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At 6 months all groups improved (primary time point:<jats:italic>n<\/jats:italic>for the generic, Renewed groups, and Renewed with support were 806, 749, and 705, respectively), with no significant between-group differences for EORTC QLQ-C30, but global health improved more in both the Renewed groups. By 12 months there were small improvements in EORTC QLQ-C30 for Renewed with support (versus generic advice: 1.42, 95% confidence interval [CI] = 0.33 to 2.51); both Renewed groups improved global health (12 months: Renewed: 3.06, 95% CI = 1.39 to 4.74; Renewed with support: 2.78, 95% CI = 1.08 to 4.48), dyspnoea, constipation and enablement, and lower primary care NHS costs (in comparison with generic advice [\u00a3265]: Renewed was \u2212\u00a3141 [95% CI = \u2212\u00a3153 to\u2013\u00a3128] and Renewed with Support was \u2212\u00a377 [95% CI = \u2212\u00a390 to \u2212\u00a365]); and for Renewed with support improvement in several other symptom subscales. No harms were identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cancer survivors\u2019 quality of life improved with detailed generic online support. Robustly developed bespoke digital support provides limited additional short-term benefit, but additional longer-term improvement in global health, enablement, and symptom management, with substantially lower NHS costs.<\/jats:p><\/jats:sec>","DOI":"10.3399\/bjgp.2023.0262","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T11:55:36Z","timestamp":1703073336000},"page":"e357-e365","source":"Crossref","is-referenced-by-count":7,"title":["Digital intervention (Renewed) to support symptom management, wellbeing, and quality of life among cancer survivors in primary care: a randomised controlled 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