{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T20:31:58Z","timestamp":1786480318282,"version":"build-2736575974"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"crossref","award":["2024YFC2511001"],"award-info":[{"award-number":["2024YFC2511001"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Major International (Regional) Joint Research Program of National Natural Science Foundation of China","award":["82120108007"],"award-info":[{"award-number":["82120108007"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82370711"],"award-info":[{"award-number":["82370711"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Facility for Translational Medicine (Shanghai) Open subjects","award":["TMSK-2024-101, NRCTM(SH)-2025-10(Ruijin Base)"],"award-info":[{"award-number":["TMSK-2024-101, NRCTM(SH)-2025-10(Ruijin Base)"]}]},{"DOI":"10.13039\/501100012247","name":"Program of Shanghai Academic\/Technology Research Leader","doi-asserted-by":"crossref","award":["21XD1402000"],"award-info":[{"award-number":["21XD1402000"]}],"id":[{"id":"10.13039\/501100012247","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology Innovation Action Plan of Shanghai Science and Technology Commettee","award":["22140904000"],"award-info":[{"award-number":["22140904000"]}]},{"name":"Shanghai Municipal Education Commission Gaofeng Clinical Medicine Grant","award":["20152207"],"award-info":[{"award-number":["20152207"]}]},{"name":"Shanghai Shenkang Hospital Development Center \u201cThree-year Action Plan for Promoting Clinical Skills and Clinical Innovation in Municipal Hospitals\u201d","award":["SHDC2020CR6017"],"award-info":[{"award-number":["SHDC2020CR6017"]}]},{"name":"Research Foundation of Ruijin Hospital","award":["JZ202408"],"award-info":[{"award-number":["JZ202408"]}]},{"name":"Shanghai Municipal Key Clinical Specialty","award":["shslczdzk02502"],"award-info":[{"award-number":["shslczdzk02502"]}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"crossref","award":["2024YFC2511001"],"award-info":[{"award-number":["2024YFC2511001"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Major International (Regional) Joint Research Program of National Natural Science Foundation of China","award":["82120108007"],"award-info":[{"award-number":["82120108007"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82370711"],"award-info":[{"award-number":["82370711"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Facility for Translational Medicine (Shanghai) Open subjects","award":["TMSK-2024-101, NRCTM(SH)-2025-10(Ruijin Base)"],"award-info":[{"award-number":["TMSK-2024-101, NRCTM(SH)-2025-10(Ruijin Base)"]}]},{"DOI":"10.13039\/501100012247","name":"Program of Shanghai Academic\/Technology Research Leader","doi-asserted-by":"crossref","award":["21XD1402000"],"award-info":[{"award-number":["21XD1402000"]}],"id":[{"id":"10.13039\/501100012247","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology Innovation Action Plan of Shanghai Science and Technology Commettee","award":["22140904000"],"award-info":[{"award-number":["22140904000"]}]},{"name":"Shanghai Municipal Education Commission Gaofeng Clinical Medicine Grant","award":["20152207"],"award-info":[{"award-number":["20152207"]}]},{"name":"Shanghai Shenkang Hospital Development Center \u201cThree-year Action Plan for Promoting Clinical Skills and Clinical Innovation in Municipal Hospitals\u201d","award":["SHDC2020CR6017"],"award-info":[{"award-number":["SHDC2020CR6017"]}]},{"name":"Research Foundation of Ruijin Hospital","award":["JZ202408"],"award-info":[{"award-number":["JZ202408"]}]},{"name":"Shanghai Municipal Key Clinical Specialty","award":["shslczdzk02502"],"award-info":[{"award-number":["shslczdzk02502"]}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Kidney360"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Key Points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>IgA nephropathy (IgAN) patients with thickening of glomerular basement membrane had a higher risk of progressing to ESKD independent of international risk-prediction tool in IgAN.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Thickening of glomerular basement membrane in IgAN patients was positively correlated with mesangial hyperplasia.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Glomerular basement membrane (GBM) ultrastructural abnormalities are common in IgA nephropathy (IgAN); however, few studies have focused on clinical significance and prognostic value of GBM ultrastructural changes in IgAN patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective longitudinal cohort with 1006 biopsy-proven primary IgAN patients was collated. GBM thickness and texture of each case were assessed under transmission electron microscope. The primary end point was ESKD. Cox proportional hazards regression model was built to determine risk factors. Immunofluorescent staining was performed on patient kidney biopsy samples to validate the correlation between mesangial proliferation and abnormal GBM thickness. Twenty single nucleotide polymorphisms independently associated with IgAN in previous genome-wide association studies were genotyped in 617 patients, and whole exome sequencing was performed in 56 patients to investigate potential variants underlying GBM ultrastructural changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 1006 patients, 52% were female, and the mean age was 37.3\u00b112.3 years old. Among all patients, 80 (8%) had abnormal thickness of GBM including 29 (3%) thickening of GBM and 51 (5%) thinning of GBM. Abnormal GBM texture was found in 25 (2%) patients. During a mean follow-up time of 46.4 months, 91 (9%) patients progressed to ESKD. By Cox regression analyses, we demonstrated that thickening of GBM at biopsy increased the risk of ESKD before (hazard ratio [HR], 3.64; 95% confidence interval [CI], 1.47 to 7.55) and after adjusted by Oxford Scoring (HR, 2.92; 95% CI, 1.12 to 6.48) or international risk-prediction tool in IgAN (HR, 3.51; 95% CI, 1.41 to 7.29). Relevance analyses showed that GBM thickening was positively correlated with mesangial hyperplasia and proliferation, but not genetic variants in IgAN patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Thickening of GBM correlated with mesangial hyperplasia and proliferation was associated with ESKD in IgAN patients, demonstrating the potential of incorporating ultrastructural changes into the pathologic evaluation system of IgAN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.34067\/kid.0000000885","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T16:00:28Z","timestamp":1758038428000},"page":"1356-1364","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Thickening of Glomerular Basement Membrane Is Associated with Long-Term Prognosis in Patients with IgA Nephropathy"],"prefix":"10.34067","volume":"7","author":[{"given":"Fang","family":"Zhengying","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Mingxin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2151-2385","authenticated-orcid":false,"given":"Wei","family":"Wenjie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Du","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zijin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma","family":"Jun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2963-7019","authenticated-orcid":false,"given":"Pan","family":"Xiaoxia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4247-8120","authenticated-orcid":false,"given":"Wang","family":"Weiming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Nan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3181-8708","authenticated-orcid":false,"given":"Yan","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5508-0664","authenticated-orcid":false,"given":"Xie","family":"Jingyuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,9,16]]},"reference":[{"issue":"8","key":"B1-20260625","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nrneph.2014.92","article-title":"Pathology of IgA nephropathy","volume":"10","author":"Roberts","year":"2014","journal-title":"Nat Rev Nephrol."},{"issue":"6","key":"B2-20260625","doi-asserted-by":"crossref","first-page":"e1002765","DOI":"10.1371\/journal.pgen.1002765","article-title":"Geographic differences in genetic susceptibility to IgA nephropathy: GWAS replication study and geospatial risk analysis","volume":"8","author":"Kiryluk","year":"2012","journal-title":"PLoS Genet."},{"issue":"9","key":"B3-20260625","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.2215\/CJN.13701217","article-title":"IgA nephropathy susceptibility loci and disease progression","volume":"13","author":"Shi","year":"2018","journal-title":"Clin J Am Soc Nephrol."},{"issue":"4","key":"B4-20260625","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/ng.787","article-title":"Genome-wide association study identifies susceptibility loci for IgA nephropathy","volume":"43","author":"Gharavi","year":"2011","journal-title":"Nat Genet."},{"issue":"10","key":"B5-20260625","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1681\/ASN.2015111210","article-title":"Fine mapping implicates a deletion of CFHR1 and CFHR3 in protection from IgA nephropathy in Han Chinese","volume":"27","author":"Xie","year":"2016","journal-title":"J Am Soc Nephrol."},{"issue":"6","key":"B6-20260625","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/j.kint.2022.08.020","article-title":"Particulate matter of air pollution may increase risk of kidney failure in IgA nephropathy","volume":"102","author":"Luo","year":"2022","journal-title":"Kidney Int."},{"key":"B7-20260625","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1159\/000348652","article-title":"Genetic studies of IgA nephropathy: what have we learned from genome-wide association studies","volume":"181","author":"Xie","year":"2013","journal-title":"Contrib Nephrol."},{"issue":"9","key":"B8-20260625","doi-asserted-by":"crossref","first-page":"e0162044","DOI":"10.1371\/journal.pone.0162044","article-title":"Underweight is an independent risk factor for renal function deterioration in patients with IgA nephropathy","volume":"11","author":"Ouyang","year":"2016","journal-title":"PLoS One."},{"key":"B9-20260625","doi-asserted-by":"crossref","first-page":"537","DOI":"10.3389\/fimmu.2019.00537","article-title":"A rare genetic defect of MBL2 increased the risk for progression of IgA nephropathy","volume":"10","author":"Ouyang","year":"2019","journal-title":"Front Immunol."},{"issue":"10","key":"B10-20260625","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1681\/ASN.2011050464","article-title":"The pathophysiology of IgA nephropathy","volume":"22","author":"Suzuki","year":"2011","journal-title":"J Am Soc Nephrol."},{"issue":"1","key":"B11-20260625","doi-asserted-by":"crossref","first-page":"6859","DOI":"10.1038\/s41467-022-34456-6","article-title":"Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits","volume":"13","author":"Liu","year":"2022","journal-title":"Nat Commun."},{"issue":"7","key":"B12-20260625","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1038\/s41588-023-01422-x","article-title":"Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy","volume":"55","author":"Kiryluk","year":"2023","journal-title":"Nat Genet."},{"issue":"5","key":"B13-20260625","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/ki.2009.243","article-title":"The Oxford classification of IgA nephropathy: rationale, clinicopathological correlations, and classification","volume":"76","author":"Cattran","year":"2009","journal-title":"Kidney Int."},{"issue":"5","key":"B14-20260625","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.kint.2017.02.003","article-title":"Oxford classification of IgA nephropathy 2016: an update from the IgA Nephropathy Classification Working Group","volume":"91","author":"Trimarchi","year":"2017","journal-title":"Kidney Int."},{"issue":"4","key":"B15-20260625","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/ki.2014.63","article-title":"Validation of the Oxford classification of IgA nephropathy in cohorts with different presentations and treatments","volume":"86","author":"Coppo","year":"2014","journal-title":"Kidney Int."},{"issue":"1","key":"B16-20260625","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s12967-018-1488-5","article-title":"A validation study of crescents in predicting ESRD in patients with IgA nephropathy","volume":"16","author":"Zhang","year":"2018","journal-title":"J Transl Med."},{"issue":"3","key":"B17-20260625","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1053\/j.ajkd.2018.01.043","article-title":"Kidney failure risk prediction equations in IgA nephropathy: a multicenter risk assessment study in Chinese patients","volume":"72","author":"Xie","year":"2018","journal-title":"Am J Kidney Dis."},{"issue":"1","key":"B18-20260625","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1080\/0886022X.2020.1811120","article-title":"IgG deposits in the mesangium and capillary loops predict poor renal outcome in patients with IgA nephropathy: a single-center retrospective study","volume":"42","author":"Peng","year":"2020","journal-title":"Ren Fail."},{"issue":"1","key":"B19-20260625","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s10157-012-0660-0","article-title":"Clinical significance of IgG deposition in the glomerular mesangial area in patients with IgA nephropathy","volume":"17","author":"Wada","year":"2013","journal-title":"Clin Exp Nephrol."},{"issue":"3","key":"B20-20260625","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s10157-018-1651-6","article-title":"Clinical significance of mesangial IgM deposition in patients with IgA nephropathy","volume":"23","author":"Heybeli","year":"2019","journal-title":"Clin Exp Nephrol."},{"issue":"6","key":"B21-20260625","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s10157-021-02034-7","article-title":"Mesangial C3 deposition and serum C3 levels predict renal outcome in IgA nephropathy","volume":"25","author":"Wu","year":"2021","journal-title":"Clin Exp Nephrol."},{"issue":"1","key":"B22-20260625","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3109\/01913128809048473","article-title":"Ultrastructural changes of glomerular basement membrane in IgA nephritis: relationship to hematuria","volume":"12","author":"Taguchi","year":"1988","journal-title":"Ultrastruct Pathol."},{"issue":"4","key":"B23-20260625","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/BF02550234","article-title":"Glomerular basement membrane thickness in primary diffuse IgA nephropathy: ultrastructural morphometric analysis","volume":"30","author":"Danilewicz","year":"1998","journal-title":"Int Urol Nephrol."},{"issue":"3","key":"B24-20260625","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/BF00858523","article-title":"A histopathological study on the prognosis of childhood IgA nephropathy and glomerular basement membrane lesions","volume":"3","author":"Nomura","year":"1989","journal-title":"Pediatr Nephrol."},{"issue":"3","key":"B25-20260625","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1053\/ajkd.2003.50117","article-title":"Different glycosylation profile of serum IgA1 in IgA nephropathy according to the glomerular basement membrane thickness: normal versus thin","volume":"41","author":"Linossier","year":"2003","journal-title":"Am J Kidney Dis."},{"issue":"1","key":"B26-20260625","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1681\/ASN.2021111447","article-title":"Genetic variants of the COL4A3, COL4A4, and COL4A5 genes contribute to thinned glomerular basement membrane lesions in sporadic IgA nephropathy patients","volume":"34","author":"Yuan","year":"2023","journal-title":"J Am Soc Nephrol."},{"issue":"7","key":"B27-20260625","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1001\/jamainternmed.2019.0600","article-title":"Evaluating a new international risk-prediction tool in IgA nephropathy","volume":"179","author":"Barbour","year":"2019","journal-title":"JAMA Intern Med."},{"issue":"1","key":"B28-20260625","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ki.2010.483","article-title":"The definition, classification, and prognosis of chronic kidney disease: a KDIGO controversies conference report","volume":"80","author":"Levey","year":"2011","journal-title":"Kidney Int."},{"issue":"3","key":"B29-20260625","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1046\/j.1523-1755.2002.00527.x","article-title":"Glomerular basement membrane thickness in children: a stereologic assessment","volume":"62","author":"Ramage","year":"2002","journal-title":"Kidney Int."},{"issue":"4","key":"B30-20260625","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1681\/ASN.2019080825","article-title":"Ultrastructural characterization of proteinuric patients predicts clinical outcomes","volume":"31","author":"Royal","year":"2020","journal-title":"J Am Soc Nephrol."},{"issue":"5","key":"B31-20260625","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med."},{"issue":"10","key":"B32-20260625","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1681\/ASN.2010010076","article-title":"HLA has strongest association with IgA nephropathy in genome-wide analysis","volume":"21","author":"Feehally","year":"2010","journal-title":"J Am Soc Nephrol."},{"issue":"2","key":"B33-20260625","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/ng.1047","article-title":"A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy","volume":"44","author":"Yu","year":"2011","journal-title":"Nat Genet."},{"issue":"11","key":"B34-20260625","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/ng.3118","article-title":"Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens","volume":"46","author":"Kiryluk","year":"2014","journal-title":"Nat Genet."},{"key":"B35-20260625","doi-asserted-by":"crossref","first-page":"7270","DOI":"10.1038\/ncomms8270","article-title":"Identification of new susceptibility loci for IgA nephropathy in Han Chinese","volume":"6","author":"Li","year":"2015","journal-title":"Nat Commun."},{"issue":"9","key":"B36-20260625","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1681\/ASN.2018111143","article-title":"A novel role for GATA3 in mesangial cells in glomerular development and injury","volume":"30","author":"Grigorieva","year":"2019","journal-title":"J Am Soc Nephrol."},{"issue":"27","key":"B37-20260625","doi-asserted-by":"crossref","first-page":"e16333","DOI":"10.1097\/MD.0000000000016333","article-title":"Histologic predictors of renal outcome in diabetic nephropathy: beyond renal pathology society classification","volume":"98","author":"Stefan","year":"2019","journal-title":"Medicine (Baltimore)."},{"issue":"3","key":"B38-20260625","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s10157-014-1008-8","article-title":"Glomerular basement membrane injuries in IgA nephropathy evaluated by double immunostaining for \u03b15(IV) and \u03b12(IV) chains of type IV collagen and low-vacuum scanning electron microscopy","volume":"19","author":"Masuda","year":"2015","journal-title":"Clin Exp Nephrol."},{"key":"B39-20260625","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000423868","article-title":"Primary IgA glomerulonephritis with thin glomerular basement membrane: a peculiar pathological marker versus thin membrane nephropathy association","volume":"111","author":"Berthoux","year":"1995","journal-title":"Contrib Nephrol."}],"container-title":["Kidney360"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.34067\/KID.0000000885","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T20:03:27Z","timestamp":1786478607000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.34067\/KID.0000000885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,16]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.34067\/kid.0000000885","relation":{},"ISSN":["2641-7650"],"issn-type":[{"value":"2641-7650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,16]]},"assertion":[{"value":"2025-04-10","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-03","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}