{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T05:57:40Z","timestamp":1793339860490,"version":"4.5.0"},"reference-count":26,"publisher":"Royal College of General Practitioners","issue":"701","license":[{"start":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T00:00:00Z","timestamp":1549929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Gen Pract"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Thrombocytosis is an excess of platelets, which is diagnosed as a platelet count &gt;400 \u00d7 10<jats:sup>9<\/jats:sup>\/l. An association of thrombocytosis with undiagnosed cancer has recently been established, but the association with non-malignant disease has not been studied in primary care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To examine, in English primary care, the 1-year incidence of non-malignant diseases in patients with new thrombocytosis and the incidence of pre-existing non-malignant diseases in patients who develop new thrombocytosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and setting<\/jats:title><jats:p>Prospective cohort study using English Clinical Practice Research Datalink data from 2000 to 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Newly incident and pre-existing rates of non-malignant diseases associated with thrombocytosis were compared between patients with thrombocytosis and age- and sex-matched patients with a normal platelet count. Fifteen candidate non-malignant diseases were identified from literature searches.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the thrombocytosis cohort of 39 850 patients, 4579 (11.5%) were newly diagnosed with any one of the candidate diseases, compared with 443 out of 9684 patients (4.6%) in the normal platelet count cohort (relative risk [RR] 2.5, 95% confidence intervals [CI] = 2.3 to 2.8); iron-deficiency anaemia was the most common new diagnosis (4.5% of patients with thrombocytosis, RR 4.9, 95% CI = 4.0 to 6.1). A total of 22 612 (57.0%) patients with thrombocytosis had a pre-existing non-malignant diagnosis compared with 4846 patients (50%) in the normal platelet count cohort (odds ratio 1.3, 95% CI = 1.2 to 1.4). There was no statistically significant difference in cancer diagnoses between patients with and without pre-existing disease in the thrombocytosis cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Thrombocytosis is associated with several non-malignant diseases. Clinicians can use these findings as part of their holistic diagnostic approach to help guide further investigations and management of patients with thrombocytosis.<\/jats:p><\/jats:sec>","DOI":"10.3399\/bjgp20x713501","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T05:25:13Z","timestamp":1605590713000},"page":"e852-e857","source":"Crossref","is-referenced-by-count":4,"title":["Association of non-malignant diseases with thrombocytosis: a prospective cohort study in general practice"],"prefix":"10.3399","volume":"70","author":[{"given":"Cansu","family":"Clarke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willie","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah ER","family":"Bailey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1987","published-online":{"date-parts":[[2020,11,16]]},"reference":[{"key":"2021050602251354000_70.701.e852.1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.035287"},{"key":"2021050602251354000_70.701.e852.2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.68.1.88"},{"key":"2021050602251354000_70.701.e852.3","doi-asserted-by":"publisher","DOI":"10.3109\/09537104.2015.1010441"},{"key":"2021050602251354000_70.701.e852.4","doi-asserted-by":"publisher","DOI":"10.1586\/17474086.2015.1069703"},{"key":"2021050602251354000_70.701.e852.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra035363"},{"key":"2021050602251354000_70.701.e852.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02175-9"},{"key":"2021050602251354000_70.701.e852.7","doi-asserted-by":"crossref","unstructured":"Bailey SE Ukoumunne OC Shephard EA Hamilton W (2017) Clinical relevance of thrombocytosis in primary care: a prospective cohort study of cancer incidence using English electronic medical records and cancer registry data. 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