{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T20:30:33Z","timestamp":1786480233544,"version":"build-2736575974"},"reference-count":62,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008028","name":"School of Medicine and Public Health, University of Wisconsin-Madison","doi-asserted-by":"crossref","award":["AAM7147 ASTOR DOM GENERAL PILOT"],"award-info":[{"award-number":["AAM7147 ASTOR DOM GENERAL PILOT"]}],"id":[{"id":"10.13039\/100008028","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008028","name":"School of Medicine and Public Health, University of Wisconsin-Madison","doi-asserted-by":"crossref","award":["AAM7147 ASTOR DOM GENERAL PILOT"],"award-info":[{"award-number":["AAM7147 ASTOR DOM GENERAL PILOT"]}],"id":[{"id":"10.13039\/100008028","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Kidney360"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Key Points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Vitamin D insufficiency is associated with higher risk of death-censored graft failure and infection-related mortality after kidney transplantation.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Vitamin D insufficiency is associated with a faster decline of graft function after kidney transplantation.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vitamin D inadequacy at or shortly after kidney transplantation is associated with poor outcomes. Circulating 25-hydroxyvitamin D [25(OH)D] levels generally increase over time after transplantation, but inadequacy remains common. Few studies have examined associations of later circulating 25(OH)D levels and long-term outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed data from the Wisconsin Allograft Recipient Database to assess the association of post-transplant 25(OH)D with overall graft failure, death-censored graft failure (DCGF), death with a functioning graft, cause-specific mortality, and eGFR trajectory over the next 4 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 2504 recipients who maintained a functioning graft for at least 13 months were included in our analysis. A total of 867 overall graft failures occurred during a median follow-up of 6.8 years. Vitamin D deficiency (\u226420 ng\/ml) was associated with a 43% higher hazard of overall graft failure (95% confidence interval [CI], 1.16 to 1.78), a 2.24-fold higher hazard of DCGF (95% CI, 1.60 to 3.12), and a 2.10-fold higher hazard (95% CI, 1.37 to 3.21) of infection-related mortality compared with sufficiency. It also was associated with a 1.38 ml\/min per 1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      per year faster (95% CI, \u22121.97 to \u22120.79) annual eGFR decline compared with sufficiency. No association was detected for death with a functioning graft or other cause-specific mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In conclusion, post-transplant vitamin D deficiency is associated with a higher risk of DCGF, infection-related mortality, and a faster decline of graft function in kidney transplant recipients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.34067\/kid.0000000942","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T16:00:28Z","timestamp":1754582428000},"page":"2236-2247","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Association of Post-Transplant Circulating 25-Hydroxyvitamin D and Long-Term Patient and Graft Outcomes among Kidney Transplant Recipients"],"prefix":"10.34067","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5545-3925","authenticated-orcid":false,"given":"Zhongyu","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin"},{"name":"Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1667-7465","authenticated-orcid":false,"given":"Sandesh","family":"Parajuli","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3326-8583","authenticated-orcid":false,"given":"Didier","family":"Mandelbrot","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2092-1136","authenticated-orcid":false,"given":"Michal L.","family":"Melamed","sequence":"additional","affiliation":[{"name":"Department of Medicine, New York University Grossman School of Medicine, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0876-0069","authenticated-orcid":false,"given":"Brad C.","family":"Astor","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin"},{"name":"Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,8,7]]},"reference":[{"issue":"3 suppl1","key":"B1-20260109","doi-asserted-by":"crossref","first-page":"A8","DOI":"10.1053\/j.ajkd.2022.12.001","article-title":"US renal data system 2022 annual data report: epidemiology of kidney disease in the United States","volume":"81","author":"Johansen","year":"2023","journal-title":"Am J Kidney Dis."},{"issue":"6","key":"B2-20260109","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1210\/jcem-57-6-1308","article-title":"Specific high-affinity receptors for 1,25-dihydroxyvitamin D3 in human peripheral blood mononuclear cells: presence in monocytes and induction in T lymphocytes following activation","volume":"57","author":"Bhalla","year":"1983","journal-title":"J Clin Endocrinol 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