{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T20:11:59Z","timestamp":1776283919461,"version":"3.50.1"},"reference-count":259,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2018,1,26]],"date-time":"2018-01-26T00:00:00Z","timestamp":1516924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Water"],"abstract":"<jats:p>Carbamazepine (CBZ), a pharmaceutical compound, has been proposed as an anthropogenic marker to assess water quality due to its persistence in conventional treatment plants and widespread presence in water bodies. This paper presents a comprehensive literature review on sources and occurrences of CBZ in water bodies, as well as toxicological effects and regulations of the drug. Given the documented side effects of CBZ on the human body when taken medicinally, its careful monitoring in water is recommended. CBZ residues in drinking water may provide a pathway to embryos and infants via intrauterine exposure or breast-feeding, which may cause congenital malformations and\/or neurodevelopmental problems over long term exposure. An in-depth technical assessment of the conventional and advanced treatment technologies revealed the inadequacy of the standalone technologies. Compared to conventional activated sludge and membrane bioreactor processes, effective removal of CBZ can be achieved by nanofiltration and reverse osmosis membranes. However, recent studies have revealed that harsh chemical cleaning, as required to mitigate membrane fouling, can often reduce the long-term removal efficiency. Furthermore, despite the efficient performance of activated carbon adsorption and advanced oxidation processes, a few challenges such as cost of chemicals and regeneration of activated carbon need to be carefully considered. The limitations of the individual technologies point to the advantages of combined and hybrid systems, namely, membrane bioreactor coupled with nanofiltration, adsorption or advanced oxidation process.<\/jats:p>","DOI":"10.3390\/w10020107","type":"journal-article","created":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T07:46:20Z","timestamp":1517211980000},"page":"107","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":188,"title":["Carbamazepine as a Possible Anthropogenic Marker in Water: Occurrences, Toxicological Effects, Regulations and Removal by Wastewater Treatment Technologies"],"prefix":"10.3390","volume":"10","author":[{"given":"Faisal","family":"Hai","sequence":"first","affiliation":[{"name":"Strategic Water Infrastructure Lab, School of Civil, Mining and Environmental Engineering, University of Wollongong, Wollongong, NSW 2522, Australia"}]},{"given":"Shufan","family":"Yang","sequence":"additional","affiliation":[{"name":"Strategic Water Infrastructure Lab, School of Civil, Mining and Environmental Engineering, University of Wollongong, Wollongong, NSW 2522, Australia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0126-4617","authenticated-orcid":false,"given":"Muhammad","family":"Asif","sequence":"additional","affiliation":[{"name":"Strategic Water Infrastructure Lab, School of Civil, Mining and Environmental Engineering, University of Wollongong, Wollongong, NSW 2522, Australia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1986-1348","authenticated-orcid":false,"given":"Vitor","family":"Sencadas","sequence":"additional","affiliation":[{"name":"School of Mechanical, Materials and Mechatronics Engineering, University of Wollongong, Wollongong, NSW 2522, Australia"}]},{"given":"Samia","family":"Shawkat","sequence":"additional","affiliation":[{"name":"Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW 2522, Australia"}]},{"given":"Martina","family":"Sanderson-Smith","sequence":"additional","affiliation":[{"name":"Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW 2522, Australia"}]},{"given":"Jody","family":"Gorman","sequence":"additional","affiliation":[{"name":"Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW 2522, Australia"}]},{"given":"Zhi-Qiang","family":"Xu","sequence":"additional","affiliation":[{"name":"Centre for Medical and Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia"}]},{"given":"Kazuo","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Environmental Science Centre, Department of Urban Engineering, University of Tokyo, Tokyo 113-0033, Japan"}]}],"member":"1968","published-online":{"date-parts":[[2018,1,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1021\/es3030148","article-title":"Global synthesis and critical evaluation of pharmaceutical data sets collected from river systems","volume":"47","author":"Hughes","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.nbt.2014.01.001","article-title":"Emerging pollutants in the environment: Present and future challenges in biomonitoring, ecological risks and bioremediation","volume":"32","author":"Gavrilescu","year":"2015","journal-title":"New Biotechnol."},{"key":"ref_3","unstructured":"Hai, F.I., Yamamoto, K., and Lee, C. (2014). Wastewater reuse: Removal of emerging trace organic contaminants. Membrane biological Reactors: Theory, Modeling, Design, Management and Applications to Wastewater Reuse, IWA publishing."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.scitotenv.2013.12.065","article-title":"A review on the occurrence of micropollutants in the aquatic environment and their fate and removal during wastewater treatment","volume":"473","author":"Luo","year":"2014","journal-title":"Sci. Total Environ."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.envpol.2011.12.034","article-title":"Emerging organic contaminants in groundwater: A review of sources, fate and occurrence","volume":"163","author":"Lapworth","year":"2012","journal-title":"Environ. Pollut."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.watres.2006.12.017","article-title":"Elimination of pharmaceuticals in sewage treatment plants in finland","volume":"41","author":"Vieno","year":"2007","journal-title":"Water Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.scitotenv.2016.10.104","article-title":"Towards the review of the european union water framework directive: Recommendations for more efficient assessment and management of chemical contamination in european surface water resources","volume":"576","author":"Brack","year":"2017","journal-title":"Sci. Total Environ."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1002\/etc.3336","article-title":"Derivation of water quality guidelines for priority pharmaceuticals","volume":"35","author":"Kumar","year":"2016","journal-title":"Environ. Toxicol. Chem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2174\/1573412912666160422123841","article-title":"Analytical features of diclofenac evaluation in water as a potential marker of anthropogenic pollution","volume":"13","author":"Osorio","year":"2017","journal-title":"Curr. Pharm. Anal."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.chemosphere.2010.09.062","article-title":"Fate and transport of carbamazepine in soil aquifer treatment (sat) infiltration basin soils","volume":"82","author":"Arye","year":"2011","journal-title":"Chemosphere"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.chroma.2012.03.059","article-title":"Analysis of 100 pharmaceuticals and their degradates in water samples by liquid chromatography\/quadrupole time-of-flight mass spectrometry","volume":"1259","author":"Ferrer","year":"2012","journal-title":"J. Chromatogr. A"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.watres.2008.11.031","article-title":"Fate of beta blockers and psycho-active drugs in conventional wastewater treatment","volume":"43","author":"Wick","year":"2009","journal-title":"Water Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.jhazmat.2014.06.031","article-title":"Understanding the removal mechanisms of ppcps and the influence of main technological parameters in anaerobic uasb and aerobic cas reactors","volume":"278","author":"Alvarino","year":"2014","journal-title":"J. Hazard. Mater."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.2166\/wst.2012.285","article-title":"Review on the fate of organic micropollutants in wastewater treatment and water reuse with membranes","volume":"66","author":"Siegrist","year":"2012","journal-title":"Water Sci. Technol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"16448","DOI":"10.1007\/s11356-016-6823-x","article-title":"Degradation of carbamazepine by uv\/chlorine advanced oxidation process and formation of disinfection by-products","volume":"23","author":"Zhou","year":"2016","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.chemosphere.2008.07.086","article-title":"Carbamazepine and diclofenac: Removal in wastewater treatment plants and occurrence in water bodies","volume":"73","author":"Zhang","year":"2008","journal-title":"Chemosphere"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1016\/j.watres.2008.02.020","article-title":"Adsorption characteristics of selected pharmaceuticals and an endocrine disrupting compound-naproxen, carbamazepine and nonylphenol-on activated carbon","volume":"42","author":"Yu","year":"2008","journal-title":"Water Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.ijheh.2011.08.002","article-title":"Emerging pollutants in wastewater: A review of the literature","volume":"214","author":"Deblonde","year":"2011","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.desal.2008.03.020","article-title":"A review of the effects of emerging contaminants in wastewater and options for their removal","volume":"239","author":"Bolong","year":"2009","journal-title":"Desalination"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.scitotenv.2012.04.028","article-title":"Occurrence of pharmaceutical compounds in urban wastewater: Removal, mass load and environmental risk after a secondary treatment\u2014A review","volume":"429","author":"Verlicchi","year":"2012","journal-title":"Sci. Total Environ."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jenvman.2012.07.023","article-title":"Chemical coagulation-based processes for trace organic contaminant removal: Current state and future potential","volume":"111","author":"Alexander","year":"2012","journal-title":"J. Environ. Manag."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/j.envpol.2009.03.017","article-title":"Illicit drugs and pharmaceuticals in the environment\u2014Forensic applications of environmental data. Part 1: Estimation of the usage of drugs in local communities","volume":"157","author":"Dinsdale","year":"2009","journal-title":"Environ. Pollut."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3054","DOI":"10.1016\/j.envpol.2010.06.013","article-title":"Determination of biocides and pesticides by on-line solid phase extraction coupled with mass spectrometry and their behaviour in wastewater and surface water","volume":"158","author":"Singer","year":"2010","journal-title":"Environ. Pollut."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.watres.2017.10.044","article-title":"Modeling sewage leakage and transport in carbonate aquifer using carbamazepine as an indicator","volume":"128","author":"Dvory","year":"2018","journal-title":"Water Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1039\/b904548a","article-title":"Occurrence and removal of pharmaceutically active compounds in sewage treatment plants with different technologies","volume":"11","author":"Ying","year":"2009","journal-title":"J. Environ. Monit."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1021\/es025834r","article-title":"Occurrence and fate of carbamazepine, clofibric acid, diclofenac, ibuprofen, ketoprofen, and naproxen in surface waters","volume":"37","author":"Tixier","year":"2003","journal-title":"Environ. Sci. Technol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.biortech.2013.06.097","article-title":"The fate of pharmaceuticals, steroid hormones, phytoestrogens, uv-filters and pesticides during mbr treatment","volume":"144","author":"Wijekoon","year":"2013","journal-title":"Bioresour. Technol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1752-1688.2008.00289.x","article-title":"Occurence of primidone, carbamazepine, caffeine and precursors for n-nitrosodimethylamine in drinding water sources impacted by wastewater","volume":"45","author":"Guo","year":"2009","journal-title":"J. Am. Water Resour. Assoc."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0378-4274(02)00041-3","article-title":"Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: A review of recent research data","volume":"131","author":"Heberer","year":"2002","journal-title":"Toxicol. Lett."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.scitotenv.2011.11.072","article-title":"Review of risk from potential emerging contaminants in UK groundwater","volume":"416","author":"Stuart","year":"2012","journal-title":"Sci. Total Environ."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1897\/02-627","article-title":"Distribution of acidic and neutral drugs in surface waters near sewage treatment plants in the lower great lakes, canada","volume":"22","author":"Metcalfe","year":"2003","journal-title":"Environ. Toxicol. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3731","DOI":"10.1021\/ac030082k","article-title":"Determination of carbamazepine and its metabolites in aqueous samples using liquid chromatography\u2212electrospray tandem mass spectrometry","volume":"75","author":"Miao","year":"2003","journal-title":"Anal. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"7469","DOI":"10.1021\/es050261e","article-title":"Carbamazepine and its metabolites in wastewater and in biosolids in a municipal wastewater treatment plant","volume":"39","author":"Miao","year":"2005","journal-title":"Environ. Sci. Technol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ecoenv.2005.04.004","article-title":"Occurrence of pharmaceutical products in a municipal effluent and toxicity to rainbow trout (Oncorhynchus mykiss) hepatocytes","volume":"64","author":"Blaise","year":"2006","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.chroma.2007.02.047","article-title":"Optimizing gas chromatographic\u2013mass spectrometric analysis of selected pharmaceuticals and endocrine-disrupting substances in water using factorial experimental design","volume":"1148","author":"Yu","year":"2007","journal-title":"J. Chromatogr. A"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.chemosphere.2011.12.018","article-title":"Pharmaceutical and personal care products in groundwater, subsurface drainage, soil, and wheat grain, following a high single application of municipal biosolids to a field","volume":"87","author":"Gottschall","year":"2012","journal-title":"Chemosphere"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"4220","DOI":"10.1016\/j.scitotenv.2009.02.028","article-title":"Pharmaceutical and personal care products in tile drainage following surface spreading and injection of dewatered municipal biosolids to an agricultural field","volume":"407","author":"Edwards","year":"2009","journal-title":"Sci. Total Environ."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"7321","DOI":"10.1021\/es061740w","article-title":"Simultaneous determination of psychoactive drugs and their metabolites in aqueous matrices by liquid chromatography mass spectrometry","volume":"40","author":"Hummel","year":"2006","journal-title":"Environ. Sci. Technol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1016\/S0043-1354(02)00570-5","article-title":"Ozonation: A tool for removal of pharmaceuticals, contrast media and musk fragrances from wastewater?","volume":"37","author":"Ternes","year":"2003","journal-title":"Water Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1016\/S0043-1354(98)00099-2","article-title":"Occurrence of drugs in german sewage treatment plants and rivers","volume":"32","author":"Ternes","year":"1998","journal-title":"Water Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.chemosphere.2004.05.017","article-title":"Pharmaceuticals in the river elbe and its tributaries","volume":"57","author":"Wiegel","year":"2004","journal-title":"Chemosphere"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1016\/j.envpol.2009.05.037","article-title":"Temporal and spatial patterns of micropollutants in urban receiving waters","volume":"157","author":"Musolff","year":"2009","journal-title":"Environ. Pollut."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1016\/j.watres.2007.05.014","article-title":"Sources and transport of selected organic micropollutants in urban groundwater underlying the city of halle (saale), Germany","volume":"41","author":"Weise","year":"2007","journal-title":"Water Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2166\/wst.2008.822","article-title":"Removal efficiency of 66 pharmaceuticals during wastewater treatment process in Japan","volume":"57","author":"Okuda","year":"2008","journal-title":"Water Sci. Technol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2166\/wst.2007.801","article-title":"Occurrence of 70 pharmaceutical and personal care products in tone river basin in Japan","volume":"56","author":"Nakada","year":"2007","journal-title":"Water Sci. Technol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"6347","DOI":"10.1021\/es7030856","article-title":"Evaluation of pharmaceuticals and personal care products as water-soluble molecular markers of sewage","volume":"42","author":"Nakada","year":"2008","journal-title":"Environ. Sci. Technol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1021\/es202059g","article-title":"Assessment of groundwater pollution in tokyo using ppcps as sewage markers","volume":"46","author":"Kuroda","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.scitotenv.2008.06.038","article-title":"Seasonal variations of several pharmaceutical residues in surface water and sewage treatment plants of Han River, Korea","volume":"405","author":"Choi","year":"2008","journal-title":"Sci. Total Environ."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"4351","DOI":"10.1016\/j.scitotenv.2011.07.015","article-title":"Occurrence and removal of antibiotics, hormones and several other pharmaceuticals in wastewater treatment plants of the largest industrial city of Korea","volume":"409","author":"Behera","year":"2011","journal-title":"Sci. Total Environ."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1248\/jhs.55.249","article-title":"Occurrence of pharmaceutical and personal care products (ppcps) in surface water from Mankyung River, South Korea","volume":"55","author":"Kim","year":"2009","journal-title":"J. Health Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.scitotenv.2009.10.049","article-title":"Occurrence of endocrine disrupting compounds, pharmaceuticals, and personal care products in the Han river (Seoul, South Korea)","volume":"408","author":"Yoon","year":"2010","journal-title":"Sci. Total Environ."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.chemosphere.2008.04.005","article-title":"Using liquid chromatography\u2013ion trap mass spectrometry to determine pharmaceutical residues in taiwanese rivers and wastewaters","volume":"72","author":"Chen","year":"2008","journal-title":"Chemosphere"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.chroma.2004.12.081","article-title":"Determination of pharmaceutical residues in waters by solid-phase extraction and large-volume on-line derivatization with gas chromatography\u2013mass spectrometry","volume":"1065","author":"Lin","year":"2005","journal-title":"J. Chromatogr. A"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.watres.2008.10.047","article-title":"The removal of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs during wastewater treatment and its impact on the quality of receiving waters","volume":"43","author":"Dinsdale","year":"2009","journal-title":"Water Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.chroma.2007.03.105","article-title":"Simultaneous determination of various pharmaceutical compounds in water by solid-phase extraction\u2013liquid chromatography\u2013tandem mass spectrometry","volume":"1154","author":"Zhang","year":"2007","journal-title":"J. Chromatogr. A"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.jhazmat.2008.11.070","article-title":"Pharmaceutical residues in wastewater treatment works effluents and their impact on receiving river water","volume":"166","author":"Zhou","year":"2009","journal-title":"J. Hazard. Mater."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.1016\/j.watres.2008.04.026","article-title":"The occurrence of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs in surface water in south wales, UK","volume":"42","author":"Dinsdale","year":"2008","journal-title":"Water Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.chroma.2007.05.074","article-title":"Multi-residue method for the determination of basic\/neutral pharmaceuticals and illicit drugs in surface water by solid-phase extraction and ultra performance liquid chromatography\u2013positive electrospray ionisation tandem mass spectrometry","volume":"1161","author":"Dinsdale","year":"2007","journal-title":"J. Chromatogr. A"},{"key":"ref_59","unstructured":"Stuart, M.E., Manamsa, K., Talbot, J.C., and Crane, E.J. (2017, October 15). Emerging Contaminants in Groundwater, 2011. Available online: https:\/\/nora.nerc.ac.uk\/14557\/."},{"key":"ref_60","unstructured":"Lapworth, D., Stuart, M., Hart, A., Crane, E., and Baran, N. (2011). Emerging Contaminants in Groundwater, Groundwater Forum. Available online: http:\/\/nora.nerc.ac.uk\/14093\/."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.scitotenv.2008.02.042","article-title":"Pharmaceutical compounds in the wastewater process stream in Northwest Ohio","volume":"397","author":"Spongberg","year":"2008","journal-title":"Sci. Total Environ."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"7312","DOI":"10.1021\/es0613198","article-title":"Analysis of pharmaceuticals in water by isotope dilution liquid chromatography\/tandem mass spectrometry","volume":"40","author":"Vanderford","year":"2006","journal-title":"Environ. Sci. Technol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"5157","DOI":"10.1021\/es048120k","article-title":"Transport of chemical and microbial compounds from known wastewater discharges:\u2009 Potential for use as indicators of human fecal contamination","volume":"39","author":"Glassmeyer","year":"2005","journal-title":"Environ. Sci. Technol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.scitotenv.2004.01.015","article-title":"Urban contribution of pharmaceuticals and other organic wastewater contaminants to streams during differing flow conditions","volume":"328","author":"Kolpin","year":"2004","journal-title":"Sci. Total Environ."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.chroma.2008.01.064","article-title":"Rapid liquid chromatography\u2013tandem mass spectrometry method for the determination of a broad mixture of pharmaceuticals in surface water","volume":"1185","author":"Conley","year":"2008","journal-title":"J. Chromatogr. A"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1016\/j.scitotenv.2009.01.022","article-title":"Groundwater quality impacts from the land application of treated municipal wastewater in a large karstic spring basin: Chemical and microbiological indicators","volume":"407","author":"Katz","year":"2009","journal-title":"Sci. Total Environ."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1016\/j.scitotenv.2011.05.053","article-title":"Occurrence and concentrations of pharmaceutical compounds in groundwater used for public drinking-water supply in california","volume":"409","author":"Fram","year":"2011","journal-title":"Sci. Total Environ."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Guasch, H., Ginebreda, A., and Geiszinger, A. (2012). Occurrence and elimination of pharmaceuticals during conventional wastewater treatment. Emerging and Priority Pollutants in Rivers, Springer.","DOI":"10.1007\/978-3-642-25722-3"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"3979","DOI":"10.1098\/rsta.2009.0105","article-title":"Fate and removal of pharmaceuticals and illicit drugs in conventional and membrane bioreactor wastewater treatment plants and by riverbank filtration","volume":"367","author":"Petrovic","year":"2009","journal-title":"Philos. Trans. R. Soc. A Math. Phys. Eng. Sci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.chemosphere.2007.04.069","article-title":"Occurrence of pharmaceutically active and non-steroidal estrogenic compounds in three different wastewater recycling schemes in Australia","volume":"69","author":"Gabelish","year":"2007","journal-title":"Chemosphere"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"4797","DOI":"10.1016\/j.watres.2005.09.015","article-title":"Removal of selected pharmaceuticals, fragrances and endocrine disrupting compounds in a membrane bioreactor and conventional wastewater treatment plants","volume":"39","author":"Clara","year":"2005","journal-title":"Water Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.watres.2003.10.058","article-title":"Carbamazepine as a possible anthropogenic marker in the aquatic environment: Investigations on the behaviour of carbamazepine in wastewater treatment and during groundwater infiltration","volume":"38","author":"Clara","year":"2004","journal-title":"Water Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.chroma.2006.08.077","article-title":"Analysis of neutral and basic pharmaceuticals in sewage treatment plants and in recipient rivers using solid phase extraction and liquid chromatography\u2013tandem mass spectrometry detection","volume":"1134","author":"Vieno","year":"2006","journal-title":"J. Chromatogr. A"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.1016\/j.watres.2005.05.031","article-title":"Removal of pharmaceuticals and fragrances in biological wastewater treatment","volume":"39","author":"Joss","year":"2005","journal-title":"Water Res."},{"key":"ref_75","unstructured":"Vochezer, K. (2010). Modelling of Carbamazepine and Diclofenac in a River Network\u2014Photolytic Degradation in Swiss Rivers, Swedish University of Agricultural Sciences."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"R105","DOI":"10.1530\/REP-13-0527","article-title":"Ubiquitous presence of paracetamol in human urine: Sources and implications","volume":"147","author":"Modick","year":"2014","journal-title":"Reproduction"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.chemosphere.2014.03.043","article-title":"Concentration evolution of pharmaceutically active compounds in raw urban and industrial wastewater","volume":"111","author":"Santos","year":"2014","journal-title":"Chemosphere"},{"key":"ref_78","first-page":"1263","article-title":"Study of pharmaceuticals in surface and wastewater from cuernavaca, morelos, mexico: Occurrence and environmental risk assessment","volume":"613","author":"Postigo","year":"2018","journal-title":"Sci. Total Environ."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.scitotenv.2012.10.001","article-title":"Seasonal variation of endocrine disrupting compounds, pharmaceuticals and personal care products in wastewater treatment plants","volume":"442","author":"Yu","year":"2013","journal-title":"Sci. Total Environ."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.scitotenv.2012.08.061","article-title":"Monitoring release of pharmaceutical compounds: Occurrence and environmental risk assessment of two wwtp effluents and their receiving bodies in the Po Valley, Italy","volume":"438","author":"Verlicchi","year":"2012","journal-title":"Sci. Total Environ."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"6062","DOI":"10.1016\/j.scitotenv.2010.09.026","article-title":"Impacts of emerging organic contaminants on freshwater resources: Review of recent occurrences, sources, fate and effects","volume":"408","author":"Pal","year":"2010","journal-title":"Sci. Total Environ."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1890\/12.WB.017","article-title":"The riverine input\u2013output paradox for organic pollutants","volume":"10","author":"Gioia","year":"2012","journal-title":"Front. Ecol. Environ."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"5551","DOI":"10.1016\/j.watres.2012.07.033","article-title":"Fate of pharmaceuticals in rivers: Deriving a benchmark dataset at favorable attenuation conditions","volume":"46","author":"Kunkel","year":"2012","journal-title":"Water Res."},{"key":"ref_84","first-page":"133","article-title":"Occurrence and in-stream attenuation of wastewater-derived pharmaceuticals in iberian rivers","volume":"503","author":"Corominas","year":"2015","journal-title":"Sci. Total Environ."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"9781","DOI":"10.1021\/es402158t","article-title":"In-stream attenuation of neuro-active pharmaceuticals and their metabolites","volume":"47","author":"Writer","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.scitotenv.2012.01.029","article-title":"Spatio-temporal evaluation of organic contaminants and their transformation products along a river basin affected by urban, agricultural and industrial pollution","volume":"420","author":"Herrera","year":"2012","journal-title":"Sci. Total Environ."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1016\/j.watres.2010.11.043","article-title":"Investigation of pharmaceuticals in missouri natural and drinking water using high performance liquid chromatography-tandem mass spectrometry","volume":"45","author":"Wang","year":"2011","journal-title":"Water Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.2166\/wst.2016.392","article-title":"Monitoring micropollutants in the swist river basin","volume":"74","author":"Christoffels","year":"2016","journal-title":"Water Sci. Technol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1002\/etc.1903","article-title":"Relationship between biodegradation and sorption of phthalate esters and their metabolites in natural sediments","volume":"31","author":"Kickham","year":"2012","journal-title":"Environ. Toxicol. Chem."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.scitotenv.2013.03.077","article-title":"Evaluating the fate of six common pharmaceuticals using a reactive transport model: Insights from a stream tracer test","volume":"458","author":"Riml","year":"2013","journal-title":"Sci. Total Environ."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.watres.2008.10.039","article-title":"Persistence and partitioning of eight selected pharmaceuticals in the aquatic environment: Laboratory photolysis, biodegradation, and sorption experiments","volume":"43","author":"Yamamoto","year":"2009","journal-title":"Water Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.chemosphere.2004.04.015","article-title":"Determination of selected pharmaceuticals and caffeine in sewage and seawater from troms\u00f8\/norway with emphasis on ibuprofen and its metabolites","volume":"56","author":"Weigel","year":"2004","journal-title":"Chemosphere"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0021-9673(01)00529-5","article-title":"New method for rapid solid-phase extraction of large-volume water samples and its application to non-target screening of north sea water for organic contaminants by gas chromatography\u2013mass spectrometry","volume":"912","author":"Weigel","year":"2001","journal-title":"J. Chromatogr. A"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1897\/05-187R.1","article-title":"Presence and distribution of wastewater-derived pharmaceuticals in soil irrigated with reclaimed water","volume":"25","author":"Kinney","year":"2006","journal-title":"Environ. Toxicol. Chem."},{"key":"ref_95","unstructured":"Melnick, E.L., and Everitt, B.S. (2008). Pharmaceuticals in the environment. Encyclopedia of Quantitative Risk Analysis and Assessment, John Wiley & Sons, Ltd."},{"key":"ref_96","first-page":"193A","article-title":"Pharmaceutical data elude researchers","volume":"39","author":"Thacker","year":"2005","journal-title":"Environ. Sci. Technol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.scitotenv.2014.06.019","article-title":"Synthetic organic compounds and their transformation products in groundwater: Occurrence, fate and mitigation","volume":"503","author":"Postigo","year":"2015","journal-title":"Sci. Total Environ."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.chemosphere.2008.06.070","article-title":"Sorption and mobility of pharmaceutical compounds in soil irrigated with reclaimed wastewater","volume":"73","author":"Chefetz","year":"2008","journal-title":"Chemosphere"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.watres.2017.07.004","article-title":"The potential implications of reclaimed wastewater reuse for irrigation on the agricultural environment: The knowns and unknowns of the fate of antibiotics and antibiotic resistant bacteria and resistance genes\u2014A review","volume":"123","author":"Christou","year":"2017","journal-title":"Water Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0147-6513(02)00082-9","article-title":"Ecotoxicological impact of pharmaceuticals found in treated wastewaters: Study of carbamazepine, clofibric acid, and diclofenac","volume":"55","author":"Ferrari","year":"2003","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1897\/05-193R.1","article-title":"Ecotoxicological risk of pharmaceuticals from wastewater treatment plants in Korea: Occurrence and toxicity to daphnia magna","volume":"25","author":"Han","year":"2006","journal-title":"Environ. Toxicol. Chem."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1897\/07-354R.1","article-title":"Toxicity of human pharmaceuticals and personal care products to benthic invertebrates","volume":"27","author":"Dussault","year":"2008","journal-title":"Environ. Toxicol. Chem."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0887-2333(03)00119-X","article-title":"Ecotoxicological evaluation of carbamazepine using six different model systems with eighteen endpoints","volume":"17","author":"Jos","year":"2003","journal-title":"Toxicol. In Vitro"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0378-4274(03)00068-7","article-title":"Aquatic ecotoxicity of pharmaceuticals including the assessment of combination effects","volume":"142","author":"Cleuvers","year":"2003","journal-title":"Toxicol. Lett."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/jat.1482","article-title":"Physiological condition status and musclebased biomarkers in rainbow trout (Oncorhynchus mykiss), after long-term exposure to carbamazepine","volume":"30","author":"Li","year":"2009","journal-title":"J. Appl. Toxicol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1016\/j.ecoenv.2010.08.031","article-title":"Fish embryo toxicity of carbamazepine, diclofenac and metoprolol","volume":"73","author":"Montforts","year":"2010","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.chemosphere.2008.05.063","article-title":"Structural responses of daucus carota root-organ cultures and the arbuscular mycorrhizal fungus, glomus intraradices, to 12 pharmaceuticals","volume":"73","author":"Hillis","year":"2008","journal-title":"Chemosphere"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.scitotenv.2007.08.038","article-title":"An investigation into the acute and chronic toxicity of eleven pharmaceuticals (and their solvents) found in wastewater effluent on the cnidarian, hydra attenuata","volume":"389","author":"Quinn","year":"2008","journal-title":"Sci. Total Environ."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1289\/ehp.7209","article-title":"Long-term exposure to environmental concentrations of the pharmaceutical ethynylestradiol causes reproductive failure in fish","volume":"112","author":"Nash","year":"2004","journal-title":"Environ. Health Perspect."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3109\/10408440903373590","article-title":"Pharmaceuticals in the aquatic environment: A critical review of the evidence for health effects in fish","volume":"40","author":"Corcoran","year":"2010","journal-title":"Crit. Rev. Toxicol."},{"key":"ref_111","unstructured":"Snyder, S.A., Vanderford, B.J., Drewes, J., Dickenson, E., Snyder, E.M., Bruce, G.M., and Pleus, R.C. (2008). State of Knowledge of Endocrine Disruptors and Pharmaceuticals in Drinking Water, IWA Publishing."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1056\/NEJMoa1009717","article-title":"Carbamazepine-induced toxic effects and HLA-B* 1502 screening in taiwan","volume":"364","author":"Chen","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jaad.2006.04.048","article-title":"Toxic epidermal necrolysis","volume":"56","author":"Pereira","year":"2007","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"6581","DOI":"10.1136\/bmj.c6581","article-title":"Intrauterine exposure to carbamazepine and specific congenital malformations: Systematic review and case-control study","volume":"341","author":"Jentink","year":"2010","journal-title":"Br. Med. J."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1136\/adc.2009.176990","article-title":"Neurodevelopment of children exposed in utero to lamotrigine, sodium valproate and carbamazepine","volume":"96","author":"Cummings","year":"2011","journal-title":"Arch. Dis. Child."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1203\/PDR.0b013e3180a02e50","article-title":"Antiepileptic medication during pregnancy: Does fetal genotype affect outcome?","volume":"62","author":"Atkinson","year":"2007","journal-title":"Pediatr. Res."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Virkutyte, J., Varma, R.S., and Jegatheesan, V. (2010). Treatment of Micropollutants in Water and Wastewater, IWA Publishing.","DOI":"10.2166\/9781780401447"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1016\/j.socscimed.2003.09.012","article-title":"Pharmaceuticals in Australia: Developments in regulation and governance","volume":"58","author":"Lofgren","year":"2004","journal-title":"Soc. Sci. Med."},{"key":"ref_119","unstructured":"MDH (2011). Carbamazepine in Drinking Water."},{"key":"ref_120","unstructured":"Cunliffe, D. (2008). Australian Guidelines for Water Recycling: Augmentation of Drinking Water Supplies, Natural Resource Management Ministerial Council."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"11708","DOI":"10.1007\/s11356-013-2448-5","article-title":"The ability of biologically based wastewater treatment systems to remove emerging organic contaminants\u2014A review","volume":"21","author":"Matamoros","year":"2014","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_122","unstructured":"Metcalf, E., and EDDY, M. (2013). Wastewater Engineering: Treatment and Resource Recovery, McGraw-Hill Professional. [5th ed.]."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.chemosphere.2017.04.048","article-title":"Influence of relaxation modes on membrane fouling in submerged membrane bioreactor for domestic wastewater treatment","volume":"181","author":"Habib","year":"2017","journal-title":"Chemosphere"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.biortech.2013.07.083","article-title":"Insight into metabolic and cometabolic activities of autotrophic and heterotrophic microorganisms in the biodegradation of emerging trace organic contaminants","volume":"146","author":"Tran","year":"2013","journal-title":"Bioresour. Technol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.watres.2014.07.048","article-title":"Modelling cometabolic biotransformation of organic micropollutants in nitrifying reactors","volume":"65","author":"Carballa","year":"2014","journal-title":"Water Res."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.watres.2008.11.043","article-title":"Fate and distribution of pharmaceuticals in wastewater and sewage sludge of the conventional activated sludge (cas) and advanced membrane bioreactor (mbr) treatment","volume":"43","year":"2009","journal-title":"Water Res."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.desal.2004.12.030","article-title":"Different fouling modes of submerged hollow-fiber and flat-sheet membranes induced by high strength wastewater with concurrent biofouling","volume":"180","author":"Hai","year":"2005","journal-title":"Desalination"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1007\/s00216-006-0883-6","article-title":"Analysis of pharmaceuticals in wastewater and removal using a membrane bioreactor","volume":"387","author":"Radjenovic","year":"2007","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1016\/j.watres.2006.06.039","article-title":"Pharmaceutical chemicals and endocrine disrupters in municipal wastewater in tokyo and their removal during activated sludge treatment","volume":"40","author":"Nakada","year":"2006","journal-title":"Water Res."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.watres.2004.08.036","article-title":"The solids retention time\u2014A suitable design parameter to evaluate the capacity of wastewater treatment plants to remove micropollutants","volume":"39","author":"Clara","year":"2005","journal-title":"Water Res."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.scitotenv.2013.09.032","article-title":"Occurrence, fate and ecotoxicological assessment of pharmaceutically active compounds in wastewater and sludge from wastewater treatment plants in chongqing, the three gorges reservoir area","volume":"470","author":"Yan","year":"2014","journal-title":"Sci. Total Environ."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.scitotenv.2015.01.098","article-title":"Occurrence and fate of select psychoactive pharmaceuticals and antihypertensives in two wastewater treatment plants in new york state, USA","volume":"514","author":"Subedi","year":"2015","journal-title":"Sci. Total Environ."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"10386","DOI":"10.1016\/j.biortech.2011.09.019","article-title":"Removal of carbamazepine and sulfamethoxazole by MBR under anoxic and aerobic conditions","volume":"102","author":"Hai","year":"2011","journal-title":"Bioresour. Technol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1016\/j.watres.2011.01.023","article-title":"Removal of trace organics by mbr treatment: The role of molecular properties","volume":"45","author":"Tadkaew","year":"2011","journal-title":"Water Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"26","DOI":"10.5004\/dwt.2017.20998","article-title":"Optimization of the operational parameters in a submerged membrane bioreactor using box behnken response surface methodology: Membrane fouling control and effluent quality","volume":"82","author":"Asif","year":"2017","journal-title":"Desalination"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Jumat, M.R., Hasan, N.A., Subramanian, P., Heberling, C., Colwell, R.R., and Hong, P.-Y. (2017). Membrane bioreactor-based wastewater treatment plant in saudi arabia: Reduction of viral diversity, load, and infectious capacity. Water, 9.","DOI":"10.3390\/w9070534"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.1021\/es061684z","article-title":"Elimination of selected acidic pharmaceuticals from municipal wastewater by an activated sludge system and membrane bioreactors","volume":"41","author":"Kimura","year":"2007","journal-title":"Environ. Sci. Technol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"8135","DOI":"10.1021\/ac801167w","article-title":"First evidence for occurrence of hydroxylated human metabolites of diclofenac and aceclofenac in wastewater using QqLIT-MS and QqTOF-MS","volume":"80","year":"2008","journal-title":"Anal. Chem."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s11157-007-9121-8","article-title":"Factors affecting the removal of organic micropollutants from wastewater in conventional treatment plants (CTP) and membrane bioreactors (MBR)","volume":"7","author":"Cirja","year":"2008","journal-title":"Rev. Environ. Sci. Biotechnol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.biortech.2014.11.084","article-title":"Effects of salinity build-up on biomass characteristics and trace organic chemical removal: Implications on the development of high retention membrane bioreactors","volume":"177","author":"Luo","year":"2015","journal-title":"Bioresour. Technol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.biortech.2017.09.114","article-title":"Effect of hydraulic retention time on the performance of a hybrid moving bed biofilm reactor-membrane bioreactor system for micropollutants removal from municipal wastewater","volume":"247","author":"Jiang","year":"2018","journal-title":"Bioresour. Technol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.scitotenv.2016.11.122","article-title":"Assessing membrane fouling and the performance of pilot-scale membrane bioreactor (mbr) to treat real municipal wastewater during winter season in nordic regions","volume":"579","author":"Gurung","year":"2017","journal-title":"Sci. Total Environ."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.desal.2004.11.033","article-title":"Removal of pharmaceutical compounds by submerged membrane bioreactors (mbrs)","volume":"178","author":"Kimura","year":"2005","journal-title":"Desalination"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1016\/j.watres.2009.02.005","article-title":"The fate of selected micropollutants in a single-house mbr","volume":"43","author":"Abegglen","year":"2009","journal-title":"Water Res."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1021\/es0351488","article-title":"Removal of estrogens in municipal wastewater treatment under aerobic and anaerobic conditions: Consequences for plant optimization","volume":"38","author":"Joss","year":"2004","journal-title":"Environ. Sci. Technol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.biortech.2014.03.094","article-title":"Simultaneous nitrification\/denitrification and trace organic contaminant (troc) removal by an anoxic\u2013aerobic membrane bioreactor (mbr)","volume":"165","author":"Phan","year":"2014","journal-title":"Bioresour. Technol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1016\/j.watres.2010.02.040","article-title":"Removal of pharmaceutical and personal care products (ppcps) under nitrifying and denitrifying conditions","volume":"44","author":"Suarez","year":"2010","journal-title":"Water Res."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.biortech.2013.01.173","article-title":"Understanding the factors controlling the removal of trace organic contaminants by white-rot fungi and their lignin modifying enzymes: A critical review","volume":"141","author":"Yang","year":"2013","journal-title":"Bioresour. Technol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jenvman.2017.06.014","article-title":"Impact of wastewater derived dissolved interfering compounds on growth, enzymatic activity and trace organic contaminant removal of white rot fungi\u2014A critical review","volume":"201","author":"Asif","year":"2017","journal-title":"J. Environ. Manag."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.desal.2005.06.050","article-title":"Development of a submerged membrane fungi reactor for textile wastewater treatment","volume":"192","author":"Hai","year":"2006","journal-title":"Desalination"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/10643380601174723","article-title":"Hybrid treatment systems for dye wastewater","volume":"37","author":"Hai","year":"2007","journal-title":"Crit. Rev. Environ. Sci. Technol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.memsci.2007.06.026","article-title":"Fouling resistant compact hollow-fiber module with spacer for submerged membrane bioreactor treating high strength industrial wastewater","volume":"317","author":"Hai","year":"2008","journal-title":"J. Membr. Sci."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.nbt.2013.06.004","article-title":"Influence of treatment conditions on the oxidation of micropollutants by trametes versicolor laccase","volume":"30","author":"Margot","year":"2013","journal-title":"New Biotechnol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s40726-017-0049-5","article-title":"Degradation of pharmaceuticals and personal care products by white-rot fungi\u2014A critical review","volume":"3","author":"Asif","year":"2017","journal-title":"Curr. Pollut. Rep."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"6800","DOI":"10.1021\/es200298t","article-title":"Transformation of the recalcitrant pharmaceutical compound carbamazepine by pleurotus ostreatus: Role of cytochrome p450 monooxygenase and manganese peroxidase","volume":"45","author":"Chefetz","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1007\/s11274-010-0642-x","article-title":"Degradation of selected pharmaceutical and personal care products (ppcps) by white-rot fungi","volume":"27","author":"Feijoo","year":"2011","journal-title":"World J. Microbiol. Biotechnol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"125","DOI":"10.2965\/jwet.2010.125","article-title":"Biodegradation characteristics of pharmaceutical substances by whole fungal culture trametes versicolor and its laccase","volume":"8","author":"Tran","year":"2010","journal-title":"J. Water Environ. Technol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ibiod.2013.12.017","article-title":"Removal of pharmaceuticals, steroid hormones, phytoestrogens, uv-filters, industrial chemicals and pesticides by trametes versicolor: Role of biosorption and biodegradation","volume":"88","author":"Nguyen","year":"2014","journal-title":"Int. Biodeterior. Biodegrad."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.bej.2012.04.011","article-title":"Operation of stirred tank reactors (strs) and fixed-bed reactors (fbrs) with free and immobilized phanerochaete chrysosporium for the continuous removal of pharmaceutical compounds","volume":"66","author":"Feijoo","year":"2012","journal-title":"Biochem. Eng. J."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.watres.2011.11.063","article-title":"Degradation of carbamazepine by trametes versicolor in an air pulsed fluidized bed bioreactor and identification of intermediates","volume":"46","author":"Jelic","year":"2012","journal-title":"Water Res."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.biortech.2013.08.142","article-title":"Removal of trace organic contaminants by an mbr comprising a mixed culture of bacteria and white-rot fungi","volume":"148","author":"Nguyen","year":"2013","journal-title":"Bioresour. Technol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ibiod.2014.12.004","article-title":"Degradation of a broad spectrum of trace organic contaminants by an enzymatic membrane reactor: Complementary role of membrane retention and enzymatic degradation","volume":"99","author":"Nguyen","year":"2015","journal-title":"Int. Biodeterior. Biodegrad."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.jhazmat.2009.10.133","article-title":"In vitro degradation of carbamazepine and diclofenac by crude lignin peroxidase","volume":"176","author":"Zhang","year":"2010","journal-title":"J. Hazard. Mater."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.biortech.2015.10.054","article-title":"Laccase\u2013syringaldehyde-mediated degradation of trace organic contaminants in an enzymatic membrane reactor: Removal efficiency and effluent toxicity","volume":"200","author":"Nguyen","year":"2016","journal-title":"Bioresour. Technol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10532-011-9494-9","article-title":"Biotransformation of three pharmaceutical active compounds by the fungus phanerochaete chrysosporium in a fed batch stirred reactor under air and oxygen supply","volume":"23","author":"Feijoo","year":"2012","journal-title":"Biodegradation"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.2166\/wst.2013.684","article-title":"Removal of trace organic contaminants by nitrifying activated sludge and whole-cell and crude enzyme extract of trametes versicolor","volume":"67","author":"Yang","year":"2013","journal-title":"Water Sci. Technol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.cej.2015.07.068","article-title":"Fungal pelleted reactors in wastewater treatment: Applications and perspectives","volume":"283","author":"Rene","year":"2016","journal-title":"Chem. Eng. J."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.jhazmat.2016.07.036","article-title":"Continuous treatment of non-sterile hospital wastewater by trametes versicolor: How to increase fungal viability by means of operational strategies and pretreatments","volume":"318","author":"Caminal","year":"2016","journal-title":"J. Hazard. Mater."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.watres.2017.03.005","article-title":"Pharmaceuticals removal and microbial community assessment in a continuous fungal treatment of non-sterile real hospital wastewater after a coagulation-flocculation pretreatment","volume":"116","author":"Llorca","year":"2017","journal-title":"Water Res."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1007\/s00253-015-7105-0","article-title":"Continuous fungal treatment of non-sterile veterinary hospital effluent: Pharmaceuticals removal and microbial community assessment","volume":"100","author":"Lucas","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.scitotenv.2014.05.117","article-title":"Hospital wastewater treatment by fungal bioreactor: Removal efficiency for pharmaceuticals and endocrine disruptor compounds","volume":"493","author":"Lucas","year":"2014","journal-title":"Sci. Total Environ."},{"key":"ref_172","unstructured":"Srivastava, S., and Goyal, P. (2010). Novel Biomaterials: Decontamination of Toxic Metals from Wasterwater, Springer."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.scitotenv.2015.12.139","article-title":"Membrane processes for removal of pharmaceutically active compounds (phacs) from water and wastewaters","volume":"547","author":"Taheran","year":"2016","journal-title":"Sci. Total Environ."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.psep.2016.11.015","article-title":"Application of uf\/nf\/ro membranes for treatment and reuse of rendering plant wastewater","volume":"105","author":"Racar","year":"2017","journal-title":"Process Saf. Environ. Prot."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"5817","DOI":"10.1021\/acs.est.5b05930","article-title":"Effect of ph and pressure on uranium removal from drinking water using nf\/ro membranes","volume":"50","author":"Chaurand","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.1016\/j.watres.2008.05.020","article-title":"Rejection of pharmaceuticals in nanofiltration and reverse osmosis membrane drinking water treatment","volume":"42","author":"Ventura","year":"2008","journal-title":"Water Res."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/j.1551-8833.2008.tb09724.x","article-title":"Comparing nanofiltration and reverse osmosis for drinking water augmentation","volume":"100","author":"Bellona","year":"2008","journal-title":"Am. Water Work. Assoc. J."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.memsci.2008.01.021","article-title":"The rejection of endocrine disrupting and pharmaceutically active compounds by nf and ro membranes as a function of compound and water matrix properties","volume":"313","author":"Comerton","year":"2008","journal-title":"J. Membr. Sci."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1002\/clen.200900040","article-title":"Elimination of carbamazepine, diclofenac and naproxen from treated wastewater by nanofiltration","volume":"37","author":"Krisam","year":"2009","journal-title":"CLEAN Soil Air Water"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.desal.2011.04.029","article-title":"Influence of seasonal and operating conditions on the rejection of pharmaceutical active compounds by ro and nf membranes","volume":"277","author":"Rufel","year":"2011","journal-title":"Desalination"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.2166\/wst.2010.119","article-title":"Treatment of hospital wastewater effluent by nanofiltration and reverse osmosis","volume":"61","author":"Beier","year":"2010","journal-title":"Water Sci. Technol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.desal.2009.03.025","article-title":"Mechanisms underlying the effects of membrane fouling on the nanofiltration of trace organic contaminants","volume":"250","author":"Nghiem","year":"2010","journal-title":"Desalination"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.seppur.2010.04.010","article-title":"Effects of fouling and scaling on the retention of trace organic contaminants by a nanofiltration membrane: The role of cake-enhanced concentration polarisation","volume":"73","author":"Vogel","year":"2010","journal-title":"Sep. Purif. Technol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.seppur.2011.12.009","article-title":"Effects of chemical cleaning on the nanofiltration of pharmaceutically active compounds (phacs)","volume":"88","author":"Simon","year":"2012","journal-title":"Sep. Purif. Technol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.seppur.2007.04.002","article-title":"Effects of membrane fouling on the nanofiltration of pharmaceutically active compounds (phacs): Mechanisms and role of membrane pore size","volume":"57","author":"Nghiem","year":"2007","journal-title":"Sep. Purif. Technol."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"117","DOI":"10.5194\/dwes-4-71-2011","article-title":"Effect of fouling on removal of trace organic compounds by nanofiltration","volume":"4","author":"Hajibabania","year":"2011","journal-title":"Drink. Water Eng. Sci."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0045-6535(03)00757-4","article-title":"Kinetic and chemical assessment of the uv\/h2o2 treatment of antiepileptic drug carbamazepine","volume":"54","author":"Vogna","year":"2004","journal-title":"Chemosphere"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.desal.2014.10.043","article-title":"Nanofiltration membranes review: Recent advances and future prospects","volume":"356","author":"Mohammad","year":"2015","journal-title":"Desalination"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.watres.2008.11.003","article-title":"The influence of natural organic matter and cations on the rejection of endocrine disrupting and pharmaceutically active compounds by nanofiltration","volume":"43","author":"Comerton","year":"2009","journal-title":"Water Res."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.jenvman.2017.02.042","article-title":"Pilot-scale removal of pharmaceuticals in municipal wastewater: Comparison of granular and powdered activated carbon treatment at three wastewater treatment plants","volume":"193","author":"Larsson","year":"2017","journal-title":"J. Environ. Manag."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.biortech.2015.03.010","article-title":"The effect of activated carbon addition on membrane bioreactor processes for wastewater treatment and reclamation\u2014A critical review","volume":"185","author":"Skouteris","year":"2015","journal-title":"Bioresour. Technol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.carbon.2003.09.022","article-title":"Adsorption of organic molecules from aqueous solutions on carbon materials","volume":"42","year":"2004","journal-title":"Carbon"},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Real, F.J., Benitez, F.J., Acero, J.L., and Casas, F. (2017). Adsorption of selected emerging contaminants onto pac and gac: Equilibrium isotherms, kinetics, and effect of the water matrix. J. Environ. Sci. Health Part A, 1\u20138.","DOI":"10.1080\/10934529.2017.1301751"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"7899","DOI":"10.1021\/es400708w","article-title":"Elimination of micropollutants during post-treatment of hospital wastewater with powdered activated carbon, ozone, and UV","volume":"47","author":"Kovalova","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jhazmat.2007.05.059","article-title":"Removal of antibiotics by coagulation and granular activated carbon filtration","volume":"151","author":"Choi","year":"2008","journal-title":"J. Hazard. Mater."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1016\/j.watres.2009.06.009","article-title":"Removal of emerging contaminants of concern by alternative adsorbents","volume":"43","author":"Rossner","year":"2009","journal-title":"Water Res."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.1021\/es015757k","article-title":"Removal of pharmaceuticals during drinking water treatment","volume":"36","author":"Ternes","year":"2002","journal-title":"Environ. Sci. Technol."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1080\/03067310903531504","article-title":"Occurrence of environmentally relevant pharmaceuticals in italian drinking water treatment plants","volume":"91","author":"Pojana","year":"2011","journal-title":"Int. J. Environ. Anal. Chem."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1016\/j.watres.2010.10.036","article-title":"Occurrence and removal of pharmaceuticals and hormones through drinking water treatment","volume":"45","author":"Galceran","year":"2011","journal-title":"Water Res."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.watres.2006.06.034","article-title":"Occurrence and removal of pharmaceuticals and endocrine disruptors in South Korean surface, drinking, and waste waters","volume":"41","author":"Kim","year":"2007","journal-title":"Water Res."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.scitotenv.2007.01.095","article-title":"Efficiency of conventional drinking-water-treatment processes in removal of pharmaceuticals and other organic compounds","volume":"377","author":"Stackelberg","year":"2007","journal-title":"Sci. Total Environ."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.jhazmat.2010.10.005","article-title":"Improved removal of estrogenic and pharmaceutical compounds in sewage effluent by full scale granular activated carbon: Impact on receiving river water","volume":"185","author":"Grover","year":"2011","journal-title":"J. Hazard. Mater."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"728","DOI":"10.2166\/wst.2010.914","article-title":"Influence of the employment of adsorption and coprecipitation agents for the removal of ppcps in conventional activated sludge (cas) systems","volume":"62","author":"Serrano","year":"2010","journal-title":"Water Sci. Technol."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1007\/s11270-014-2260-y","article-title":"Pilot-scale investigation of micropollutant removal with granular and powdered activated carbon","volume":"226","author":"Meinel","year":"2015","journal-title":"Water Air Soil Pollut."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.desal.2005.12.052","article-title":"Role of membranes and activated carbon in the removal of endocrine disruptors and pharmaceuticals","volume":"202","author":"Snyder","year":"2007","journal-title":"Desalination"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"65","DOI":"10.5004\/dwt.2012.2458","article-title":"Improved elimination of organic micropollutants by a process combination of membrane bioreactor (mbr) and powdered activated carbon (pac)","volume":"42","author":"Lipp","year":"2012","journal-title":"Desalin. Water Treat."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"6649","DOI":"10.1021\/es0484799","article-title":"Fate of endocrine-disruptor, pharmaceutical, and personal care product chemicals during simulated drinking water treatment processes","volume":"39","author":"Westerhoff","year":"2005","journal-title":"Environ. Sci. Technol."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.envint.2008.01.004","article-title":"Nonylphenol in the environment: A critical review on occurrence, fate, toxicity and treatment in wastewaters","volume":"34","author":"Soares","year":"2008","journal-title":"Environ. Int."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1006\/jcis.2000.7300","article-title":"Comparative study of the adsorption from aqueous solutions and the desorption of phenol and nonylphenol substrates on activated carbons","volume":"234","author":"Nevskaia","year":"2001","journal-title":"J. Colloid Interface Sci."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.biortech.2012.11.131","article-title":"Comparison between sequential and simultaneous application of activated carbon with membrane bioreactor for trace organic contaminant removal","volume":"130","author":"Nguyen","year":"2013","journal-title":"Bioresour. Technol."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"5319","DOI":"10.1016\/j.biortech.2010.11.070","article-title":"Simultaneous activated carbon adsorption within a membrane bioreactor for an enhanced micropollutant removal","volume":"102","author":"Li","year":"2011","journal-title":"Bioresour. Technol."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1016\/j.watres.2011.03.009","article-title":"Removal of micropollutants from aerobically treated grey water via ozone and activated carbon","volume":"45","author":"Temmink","year":"2011","journal-title":"Water Res."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.envint.2008.07.009","article-title":"Removal of residual pharmaceuticals from aqueous systems by advanced oxidation processes","volume":"35","author":"Klavarioti","year":"2009","journal-title":"Environ. Int."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1007\/s40726-017-0072-6","article-title":"Degradation and fate of pharmaceutically active contaminants by advanced oxidation processes","volume":"3","author":"Alharbi","year":"2017","journal-title":"Curr. Pollut. Rep."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1016\/S0043-1354(01)00500-0","article-title":"Carbamazepine in water: Persistence in the environment, ozonation treatment and preliminary assessment on algal toxicity","volume":"36","author":"Andreozzi","year":"2002","journal-title":"Water Res."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1016\/j.watres.2006.04.033","article-title":"Ozone treatment and the depletion of detectable pharmaceuticals and atrazine herbicide in drinking water sourced from the upper detroit river, ontario, canada","volume":"40","author":"Hua","year":"2006","journal-title":"Water Res."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1021\/es025896h","article-title":"Oxidation of pharmaceuticals during ozonation and advanced oxidation processes","volume":"37","author":"Huber","year":"2003","journal-title":"Environ. Sci. Technol."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.watres.2008.11.050","article-title":"Effect of ozone exposure on the oxidation of trace organic contaminants in wastewater","volume":"43","author":"Wert","year":"2009","journal-title":"Water Res."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1016\/j.watres.2006.02.026","article-title":"Measurement of the initial phase of ozone decomposition in water and wastewater by means of a continuous quench-flow system: Application to disinfection and pharmaceutical oxidation","volume":"40","author":"Buffle","year":"2006","journal-title":"Water Res."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.psep.2017.07.015","article-title":"Photolysis and UV\/H2O2 of diclofenac, sulfamethoxazole, carbamazepine, and trimethoprim: Identification of their major degradation products by ESI\u2013LC\u2013MS and assessment of the toxicity of reaction mixtures","volume":"112","author":"Alharbi","year":"2017","journal-title":"Process Saf. Environ. Prot."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.desal.2011.10.018","article-title":"Optimization of carbamazepine removal in O3\/UV\/H2O2 system using a response surface methodology with central composite design","volume":"285","author":"Im","year":"2012","journal-title":"Desalination"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.apcatb.2015.03.055","article-title":"In situ chemical oxidation of carbamazepine solutions using persulfate simultaneously activated by heat energy, UV light, Fe2+ ions, and H2O2","volume":"176","author":"Monteagudo","year":"2015","journal-title":"Appl. Catal. B Environ."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1002\/clen.201200222","article-title":"Carbamazepine removal from groundwater: Effectiveness of the Tio2\/UV, nanoparticulate zero-valent iron, and fenton (NZVI\/H2O2) processes","volume":"41","author":"Shirazi","year":"2013","journal-title":"CLEAN Soil Air Water"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.watres.2016.04.011","article-title":"Ppcp degradation by uv\/chlorine treatment and its impact on dbp formation potential in real waters","volume":"98","author":"Yang","year":"2016","journal-title":"Water Res."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.watres.2009.10.031","article-title":"Evaluation of UV\/H2O2 treatment for the oxidation of pharmaceuticals in wastewater","volume":"44","author":"Wert","year":"2010","journal-title":"Water Res."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"6371","DOI":"10.1016\/j.watres.2011.09.025","article-title":"Feasibility studies: UV\/chlorine advanced oxidation treatment for the removal of emerging contaminants","volume":"45","author":"Sichel","year":"2011","journal-title":"Water Res."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"4413","DOI":"10.1016\/j.watres.2007.05.056","article-title":"Evaluation of uv irradiation for photolytic and oxidative degradation of pharmaceutical compounds in water","volume":"41","author":"Pereira","year":"2007","journal-title":"Water Res."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.watres.2004.09.016","article-title":"Photocatalytic degradation of carbamazepine, clofibric acid and iomeprol with p25 and hombikat UV100 in the presence of natural organic matter (nom) and other organic water constituents","volume":"39","author":"Doll","year":"2005","journal-title":"Water Res."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cej.2012.05.056","article-title":"Solar photo-fenton at mild conditions to treat a mixture of six emerging pollutants","volume":"198\u2013199","author":"Bernabeu","year":"2012","journal-title":"Chem. Eng. J."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.watres.2009.09.059","article-title":"Degradation of fifteen emerging contaminants at \u03bcg\/L initial concentrations by mild solar photo-fenton in mwtp effluents","volume":"44","author":"Klamerth","year":"2010","journal-title":"Water Res."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"7015","DOI":"10.1007\/s11164-014-1795-2","article-title":"Aquatic photolysis of carbamazepine by UV\/H2O2 and UV\/Fe(ii) processes","volume":"41","author":"Liu","year":"2015","journal-title":"Res. Chem. Interm."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1080\/09593330.2011.610359","article-title":"Comparative study of the degradation of carbamazepine in water by advanced oxidation processes","volume":"33","author":"Dai","year":"2011","journal-title":"Environ. Technol."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"7862","DOI":"10.1021\/es9014629","article-title":"Elimination of organic micropollutants in a municipal wastewater treatment plant upgraded with a full-scale post-ozonation followed by sand filtration","volume":"43","author":"Hollender","year":"2009","journal-title":"Environ. Sci. Technol."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.watres.2009.09.048","article-title":"Removal of micropollutants and reduction of biological activity in a full scale reclamation plant using ozonation and activated carbon filtration","volume":"44","author":"Reungoat","year":"2010","journal-title":"Water Res."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1002\/jctb.1873","article-title":"Advanced oxidation processes for water treatment: Advances and trends for R&D","volume":"83","author":"Comninellis","year":"2008","journal-title":"J. Chem. Technol. Biotechnol."},{"key":"ref_236","unstructured":"Fatta-Kassinos, D., Dionysiou, D.D., and K\u00fcmmerer, K. (2014). Trace organic contaminants removal by combined processes for wastewater reuse. Advanced Treatment Technologies for Urban Wastewater Reuse, Springer."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.ibiod.2013.03.014","article-title":"Removal of emerging trace organic contaminants by mbr-based hybrid treatment processes","volume":"85","author":"Nguyen","year":"2013","journal-title":"Int. Biodeterior. Biodegrad."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"7012","DOI":"10.1016\/j.biortech.2011.04.056","article-title":"An integrated MBR\u2013Tio2 photocatalysis process for the removal of carbamazepine from simulated pharmaceutical industrial effluent","volume":"102","author":"Laera","year":"2011","journal-title":"Bioresour. Technol."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.jhazmat.2016.09.053","article-title":"Carbamazepine degradation by gamma irradiation coupled to biological treatment","volume":"321","author":"Wang","year":"2017","journal-title":"J. Hazard. Mater."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.desal.2010.01.005","article-title":"Removal of organic xenobiotics by combined out\/in ultrafiltration and powdered activated carbon adsorption","volume":"255","author":"Hobby","year":"2010","journal-title":"Desalination"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"5323","DOI":"10.1016\/j.watres.2011.07.037","article-title":"Removal of persistent pharmaceutical micropollutants from sewage by addition of pac in a sequential membrane bioreactor","volume":"45","author":"Serrano","year":"2011","journal-title":"Water Res."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.biortech.2011.10.051","article-title":"Removal of trace organic contaminants by a membrane bioreactor\u2013granular activated carbon (mbr\u2013gac) system","volume":"113","author":"Nguyen","year":"2012","journal-title":"Bioresour. Technol."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.watres.2013.11.016","article-title":"Ozonation products of carbamazepine and their removal from secondary effluents by soil aquifer treatment\u2013indications from column experiments","volume":"49","author":"Seiwert","year":"2014","journal-title":"Water Res."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/j.scitotenv.2011.01.010","article-title":"Pharmaceuticals, hormones and bisphenol a in untreated source and finished drinking water in Ontario, Canada\u2014Occurrence and treatment efficiency","volume":"409","author":"Kleywegt","year":"2011","journal-title":"Sci. Total Environ."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1021\/es8023513","article-title":"Oxidation of carbamazepine by Mn(vii) and Fe(vi): Reaction kinetics and mechanism","volume":"43","author":"Hu","year":"2008","journal-title":"Environ. Sci. Technol."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"6256","DOI":"10.1021\/es900070h","article-title":"Fate of carbamazepine during water treatment","volume":"43","author":"Kosjek","year":"2009","journal-title":"Environ. Sci. Technol."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.ibiod.2016.10.044","article-title":"Removal of emerging contaminant and fouling control in membrane bioreactors by combined ozonation and sonolysis","volume":"119","author":"Prado","year":"2017","journal-title":"Int. Biodeterior. Biodegrad."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1016\/j.biortech.2008.11.015","article-title":"Pre-treatment of hospital wastewater by coagulation-flocculation and flotation","volume":"100","author":"Suarez","year":"2009","journal-title":"Bioresour. Technol."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1080\/09593332708618632","article-title":"Removal of pharmaceuticals in drinking water treatment: Effect of chemical coagulation","volume":"27","author":"Vieno","year":"2006","journal-title":"Environ. Technol."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"5077","DOI":"10.1021\/es062720x","article-title":"Occurrence of pharmaceuticals in river water and their elimination in a pilot-scale drinking water treatment plant","volume":"41","author":"Vieno","year":"2007","journal-title":"Environ. Sci. Technol."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"5191","DOI":"10.1016\/j.watres.2011.07.021","article-title":"Evaluation of enhanced coagulation pretreatment to improve ozone oxidation efficiency in wastewater","volume":"45","author":"Wert","year":"2011","journal-title":"Water Res."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0043-1354(00)00286-4","article-title":"The treatment and reuse of wastewater in the textile industry by means of ozonation and electroflocculation","volume":"35","author":"Ciardelli","year":"2001","journal-title":"Water Res."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"8014","DOI":"10.1021\/es050043l","article-title":"Ozonation of carbamazepine in drinking water: Identification and kinetic study of major oxidation products","volume":"39","author":"McDowell","year":"2005","journal-title":"Environ. Sci. Technol."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.watres.2009.09.049","article-title":"Oxidation of atenolol, propranolol, carbamazepine and clofibric acid by a biological fenton-like system mediated by the white-rot fungus trametes versicolor","volume":"44","author":"Caminal","year":"2010","journal-title":"Water Res."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1002\/rcm.3220","article-title":"Identification of primary and sequential bioactivation pathways of carbamazepine in human liver microsomes using liquid chromatography\/tandem mass spectrometry","volume":"21","author":"Bu","year":"2007","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1007\/s00244-008-9202-x","article-title":"Presence and fate of carbamazepine, oxcarbazepine, and seven of their metabolites at wastewater treatment plants","volume":"56","author":"Leclercq","year":"2009","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.scitotenv.2012.12.072","article-title":"A comparative study of ultrasonication, fenton\u2019s oxidation and ferro-sonication treatment for degradation of carbamazepine from wastewater and toxicity test by yeast estrogen screen (yes) assay","volume":"447","author":"Mohapatra","year":"2013","journal-title":"Sci. Total Environ."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.2166\/wst.2013.452","article-title":"Chemical and toxicological evaluation of transformation products during advanced oxidation processes","volume":"68","author":"Richard","year":"2013","journal-title":"Water Sci. Technol."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/j.watres.2010.11.038","article-title":"Transformation of the antiepileptic drug oxcarbazepine upon different water disinfection processes","volume":"45","author":"Li","year":"2011","journal-title":"Water Res."}],"container-title":["Water"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4441\/10\/2\/107\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T14:52:44Z","timestamp":1760194364000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4441\/10\/2\/107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,26]]},"references-count":259,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,2]]}},"alternative-id":["w10020107"],"URL":"https:\/\/doi.org\/10.3390\/w10020107","relation":{},"ISSN":["2073-4441"],"issn-type":[{"value":"2073-4441","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,26]]}}}