{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:30:18Z","timestamp":1792189818478,"version":"4.4.0"},"reference-count":41,"publisher":"Royal College of General Practitioners","issue":"655","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Gen Pract"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Arteriosclerotic disorders increase the risk of dementia. As they have common causes and risk factors, coronary heart disease (CHD) could influence the course of dementia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine whether CHD increases the speed of cognitive decline in Alzheimer\u2019s disease, and to discuss the potential for secondary cardiovascular prevention to modify this decline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and setting<\/jats:title><jats:p>Prospective multicentre cohort study in general practices in six cities in Germany.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Participants were patients with probable mild-to-moderate Alzheimer\u2019s dementia or mixed dementia (<jats:italic>n<\/jats:italic> = 118; mean age 85.6 [\u00b13.4] years, range 80\u201396 years). The authors assessed the presence of CHD according to the family physicians\u2019 diagnosis. Cognitive performance was measured during home visits for up to 3 years in intervals of 6 months, using Mini Mental State Examination (MMSE) and Clinical Dementia Rating Sum of Boxes (CDR-SoB). The authors also recorded whether patients died in the observation period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, 65 patients (55%) had CHD and\/or a heart condition following a myocardial infarction. The presence of CHD accelerated cognitive decline (MMSE, <jats:italic>P<\/jats:italic>&lt;0.05) by about 66%, and reduced cognitive-functional ability (CDR-SoB, <jats:italic>P<\/jats:italic>&lt;0.05) by about 83%, but had no impact on survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study shows that CHD has a significant influence on cognitive decline in older patients with late-onset dementia. The dementia process might therefore be positively influenced by cardiovascular prevention, and this possible effect should be further investigated.<\/jats:p><\/jats:sec>","DOI":"10.3399\/bjgp16x688813","type":"journal-article","created":{"date-parts":[[2017,1,11]],"date-time":"2017-01-11T12:55:22Z","timestamp":1484139322000},"page":"e111-e117","source":"Crossref","is-referenced-by-count":39,"title":["Impact of coronary heart disease on cognitive decline in Alzheimer\u2019s disease: a prospective longitudinal cohort study in primary care"],"prefix":"10.3399","volume":"67","author":[{"given":"Markus","family":"Bleckwenn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Kleineidam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Jessen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siegfried","family":"Weyerer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Werle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitt","family":"Wiese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"L\u00fchmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Posselt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Helmut","family":"K\u00f6nig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Brettschneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edelgard","family":"M\u00f6sch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Weeg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Pentzek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Luck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffi G","family":"Riedel-Heller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Maier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Scherer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1987","published-online":{"date-parts":[[2016,12,19]]},"reference":[{"key":"2020081209295816000_67.655.e111.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.11.007"},{"key":"2020081209295816000_67.655.e111.2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70169-8"},{"key":"2020081209295816000_67.655.e111.3","doi-asserted-by":"publisher","DOI":"10.1037\/0278-6133.22.6.559"},{"key":"2020081209295816000_67.655.e111.4","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31823ac046"},{"key":"2020081209295816000_67.655.e111.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15900-X"},{"key":"2020081209295816000_67.655.e111.6","first-page":"363","article-title":"Apolipoprotein E polymorphism in cerebrovascular and coronary heart diseases","volume":"132","author":"Anoop","year":"2010","journal-title":"Indian J Med Res"},{"key":"2020081209295816000_67.655.e111.7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb04796.x"},{"key":"2020081209295816000_67.655.e111.8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06408.x"},{"key":"2020081209295816000_67.655.e111.9","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2010.393"},{"key":"2020081209295816000_67.655.e111.10","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(90)90024-T"},{"key":"2020081209295816000_67.655.e111.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.12.035"},{"key":"2020081209295816000_67.655.e111.12","doi-asserted-by":"crossref","unstructured":"Murphy E Vellinga A Byrne M (2015) Br J Gen Pract, Primary care organisational interventions for secondary prevention of ischaemic heart disease: a systematic review and meta-analysis. 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