{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T01:36:48Z","timestamp":1783129008685,"version":"3.54.6"},"reference-count":36,"publisher":"Royal College of General Practitioners","issue":"721","license":[{"start":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T00:00:00Z","timestamp":1549929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Gen Pract"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The majority of colorectal cancer is diagnosed in patients following symptomatic presentation in the UK.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To identify windows of opportunity for timely investigations or referrals in patients presenting with colon and rectal cancer-relevant symptoms or abnormal blood tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and setting<\/jats:title><jats:p>A retrospective cohort study was undertaken using linked primary care and cancer registry data for patients with colorectal cancer diagnosed in England between 2012 and 2015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Monthly consultation rates for relevant clinical features (change in bowel habit, rectal bleeding, abdominal pain, abdominal mass, constitutional symptoms, and other bowel symptoms) and abnormal blood test results (low haemoglobin, high platelets, and high inflammatory markers) up to 24 months pre-diagnosis were calculated. Poisson regression adjusted for age, sex, and relevant comorbidities was used to estimate the most likely month when consultation rates increased above baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 5033 patients with colon cancer and 2516 with rectal cancer were included. Consultations for all examined clinical features and abnormal blood tests increased in the year pre-diagnosis. Rectal bleeding was the earliest clinical feature to increase from the baseline rate: at 10 months (95% confidence interval [CI] = 8.3 to 11.7) pre-diagnosis for colon cancer and at 8 months (95% CI = 6.1 to 9.9) pre-diagnosis for rectal cancer. Low haemoglobin, high platelets, and high inflammatory markers increased from as early as 9 months pre-diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study found evidence for an early increase in rates of consultation for relevant clinical features and abnormal blood tests in patients with colorectal cancer, suggesting that earlier instigation of cancer-specific investigations or referrals may be warranted in some patients who were symptomatic.<\/jats:p><\/jats:sec>","DOI":"10.3399\/bjgp.2021.0563","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T17:16:47Z","timestamp":1649697407000},"page":"e556-e563","source":"Crossref","is-referenced-by-count":27,"title":["Pre-diagnostic clinical features and blood tests in patients with colorectal cancer: a retrospective linked-data study"],"prefix":"10.3399","volume":"72","author":[{"given":"Marie","family":"Moullet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garth","family":"Funston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke TA","family":"Mounce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary A","family":"Abel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niek","family":"de Wit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona M","family":"Walter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1987","published-online":{"date-parts":[[2022,3,24]]},"reference":[{"key":"2022072817254100000_72.721.e556.1","unstructured":"Cancer Research UK Bowel cancer statistics. https:\/\/www.cancerresearchuk.org\/health-professional\/cancer-statistics\/statistics-by-cancer-type\/bowel-cancer (accessed 16 May 2022)."},{"key":"2022072817254100000_72.721.e556.2","unstructured":"National Cancer Registration and Analysis Service (2018) Routes to diagnosis 2006\u20132016 workbook. http:\/\/www.ncin.org.uk\/publications\/routes_to_diagnosis (accessed 16 May 2022)."},{"key":"2022072817254100000_72.721.e556.3","unstructured":"Office for National Statistics (2019) Cancer survival in England \u2014 adults diagnosed 2013\u20132017. https:\/\/www.ons.gov.uk\/peoplepopulationandcommunity\/healthandsocialcare\/conditionsanddiseases\/datasets\/cancersurvivalratescancersurvivalinenglandadultsdiagnosed (accessed 16 May 2022)."},{"key":"2022072817254100000_72.721.e556.4","unstructured":"National Institute for Health and Care Excellence (2005) Referral guidelines for suspected cancer, CG27, https:\/\/www.nice.org.uk\/guidance\/cg27 (accessed 16 May 2022)."},{"key":"2022072817254100000_72.721.e556.5","unstructured":"National Institute for Health and Care Excellence (2021) Suspected cancer: recognition and referral NG12, nice.org.uk\/guidance\/ng12 (accessed 16 May 2022)."},{"key":"2022072817254100000_72.721.e556.6","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2016.221"},{"key":"2022072817254100000_72.721.e556.7","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2016.250"},{"key":"2022072817254100000_72.721.e556.8","doi-asserted-by":"crossref","unstructured":"Brandenbarg D Groenhof F Siewers IM (2018) Possible missed opportunities for diagnosing colorectal cancer in Dutch primary care: a multimethods approach. 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