{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T03:31:40Z","timestamp":1783049500021,"version":"3.54.6"},"reference-count":42,"publisher":"Informa UK Limited","issue":"1","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Journal of Oral Microbiology"],"published-print":{"date-parts":[[2014,1,1]]},"DOI":"10.3402\/jom.v6.25739","type":"journal-article","created":{"date-parts":[[2014,10,30]],"date-time":"2014-10-30T02:56:04Z","timestamp":1414637764000},"page":"25739","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":51,"title":["The oral microbiota of patients with recurrent aphthous stomatitis"],"prefix":"10.1080","volume":"6","author":[{"given":"Maria","family":"Bankvall","sequence":"first","affiliation":[{"name":"Department of Oral Medicine & PathologyInstitute of Odontology, Sahlgrenska Academy, University of Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Sj\u00f6berg","sequence":"additional","affiliation":[{"name":"Department of Infectious DiseasesInstitute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gita","family":"Gale","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine & PathologyInstitute of Odontology, Sahlgrenska Academy, University of Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Wold","sequence":"additional","affiliation":[{"name":"Department of Infectious DiseasesInstitute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Jontell","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine & PathologyInstitute of Odontology, Sahlgrenska Academy, University of Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"\u00d6stman","sequence":"additional","affiliation":[{"name":"Department of Infectious DiseasesInstitute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2014,10,29]]},"reference":[{"key":"CIT0001","doi-asserted-by":"crossref","unstructured":"Jurge S, Kuffer R, Scully C, Porter SR. Mucosal disease series. Number VI. Recurrent aphthous stomatitis. Oral Dis. 2006; 12: 1\u201321. [PubMed Abstract].","DOI":"10.1111\/j.1601-0825.2005.01143.x"},{"key":"CIT0002","doi-asserted-by":"crossref","unstructured":"Barile MF, Graykowski EA, Driscoll EJ, Riggs DB. L Form of bacteria isolated from recurrent aphthous stomatitis lesions. Oral Surg Oral Med Oral Pathol. 1963; 16: 1395\u2013402. [PubMed Abstract].","DOI":"10.1016\/0030-4220(63)90416-X"},{"key":"CIT0003","doi-asserted-by":"crossref","unstructured":"Ship II. Inheritance of aphthous ulcers of the mouth. J Dent Res. 1965; 44: 837\u201344. [PubMed Abstract].","DOI":"10.1177\/00220345650440051501"},{"key":"CIT0004","doi-asserted-by":"crossref","unstructured":"Hoover CI, Greenspan JS. Immunochemical comparison of cell-wall antigens of various viridans streptococci, including strain 2A2 + 3 hot from recurrent oral aphthous ulceration in man. Arch Oral Biol. 1983; 28: 917\u201322. [PubMed Abstract].","DOI":"10.1016\/0003-9969(83)90087-0"},{"key":"CIT0005","doi-asserted-by":"crossref","unstructured":"Narikawa S, Suzuki Y, Takahashi M, Furukawa A, Sakane T, Mizushima Y. Streptococcus oralis previously identified as uncommon Streptococcus sanguis in Behcet's disease. Arch Oral Biol. 1995; 40: 685\u201390. [PubMed Abstract].","DOI":"10.1016\/0003-9969(95)00042-N"},{"key":"CIT0006","doi-asserted-by":"crossref","unstructured":"Lehner T, Lavery E, Smith R, van der Zee R, Mizushima Y, Shinnick T. Association between the 65-kilodalton heat shock protein, Streptococcus sanguis, and the corresponding antibodies in Behcet's syndrome. Infect Immun. 1991; 59: 1434\u201341. [PubMed Abstract] [PubMed CentralFull Text].","DOI":"10.1128\/IAI.59.4.1434-1441.1991"},{"key":"CIT0007","doi-asserted-by":"crossref","unstructured":"Leimola-Virtanen R, Happonen RP, Syrjanen S. Cytomegalovirus (CMV) and Helicobacter pylori (HP) found in oral mucosal ulcers. J Oral Pathol Med. 1995; 24: 14\u201317. [PubMed Abstract].","DOI":"10.1111\/j.1600-0714.1995.tb01123.x"},{"key":"CIT0008","doi-asserted-by":"crossref","unstructured":"Greenspan JS, Gadol N, Olson JA, Hoover CI, Jacobsen PL, Shillitoe EJ, etal. Lymphocyte function in recurrent aphthous ulceration. J Oral Pathol. 1985; 14: 592\u2013602. [PubMed Abstract].","DOI":"10.1111\/j.1600-0714.1985.tb00536.x"},{"key":"CIT0009","doi-asserted-by":"crossref","unstructured":"Khor B, Gardet A, Xavier RJ. Genetics and pathogenesis of inflammatory bowel disease. Nature. 2011; 474: 307\u201317. [PubMed Abstract] [PubMed CentralFull Text].","DOI":"10.1038\/nature10209"},{"key":"CIT0010","doi-asserted-by":"crossref","unstructured":"Berry D, Reinisch W. Intestinal microbiota: a source of novel biomarkers in inflammatory bowel diseases? Best Pract Res Clin Gastroenterol. 2013; 27: 47\u201358. [PubMed Abstract].","DOI":"10.1016\/j.bpg.2013.03.005"},{"key":"CIT0011","doi-asserted-by":"crossref","unstructured":"Liu WT, Marsh TL, Cheng H, Forney LJ. Characterization of microbial diversity by determining terminal restriction fragment length polymorphisms of genes encoding 16S rRNA. Appl Environ Microbiol. 1997; 63: 4516\u201322. [PubMed Abstract] [PubMed CentralFull Text].","DOI":"10.1128\/AEM.63.11.4516-4522.1997"},{"key":"CIT0012","doi-asserted-by":"crossref","unstructured":"Donatsky O, Justesen T, Lind K, Vestergaard BF. Microorganisms in recurrent aphthous ulcerations. Scand J Dent Res. 1977; 85: 426\u201333. [PubMed Abstract].","DOI":"10.1111\/j.1600-0722.1977.tb00576.x"},{"key":"CIT0013","doi-asserted-by":"crossref","unstructured":"Marchini L, Campos MS, Silva AM, Paulino LC, Nobrega FG. Bacterial diversity in aphthous ulcers. Oral Microbiol Immunol. 2007; 22: 225\u201331. [PubMed Abstract].","DOI":"10.1111\/j.1399-302X.2006.00345.x"},{"key":"CIT0014","doi-asserted-by":"crossref","unstructured":"Jontell M, Mattsson U, Torgersson O. MedView: an instrument for clinical research and education in oral medicine. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005; 99: 55\u201363. [PubMed Abstract].","DOI":"10.1016\/j.tripleo.2004.01.009"},{"key":"CIT0015","doi-asserted-by":"crossref","unstructured":"Sjoberg F, Nowrouzian F, Rangel I, Hannoun C, Moore E, Adlerberth I, etal. Comparison between Terminal-Restriction Fragment Length Polymorphism (T-RFLP) and quantitative culture for analysis of infants\u2019 gut microbiota. J Microbiol Methods. 2013; 94: 37\u201346. [PubMed Abstract].","DOI":"10.1016\/j.mimet.2013.04.002"},{"key":"CIT0016","doi-asserted-by":"crossref","unstructured":"Gutell RR. Collection of small subunit (16S- and 16S-like) ribosomal RNA structures: 1994. Nucleic Acids Res. 1994; 22: 3502\u20137. [PubMed Abstract] [PubMed CentralFull Text].","DOI":"10.1093\/nar\/22.17.3502"},{"key":"CIT0017","doi-asserted-by":"crossref","unstructured":"Bikandi J, San Millan R, Rementeria A, Garaizar J. In silico analysis of complete bacterial genomes: PCR, AFLP-PCR and endonuclease restriction. Bioinformatics. 2004; 20: 798\u20139. [PubMed Abstract].","DOI":"10.1093\/bioinformatics\/btg491"},{"key":"CIT0018","doi-asserted-by":"crossref","unstructured":"Abdo Z, Schuette UM, Bent SJ, Williams CJ, Forney LJ, Joyce P. Statistical methods for characterizing diversity of microbial communities by analysis of terminal restriction fragment length polymorphisms of 16S rRNA genes. Environ Microbiol. 2006; 8: 929\u201338. [PubMed Abstract].","DOI":"10.1111\/j.1462-2920.2005.00959.x"},{"key":"CIT0019","doi-asserted-by":"crossref","unstructured":"Westerhuis JA, van Velzen EJ, Hoefsloot HC, Smilde AK. Multivariate paired data analysis: multilevel PLSDA versus OPLSDA. Metabolomics. 2010; 6: 119\u201328. [PubMed Abstract] [PubMed CentralFull Text].","DOI":"10.1007\/s11306-009-0185-z"},{"key":"CIT0020","doi-asserted-by":"crossref","unstructured":"Tuomisto H. A consistent terminology for quantifying species diversity? Yes, it does exist. Oecologia. 2010; 164: 853\u201360. [PubMed Abstract].","DOI":"10.1007\/s00442-010-1812-0"},{"key":"CIT0021","doi-asserted-by":"crossref","unstructured":"Baccaglini L, Lalla RV, Bruce AJ, Sartori-Valinotti JC, Latortue MC, Carrozzo M, etal. Urban legends: recurrent aphthous stomatitis. Oral Dis. 2011; 17: 755\u201370. [PubMed Abstract] [PubMed CentralFull Text].","DOI":"10.1111\/j.1601-0825.2011.01840.x"},{"key":"CIT0022","doi-asserted-by":"crossref","unstructured":"Sakamoto M, Takeuchi Y, Umeda M, Ishikawa I, Benno Y. Application of terminal RFLP analysis to characterize oral bacterial flora in saliva of healthy subjects and patients with periodontitis. J Med Microbiol. 2003; 52: 79\u201389. [PubMed Abstract].","DOI":"10.1099\/jmm.0.04991-0"},{"key":"CIT0023","doi-asserted-by":"crossref","unstructured":"Aas JA, Paster BJ, Stokes LN, Olsen I, Dewhirst FE. Defining the normal bacterial flora of the oral cavity. J Clin Microbiol. 2005; 43: 5721\u201332. [PubMed Abstract] [PubMed CentralFull Text].","DOI":"10.1128\/JCM.43.11.5721-5732.2005"},{"key":"CIT0024","unstructured":"Kang JG, Kim SH, Ahn TY. Bacterial diversity in the human saliva from different ages. J Microbiol. 2006; 44: 572\u20136. [PubMed Abstract]."},{"key":"CIT0025","doi-asserted-by":"crossref","unstructured":"Nasidze I, Li J, Quinque D, Tang K, Stoneking M. Global diversity in the human salivary microbiome. Genome Res. 2009; 19: 636\u201343. [PubMed Abstract] [PubMed CentralFull Text].","DOI":"10.1101\/gr.084616.108"},{"key":"CIT0026","doi-asserted-by":"crossref","unstructured":"Wade WG. The oral microbiome in health and disease. Pharmacol Res. 2013; 69: 137\u201343. [PubMed Abstract].","DOI":"10.1016\/j.phrs.2012.11.006"},{"key":"CIT0027","doi-asserted-by":"crossref","unstructured":"Costello EK, Lauber CL, Hamady M, Fierer N, Gordon JI, Knight R. Bacterial community variation in human body habitats across space and time. Science. 2009; 326: 1694\u20137. [PubMed Abstract] [PubMed CentralFull Text].","DOI":"10.1126\/science.1177486"},{"key":"CIT0028","doi-asserted-by":"crossref","unstructured":"Graykowski EA, Barile MF, Lee WB, Stanley HRJr. Recurrent aphthous stomatitis. Clinical, therapeutic, histopathologic, and hypersensitivity aspects. JAMA. 1966; 196: 637\u201344. [PubMed Abstract].","DOI":"10.1001\/jama.196.7.637"},{"key":"CIT0029","doi-asserted-by":"crossref","unstructured":"Donatsky O, Bendixen G. In vitro demonstration of cellular hypersensitivity to strep 2A in recurrent aphthous stomatitis by means of the leucocyte migration test. Acta Allergol. 1972; 27: 137\u201344. [PubMed Abstract].","DOI":"10.1111\/j.1398-9995.1972.tb01410.x"},{"key":"CIT0030","first-page":"107","volume":"82","author":"Donatsky O","year":"1974","journal-title":"Acta Pathol Microbiol Scand Section B: Microbiol Immunol"},{"key":"CIT0031","doi-asserted-by":"crossref","unstructured":"Oppenheim JJ, Francis TC. The role of delayed hypersensitivity in immunological processes and its relationship to aphthous stomatitis. J Periodontol. 1970; 41: 205\u20139. [PubMed Abstract].","DOI":"10.1902\/jop.1970.41.4.205"},{"key":"CIT0032","doi-asserted-by":"crossref","unstructured":"Martin DK, Nelms DC, Mackler BF, Peavy DL. Lymphoproliferative responses induced by streptococcal antigens in recurrent aphthous stomatitis and Behcet's syndrome. Clin Immunol Immunopathol. 1979; 13: 146\u201355. [PubMed Abstract].","DOI":"10.1016\/0090-1229(79)90058-8"},{"key":"CIT0033","doi-asserted-by":"crossref","unstructured":"Birek C, Grandhi R, McNeill K, Singer D, Ficarra G, Bowden G. Detection of Helicobacter pylori in oral aphthous ulcers. J Oral Pathol Med. 1999; 28: 197\u2013203. [PubMed Abstract].","DOI":"10.1111\/j.1600-0714.1999.tb02024.x"},{"key":"CIT0034","doi-asserted-by":"crossref","unstructured":"Albanidou-Farmaki E, Giannoulis L, Markopoulos A, Fotiades S, Aggouridaki X, Farmakis K, etal. Outcome following treatment for Helicobacter pylori in patients with recurrent aphthous stomatitis. Oral Dis. 2005; 11: 22\u20136. [PubMed Abstract].","DOI":"10.1111\/j.1601-0825.2004.01053.x"},{"key":"CIT0035","doi-asserted-by":"crossref","unstructured":"Tas DA, Yakar T, Sakalli H, Serin E. Impact of Helicobacter pylori on the clinical course of recurrent aphthous stomatitis. J Oral Pathol Med. 2013; 42: 89\u201394. [PubMed Abstract].","DOI":"10.1111\/j.1600-0714.2012.01197.x"},{"key":"CIT0036","doi-asserted-by":"crossref","unstructured":"Porter SR, Barker GR, Scully C, Macfarlane G, Bain L. Serum IgG antibodies to Helicobacter pylori in patients with recurrent aphthous stomatitis and other oral disorders. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997; 83: 325\u20138. [PubMed Abstract].","DOI":"10.1016\/S1079-2104(97)90237-7"},{"key":"CIT0037","doi-asserted-by":"crossref","unstructured":"Mravak-Stipetic M, Gall-Troselj K, Lukac J, Kusic Z, Pavelic K, Pavelic J. Detection of Helicobacter pylori in various oral lesions by nested polymerase chain reaction (PCR). J Oral Pathol Med. 1998; 27: 1\u20133. [PubMed Abstract].","DOI":"10.1111\/j.1600-0714.1998.tb02081.x"},{"key":"CIT0038","unstructured":"Mansour-Ghanaei F, Asmar M, Bagherzadeh AH, Ekbataninezhad S. Helicobacter pylori infection in oral lesions of patients with recurrent aphthous stomatitis. Med Sci Monit. 2005; 11: CR576\u20139. [PubMed Abstract]."},{"key":"CIT0039","doi-asserted-by":"crossref","unstructured":"Wang M, Karlsson C, Olsson C, Adlerberth I, Wold AE, Strachan DP, etal. Reduced diversity in the early fecal microbiota of infants with atopic eczema. J Allergy Clin Immunol. 2008; 121: 129\u201334. [PubMed Abstract].","DOI":"10.1016\/j.jaci.2007.09.011"},{"key":"CIT0040","doi-asserted-by":"crossref","unstructured":"Abrahamsson TR, Jakobsson HE, Andersson AF, Bjorksten B, Engstrand L, Jenmalm MC. Low diversity of the gut microbiota in infants with atopic eczema. J Allergy Clin Immunol. 2012; 129: 434\u201340, 440. e1\u20132. [PubMed Abstract].","DOI":"10.1016\/j.jaci.2011.10.025"},{"key":"CIT0041","doi-asserted-by":"crossref","unstructured":"Ismail IH, Oppedisano F, Joseph SJ, Boyle RJ, Licciardi PV, Robins-Browne RM. Reduced gut microbial diversity in early life is associated with later development of eczema but not atopy in high-risk infants. Pediatr Allergy Immunol. 2012; 23: 674\u201381.","DOI":"10.1111\/j.1399-3038.2012.01328.x"},{"key":"CIT0042","doi-asserted-by":"crossref","unstructured":"Pandey J, Ganesan K, Jain RK. Variations in T-RFLP profiles with differing chemistries of fluorescent dyes used for labeling the PCR primers. J Microbiol Methods. 2007; 68: 633\u20138. [PubMed Abstract].","DOI":"10.1016\/j.mimet.2006.11.012"}],"container-title":["Journal of Oral Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.3402\/jom.v6.25739","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T01:37:05Z","timestamp":1597714625000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.3402\/jom.v6.25739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1,1]]}},"alternative-id":["10.3402\/jom.v6.25739"],"URL":"https:\/\/doi.org\/10.3402\/jom.v6.25739","relation":{},"ISSN":["2000-2297"],"issn-type":[{"value":"2000-2297","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,1]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=zjom20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=zjom20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2014-08-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-10-07","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-10-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-10-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}