{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T11:30:17Z","timestamp":1767007817888,"version":"build-2065373602"},"reference-count":60,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Public Ministry of Labor Campinas","award":["13\/2021"],"award-info":[{"award-number":["13\/2021"]}]},{"name":"Pio XII Foundation, Barretos Cancer Hospital internal funds","award":["13\/2021"],"award-info":[{"award-number":["13\/2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Sciences"],"abstract":"<jats:p>The Barretos Cancer Hospital Animal Facility (BCHAF) is a unique facility in Brazil exclusively dedicated to working with animal models for cancer research. In this article, we briefly present our modern facility and the main experiments performed, focusing on mutant strains of mice (PTCH-knockout and ApcMin mice), xenograft models, and patient-derived xenografts (PDXs). Our results show the progress and challenges in establishing these models and the need for having an appropriate representation of our cancer population to better understand tumor biology and to identify cancer biomarkers, which could be putatively targeted, allowing for personalized therapy.<\/jats:p>","DOI":"10.3390\/vetsci9110636","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T03:27:44Z","timestamp":1668655664000},"page":"636","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Barretos Cancer Hospital Animal Facility: Implementation and Results of a Dedicated Platform for Preclinical Oncology Models"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2462-8535","authenticated-orcid":false,"given":"Silvia A.","family":"Teixeira","sequence":"first","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, S\u00e3o Paulo, Brazil"}]},{"given":"Mayara de Cassia","family":"Luzzi","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, S\u00e3o Paulo, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5426-2223","authenticated-orcid":false,"given":"Ana Carolina Baptista Moreno","family":"Martin","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, S\u00e3o Paulo, Brazil"}]},{"given":"Terence Teixeira","family":"Duarte","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, S\u00e3o Paulo, Brazil"}]},{"given":"M\u00f4nica de Oliveira","family":"Leal","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, S\u00e3o Paulo, Brazil"}]},{"given":"Gustavo Ramos","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Department of Pathology, Barretos Cancer Hospital, Barretos 14784-400, S\u00e3o Paulo, Brazil"},{"name":"Barretos School of Health Sciences, Dr. Paulo Prata\u2014FACISB, Barretos 14785-002, S\u00e3o Paulo, Brazil"}]},{"given":"Monise Tadin","family":"Reis","sequence":"additional","affiliation":[{"name":"Department of Pathology, Barretos Cancer Hospital, Barretos 14784-400, S\u00e3o Paulo, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1469-0124","authenticated-orcid":false,"given":"Carlos Roberto Almeida","family":"Junior","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Barretos Cancer Hospital, Barretos 14784-400, S\u00e3o Paulo, Brazil"}]},{"given":"Karina","family":"Santos","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, S\u00e3o Paulo, Brazil"},{"name":"Department of Radiology, Barretos Cancer Hospital, Barretos 14784-400, S\u00e3o Paulo, Brazil"}]},{"given":"Matias Eliseo","family":"Melendez","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, S\u00e3o Paulo, Brazil"},{"name":"Molecular Carcinogenesis Program, National Cancer Institute, Rio de Janeiro 20231-050, Brazil"}]},{"given":"Diego da Cunha Silveira Alves da","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Radiology, Barretos Cancer Hospital, Barretos 14784-400, S\u00e3o Paulo, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1922-4560","authenticated-orcid":false,"given":"Priscila Neves","family":"Bern\u00e9cule","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, S\u00e3o Paulo, Brazil"},{"name":"Barretos School of Health Sciences, Dr. Paulo Prata\u2014FACISB, Barretos 14785-002, S\u00e3o Paulo, Brazil"}]},{"given":"Higor Vinicius Louren\u00e7o","family":"Firmino","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, S\u00e3o Paulo, Brazil"},{"name":"Barretos School of Health Sciences, Dr. Paulo Prata\u2014FACISB, Barretos 14785-002, S\u00e3o Paulo, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8672-3768","authenticated-orcid":false,"given":"Ana Laura Vieira","family":"Alves","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, S\u00e3o Paulo, Brazil"}]},{"given":"Denise Peixoto","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, S\u00e3o Paulo, Brazil"},{"name":"Department of Endoscopy, Barretos Cancer Hospital, Barretos 14780-000, S\u00e3o Paulo, Brazil"}]},{"given":"Jo\u00e3o Vitor","family":"Borduqui","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, S\u00e3o Paulo, Brazil"},{"name":"Barretos School of Health Sciences, Dr. Paulo Prata\u2014FACISB, Barretos 14785-002, S\u00e3o Paulo, Brazil"}]},{"given":"Ana Carolina","family":"Laus","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, S\u00e3o Paulo, Brazil"}]},{"given":"Bruna Minniti","family":"Man\u00e7ano","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, S\u00e3o Paulo, Brazil"},{"name":"Department of Neurosurgery, Barretos Cancer Hospital, Barretos 14784-400, S\u00e3o Paulo, Brazil"}]},{"given":"Rui Manuel","family":"Reis","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, S\u00e3o Paulo, Brazil"},{"name":"Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057 Braga, Portugal"},{"name":"ICVS\/3B\u2019s-PT Government Associate Laboratory, 4710-057 Braga\/Guimar\u00e3es, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Carneseca, E.C., Mauad, E.C., de Araujo, M.A., Dalb\u00f3, R.M., Longatto Filho, A., and Vazquez, V. 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