{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T04:11:52Z","timestamp":1788149512206,"version":"build-2803163510"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Kidney360"],"published-print":{"date-parts":[[2024,11]]},"abstract":"\n Key Points<\/jats:title>\n \n \n \n High mortality was found in patients on peritoneal dialysis who were hospitalized early or frequently because of fluid overload.<\/jats:p>\n <\/jats:list-item>\n \n Interval time and frequency of hospitalization because of fluid overload are clinical indicators for the need of intensive fluid management.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Background<\/jats:title>\n Fluid overload (FO) is common and linked to high mortality in patients undergoing peritoneal dialysis (PD). This study evaluates the effect of time interval and frequency of FO-related hospitalizations on mortality and patient survival rates in patients on PD.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Data from patients on PD voluntarily registered in the Database of Peritoneal Dialysis in EXcel were reviewed. We included patients who started PD between January 2008 and December 2018, had a history of FO-related hospitalizations after starting PD, and were followed until December 2020 or death. We analyzed the time interval to the first FO-related hospitalization after starting PD, number of such hospitalizations, and cumulative FO-free time. Mortality and patient survival rates were calculated, and multiple Cox regression identified factors associated with mortality.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Among 1858 patients hospitalized because of FO, those hospitalized within 12 months of starting PD or with <12 months of cumulative FO-free time had high mortality rates of 38.8 and 40.3 per 100 patient-years, respectively. One-year survival rates were 70.1% for those with a time to first FO-related hospitalization within 12 months of starting PD and 68.7% for those with <12 months of cumulative FO-free time. Adjusted hazard ratios were 2.92 (2.31\u20133.69) for a cumulative FO-free time of <12 months, 1.53 (1.18\u20131.99) for time to first FO-related hospitalization within 12 months and 1.05 (1.03\u20131.07) per FO-related hospitalization.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The time interval to the development of FO significantly affects mortality in patients undergoing PD.<\/jats:p>\n <\/jats:sec>\n \n Podcast<\/jats:title>\n This article contains a podcast at https:\/\/dts.podtrac.com\/redirect.mp3\/www.asn-online.org\/media\/podcast\/K360\/2024_11_21_KID0000000576.mp3<\/jats:p>\n <\/jats:sec>","DOI":"10.34067\/kid.0000000576","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T12:11:53Z","timestamp":1726056713000},"page":"1675-1682","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Effect of Time Interval and Frequency of Hospitalization Because of Fluid Overload on Survival in Peritoneal Dialysis: Thailand Experience"],"prefix":"10.34067","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6797-602X","authenticated-orcid":false,"given":"Jaruwan","family":"Thuanman","sequence":"first","affiliation":[{"name":"Epidemiology and Biostatistics Program, Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand"},{"name":"Data Management and Statistical Analysis Center (DAMASAC), Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8229-0536","authenticated-orcid":false,"given":"Pornpen","family":"Sangthawan","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2727-2925","authenticated-orcid":false,"given":"Kavin","family":"Thinkhamrop","sequence":"additional","affiliation":[{"name":"Health and Epidemiology Geoinformatics Research (HEGER), Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6486-1948","authenticated-orcid":false,"given":"Bandit","family":"Thinkhamrop","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistics Program, Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand"},{"name":"Data Management and Statistical Analysis Center (DAMASAC), Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0260-2131","authenticated-orcid":false,"given":"Jadsada","family":"Thinkhamrop","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2958-3823","authenticated-orcid":false,"given":"Siribha","family":"Changsirikulchai","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Faculty of Medicine, Srinakharinwirot University, Nakhonnayok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,9,11]]},"reference":[{"issue":"7","key":"B1-20250823","doi-asserted-by":"crossref","first-page":"691","DOI":"10.3747\/pdi.2014.00008","article-title":"The effect of fluid overload on clinical outcome in 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patients: the European Body Composition Monitoring (EuroBCM) study cohort","volume":"6","author":"Van Biesen","year":"2011","journal-title":"PLoS One."},{"issue":"6","key":"B5-20250823","doi-asserted-by":"crossref","first-page":"882","DOI":"10.2215\/CJN.11590918","article-title":"Evolution over time of volume status and PD-related practice patterns in an incident peritoneal dialysis cohort","volume":"14","author":"Van Biesen","year":"2019","journal-title":"Clin J Am Soc Nephrol."},{"issue":"3","key":"B6-20250823","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1177\/08968608221110491","article-title":"Predictors and prognostic significance of persistent fluid overload: a longitudinal study in Chinese peritoneal dialysis patients","volume":"43","author":"Ng","year":"2023","journal-title":"Perit Dial Int."},{"issue":"10","key":"B7-20250823","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1111\/nep.13716","article-title":"Determinants of volume status in peritoneal dialysis: a longitudinal study","volume":"25","author":"Jaques","year":"2020","journal-title":"Nephrology (Carlton)."},{"issue":"8","key":"B8-20250823","doi-asserted-by":"crossref","first-page":"e0202203","DOI":"10.1371\/journal.pone.0202203","article-title":"Asymptomatic fluid overload predicts survival and cardiovascular event in incident Chinese peritoneal dialysis patients","volume":"13","author":"Ng","year":"2018","journal-title":"PLoS One."},{"issue":"2","key":"B9-20250823","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3747\/pdi.2016.00241","article-title":"Does routine bioimpedance-guided fluid management provide additional benefit to non-anuric peritoneal dialysis patients? 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Nephrol."},{"issue":"3","key":"B19-20250823","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1177\/0896860819898307","article-title":"2005 Guidelines on targets for solute and fluid removal in adults being treated with chronic peritoneal dialysis: 2019 Update of the literature and revision of recommendations","volume":"40","author":"Boudville","year":"2020","journal-title":"Perit Dial Int."},{"issue":"1","key":"B20-20250823","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1023\/B:UROL.0000032699.91947.7f","article-title":"Sodium and volume overload in peritoneal dialysis: limitations of current treatment and possible solutions","volume":"36","author":"Khandelwal","year":"2004","journal-title":"Int Urol Nephrol."},{"issue":"1","key":"B21-20250823","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.semnephrol.2016.10.006","article-title":"Fluid overload in peritoneal dialysis patients","volume":"37","author":"Kim","year":"2017","journal-title":"Semin 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