{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T18:33:18Z","timestamp":1775500398944,"version":"3.50.1"},"reference-count":34,"publisher":"Royal College of General Practitioners","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BJGP Open"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>During left-sided heart failure (HF), left atrial and pulmonary venous pressure increase, which may lead to pulmonary congestion. Previous cohort studies, examining participants with symptomatic HF or rheumatic heart disease, suggest a relationship between increased left atrial pressure (LAP) and fractional exhaled nitric oxide (FeNO).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To examine the strength of association between FeNO and echocardiographic assessment of LAP by the E\/e\u2019 ratio, to determine if FeNO could be used to identify those with elevated LAP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design &amp; setting<\/jats:title><jats:p>This cross-sectional cohort study examined a subset of the OxVALVE cohort aged \u226565 years. Data collection was undertaken in primary care practices in central England.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Each participant underwent a focused cardiovascular history and clinical examination. Standard transthoracic echocardiographic (TTE) assessment was performed on all participants, with the E\/e\u2019 ratio calculated to obtain a validated surrogate of LAP. FeNO was measured in 227 participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>FeNO was higher in males compared with females and no different in participants with asthma, chronic obstructive pulmonary disease (COPD), or those using inhaled steroids. Participants with a high E\/e\u2019 (&gt;14) were older, with a higher proportion of females than males. There was no relationship between E\/e\u2019 and FeNO, either when measured as a continuous variable or in the group with high E\/e\u2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>FeNO was not found to be an accurate predictor of elevated LAP in a primary care setting.<\/jats:p><\/jats:sec>","DOI":"10.3399\/bjgpo.2022.0105","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T14:21:16Z","timestamp":1667571676000},"page":"BJGPO.2022.0105","source":"Crossref","is-referenced-by-count":1,"title":["Effectiveness of exhaled nitric oxide for the prediction of non-invasive left atrial pressure in older people: a cross-sectional cohort study"],"prefix":"10.3399","volume":"7","author":[{"given":"Samuel 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