{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T17:15:10Z","timestamp":1773249310229,"version":"3.50.1"},"reference-count":31,"publisher":"Informa UK Limited","issue":"1","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Journal of Oral Microbiology"],"published-print":{"date-parts":[[2014,1,1]]},"DOI":"10.3402\/jom.v6.24349","type":"journal-article","created":{"date-parts":[[2014,7,4]],"date-time":"2014-07-04T07:16:07Z","timestamp":1404458167000},"page":"24349","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":12,"title":["Intracellular localization of <i>Treponema denticola<\/i> chymotrypsin-like proteinase in chronic periodontitis"],"prefix":"10.1080","volume":"6","author":[{"given":"Emilia","family":"Marttila","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial DiseasesHelsinki University Central Hospital, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"J\u00e4rvensivu","sequence":"additional","affiliation":[{"name":"Institute of DentistryUniversity of Helsinki, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Sorsa","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial DiseasesHelsinki University Central Hospital, Helsinki, Finland"},{"name":"Institute of DentistryUniversity of Helsinki, Helsinki, Finland"},{"name":"Division of PeriodontologyDepartment of Dental Medicine, Karolinska Institute, Huddinge, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Grenier","sequence":"additional","affiliation":[{"name":"Faculte de Medecine DentaireGroupe de Recherche en Ecologie Buccale, Universite Laval, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malcolm","family":"Richardson","sequence":"additional","affiliation":[{"name":"Mycology Reference Centre, University Hospital of South Manchester, Manchester Academic Health Science Centre, School of Translational Medicine, University of Manchester, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsti","family":"Kari","sequence":"additional","affiliation":[{"name":"Institute of DentistryUniversity of Helsinki, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taina","family":"Tervahartiala","sequence":"additional","affiliation":[{"name":"Institute of DentistryUniversity of Helsinki, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riina","family":"Rautemaa","sequence":"additional","affiliation":[{"name":"Manchester Academic Health Science Centre, NIHR Translational Research Facility, Translational Research Facility, Institute of Inflammation and Repair, University of Manchester and University Hospital of South Manchester, Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2014,7,4]]},"reference":[{"key":"CIT0001","doi-asserted-by":"crossref","unstructured":"Dewhirst FE, Chen T, Izard J, Paster BJ, Tanner AC, Yu WH, etal. The human oral microbiome. J Bacteriol. 2010; 192: 5002\u201317. [PubMed Abstract] [PubMed CentralFull Text].","DOI":"10.1128\/JB.00542-10"},{"key":"CIT0002","doi-asserted-by":"crossref","unstructured":"Chan EC, McLaughlin R. Taxonomy and virulence of oral spirochetes. Oral Microbiol Immunol. 2000; 15: 1\u20139. [PubMed Abstract].","DOI":"10.1034\/j.1399-302x.2000.150101.x"},{"key":"CIT0003","doi-asserted-by":"crossref","unstructured":"Sela MN. Role of Treponema denticola in periodontal diseases. Crit Rev Oral Biol Med. 2001; 12: 399\u2013413. [PubMed Abstract].","DOI":"10.1177\/10454411010120050301"},{"key":"CIT0004","doi-asserted-by":"crossref","unstructured":"Haffajee AD, Yaskell T, Torresyap G, Teles R, Socransky SS. Comparison between polymerase chain reaction-based and checkerboard DNA hybridization techniques for microbial assessment of subgingival plaque samples. J Clin Periodontol. 2009; 36: 642\u20139. [PubMed Abstract].","DOI":"10.1111\/j.1600-051X.2009.01434.x"},{"key":"CIT0005","doi-asserted-by":"crossref","unstructured":"You M, Mo S, Leung WK, Watt RM. Comparative analysis of oral treponemes associated with periodontal health and disease. BMC Infect Dis. 2013; 13: 174. [PubMed Abstract] [PubMed CentralFull Text].","DOI":"10.1186\/1471-2334-13-174"},{"key":"CIT0006","doi-asserted-by":"crossref","unstructured":"Uitto VJ, Grenier D, Chan EC, McBride BC. Isolation of a chymotrypsin-like enzyme from Treponema denticola. Infect Immun. 1988; 56: 2717\u201322. [PubMed Abstract] [PubMed CentralFull Text].","DOI":"10.1128\/IAI.56.10.2717-2722.1988"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1111\/j.2041-1014.2012.00660.x"},{"key":"CIT0008","doi-asserted-by":"crossref","unstructured":"Kigure T, Saito A, Seida K, Yamada S, Ishihara K, Okuda K. Distribution of Porphyromonas gingivalis and Treponema denticola in human subgingival plaque at different periodontal pocket depths examined by immunohistochemical methods. J Periodontal Res. 1995; 30: 332\u201341. [PubMed Abstract].","DOI":"10.1111\/j.1600-0765.1995.tb01284.x"},{"key":"CIT0009","first-page":"S202","volume":"9","author":"Scapoli L","year":"2012","journal-title":"Dent Res J"},{"key":"CIT0010","doi-asserted-by":"crossref","unstructured":"Rosen G, Genzler T, Sela MN. Coaggregation of Treponema denticola with Porphyromonas gingivalis and Fusobacterium nucleatum is mediated by the major outer sheath protein of Treponema denticola. FEMS Microbiol Lett. 2008; 289: 59\u201366. [PubMed Abstract].","DOI":"10.1111\/j.1574-6968.2008.01373.x"},{"key":"CIT0011","doi-asserted-by":"crossref","unstructured":"Grenier D, Uitto V-J, McBride B. Cellular location of a Treponema denticola chymotrypsin-like protease and importance of the protease in migration through the basement membrane. Infect Immun. 1990; 58: 347\u201351. [PubMed Abstract] [PubMed CentralFull Text].","DOI":"10.1128\/IAI.58.2.347-351.1990"},{"key":"CIT0012","doi-asserted-by":"crossref","unstructured":"Chi B, Qi M, Kuramitsu HK. Role of dentilisin in Treponema denticola epithelial cell layer penetration. Res Microbiol. 2003; 154: 637\u201343. [PubMed Abstract].","DOI":"10.1016\/j.resmic.2003.08.001"},{"key":"CIT0013","doi-asserted-by":"crossref","unstructured":"Cogoni V, Morgan-Smith A, Fenno JC, Jenkinson HF, Dymock D. Treponema denticola chymotrypsin-like proteinase (CTLP) integrates spirochaetes within oral microbial communities. Microbiology. 2012; 158: 759\u201370. [PubMed Abstract].","DOI":"10.1099\/mic.0.055939-0"},{"key":"CIT0014","doi-asserted-by":"crossref","unstructured":"Bamford CV, Fenno JC, Jenkinson HF, Dymock D. The chymotrypsin-like protease complex of Treponema denticola ATCC 35405 mediates fibrinogen adherence and degradation. Infect Immun. 2007; 75: 4364\u201372. [PubMed Abstract] [PubMed CentralFull Text].","DOI":"10.1128\/IAI.00258-07"},{"key":"CIT0015","doi-asserted-by":"crossref","unstructured":"Miao D, Fenno JC, Timm JC, Joo NE, Kapila YL. The Treponema denticola chymotrypsin-like protease dentilisin induces matrix metalloproteinase-2 dependent fibronectin fragmentation in periodontal ligament cells. Infect Immun. 2011; 79: 806\u201311. [PubMed Abstract] [PubMed CentralFull Text].","DOI":"10.1128\/IAI.01001-10"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1046\/j.1354-523X.2003.00978.x"},{"key":"CIT0017","doi-asserted-by":"crossref","unstructured":"Rautemaa R, J\u00e4rvensivu A, Kari K, Wahlgren J, DeCarlo A, Richardson M, etal. Intracellular localization of Porphyromonas gingivalis thiol proteinase in periodontal tissues of chronic periodontitis patients. Oral Dis. 2004; 10: 298\u2013305. [PubMed Abstract].","DOI":"10.1111\/j.1601-0825.2004.01021.x"},{"key":"CIT0018","doi-asserted-by":"crossref","unstructured":"Ashimoto A, Chen C, Bakker I, Slots J. Polymerase chain reaction detection of 8 putative periodontal pathogens in subgingival plaque of gingivitis and advanced periodontitis lesions. Oral Microbiol Immunol. 1996; 11: 266\u201371. [PubMed Abstract].","DOI":"10.1111\/j.1399-302X.1996.tb00180.x"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2006.01228.x"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.05903-11"},{"key":"CIT0021","doi-asserted-by":"crossref","unstructured":"Li J, Helmerhorst EJ, Leone CW, Troxler RF, Yaskell T, Haffajee AD, etal. Identification of early microbial colonizers in human dental biofilm. J Appl Microbiol. 2004; 97: 1311\u20138. [PubMed Abstract].","DOI":"10.1111\/j.1365-2672.2004.02420.x"},{"key":"CIT0022","doi-asserted-by":"crossref","unstructured":"Grenier D. Degradation of host protease inhibitors and activation of plasminogen by proteolytic enzymes from Porphyromonas gingivalis and Treponema denticola. Microbiology. 1996; 142: 955\u201361. [PubMed Abstract].","DOI":"10.1099\/00221287-142-4-955"},{"key":"CIT0023","doi-asserted-by":"crossref","unstructured":"Ding Y, Uitto VJ, Haapasalo M, Lounatmaa K, Konttinen YT, Salo T, etal. Membrane components of Treponema denticola trigger proteinase release from human polymorphonuclear leukocytes. J Dent Res. 1996; 75: 1986\u201393. [PubMed Abstract].","DOI":"10.1177\/00220345960750121101"},{"key":"CIT0024","doi-asserted-by":"crossref","unstructured":"Lux R, Miller JN, Park NH, Shi W. Motility and chemotaxis in tissue penetration of oral epithelial cells layer by Treponema denticola. Infect Immun. 2001; 69: 6276\u201383. [PubMed Abstract] [PubMed CentralFull Text].","DOI":"10.1128\/IAI.69.10.6276-6283.2001"},{"key":"CIT0025","doi-asserted-by":"crossref","unstructured":"Zhu Y, Dashper SG, Chen YY, Crawford S, Slakeski N, Reynolds EC. Porphyromonas gingivalis and Treponema denticola synergistic polymicrobial biofilm development. PLoS One. 2013; 8: e71727. [PubMed Abstract] [PubMed CentralFull Text].","DOI":"10.1371\/journal.pone.0071727"},{"key":"CIT0026","doi-asserted-by":"crossref","unstructured":"Grenier D. Nutritional interactions between two suspected periodontopathogens, Treponema denticola and Porphyromonas gingivalis. Infect Immun. 1992; 60: 5298\u2013301. [PubMed Abstract] [PubMed CentralFull Text].","DOI":"10.1128\/IAI.60.12.5298-5301.1992"},{"key":"CIT0027","doi-asserted-by":"crossref","unstructured":"Yamazaki T, Miyamoto M, Yamada S, Okuda K, Ishihara K. Surface protease of Treponema denticola hydrolyzes C3 and influences function of polymorphonuclear leukocytes. Microbes Infect. 2006; 8: 1758\u201363. [PubMed Abstract].","DOI":"10.1016\/j.micinf.2006.02.013"},{"key":"CIT0028","doi-asserted-by":"crossref","unstructured":"Yakob M, Meurman JH, Sorsa T, S\u00f6der B. Treponema denticola associates with increased levels of MMP-8 and MMP-9 in gingival crevicular fluid. Oral Dis. 2013; 19: 694\u2013701. [PubMed Abstract].","DOI":"10.1111\/odi.12057"},{"key":"CIT0029","doi-asserted-by":"crossref","unstructured":"Sorsa T, Ingman T, Suomalainen K, Haapasalo M, Konttinen YT, Lindy O, etal. Identification of proteases from periodontopathogenic bacteria as activators of latent human neutrophil and fibroblast-type interstitial collagenases. Infect Immun. 1992; 60: 4491\u201395. [PubMed Abstract] [PubMed CentralFull Text].","DOI":"10.1128\/IAI.60.11.4491-4495.1992"},{"key":"CIT0030","doi-asserted-by":"crossref","unstructured":"Grenier D, Plamondon P, Sorsa T, Lee HM, McNamara T, Ramamurthy NS, etal. Inhibition of proteolytic, serpinolytic, and progelatinase-b activation activities of periodontopathogens by doxycycline and the non-antimicrobial chemically modified tetracycline derivatives. J Periodontol. 2002; 73: 79\u201385. [PubMed Abstract].","DOI":"10.1902\/jop.2002.73.1.79"},{"key":"CIT0031","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1128\/CDLI.6.3.437-439.1999","volume":"6","author":"Gendron R","year":"1999","journal-title":"Clin Diag Lab Immunol"}],"container-title":["Journal of Oral Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.3402\/jom.v6.24349","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T01:38:08Z","timestamp":1597714688000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.3402\/jom.v6.24349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1,1]]}},"alternative-id":["10.3402\/jom.v6.24349"],"URL":"https:\/\/doi.org\/10.3402\/jom.v6.24349","relation":{},"ISSN":["2000-2297"],"issn-type":[{"value":"2000-2297","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,1]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=zjom20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=zjom20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2014-03-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-05-21","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-06-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-07-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}