{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:41:44Z","timestamp":1761514904135,"version":"3.37.3"},"reference-count":22,"publisher":"Royal College of General Practitioners","issue":"721","license":[{"start":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T00:00:00Z","timestamp":1549929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Gen Pract"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Non-acute abdominal pain in primary care is diagnostically challenging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To quantify the 1-year cumulative incidence of 35 non-malignant diagnoses and nine cancers in adults after newly recorded abdominal pain in primary care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and setting<\/jats:title><jats:p>Observational cohort study of 125 793 Clinical Practice Research Datalink GOLD records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Participants, aged \u226540 years, had newly recorded abdominal pain between 1 January 2009 and 31 December 2013. Age- and sex-stratified 1-year cumulative incidence by diagnosis is reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most (&gt;70%) participants had no pre-specified diagnoses after newly recorded abdominal pain. Non-malignant diagnoses were most common: upper gastrointestinal problems (gastro-oesophageal reflux disease, hiatus hernia, gastritis, oesophagitis, and gastric\/duodenal ulcer) in males and urinary tract infection in females. The incidence of upper gastrointestinal problems plateaued at age \u226560 years (aged 40\u201359 years: males 4.9%, 95% confidence interval [CI] = 4.6 to 5.1, females 4.0%, 95% CI = 3.8 to 4.2; aged 60\u201369 years: males 5.8%, 95% CI = 5.4 to 6.2, females 5.4%, 95% CI = 5.1 to 5.8). Urinary tract infection incidence increased with age (aged 40\u201359 years: females 5.1%, 95% CI = 4.8 to 5.3, males 1.1%, 95% CI = 1.0 to 1.2; aged \u226570 years: females 8.0%, 95% CI = 7.6 to 8.4, males 3.3%, 95% CI = 3.0 to 3.6%). Diverticular disease incidence rose with age, plateauing at 4.2% (95% CI = 3.9 to 4.6) in males aged \u226560 years, increasing to 6.1% (95% CI = 5.8 to 6.4) in females aged \u226570 years. Irritable bowel syndrome incidence was higher in females (aged 40\u201359 years: 2.9%, 95% CI = 2.7 to 3.1) than males (aged 40\u201359 years: 2.1%, 95% CI = 1.9 to 2.3), decreasing with age to 1.3% (95% CI = 1.2 to 1.5) in females and 0.6% (95% CI = 0.5 to 0.8) in males aged \u226570 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although abdominal pain commonly remains unexplained, non-malignant diagnosis are more likely than cancer.<\/jats:p><\/jats:sec>","DOI":"10.3399\/bjgp.2021.0709","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T15:15:36Z","timestamp":1653318936000},"page":"e564-e570","source":"Crossref","is-referenced-by-count":9,"title":["Diagnoses after newly recorded abdominal pain in primary care: observational cohort study"],"prefix":"10.3399","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2228-2374","authenticated-orcid":false,"given":"Sarah J","family":"Price","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0480-5020","authenticated-orcid":false,"given":"Niamh","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1611-1373","authenticated-orcid":false,"given":"William T","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9261-9350","authenticated-orcid":false,"given":"Jennifer","family":"Bostock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3610-3680","authenticated-orcid":false,"given":"Elizabeth A","family":"Shephard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1987","published-online":{"date-parts":[[2022,4,20]]},"reference":[{"key":"2022072817254218000_72.721.e564.1","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/cmu036"},{"key":"2022072817254218000_72.721.e564.2","doi-asserted-by":"crossref","first-page":"789","DOI":"10.2147\/IJGM.S25936","article-title":"Evaluation and management of acute abdominal pain in the emergency department","volume":"5","author":"Macaluso","year":"2012","journal-title":"Int J Gen Med"},{"key":"2022072817254218000_72.721.e564.3","unstructured":"Silen W (2010) Cope\u2019s early diagnosis of the acute abdomen (Oxford University Press, Oxford), 22nd edn."},{"key":"2022072817254218000_72.721.e564.4","unstructured":"Leath CA Lowery WJ (2022) Assessment of acute abdomen. https:\/\/bestpractice.bmj.com\/topics\/en-gb\/503#referencePop2 (accessed 1 Jun 2022)."},{"key":"2022072817254218000_72.721.e564.5","unstructured":"Ringel-Kulka T Ringer Y (2021) Assessment of chronic abdominal pain - diagnosis approach. https:\/\/bestpractice.bmj.com\/topics\/en-gb\/767\/diagnosis-approach (accessed 8 May 2022)."},{"key":"2022072817254218000_72.721.e564.6","unstructured":"National Institute for Health and Care Excellence (2013) Faecal calprotectin diagnostic tests for inflammatory diseases of the bowel DG11, https:\/\/www.nice.org.uk\/guidance\/dg11 (accessed 1 Jun 2022)."},{"key":"2022072817254218000_72.721.e564.7","unstructured":"National Institute for Health and Care Excellence (2015) Coeliac disease: recognition, assessment and management. 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