{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:16:35Z","timestamp":1792736195253,"version":"4.5.0"},"reference-count":65,"publisher":"The Editorial Committee of Annals of Vascular Diseases","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Annals of Vascular Diseases","Ann Vasc Dis","AVD"],"published-print":{"date-parts":[[2018,6,25]]},"DOI":"10.3400\/avd.ra.17-00130","type":"journal-article","created":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T22:24:24Z","timestamp":1524781464000},"page":"159-168","source":"Crossref","is-referenced-by-count":19,"title":["Pathological Implication of Adipocytes in AAA Development and the Rupture"],"prefix":"10.3400","volume":"11","author":[{"given":"Hirona","family":"Kugo","sequence":"first","affiliation":[{"name":"Department of Applied Biological Chemistry, Graduate School of Agriculture, Kindai University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Medical Physiology, Hamamatsu University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Moriyama","sequence":"additional","affiliation":[{"name":"Department of Applied Biological Chemistry, Graduate School of Agriculture, Kindai University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Zaima","sequence":"additional","affiliation":[{"name":"Department of Applied Biological Chemistry, Graduate School of Agriculture, Kindai University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1983","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Kugo H, Zaima N, Tanaka H, et al. Adipocyte in vascular wall can induce the rupture of abdominal aortic aneurysm. Sci Rep 2016; <b>6<\/b>: 31268.","DOI":"10.1038\/srep31268"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Kugo H, Zaima N, Tanaka H, et al. Pathological analysis of the ruptured vascular wall of hypoperfusion-induced abdominal aortic aneurysm animal model. J Oleo Sci 2017; <b>66<\/b>: 499-506.","DOI":"10.5650\/jos.ess16219"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Hajer GR, van Haeften TW, Visseren FL. Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur Heart J 2008; <b>29<\/b>: 2959-71.","DOI":"10.1093\/eurheartj\/ehn387"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Shimabukuro M. Cardiac adiposity and global cardiometabolic risk: new concept and clinical implication. Circ J 2009; <b>73<\/b>: 27-34.","DOI":"10.1253\/circj.CJ-08-1012"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Byrne CD, Targher G. Ectopic fat, insulin resistance, and nonalcoholic fatty liver disease: implications for cardiovascular disease. Arterioscler Thromb Vasc Biol 2014; <b>34<\/b>: 1155-61.","DOI":"10.1161\/ATVBAHA.114.303034"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Snel M, Jonker JT, Schoones J, et al. Ectopic fat and insulin resistance: pathophysiology and effect of diet and lifestyle interventions. Int J Endocrinol 2012; <b>2012<\/b>: 983814.","DOI":"10.1155\/2012\/983814"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Thalmann S, Meier CA. Local adipose tissue depots as cardiovascular risk factors. Cardiovasc Res 2007; <b>75<\/b>: 690-701.","DOI":"10.1016\/j.cardiores.2007.03.008"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Boring L, Gosling J, Cleary M, et al. Decreased lesion formation in CCR2\u2212\/\u2212 mice reveals a role for chemokines in the initiation of atherosclerosis. Nature 1998; <b>394<\/b>: 894-7.","DOI":"10.1038\/29788"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Zaima N, Goto-Inoue N, Moriyama T. Matrix-assisted laser desorption\/ionization imaging mass spectrometry: new technology for vascular pathology. J Vasc Res 2014; <b>51<\/b>: 144-8.","DOI":"10.1159\/000362123"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Karas M, Hillenkamp F. Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons. Anal Chem 1988; <b>60<\/b>: 2299-301.","DOI":"10.1021\/ac00171a028"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Zaima N, Hayasaka T, Goto-Inoue N, et al. Matrix-assisted laser desorption\/ionization imaging mass spectrometry. Int J Mol Sci 2010; <b>11<\/b>: 5040-55.","DOI":"10.3390\/ijms11125040"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Ikeda Y, Zaima N, Hirano K, et al. Coronary triglyceride deposition in contemporary advanced diabetics. Pathol Int 2014; <b>64<\/b>: 325-35.","DOI":"10.1111\/pin.12177"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Tanaka H, Zaima N, Sasaki T, et al. Imaging mass spectrometry reveals a unique distribution of triglycerides in the abdominal aortic aneurysmal wall. J Vasc Res 2015; <b>52<\/b>: 127-35.","DOI":"10.1159\/000439169"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Zaima N, Sasaki T, Tanaka H, et al. Imaging mass spectrometry-based histopathologic examination of atherosclerotic lesions. Atherosclerosis 2011; <b>217<\/b>: 427-32.","DOI":"10.1016\/j.atherosclerosis.2011.03.044"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Hirano K, Ikeda Y, Zaima N, et al. Triglyceride deposit cardiomyovasculopathy. N Engl J Med 2008; <b>359<\/b>: 2396-8.","DOI":"10.1056\/NEJMc0805305"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Shimomura I, Funahashi T, Takahashi M, et al. Enhanced expression of PAI-1 in visceral fat: possible contributor to vascular disease in obesity. Nat Med 1996; <b>2<\/b>: 800-3.","DOI":"10.1038\/nm0796-800"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Maeda K, Okubo K, Shimomura I, et al. Analysis of an expression profile of genes in the human adipose tissue. Gene 1997; <b>190<\/b>: 227-35.","DOI":"10.1016\/S0378-1119(96)00730-5"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Rosen ED, Spiegelman BM. Molecular regulation of adipogenesis. Annu Rev Cell Dev Biol 2000; <b>16<\/b>: 145-71.","DOI":"10.1146\/annurev.cellbio.16.1.145"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Chamberlain G, Fox J, Ashton B, et al. Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing. Stem Cells 2007; <b>25<\/b>: 2739-49.","DOI":"10.1634\/stemcells.2007-0197"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Rosen ED, MacDougald OA. Adipocyte differentiation from the inside out. Nat Rev Mol Cell Biol 2006; <b>7<\/b>: 885-96.","DOI":"10.1038\/nrm2066"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Wu Z, Rosen ED, Brun R, et al. Cross-regulation of C\/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity. Mol Cell 1999; <b>3<\/b>: 151-8.","DOI":"10.1016\/S1097-2765(00)80306-8"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Spiegelman BM, Choy L, Hotamisligil GS, et al. Regulation of adipocyte gene expression in differentiation and syndromes of obesity\/diabetes. J Biol Chem 1993; <b>268<\/b>: 6823-6.","DOI":"10.1016\/S0021-9258(18)53107-0"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Kohn AD, Summers SA, Birnbaum MJ, et al. Expression of a constitutively active Akt Ser\/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. J Biol Chem 1996; <b>271<\/b>: 31372-8.","DOI":"10.1074\/jbc.271.49.31372"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Hu E, Kim JB, Sarraf P, et al. Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma. Science 1996; <b>274<\/b>: 2100-3.","DOI":"10.1126\/science.274.5295.2100"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Mori T, Sakaue H, Iguchi H, et al. Role of Kr\u00fcppel-like factor 15 (KLF15) in transcriptional regulation of adipogenesis. J Biol Chem 2005; <b>280<\/b>: 12867-75.","DOI":"10.1074\/jbc.M410515200"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Gray S, Feinberg MW, Hull S, et al. The Kr\u00fcppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4. J Biol Chem 2002; <b>277<\/b>: 34322-8.","DOI":"10.1074\/jbc.M201304200"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Nobusue H, Onishi N, Shimizu T, et al. Regulation of MKL1 via actin cytoskeleton dynamics drives adipocyte differentiation. Nat Commun 2014; <b>5<\/b>: 3368.","DOI":"10.1038\/ncomms4368"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Lindeman JH, Abdul-Hussien H, Schaapherder AF, et al. Enhanced expression and activation of pro-inflammatory transcription factors distinguish aneurysmal from atherosclerotic aorta: IL-6- and IL-8-dominated inflammatory responses prevail in the human aneurysm. Clin Sci (Lond) 2008; <b>114<\/b>: 687-97.","DOI":"10.1042\/CS20070352"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Abdul-Hussien H, Hanemaaijer R, Kleemann R, et al. The pathophysiology of abdominal aortic aneurysm growth: corresponding and discordant inflammatory and proteolytic processes in abdominal aortic and popliteal artery aneurysms. J Vasc Surg 2010; <b>51<\/b>: 1479-87.","DOI":"10.1016\/j.jvs.2010.01.057"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Sakalihasan N, Limet R, Defawe OD. Abdominal aortic aneurysm. Lancet 2005; <b>365<\/b>: 1577-89.","DOI":"10.1016\/S0140-6736(05)66459-8"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Sakalihasan N, Delvenne P, Nusgens BV, et al. Activated forms of MMP2 and MMP9 in abdominal aortic aneurysms. J Vasc Surg 1996; <b>24<\/b>: 127-33.","DOI":"10.1016\/S0741-5214(96)70153-2"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Tanaka H, Zaima N, Sasaki T, et al. Adventitial vasa vasorum arteriosclerosis in abdominal aortic aneurysm. PLoS ONE 2013; <b>8<\/b>: e57398.","DOI":"10.1371\/journal.pone.0057398"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Tanaka H, Zaima N, Sasaki T, et al. Hypoperfusion of the adventitial vasa vasorum develops an abdominal aortic aneurysm. PLoS ONE 2015; <b>10<\/b>: e0134386.","DOI":"10.1371\/journal.pone.0134386"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Hashimoto K, Kugo H, Tanaka H, et al. The effect of high fat diet on development of abdominal aortic aneurysm in vascular hypoperfusion-induced animal model. J Vasc Res 2018; <b>55<\/b>: 63-74.","DOI":"10.1159\/000481780"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Wellen KE, Hotamisligil GS. Obesity-induced inflammatory changes in adipose tissue. J Clin Invest 2003; <b>112<\/b>: 1785-8.","DOI":"10.1172\/JCI20514"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Bouloumi\u00e9 A, Sengen\u00e8s C, Portolan G, et al. Adipocyte produces matrix metalloproteinases 2 and 9: involvement in adipose differentiation. Diabetes 2001; <b>50<\/b>: 2080-6.","DOI":"10.2337\/diabetes.50.9.2080"},{"key":"37","unstructured":"37) Doderer SA, Gabel G, Kokje VBC, et al. Adventitial adipogenic degeneration is an unidentified contributor to aortic wall weakening in the abdominal aortic aneurysm. J Vasc Surg 2017; <b>17<\/b>: 31601-4."},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Krueger F, Kappert K, Foryst-Ludwig A, et al. AT1-receptor blockade attenuates outward aortic remodeling associated with diet-induced obesity in mice. Clin Sci (Lond) 2017; <b>131<\/b>: 1989-2005.","DOI":"10.1042\/CS20170131"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Police SB, Thatcher SE, Charnigo R, et al. Obesity promotes inflammation in periaortic adipose tissue and angiotensin II-induced abdominal aortic aneurysm formation. Arterioscler Thromb Vasc Biol 2009; <b>29<\/b>: 1458-64.","DOI":"10.1161\/ATVBAHA.109.192658"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Kurobe H, Hirata Y, Matsuoka Y, et al. Protective effects of selective mineralocorticoid receptor antagonist against aortic aneurysm progression in a novel murine model. J Surg Res 2013; <b>185<\/b>: 455-62.","DOI":"10.1016\/j.jss.2013.05.002"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Li MW, Mian MO, Barhoumi T, et al. Endothelin-1 overexpression exacerbates atherosclerosis and induces aortic aneurysms in apolipoprotein E knockout mice. Arterioscler Thromb Vasc Biol 2013; <b>33<\/b>: 2306-15.","DOI":"10.1161\/ATVBAHA.113.302028"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Blomkalns AL, Gavrila D, Thomas M, et al. CD14 directs adventitial macrophage precursor recruitment: role in early abdominal aortic aneurysm formation. J Am Heart Assoc 2013; <b>2<\/b>: e000065.","DOI":"10.1161\/JAHA.112.000065"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Sakaue T, Suzuki J, Hamaguchi M, et al. Perivascular adipose tissue angiotensin II type 1 receptor promotes vascular inflammation and aneurysm formation. Hypertension 2017; <b>70<\/b>: 780-9.","DOI":"10.1161\/HYPERTENSIONAHA.117.09512"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Folkesson M, Vorkapic E, Gulbins E, et al. Inflammatory cells, ceramides, and expression of proteases in perivascular adipose tissue adjacent to human abdominal aortic aneurysms. J Vasc Surg 2017; <b>65<\/b>: 1171-9.e1.","DOI":"10.1016\/j.jvs.2015.12.056"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Thanassoulis G, Massaro JM, Corsini E, et al. Periaortic adipose tissue and aortic dimensions in the Framingham Heart Study. J Am Heart Assoc 2012; <b>1<\/b>: e000885.","DOI":"10.1161\/JAHA.112.000885"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Watt HC, Law MR, Wald NJ, et al. Serum triglyceride: a possible risk factor for ruptured abdominal aortic aneurysm. Int J Epidemiol 1998; <b>27<\/b>: 949-52.","DOI":"10.1093\/ije\/27.6.949"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47) Norrg\u00e5rd \u00d6, \u00c4ngquist KA, Johnson O. Familial aortic aneurysms: serum concentrations of triglyceride, cholesterol, HDL-cholesterol and (VLDL+LDL)-cholesterol. Br J Surg 1985; <b>72<\/b>: 113-6.","DOI":"10.1002\/bjs.1800720215"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48) Dyerberg J, Bang HO, Stoffersen E, et al. Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis? Lancet 1978; <b>312<\/b>: 117-9.","DOI":"10.1016\/S0140-6736(78)91505-2"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49) Adkins Y, Kelley DS. Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids. J Nutr Biochem 2010; <b>21<\/b>: 781-92.","DOI":"10.1016\/j.jnutbio.2009.12.004"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50) Yoshikawa T, Shimano H, Yahagi N, et al. Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements. J Biol Chem 2002; <b>277<\/b>: 1705-11.","DOI":"10.1074\/jbc.M105711200"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51) Zaima N, Sugawara T, Goto D, et al. Trans geometric isomers of EPA decrease LXRalpha-induced cellular triacylglycerol via suppression of SREBP-1c and PGC-1beta. J Lipid Res 2006; <b>47<\/b>: 2712-7.","DOI":"10.1194\/jlr.M600273-JLR200"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52) Wang JH, Eguchi K, Matsumoto S, et al. The omega-3 polyunsaturated fatty acid, eicosapentaenoic acid, attenuates abdominal aortic aneurysm development via suppression of tissue remodeling. PLoS ONE 2014; <b>9<\/b>: e96286.","DOI":"10.1371\/journal.pone.0096286"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53) Yoshihara T, Shimada K, Fukao K, et al. Omega 3 polyunsaturated fatty acids suppress the development of aortic aneurysms through the inhibition of macrophage-mediated inflammation. Circ J 2015; <b>79<\/b>: 1470-8.","DOI":"10.1253\/circj.CJ-14-0471"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54) Kugo H, Zaima N, Mouri Y, et al. The preventive effect of fish oil on abdominal aortic aneurysm development. Biosci Biotechnol Biochem 2016; <b>80<\/b>: 1186-91.","DOI":"10.1080\/09168451.2016.1146073"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55) Kamata R, Bumdelger B, Kokubo H, et al. EPA prevents the development of abdominal aortic aneurysms through Gpr-120\/Ffar-4. PLoS ONE 2016; <b>11<\/b>: e0165132.","DOI":"10.1371\/journal.pone.0165132"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56) Schwab JM, Chiang N, Arita M, et al. Resolvin E1 and protectin D1 activate inflammation-resolution programmes. Nature 2007; <b>447<\/b>: 869-74.","DOI":"10.1038\/nature05877"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57) Pope NH, Salmon M, Davis JP, et al. D-series resolvins inhibit murine abdominal aortic aneurysm formation and increase M2 macrophage polarization. FASEB J 2016; <b>30<\/b>: 4192-201.","DOI":"10.1096\/fj.201600144RR"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58) Zaima N. The effect of n-3 PUFA on the development of abdominal aortic aneurysm. J Atheroscler Thromb 2017; <b>24<\/b>: 908-9.","DOI":"10.5551\/jat.ED078"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59) Meital LT, Sandow SL, Calder PC, et al. Abdominal aortic aneurysm and omega-3 polyunsaturated fatty acids: mechanisms, animal models, and potential treatment. Prostaglandins Leukot Essent Fatty Acids 2017; <b>118<\/b>: 1-9.","DOI":"10.1016\/j.plefa.2017.02.001"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60) Aikawa T, Miyazaki T, Shimada K, et al. Low serum levels of EPA are associated with the size and growth rate of abdominal aortic aneurysm. J Atheroscler Thromb 2017; <b>24<\/b>: 912-20.","DOI":"10.5551\/jat.38315"},{"key":"61","doi-asserted-by":"crossref","unstructured":"61) Lederle FA, Nelson DB, Joseph AM. Smokers\u2019 relative risk for aortic aneurysm compared with other smoking-related diseases: a systematic review. J Vasc Surg 2003; <b>38<\/b>: 329-34.","DOI":"10.1016\/S0741-5214(03)00136-8"},{"key":"62","unstructured":"62) Aggarwal S, Qamar A, Sharma V, et al. Abdominal aortic aneurysm: a comprehensive review. Exp Clin Cardiol 2011; <b>16<\/b>: 11-5."},{"key":"63","doi-asserted-by":"crossref","unstructured":"63) Wang S, Zhang C, Zhang M, et al. Activation of AMP-activated protein kinase alpha2 by nicotine instigates formation of abdominal aortic aneurysms in mice in vivo. Nat Med 2012; <b>18<\/b>: 902-10.","DOI":"10.1038\/nm.2711"},{"key":"64","doi-asserted-by":"crossref","unstructured":"64) Kugo H, Zaima N, Tanaka H, et al. The effects of nicotine administration on the pathophysiology of rat aortic wall. Biotech Histochem 2017; <b>92<\/b>: 141-8.","DOI":"10.1080\/10520295.2017.1287428"},{"key":"65","doi-asserted-by":"crossref","unstructured":"65) Kugo H, Zaima N, Onozato M, et al. Suppressive effects of dietary EPA-rich fish oil on the degradation of elastin fibers in the aortic wall in nicotine-administered mice. Food Funct 2017; <b>8<\/b>: 2829-35.","DOI":"10.1039\/C7FO00553A"}],"container-title":["Annals of Vascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/avd\/11\/2\/11_ra.17-00130\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T03:25:02Z","timestamp":1661052302000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/avd\/11\/2\/11_ra.17-00130\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,25]]},"references-count":65,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.3400\/avd.ra.17-00130","relation":{},"ISSN":["1881-641X","1881-6428"],"issn-type":[{"value":"1881-641X","type":"print"},{"value":"1881-6428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,25]]}}}