{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T20:32:03Z","timestamp":1786480323349,"version":"build-2736575974"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Kidney360"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Key Points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Dialysis linked with poorer quality of life compared with transplant patients and patients with CKD.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Quality of life trends were similar in both domain-specific and overall quality-of-life measures.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There are sparse data about the change in health-related quality of life (HRQoL) with the temporal progression of CKD. In this study, we assessed the association between change in CKD stages, overall and domain-specific quality of life and determined the factors that were associated with this change.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were sourced from a multicenter study that included 1290 adult patients aged 18 years and older across six centers in Australia. Three-level EuroQol five-dimensional questionnaire was collected at baseline and 2 and 4 years. Changes in CKD stages were treated as a time-varying exposure; generalized estimating equations were used to model the changes in HRQoL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      With reference to patients with CKD (G3-5), patients treated with dialysis had a reduction of 0.06 (\u22120.09 to \u22120.04) in overall HRQoL scores over the 4 years and experienced higher odds of reporting lower HRQoL across all domains: mobility (1.91 [1.53\u20132.38]), self-care (2.30 [1.67\u20133.16]), usual activity (2.70 [2.18\u20133.38]), pain (1.19 [0.97\u20131.46]), and anxiety (1.40 [1.12\u20131.75]). Transplant recipients showed no significant decline in overall HRQoL (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.13), but had increased odds of reduced mobility (1.74 [1.40\u20132.18]) and usual activity (1.35 [1.07\u20131.71]). Female sex, smoking, prevalent diabetes mellitus, lower educational attainment, and Middle Eastern ethnicity were associated with lower HRQoL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients on maintenance dialysis, but not transplant recipients, experienced a significant decline in overall HRQoL (0.06) over the 4 years compared with patients with CKD (G3-5). These utility-based HRQoL estimates are essential for future economic evaluations in kidney trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.34067\/kid.0000001009","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T17:00:40Z","timestamp":1765213240000},"page":"767-776","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal Assessment of Health-Related Quality of Life in Adults with CKD"],"prefix":"10.34067","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9414-675X","authenticated-orcid":false,"given":"Owen","family":"Ng","sequence":"first","affiliation":[{"name":"Centre for Kidney Research, Kids Research Institute, The Children's Hospital at Westmead, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9389-2516","authenticated-orcid":false,"given":"Armando","family":"Teixeira-Pinto","sequence":"additional","affiliation":[{"name":"Centre for Kidney Research, Kids Research Institute, The Children's Hospital at Westmead, Sydney, New South Wales, Australia"},{"name":"Sydney School of Public Health, University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anh","family":"Kieu","sequence":"additional","affiliation":[{"name":"Centre for Kidney Research, Kids Research Institute, The Children's Hospital at Westmead, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4564-5825","authenticated-orcid":false,"given":"Anita","family":"van Zwieten","sequence":"additional","affiliation":[{"name":"Centre for Kidney Research, Kids Research Institute, The Children's Hospital at Westmead, Sydney, New South Wales, Australia"},{"name":"Sydney School of Public Health, University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoushka","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Centre for Kidney Research, Kids Research Institute, The Children's Hospital at Westmead, Sydney, New South Wales, Australia"},{"name":"Leeder Centre for Health Policy, Economics and Data, Sydney School of Public Health, University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Howard","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health, University of Sydney, Sydney, New South Wales, Australia"},{"name":"Leeder Centre for Health Policy, Economics and Data, Sydney School of Public Health, University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3410-3572","authenticated-orcid":false,"given":"Wai H.","family":"Lim","sequence":"additional","affiliation":[{"name":"School of Medical and Health Science, Edith Cowan University, Perth, Western Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy R.","family":"Chapman","sequence":"additional","affiliation":[{"name":"Department of Renal and Transplant Medicine, Westmead Hospital, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8299-2650","authenticated-orcid":false,"given":"Simon D.","family":"Roger","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Gosford Hospital, Gosford, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Bourke","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Westmead Hospital, Westmead, University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaundeep","family":"Sen","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Concord Repatriation General Hospital, Concord, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0527-898X","authenticated-orcid":false,"given":"Steven J.","family":"Chadban","sequence":"additional","affiliation":[{"name":"Dpartment of Renal Medicine, Royal Prince Alfred Hospital, and Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7167-6495","authenticated-orcid":false,"given":"Carol 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