{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T11:48:31Z","timestamp":1773229711950,"version":"3.50.1"},"reference-count":158,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T00:00:00Z","timestamp":1471305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Foundation (FCT) from Portugal","award":["SFRH\/BD\/48392\/ 2008"],"award-info":[{"award-number":["SFRH\/BD\/48392\/ 2008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>The records are not clear, but Man has been sheltering the cat inside his home for over 12,000 years. The close proximity of this companion animal, however, goes beyond sharing the same roof; it extends to the great similarity found at the cellular and molecular levels. Researchers have found a striking resemblance between subtypes of feline mammary tumors and their human counterparts that goes from the genes to the pathways involved in cancer initiation and progression. Spontaneous cat mammary pre-invasive intraepithelial lesions (hyperplasias and neoplasias) and malignant lesions seem to share a wide repertoire of molecular features with their human counterparts. In the present review, we tried to compile all the genetics aspects published (i.e., chromosomal alterations, critical cancer genes and their expression) regarding cat mammary tumors, which support the cat as a valuable alternative in vitro cell and animal model (i.e., cat mammary cell lines and the spontaneous tumors, respectively), but also to present a critical point of view of some of the issues that really need to be investigated in future research.<\/jats:p>","DOI":"10.3390\/vetsci3030017","type":"journal-article","created":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T10:03:21Z","timestamp":1471341801000},"page":"17","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Cat Mammary Tumors: Genetic Models for the Human Counterpart"],"prefix":"10.3390","volume":"3","author":[{"given":"Filomena","family":"Adega","sequence":"first","affiliation":[{"name":"Laboratory of Cytogenomics and Animal Genomics (CAG), Department of Genetics and Biotechnology (DGB), University of Tr\u00e1s-os-Montes and Alto Douro (UTAD), Vila Real 5001-801, Portugal"},{"name":"Faculty of Sciences, BioISI\u2014Biosystems &amp; Integrative Sciences Institute, University of Lisboa, Campo Grande, Lisboa 1749-016, Portugal"}]},{"given":"Ana","family":"Borges","sequence":"additional","affiliation":[{"name":"Laboratory of Cytogenomics and Animal Genomics (CAG), Department of Genetics and Biotechnology (DGB), University of Tr\u00e1s-os-Montes and Alto Douro (UTAD), Vila Real 5001-801, Portugal"},{"name":"Faculty of Sciences, BioISI\u2014Biosystems &amp; Integrative Sciences Institute, University of Lisboa, Campo Grande, Lisboa 1749-016, Portugal"}]},{"given":"Raquel","family":"Chaves","sequence":"additional","affiliation":[{"name":"Laboratory of Cytogenomics and Animal Genomics (CAG), Department of Genetics and Biotechnology (DGB), University of Tr\u00e1s-os-Montes and Alto Douro (UTAD), Vila Real 5001-801, Portugal"},{"name":"Faculty of Sciences, BioISI\u2014Biosystems &amp; Integrative Sciences Institute, University of Lisboa, Campo Grande, Lisboa 1749-016, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2016,8,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3390\/vetsci2030111","article-title":"Cats, cancer and comparative oncology","volume":"2","author":"Cannon","year":"2015","journal-title":"Vet. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1158\/0008-5472.907.65.3","article-title":"Spontaneous feline mammary carcinoma is a model of HER2 overexpressing poor prognosis human breast cancer","volume":"65","author":"Olivero","year":"2005","journal-title":"Cancer Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"927","DOI":"10.4161\/cbt.11.11.15525","article-title":"Studies on the inhibition of feline EGFR in squamous cell carcinoma: Enhancement of radiosensitivity and rescue of resistance to small molecule inhibitors","volume":"11","author":"Bergkvist","year":"2011","journal-title":"Cancer Biol. Ther."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.3390\/ijms13032783","article-title":"Sequence variants and haplotype analysis of cat ERBB2 gene: A survey on spontaneous cat mammary neoplastic and non-neoplastic lesions","volume":"13","author":"Santos","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/nrc2273","article-title":"Translation of new cancer treatments from pet dogs to humans","volume":"8","author":"Paoloni","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.2147\/DDDT.S49584","article-title":"Animal models and therapeutic molecular targets of cancer: Utility and limitations","volume":"8","author":"Cekanova","year":"2014","journal-title":"Drug Des. Devel. Ther."},{"key":"ref_7","unstructured":"Thomas, R., Seixas, F., Borst, L., and Breen, M. (2015, January 22\u201326). Landscapes of Genomic Copy Number Aberrations in Feline Mammary Cancer. Proceedings of the 8th International Conference on Advances in Canine and Feline Genomics and Inherited Diseases, Cambridge, UK. Available online: http:\/\/www.caninefelinegenomicsconference.org\/."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/BF00046339","article-title":"Spontaneous tumors in dogs and cats: Models for the study of cancer biology and treatment","volume":"9","author":"MacEwen","year":"1990","journal-title":"Cancer Metast. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"246","DOI":"10.3390\/vetsci2030246","article-title":"Cytogenomics of feline cancers: Advances and opportunities","volume":"2","author":"Thomas","year":"2015","journal-title":"Vet. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1177\/0300985814528221","article-title":"Prognostic evaluation of feline mammary carcinomas: A review of the literature","volume":"52","author":"Zappulli","year":"2015","journal-title":"Vet. Pathol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.tvjl.2012.05.008","article-title":"Prognostic histopathological and molecular markers in feline mammary neoplasia","volume":"194","author":"Hughes","year":"2012","journal-title":"Vet. J."},{"key":"ref_12","first-page":"11","article-title":"Cancer statistics","volume":"63","author":"Siegel","year":"2013","journal-title":"CA: Cancer J. Clin."},{"key":"ref_13","unstructured":"Withrow, S.J., and MacEwen, B.R. (1996). Small Animal Clinical Oncology, WB Saunders Company."},{"key":"ref_14","unstructured":"Damjanov, I., and Linder, J. (1996). Anderson\u2019s Pathology, Mosby. [10th ed.]."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/BF02979590","article-title":"Animal models of human breast carcinoma: Canine and feline neoplasms","volume":"2","author":"Reymundo","year":"2000","journal-title":"Rev. Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1017\/S0022029905001263","article-title":"Feline mammary tumours in comparative oncology","volume":"72","author":"Zappulli","year":"2005","journal-title":"J. Dairy Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/1471-2407-10-156","article-title":"Spontaneous feline mammary intraepithelial lesions as a model for human estrogen receptor- and progesterone receptor-negative breast lesions","volume":"10","author":"Burrai","year":"2010","journal-title":"BMC Cancer"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jfms.2010.01.004","article-title":"Early detection, aggressive therapy: Optimizing the management of feline mammary masses","volume":"12","author":"Gimenez","year":"2010","journal-title":"J. Feline Med. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Mitelman, F. (2010). Cancer: Chromosomal Abnormalities in: eLS, John Wiley & Sons Ltd.","DOI":"10.1002\/9780470015902.a0005552.pub2"},{"key":"ref_20","first-page":"4028","article-title":"Isolation of two distinct epithelial cell lines from a single feline mammary carcinoma with different tumorigenic potential in nude mice and expressing different levels of epidermal growth factor receptors","volume":"51","author":"Minke","year":"1991","journal-title":"Cancer Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0034-5288(95)90032-2","article-title":"Loss of chromosome B2-material in three cases of feline mammary tumours","volume":"59","author":"Mayr","year":"1995","journal-title":"Res. Vet. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1046\/j.1439-0442.1999.00228.x","article-title":"Cytogenetic variation in six cases of feline mammary tumours","volume":"46","author":"Mayr","year":"1999","journal-title":"Zentralbl. Veterinarmed. A"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/jhered\/esj016","article-title":"Amplification of the major satellite DNA family (FA-SAT) in a cat fibrosarcoma might be related to chromosomal instability","volume":"97","author":"Santos","year":"2006","journal-title":"J. Hered."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1007\/s10616-015-9912-7","article-title":"Establishment and characterization of a New Feline Mammary Cancer cell line, FkMTp","volume":"68","author":"Borges","year":"2016","journal-title":"Cytotechnology"},{"key":"ref_25","first-page":"1009","article-title":"Genetic alteration mapping on chromosome 7 in primary breast cancer","volume":"3","author":"Khodja","year":"1997","journal-title":"Clin. Cancer Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/ajmg.10696","article-title":"Chromosome and gene alterations in breast cancer as markers for diagnosis and prognosis as well as pathogenetic targets for therapy","volume":"115","author":"Popescu","year":"2002","journal-title":"Am. J. Med. Genet. (Semin. Med. Genet.)"},{"key":"ref_27","first-page":"7110","article-title":"Molecular classification of breast carcinomas by comparative genomic hybridization: A specific somatic genetic profile for BRCA1 tumors","volume":"62","author":"Wessels","year":"2002","journal-title":"Cancer Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1002\/gcc.20366","article-title":"Distinct patterns of DNA copy number alteration are associated with different clinicopathological features and gene-expression subtypes of breast cancer","volume":"45","author":"Bergamaschi","year":"2006","journal-title":"Genes Chromosomes Cancer"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.gde.2009.11.005","article-title":"Breast cancer genomes\u2014Form and function","volume":"20","author":"Korkola","year":"2010","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1007\/s10577-009-9096-0","article-title":"Microarray-based cytogenetic profiling reveals recurrent and subtype-associated genomic copy number aberrations in feline sarcomas","volume":"17","author":"Thomas","year":"2009","journal-title":"Chromosome Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"6631","DOI":"10.1073\/pnas.79.21.6631","article-title":"Conserved regions of homologous G-banded chromosomes between orders in mammalian evolution: Carnivores and primates","volume":"79","author":"Nash","year":"1982","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/BF00713962","article-title":"Zoo-FISH analysis: Cat and human karyotypes closely resemble the putative ancestral mammalian karyotype","volume":"3","author":"Rettenberger","year":"1995","journal-title":"Chromosome Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1159\/000015244","article-title":"Reciprocal chromosome painting shows that genomic rearrangement between rat and mouse proceeds ten times faster than between humans and cats","volume":"84","author":"Stanyon","year":"1999","journal-title":"Cytogenet. Cell Genet."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1023\/A:1009210803123","article-title":"Reciprocal chromosome painting illuminates the history of genome evolution of the domestic cat, dog and human","volume":"8","author":"Yang","year":"2000","journal-title":"Chromosome Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1101\/gr.6380007","article-title":"Initial sequence and comparative analysis of the cat genome","volume":"17","author":"Pontius","year":"2007","journal-title":"Genome Res."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Graphodatsky, A.S., Trifonov, V.A., and Stanyon, R. (2011). The genome diversity and karyotype evolution of mammals. Mol. Cytogenet., 4.","DOI":"10.1186\/1755-8166-4-22"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"17230","DOI":"10.1073\/pnas.1410083111","article-title":"Comparative analysis of the domestic cat genome reveals genetic signatures underlying feline biology and domestication","volume":"111","author":"Montague","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/2047-217X-3-13","article-title":"Annotated features of domestic cat-Felis catus genome","volume":"3","author":"Tamazian","year":"2014","journal-title":"Gigascience"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"4658","DOI":"10.1073\/pnas.89.10.4658","article-title":"Coupling of dual signaling pathways: Epidermal growth factor action involves the estrogen receptor","volume":"89","author":"Nelson","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_40","first-page":"854","article-title":"Length and loss of heterozygosity of an intron 1 polymorphic sequence of egfr is related to cytogenetic alterations and epithelial growth factor receptor expression","volume":"60","author":"Buerger","year":"2000","journal-title":"Cancer Res."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Santos, S., Baptista, C., Abreu, R.M.V., Bastos, E., Amorim, I., Gut, I.G., G\u00e4rtner, F., and Chaves, R. (2013). ERBB2 in cat mammary neoplasias disclosed a positive correlation between RNA and protein low expression levels: A model for erbB-2 negative human breast cancer. PLoS ONE.","DOI":"10.1371\/journal.pone.0083673"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0065-230X(08)60784-8","article-title":"Biochemical and clinical implications of the ErbB\/HER signaling network of growth factor receptors","volume":"77","author":"Klapper","year":"2000","journal-title":"Adv. Cancer Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.bbrc.2006.05.206","article-title":"Stable RNA interference of ErbB-2 gene synergistic with epirubicin suppresses breast cancer growth in vitro and in vivo","volume":"346","author":"Hu","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/gcc.20558","article-title":"High resolution genomic and expression analyses of copy number alterations in breast tumors","volume":"47","author":"Haverty","year":"2008","journal-title":"Genes Chromosomes Cancer"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nature07423","article-title":"Somatic mutations affect key pathways in lung adenocarcinoma","volume":"455","author":"Ding","year":"2008","journal-title":"Nature"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"16224","DOI":"10.1073\/pnas.0808041105","article-title":"Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers","volume":"105","author":"Leary","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Teschendorff, A.E., and Caldas, C. (2009). The breast cancer somatic \u201cmuta-ome\u201d: Tackling the complexity. Breast Cancer Res.","DOI":"10.1186\/bcr2236"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1038\/sj.onc.1205221","article-title":"Feline STK gene expression in mammary carcinomas","volume":"21","author":"Maggiore","year":"2002","journal-title":"Oncogene"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.tvjl.2011.01.011","article-title":"Sequence variation and mRNA expression of the TWIST1 gene in cats with mammary hyperplasia and neoplasia","volume":"191","author":"Baptista","year":"2012","journal-title":"Vet. J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jsbmb.2005.02.013","article-title":"Full-length sequence and expression analysis of estrogen receptor alpha mRNA in feline mammary tumors","volume":"96","author":"Cardazzo","year":"2005","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1292\/jvms.62.783","article-title":"Amplification of the cyclin A gene in canine and feline mammary tumors","volume":"62","author":"Murakami","year":"2000","journal-title":"J. Vet. Med. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1023\/A:1006412623142","article-title":"Absence of p21 WAF1 and p27 kip1 gene mutations in various feline tumours","volume":"24","author":"Mayr","year":"2000","journal-title":"Vet. Res. Commun."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/mc.1027","article-title":"Comparative analysis of ras proto-oncogene mutations in selected mammalian tumors","volume":"30","author":"Watzinger","year":"2001","journal-title":"Mol. Carcinog."},{"key":"ref_54","first-page":"4855","article-title":"Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis","volume":"54","author":"Greenblatt","year":"1994","journal-title":"Cancer Res."},{"key":"ref_55","unstructured":"Cooper, G.M. (1995). Oncogenes, Jones & Bartlett Publishers International. [2nd ed.]."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1006\/jmbi.1996.0425","article-title":"Structural aspects of the p53 protein in relation to gene evolution: A second look","volume":"260","author":"Soussi","year":"1996","journal-title":"J. Mol. Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/nar\/26.1.205","article-title":"IARC database of p53 gene mutations in human tumors and cell lines: Updated compilation, revised formats and new visualisation tools","volume":"25","author":"Hainaut","year":"1998","journal-title":"Nucleic Acids Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/35042675","article-title":"Sur\ufb01ng the p53 network","volume":"408","author":"Vogelstein","year":"2000","journal-title":"Nature"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1093\/carcin\/bgs232","article-title":"The rebel angel: Mutant p53 as the driving oncogene in breast cancer","volume":"33","author":"Walerych","year":"2012","journal-title":"Carcinogenesis"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1053\/rvsc.1999.0339","article-title":"Presence of p53 mutations in feline neoplasms","volume":"68","author":"Mayr","year":"2000","journal-title":"Res. Vet. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0007-1935(95)80183-9","article-title":"Sequence of an exon of tumour suppressor p53 gene\u2014A comparative study in domestic animals: Mutation in a feline solid mammary carcinoma","volume":"151","author":"Mayr","year":"1995","journal-title":"Br. Vet. J."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S1090-0233(98)80044-0","article-title":"Polymorphisms in felinetumour suppressor gene p53. Mutations in an osteosarcoma and a mammary carcinoma","volume":"155","author":"Mayr","year":"1998","journal-title":"Vet. J."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1431927613001529","article-title":"Feline HER2 protein expression levels and gene status in feline mammary carcinoma: Optimization of immunohistochemistry (IHC) and in situ hybridization (ISH) techniques","volume":"19","author":"Soares","year":"2013","journal-title":"Microsc. Microanal."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1309\/PCFK8YTQPYWD534F","article-title":"HER-2\/neu and topoisomerase II a gene amplification and protein expression in invasive breast carcinomas: Chromogenic in situ hybridization and immunohistochemical analyses","volume":"123","author":"Bhargava","year":"2005","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.ctrv.2009.08.006","article-title":"The role of topoisomerase II alpha and Her-2 in predicting sensitivity to anthracyclines in breast cancer patients","volume":"35","author":"Oakman","year":"2009","journal-title":"Cancer Treat. Rev."},{"key":"ref_66","first-page":"F217","article-title":"Protein tyrosine kinases and cancer","volume":"1333","author":"Kolibaba","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/sj.onc.1201994","article-title":"Point mutations in the tyrosine kinase domain release the oncogenic and metastatic potential of the Ron receptor","volume":"17","author":"Santoro","year":"1998","journal-title":"Oncogene"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/S0303-7207(00)00328-2","article-title":"Expression of an estrogen receptor alpha variant protein in cell lines and tumors","volume":"166","author":"Fasco","year":"2000","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0003-2697(02)00614-0","article-title":"Molecular assay to generate expression profile of eight estrogen receptor alpha isoform mRNA copy numbers in pictogram amounts of total RNA from breast cancer tissues","volume":"314","author":"Poola","year":"2003","journal-title":"Anal. Biochem."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0960-0760(01)00118-2","article-title":"Expression of alternatively spliced estrogen receptor alpha mRNAs is increased in breast cancer tissues","volume":"78","author":"Poola","year":"2001","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1002\/gcc.20449","article-title":"Women with Saethre-Chotzen syndrome are at increased risk of breast cancer","volume":"46","author":"Sahlin","year":"2007","journal-title":"Genes Chromosomes Cancer"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.cell.2004.06.006","article-title":"Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis","volume":"117","author":"Yang","year":"2004","journal-title":"Cell"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1111\/j.1365-313X.2004.02172.x","article-title":"Intron retention is a major phenomenon in alternative splicing in Arabidopsis","volume":"39","author":"Halachmi","year":"2004","journal-title":"Plant J."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1101\/gr.134106.111","article-title":"Transcriptome survey reveals increased complexity of the alternative splicing landscape in Arabidopsis","volume":"22","author":"Marquez","year":"2012","journal-title":"Genome Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1101\/gr.186585.114","article-title":"Unmasking alternative splicing inside protein-coding exons defines exitrons and their role in proteome plasticity","volume":"25","author":"Marquez","year":"2015","journal-title":"Genome Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1354\/vp.36-6-565","article-title":"Topographic distribution of BCL-2 protein in feline tissues in health and neoplasia","volume":"36","author":"Madewell","year":"1999","journal-title":"Vet. Pathol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-3835(00)00337-2","article-title":"Immunocytochemical analysis of the tumour suppressor protein (p53) in feline neoplasia","volume":"3","author":"Nasir","year":"2000","journal-title":"Cancer Lett."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"4053","DOI":"10.1007\/s13277-015-4251-z","article-title":"St Gallen molecular subtypes in feline mammary carcinoma and paired metastases-disease progression and clinical implications from a 3-year follow-up study","volume":"37","author":"Soares","year":"2016","journal-title":"Tumour Biol."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"\u00d3rdas, J., Mill\u00e1n, Y., Dios, R., Reymundo, C., and de Las Mulas, J.M. (2007). Proto-oncogene HER-2 in normal, dysplastic and tumorous feline mammary glands: An immunohistochemical and chromogenic in situ hybridization study. BMC Cancer.","DOI":"10.1186\/1471-2407-7-179"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1354\/vp.08-VP-0161-D-FL","article-title":"Molecular characterization of feline COX-2 and expression in feline mammary carcinomas","volume":"46","author":"Sayasith","year":"2009","journal-title":"Vet. Pathol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1354\/vp.08-VP-0273-P-FL","article-title":"Reduced pten protein expression and its prognostic implications in canine and feline mammary tumors","volume":"46","author":"Ressel","year":"2009","journal-title":"Vet. Pathol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.tvjl.2010.12.016","article-title":"Activation of AKT in feline mammary carcinoma: A new prognostic factor for feline mammary tumours","volume":"191","author":"Maniscalco","year":"2012","journal-title":"Vet. J."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Maniscalco, L., Mill\u00e1n, Y., Iussich, S., Denina, M., S\u00e1nchez-C\u00e9spedes, R., Gattino, F., Biolatti, B., Sasaki, N., Nakagawa, T., and Di Renzo, M.F. (2013). Activation of mammalian target of rapamycin (mTOR) in triple negative feline mammary carcinomas. BMC Vet. Res.","DOI":"10.1186\/1746-6148-9-80"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Ferrari, A., Petterino, C., Ratto, A., Campanella, C., Wurth, R., Thellung, S., Vito, G., Barbieri, F., and Florio, T. (2012). CXCR4 expression in feline mammary carcinoma cells: Evidence of a proliferative role for the SDF-1\/CXCR4 axis. BMC Vet. Res.","DOI":"10.1186\/1746-6148-8-27"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jcpa.2012.02.004","article-title":"Immunohistochemical expression of E-cadherin and b-catenin in feline mammary tumours","volume":"147","author":"Zappulli","year":"2012","journal-title":"J. Comp. Pathol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1177\/0300985813505115","article-title":"N-cadherin expression in feline mammary tumors is associated with a reduced E-cadherin expression and the presence of regional metastasis","volume":"51","author":"Buendia","year":"2014","journal-title":"Vet. Pathol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jcpa.2013.09.004","article-title":"Reduced expression of claudin-2 is associated with high histological grade and metastasis of feline mammary carcinomas","volume":"150","author":"Flores","year":"2014","journal-title":"Comp. Pathol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.jcpa.2014.07.006","article-title":"Clinicopathological significance of immunoexpression of claudin-1 and claudin-7 in feline mammary carcinomas","volume":"151","author":"Flores","year":"2014","journal-title":"J. Comp. Pathol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jcpa.2013.11.213","article-title":"Aberrant subcellular immunolocalization of NOTCH-1 activated intracellular domain in feline mammary tumours","volume":"150","author":"Ressel","year":"2014","journal-title":"J. Comp. Pathol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1177\/0300985815588606","article-title":"Ki-67 as a prognostic factor in feline mammary carcinoma: What is the optimal cutoff value?","volume":"53","author":"Soares","year":"2016","journal-title":"Vet. Pathol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1038\/onc.2015.287","article-title":"Targeting BCL-2 to enhance vulnerability to therapy in estrogen receptor-positive breast cancer","volume":"35","author":"Merino","year":"2016","journal-title":"Oncogene"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/sj.bjc.6605736","article-title":"BCL-2 in breast cancer: A favourable prognostic marker across molecular subtypes and independent of adjuvant therapy received","volume":"103","author":"Dawson","year":"2010","journal-title":"Br. J. Cancer"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1038\/nrd2658","article-title":"Colman BCL-2 family antagonists for cancer therapy","volume":"7","author":"Lessene","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_94","first-page":"493","article-title":"Immunohistochemical detection of p53 protein overexpression in primary human osteosarcomas","volume":"17","author":"Bodey","year":"1997","journal-title":"Anticancer Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1292\/jvms.55.801","article-title":"Molecular cloning and chromosomal mapping of feline p53 tumour suppressor gene","volume":"55","author":"Okuda","year":"1993","journal-title":"J. Vet. Med. Sci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1002\/ijc.2910580425","article-title":"Cloning of feline p53 tumor-suppressor gene and its aberration in hematopoietic tumor","volume":"58","author":"Okuda","year":"1994","journal-title":"Int. J. Cancer"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1093\/annonc\/mdp028","article-title":"Does confirmatory tumor biopsy alter the management of breast cancer patients with distant metastases?","volume":"20","author":"Simmons","year":"2009","journal-title":"Ann. Oncol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.ejca.2013.10.004","article-title":"A meta-analysis of oestrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 discordance between primary breast cancer and metastases","volume":"50","author":"Aurilio","year":"2014","journal-title":"Eur. J. Cancer"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/path.4288","article-title":"Metastatic progression of breast cancer: Insights from 50 years of autopsies","volume":"232","author":"Cummings","year":"2014","journal-title":"J. Pathol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s10549-014-2964-0","article-title":"Prognostic factors for survival in metastatic breast cancer by hormone receptor status","volume":"145","author":"Kwast","year":"2014","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1002\/ijc.11273","article-title":"Prognostic value of ERBB family mRNA expression in breast carcinomas","volume":"106","author":"Bieche","year":"2003","journal-title":"Int. J. Cancer"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1593\/neo.08314","article-title":"A splice variant of HER2 corresponding to Herstatin is expressed in the noncancerous breast and in breast carcinomas","volume":"10","author":"Koletsa","year":"2008","journal-title":"Neoplasia"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"17314","DOI":"10.18632\/oncotarget.7551","article-title":"Serum HER2 levels are increased in cats with mammary carcinomas and predict tissue HER2 status","volume":"7","author":"Soares","year":"2016","journal-title":"Oncotarget"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"7908","DOI":"10.1038\/sj.onc.1203286","article-title":"The role of cyclooxygenases in inflammation, cancer and development","volume":"18","author":"Williams","year":"1999","journal-title":"Oncogene"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"e39","DOI":"10.1016\/j.jss.2010.03.003","article-title":"Role of COX-2 in tumorospheres derived from a breast cancer cell line","volume":"168","author":"Singh","year":"2011","journal-title":"J. Surg. Res."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Guo, Z., Jiang, J.H., Zhang, J., Yang, H.J., Yang, F.Q., Qi, Y.P., Zhong, Y.P., Su, J., Yang, R.R., Li, L.Q., and Xiang, B.D. (2015). COX-2 promotes migration and invasion by the side population of cancer stem cell-like hepatocellular carcinoma cells. Medicine (Baltim.).","DOI":"10.1097\/MD.0000000000001806"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0002-9440(10)61714-2","article-title":"AKT1\/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells","volume":"159","author":"Sun","year":"2001","journal-title":"Am. J. Pathol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s10549-005-9121-8","article-title":"The role of CXCR4 receptor expression in breast cancer: A large tissue microarray study","volume":"97","author":"Salvucci","year":"2006","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s11912-012-0227-y","article-title":"PI3K and mTOR signaling pathways in cancer: New data on targeted therapies","volume":"14","author":"Willems","year":"2012","journal-title":"Curr. Oncol. Rep."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/ajcp\/105.4.394","article-title":"Reduced E-caderin expression is associated with invasiveness and unfavorable prognosis in breast cancer","volume":"105","author":"Siitonen","year":"1996","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/(SICI)1096-9896(199807)185:3<262::AID-PATH97>3.0.CO;2-Y","article-title":"E-cadherin and a-, b-, and g-catenin protein expression in relation to metastasis in human breast carcinoma","volume":"185","author":"Burkholm","year":"1998","journal-title":"J. Pathol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1136\/vr.153.10.297","article-title":"Expression of e-cadherin in normal, hyperplastic and neoplastic feline mammary tissue","volume":"153","author":"Gartner","year":"2003","journal-title":"Vet. Rec."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1177\/0300985812436744","article-title":"Reduced expression of E-cadherin and \u03b2- -catenin and high expression of basal cytokeratins in feline mammary carcinomas with regional metastasis","volume":"49","author":"Buendia","year":"2012","journal-title":"Vet. Pathol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1292\/jvms.69.831","article-title":"Expression and subcellular localization of e-cadherin, a-catenin, and b-catenin in 8 feline mammary tumour cell lines","volume":"69","author":"Takauji","year":"2007","journal-title":"J. Vet. Med. Sci."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s004280100516","article-title":"Defective E-cadherin\/catenin complexes in human cancer","volume":"439","author":"Mareel","year":"2001","journal-title":"Virchows Arch."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s10911-007-9044-6","article-title":"Differential cadherin expression: Potential markers for epithelial to mesenchymal transformation during tumor progression","volume":"12","author":"Agiostratidou","year":"2007","journal-title":"J. Mammary Gland Biol. Neoplasia"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Rezaei, M., Friedrich, K., Wielockx, B., Kuzmanov, A., Kettelhake, A., Labelle, M., Schnittler, H., Baretton, G., and Breier, G. (2012). Interplay between neural-cadherin and vascular endothelial-cadherin in breast cancer progression. Breast Cancer Res.","DOI":"10.1186\/bcr3367"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.tvjl.2009.10.030","article-title":"Grade is an independent prognostic factor for feline mammary carcinomas: A clinicopathological and survival analysis","volume":"187","author":"Seixas","year":"2011","journal-title":"Vet. J."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Figueira, A.C., Gomes, C., de Oliveira, J.T., Vilhena, H., Carvalheira, J., de Matos, A.J., Pereira, P.D., and G\u00e4rtner, F. (2014). Aberrant P-cadherin expression is associated to aggressive feline mammary carcinomas. BMC Vet. Res.","DOI":"10.1186\/s12917-014-0270-z"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.humpath.2010.05.019","article-title":"Repression of E-cadherin by SNAIL, ZEB1, and TWIST in invasive ductal carcinomas of the breast: A cooperative effort?","volume":"42","author":"Montserrat","year":"2011","journal-title":"Hum. Pathol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1158\/1055-9965.EPI-08-0472","article-title":"Methylation of the TWIST1 promoter, TWIST1 mRNA levels, and immunohistochemical expression of TWIST1 in breast cancer","volume":"17","author":"Gort","year":"2008","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_122","first-page":"3851","article-title":"Expression of twist and wnt in human breast cancer","volume":"24","author":"Watanabe","year":"2004","journal-title":"Anticancer Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1245\/ASO.2005.04.010","article-title":"Expression of the transcription factors Snail, Slug, and Twist and their clinical significance in human breast cancer","volume":"12","author":"Martin","year":"2005","journal-title":"Ann. Surg. Oncol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"5001","DOI":"10.1158\/1078-0432.CCR-07-0024","article-title":"Isolation and molecular profiling of bone marrow micrometastases identifies TWIST1 as a marker of early tumor relapse in breast cancer patients","volume":"13","author":"Watson","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"378","DOI":"10.3816\/CBC.2010.n.050","article-title":"Disseminated tumor cells in bone marrow assessed by TWIST1, cytokeratin 19, and mammaglobin A mRNA predict clinical outcome in operable breast cancer patients","volume":"10","author":"Tjensvoll","year":"2010","journal-title":"Clin. Breast Cancer"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1038\/sj.onc.1206199","article-title":"Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast","volume":"22","author":"Kominsky","year":"2003","journal-title":"Oncogene"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1365-2303.2005.00257.x","article-title":"Reduced expression of claudin-7 in fine needle aspirates from breast carcinomas correlates with grading and metastatic disease","volume":"16","author":"Sauer","year":"2005","journal-title":"Cytopathology"},{"key":"ref_128","first-page":"28","article-title":"Prognostic significance of CD24 and claudin-7 immunoexpression in ductal invasive breast cancer","volume":"27","author":"Bernardi","year":"2012","journal-title":"Oncol. Rep."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jcpa.2008.08.001","article-title":"Expression of claudin-1, -2, -3, -4, -5 and -7 proteins in benign and malignant canine mammary gland epithelial tumours","volume":"139","author":"Jakab","year":"2008","journal-title":"J. Comp. Pathol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/onc.2010.518","article-title":"Claudin-2 is selectively enriched in and promotes the formation of breast cancer liver metastases through engagement of integrin complexes","volume":"30","author":"Tabaries","year":"2011","journal-title":"Oncogene"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Prat, A., Parker, J., Karginova, O., Fan, C., Livasy, C., Herschkowitz, J.I., He, X., and Perou, C.M. (2010). Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer. Breast Cancer Res.","DOI":"10.1186\/bcr2635"},{"key":"ref_132","first-page":"1","article-title":"Claudin expression in high-grade invasive ductal carcinoma of the breast: Correlation with the molecular subtype","volume":"187","author":"Lu","year":"2012","journal-title":"Mod. Pathol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"4370","DOI":"10.2741\/2394","article-title":"Notch signaling and its role in breast cancer","volume":"12","author":"Wu","year":"2007","journal-title":"Front. Biosci."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s11060-009-0007-1","article-title":"The oncogenic roles of Notch1 in astrocytic gliomas in vitro and in vivo","volume":"97","author":"Xu","year":"2010","journal-title":"J. Neuro-Oncol."},{"key":"ref_135","first-page":"7291","article-title":"Dynamics of notch expression during murine prostate development and tumorigenesis","volume":"61","author":"Shou","year":"2001","journal-title":"Cancer Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1002\/jcb.22199","article-title":"Notch-1 signaling is lost in prostate adenocarcinoma and promotes PTEN gene expression","volume":"107","author":"Whelan","year":"2009","journal-title":"J. Cell. Biochem."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"8530","DOI":"10.1158\/0008-5472.CAN-05-1069","article-title":"High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival","volume":"65","author":"Reedijk","year":"2005","journal-title":"Cancer Res."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/stem.261","article-title":"Notch promotes radioresistance of glioma stem cells","volume":"28","author":"Wang","year":"2010","journal-title":"Stem Cells"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nrc3035","article-title":"Notch signalling in solid tumours: A little bit of everything but not all the time","volume":"11","author":"Ranganathan","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"5019","DOI":"10.1038\/onc.2008.149","article-title":"ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor","volume":"27","author":"Osipo","year":"2008","journal-title":"Oncogene"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1053\/jcpa.2001.0488","article-title":"Metallothionein expression in canine and feline mammary and melanotic tumours","volume":"125","author":"Dincer","year":"2001","journal-title":"J. Comp. Pathol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1354\/vp.39-6-690","article-title":"Correlation of vascular endothelial growth factor expression to overall survival in feline invasive mammary carcinomas","volume":"39","author":"Millanta","year":"2002","journal-title":"Vet. Pathol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S1470-2045(09)70262-1","article-title":"Ki67 in breast cancer: Prognostic and predictive potential","volume":"11","author":"Yerushalmi","year":"2010","journal-title":"Lancet Oncol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1093\/jnci\/djr393","article-title":"Assessment of Ki67 in breast cancer: Recommendations from the international Ki67 in Breast Cancer Working Group","volume":"103","author":"Dowsett","year":"2011","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_145","unstructured":"Withrow, S.J., Vail, D.M., and Page, R.L. (2013). Withrow & MacEwen\u2019s Small Animal Clinical Oncology, Saunders Elsevier. [5th ed.]."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Louzada, S., Adega, F., and Chaves, R. (2012). Defining the sister rat mammary tumor cell lines HH-16 cl.2\/1 and HH-16.cl.4 as an in vitro cell model for Erbb2. PLoS ONE.","DOI":"10.1371\/journal.pone.0029923"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/nrc2193","article-title":"Modelling breast cancer: One size does not fit all","volume":"7","author":"Rosen","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"ref_148","first-page":"92","article-title":"Human cancer cell lines: Experimental models for cancer cells in situ? For cancer stem cells?","volume":"1795","author":"Solis","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1093\/jnci\/djq279","article-title":"Lung cancer cell lines as tools for biomedical discovery and research","volume":"102","author":"Gazdar","year":"2010","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_150","unstructured":"Ce\u0301sar, L.C., and Elena, A.O. (2012). Oncogenomics and Cancer Proteomics\u2014Novel Approaches in Biomarkers Discovery and Therapeutic Targets in Cancer, InTech."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1023\/B:BREA.0000014042.54925.cc","article-title":"Relevance of breast cancer cell lines as models for breast tumours: An update","volume":"83","author":"Lacroix","year":"2004","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_152","first-page":"2931","article-title":"Comparison of features of human breast cancer cell lines and their corresponding tumors","volume":"4","author":"Wistuba","year":"1998","journal-title":"Clin. Cancer Res."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Kao, J., Salari, K., Bocanegra, M., Choi, Y.L., Girard, L., Gandhi, J., Kwei, K.A., Hernandez-Boussard, T., Wang, P., Gazdar, A.F., and Minna, J.D. (2009). Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery. PLoS ONE.","DOI":"10.1371\/journal.pone.0006146"},{"key":"ref_154","first-page":"1255","article-title":"Molecular characterization of permanent cell lines from primary, metastatic and recurrent malignant peripheral nerve sheath tumors (MPNST) with underlying neurofibromatosis-1","volume":"29","author":"Fang","year":"2009","journal-title":"Anticancer Res."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1292\/jvms.15-0550","article-title":"Anti-tumor effect of bevacizumab on a xenograft model of feline mammary carcinoma","volume":"78","author":"Michishita","year":"2016","journal-title":"J. Vet. Med. Sci."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0034-5288(18)31739-9","article-title":"Characteristics of a feline mammary carcinoma cell line","volume":"39","author":"Norval","year":"1985","journal-title":"Res. Vet. Sci."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1292\/jvms.60.931","article-title":"Establishment and characterization of a new cell line derived from feline mammary tumor","volume":"60","author":"Muleya","year":"1998","journal-title":"J. Vet. Med. Sci."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1292\/jvms.67.1273","article-title":"Establishment and characterization of eight feline mammary adenocarcinoma cell lines","volume":"67","author":"Uyama","year":"2005","journal-title":"J. Vet. Med. Sci."}],"container-title":["Veterinary Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2306-7381\/3\/3\/17\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:28:29Z","timestamp":1760210909000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2306-7381\/3\/3\/17"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,16]]},"references-count":158,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,9]]}},"alternative-id":["vetsci3030017"],"URL":"https:\/\/doi.org\/10.3390\/vetsci3030017","relation":{},"ISSN":["2306-7381"],"issn-type":[{"value":"2306-7381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,16]]}}}