":"160","author":"Stella","year":"2014","journal-title":"Appl. Anim. Behav. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1177\/1098612X15599420","article-title":"Improving the feline veterinary consultation: The usefulness of Feliway spray in reducing cats\u2019 stress","volume":"18","author":"Pereira","year":"2016","journal-title":"J. Feline Med. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Rodan, I., and Heath, S. (2016). Feline Behavioral Health and Welfare, Elsevier.","DOI":"10.1016\/B978-1-4557-7401-2.00002-7"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Rodan, I., and Heath, S. (2016). Feline Behavioral Health and Welfare, Elsevier.","DOI":"10.1016\/B978-1-4557-7401-2.00002-7"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1080\/10888705.2016.1173548","article-title":"Guardians \u2018Perceptions of Cats\u2019 Welfare and Behavior Regarding Visiting Veterinary Clinics","volume":"19","author":"Mariti","year":"2016","journal-title":"J. Apply Anim. Welf. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"202","DOI":"10.2460\/javma.249.2.202","article-title":"Efficacy of a single dose of trazodone hydrochloride given to cats prior to veterinary visits to reduce signs of transport- and examination-related anxiety","volume":"249","author":"Stevens","year":"2016","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_17","unstructured":"Overall, K.L., Rodan, I., Beaver, B.V., Carney, H., Crowell-Davis, S., Hird, N., Kudrak, S., and Wexler-Mitchell, E. (2024, March 13). Feline Behavior Guidelines from the American Association of Feline Practitioners. Obtained from American Association of Feline Practitioners: Veterinary Professionals Passionate about the Care of Cats. Available online: http:\/\/www.catvets.com\/guidelines\/practice-guidelines\/behavior-guidelines."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.applanim.2015.04.001","article-title":"A Standardized Ethogram for the Felidae: A Tool for Behavioral Researchers","volume":"173","author":"Stanton","year":"2015","journal-title":"Appl. Anim. Behav. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1017\/S0962728600019837","article-title":"Stress and adaptation of cats (Felis silvestris catus) housed singly, in pairs and in groups in boarding catteries","volume":"6","author":"Kessler","year":"1997","journal-title":"Anim. Welf."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1037\/1040-3590.6.4.284","article-title":"Guidelines, criteria, and rules of thumb for evaluating normed and standardized assessment instruments in psychology","volume":"6","author":"Cicchetti","year":"1994","journal-title":"Psychol. Assess."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Rodan, I., and Heath, S. (2016). Feline Behavioral Health and Welfare, Elsevier.","DOI":"10.1016\/B978-1-4557-7401-2.00002-7"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Doi, S.A.R., and Williams, G.M. (2013). Methods of Clinical Epidemiology, Springer.","DOI":"10.1007\/978-3-642-37131-8"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s10571-012-9814-6","article-title":"What can we know from pituitary-adrenal hormones about the nature and consequences of exposure to emotional stressors?","volume":"32","author":"Armario","year":"2012","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1242\/jeb.089722","article-title":"What is environmental stress: Insights from fish living in a variable environment","volume":"217","author":"Schulte","year":"2014","journal-title":"J. Exp. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1097\/00006842-199509000-00009","article-title":"Persistent high cortisol responses to repeated psychological stress in a subpopulation of healthy men","volume":"57","author":"Kirschbaum","year":"1995","journal-title":"Psychosom. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0031-9384(96)00465-9","article-title":"Adrenocortical responses to repeated parachute jumping and subsequent h-CRH challenge in inexperienced healthy subjects","volume":"61","author":"Deinzer","year":"1997","journal-title":"Physiol. Behav."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Antony, M.M., and Swinson, R.P. (2000). Phobic Disorders and Panic in Adults: A Guide to Assessment and Treatment, American Psychological Association.","DOI":"10.1037\/10348-000"},{"key":"ref_28","unstructured":"Barlow, D.H. (2002). Anxiety and Its Disorders: The Nature and Treatment of Anxiety and Panic, Guilford. [2nd ed.]."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1248\/bpb.28.2146","article-title":"Comparison of the effects of cytoprotective drugs on human plasma adrenocorticotropic hormone and cortisol levels with continual stress exposure","volume":"28","author":"Katagiri","year":"2005","journal-title":"Biol. Pharm. Bull."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.biopha.2006.01.004","article-title":"Comparison of the effects of proton pump inhibitors on human plasma adrenocorticotropic hormone and cortisol levels under the starved condition","volume":"60","author":"Katagiri","year":"2006","journal-title":"Biomed. Pharmacother."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"193","DOI":"10.4103\/0250-474X.91582","article-title":"Influence of proton pump inhibitors on dexamethasone-induced gastric mucosal damage in rats","volume":"7","author":"Swamy","year":"2011","journal-title":"Indian J. Pharm. Sci."},{"key":"ref_32","first-page":"718","article-title":"Environmental strategies to promote health and wellness","volume":"Volume 7","author":"Little","year":"2016","journal-title":"August\u2019s Consultations in Feline Internal Medicine"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1177\/1098612X15575778","article-title":"Influence of music and its genres on respiratory rate and pupil diameter variations in cats under general anaesthesia: Contribution to promoting patient safety","volume":"18","author":"Mira","year":"2016","journal-title":"J. Feline Med. Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1177\/1098612X15588968","article-title":"A pilot study exploring the effects of musical genres on the depth of general anaesthesia assessed by haemodynamic responses","volume":"18","author":"Mira","year":"2016","journal-title":"J. Feline Med. Surg."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.applanim.2006.05.032","article-title":"Sources of stress in captivity","volume":"102","author":"Morgan","year":"2007","journal-title":"Appl. Anim. Behav. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1177\/0146167206293986","article-title":"Stress on the Dance Floor: The Cortisol Stress Response to Social-Evaluative Threat in Competitive Ballroom Dancers","volume":"33","author":"Rohleder","year":"2007","journal-title":"Personal. Soc. Psychol. Bull."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.applanim.2012.10.014","article-title":"Effects of stressors on the behavior and physiology of domestic cats","volume":"143","author":"Stella","year":"2013","journal-title":"Appl. Anim. Behav. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"548","DOI":"10.2460\/javma.2005.226.548","article-title":"Assessment of stress levels among cats in four animal shelters","volume":"226","author":"McCobb","year":"2005","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.resp.2008.10.001","article-title":"Cortical and subcortical central neural pathways in respiratory sensations","volume":"167","author":"Davenport","year":"2008","journal-title":"Respir. Physiol. Neurobiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0167-8760(97)00052-4","article-title":"Anxiety and respiratory patterns: Their relationship during mental stress and physical load","volume":"27","author":"Masaoka","year":"1997","journal-title":"Int. J. Psychophysiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"465","DOI":"10.2170\/jjphysiol.54.465","article-title":"Breathing patterns associated with trait anxiety and breathlessness in humans","volume":"54","author":"Masaoka","year":"2004","journal-title":"Jpn. J. Physiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1159\/000066388","article-title":"Nonlinear measures of respiration: Respiratory irregularity and increased chaos of respiration in patients with panic disorder","volume":"46","author":"Yeragani","year":"2002","journal-title":"Neuropsychobiology"},{"key":"ref_43","unstructured":"Lewis, M., Haviland-Jones, J.M., and Feldman Barrett, L. (2007). Handbook of Emotions, Guilford Press."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2170\/physiolsci.RP000607","article-title":"State anxiety dependent on perspiration during mental stress and deep inspiration","volume":"57","author":"Masaoka","year":"2007","journal-title":"J. Physiol. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.neuroimage.2010.11.050","article-title":"The impact of anxiety on the neural processing of respiratory sensations","volume":"55","author":"Chan","year":"2011","journal-title":"Neuroimage"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/da.22076","article-title":"The breathing conundrum-interoceptive sensitivity and anxiety","volume":"30","author":"Paulus","year":"2013","journal-title":"Depress. Anxiety"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.2460\/javma.233.12.1902","article-title":"Use of trazodone as an adjunctive agent in the treatment of canine anxiety disorders: 56 cases (1995\u20132007)","volume":"233","author":"Gruen","year":"2008","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_48","unstructured":"Landsberg, G.M., and Hunthausen, W.L. (1997). Handbook of Behavior Problems of the Dog and Cat, Elsevier Health Sciences."},{"key":"ref_49","unstructured":"Yin, S. (2011). Low Stress Handling, Restraint and Behavior Modification of Dogs & Cats: Techniques for Developing Patients Who Love Their Visits, CattleDog Publishing."}],"container-title":["Veterinary Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-7381\/11\/4\/173\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:27:23Z","timestamp":1760106443000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-7381\/11\/4\/173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,12]]},"references-count":49,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["vetsci11040173"],"URL":"https:\/\/doi.org\/10.3390\/vetsci11040173","relation":{},"ISSN":["2306-7381"],"issn-type":[{"value":"2306-7381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,12]]}}}