{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T08:43:02Z","timestamp":1768466582262,"version":"3.49.0"},"reference-count":43,"publisher":"Royal College of General Practitioners","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BJGP Open"],"accepted":{"date-parts":[[2025,4,29]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is limited evidence that anti-vertigo drugs (AVDs) are effective in patients with vestibular symptoms. Still, betahistine is one of the most frequently prescribed off-label drugs. GPs are likely to contribute substantially to these potentially inappropriate prescriptions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the frequency of (long-term) AVD prescriptions in primary care and characteristics associated with long-term prescriptions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design &amp; setting<\/jats:title>\n                    <jats:p>We conducted a retrospective observational cohort study using anonymised routine primary care data from \u22651.2 million patients registered at 269 general practices throughout the Netherlands, covering the period 2018\u20132021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We included adult patients with vestibular symptoms and\/or AVD prescriptions. Outcomes were the prevalence and incidence of (long-term) AVD prescriptions. We used a multivariable logistic regression analysis to identify characteristics associated with long-term prescriptions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 66718 patients with vestibular symptoms, 6172 patients (9%) received AVD prescriptions of which 32% were long term. The majority of patients with prescriptions and long-term prescriptions (88% and 77%, respectively) had any other vestibular disorder than M\u00e9ni\u00e8re\u2019s disease. Still, M\u00e9ni\u00e8re\u2019s disease was associated with long-term prescriptions as well as increasing age. Patients with benign paroxysmal positional vertigo (BPPV) and a symptom diagnosis of lightheadedness were less likely to receive long-term prescriptions, in addition to patients registered at practices in extremely urbanised areas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AVD prescriptions, including long-term prescriptions, are common among patients with a wide array of vestibular symptoms and disorders, despite limited evidence. Management of vestibular symptoms by GPs can be improved by reducing these potentially inappropriate prescriptions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3399\/bjgpo.2025.0052","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T11:05:12Z","timestamp":1750676712000},"page":"BJGPO.2025.0052","source":"Crossref","is-referenced-by-count":1,"title":["Anti-vertigo drug prescribing for patients with vestibular symptoms in primary care: a retrospective observational cohort study"],"prefix":"10.3399","author":[{"given":"H\u00e0 TN","family":"Ngo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3747-9217","authenticated-orcid":false,"given":"Otto 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