{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T20:31:59Z","timestamp":1786480319351,"version":"build-2736575974"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Kidney360"],"published-print":{"date-parts":[[2026,2]]},"abstract":"\n Key Points<\/jats:title>\n \n \n \n Residual kidney function does not modify the response of left ventricular mass (LVM) to frequent hemodialysis in patients with ESKD.<\/jats:p>\n <\/jats:list-item>\n \n Both anuric and nonanuric patients showed similar improvements in LVM with intensive hemodialysis.<\/jats:p>\n <\/jats:list-item>\n \n Changes in residual kidney function were not associated with response of LVM to frequent hemodialysis.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Background<\/jats:title>\n Frequent (6 times\/wk) hemodialysis has been shown to reduce left ventricular mass (LVM) more than conventional (3 times\/wk) hemodialysis in patients with ESKD. Previous work suggested that the LVM benefits of frequent hemodialysis might be attenuated in the presence of residual kidney function (RKF). We hypothesized that patients without RKF would have greater LVM reduction with frequent hemodialysis compared with patients with RKF.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We analyzed data from the Frequent Hemodialysis Network (FHN) Daily (in-center) and Nocturnal (home-based) trials, which randomized patients with ESKD to either frequent or conventional hemodialysis over 12 months. RKF was evaluated through timed 24-hour urine collections, with anuria defined as urine output <100 ml\/day. LVM was assessed through magnetic resonance imaging at baseline and 12 months. Combined trial data were analyzed using log-transformed LVM to evaluate the effect of RKF on LVM change.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 332 patients from both FHN trials (170 frequent, 162 conventional hemodialysis), 189 (57%) were anuric at baseline. Baseline LVM did not differ between anuric and nonanuric patients (log LVM: 4.90\u00b10.32 versus 4.85\u00b10.40;\n P<\/jats:italic>\n = 0.18). At 12 months, both anuric and nonanuric patients experienced similar LVM reductions with frequent hemodialysis (mean change in log LVM: \u22120.11\u00b10.23 versus \u22120.08\u00b10.23;\n P<\/jats:italic>\n = 0.44). No association was found between baseline urine volume and LVM response (rho=\u22120.002,\n P<\/jats:italic>\n = 0.98 for frequent; rho=0.003,\n P<\/jats:italic>\n = 0.97 for conventional hemodialysis). Changes in urine volume over 12 months did not correlate with LVM changes. In an exploratory analysis, LVM reduction correlated with urine volume decline in men (rho=0.23;\n P<\/jats:italic>\n < 0.01) but not in women (rho= \u22120.19;\n P<\/jats:italic>\n = 0.10;\n P<\/jats:italic>\n interaction<\/jats:sub>\n = 0.003).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Both anuric and nonanuric patients experienced similar LVM reductions with frequent hemodialysis, and no association between urine output and LVM response was observed in the FHN trials. These data suggest that the response of LVM to frequent hemodialysis is independent of baseline RKF.<\/jats:p>\n <\/jats:sec>","DOI":"10.34067\/kid.0000000987","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T16:00:28Z","timestamp":1758643228000},"page":"344-352","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Residual Kidney Function and Response of Left Ventricular Mass to Intensive Hemodialysis"],"prefix":"10.34067","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1753-4263","authenticated-orcid":false,"given":"Amin","family":"Tajerian","sequence":"first","affiliation":[{"name":"Baylor Scott and White Research Institute, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7222-4666","authenticated-orcid":false,"given":"Tariq","family":"Shafi","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Baylor Scott and White Health, Temple, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Zhang","sequence":"additional","affiliation":[{"name":"Renaissance School of Medicine, Stony Brook University, Stony Brook, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4558-1798","authenticated-orcid":false,"given":"Sobia","family":"Khan","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Medicine, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6324-7807","authenticated-orcid":false,"given":"Sandeep K.","family":"Mallipattu","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Medicine, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York"},{"name":"Division of Nephrology, Department of Medicine, Northport Veterans Affairs Medical Center, Northport, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1284-429X","authenticated-orcid":false,"given":"Andreas P.","family":"Kalogeropoulos","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,9,23]]},"reference":[{"issue":"4","key":"B2-20260226","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1111\/j.1523-1755.2004.00530.x","article-title":"Left ventricular mass monitoring in the follow-up of dialysis patients: prognostic value of left ventricular hypertrophy progression","volume":"65","author":"Zoccali","year":"2004","journal-title":"Kidney Int."},{"issue":"2","key":"B3-20260226","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1159\/000439447","article-title":"Eccentric left ventricular hypertrophy and sudden death in patients with end-stage kidney disease","volume":"42","author":"de Roij van Zuijdewijn","year":"2015","journal-title":"Am J Nephrol."},{"issue":"4","key":"B4-20260226","doi-asserted-by":"crossref","first-page":"101590","DOI":"10.1016\/j.cpcardiol.2023.101590","article-title":"Left ventricular hypertrophy (LVH) and left ventricular geometric patterns in patients with chronic kidney disease (CKD) stage 2-5 with preserved ejection fraction (EF): a systematic review to explore CKD stage-wise LVH patterns","volume":"48","author":"Maqbool","year":"2023","journal-title":"Curr Probl Cardiol."},{"issue":"5S1","key":"B5-20260226","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1053\/j.ajkd.2016.05.025","article-title":"Intensive hemodialysis, left ventricular hypertrophy, and cardiovascular 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