{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T20:30:21Z","timestamp":1786480221980,"version":"build-2736575974"},"reference-count":53,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Kidney360"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:p>\n                    Biorepositories\u2014centralized facilities for storing biologic specimens (such as blood, urine, and tissue) along with associated patient data\u2014are critical resources that can drive progress in AKI research. To highlight their importance, the American Society of Nephrology's AKINow Basic Science Workgroup hosted a webinar titled \u201c\n                    <jats:italic toggle=\"yes\">How to Build and Best Use Kidney Biorepositories<\/jats:italic>\n                    ,\u201d featuring expert panelists Drs. A. Hung, S. Jain, and C. Parikh. This discussion, summarized here, focused on: (\n                    <jats:italic toggle=\"yes\">1<\/jats:italic>\n                    ) How biorepositories can support research, especially for early-stage investigators; (\n                    <jats:italic toggle=\"yes\">2<\/jats:italic>\n                    ) key logistical considerations for establishing a new biorepository; and (\n                    <jats:italic toggle=\"yes\">3<\/jats:italic>\n                    ) the benefits and trade-offs of creating a new biorepository versus existing ones. In addition, details related to existing biorepositories are provided to foster better utilization of these valuable resources. The goal is to inform nephrology investigators about how to leverage existing biorepositories to advance their research and to provide guidance for those interested in generating their own.\n                  <\/jats:p>","DOI":"10.34067\/kid.0000001085","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T17:03:25Z","timestamp":1764954205000},"page":"426-434","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Kidney Biorepositories"],"prefix":"10.34067","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6146-1092","authenticated-orcid":false,"given":"Leslie S.","family":"Gewin","sequence":"first","affiliation":[{"name":"Division of Nephrology, Washington University in St. Louis, St. Louis, Missouri"},{"name":"Department of Medicine, Veterans Affairs Hospital, St. Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9051-7385","authenticated-orcid":false,"given":"Chirag","family":"Parikh","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2804-127X","authenticated-orcid":false,"given":"Sanjay","family":"Jain","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Washington University in St. Louis, St. Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3203-1608","authenticated-orcid":false,"given":"Adriana","family":"Hung","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Vanderbilt University School of Medicine, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0517-8871","authenticated-orcid":false,"given":"Amandeep","family":"Bajwa","sequence":"additional","affiliation":[{"name":"Department of Surgery, The University of Tennessee Health Science Center, Memphis, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0801-0532","authenticated-orcid":false,"given":"Mark","family":"Okusa","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0601-0627","authenticated-orcid":false,"given":"Sanjeev","family":"Kumar","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Cedars-Sinai Medical Center, Los Angeles, California"},{"name":"Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California"},{"name":"Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7837-0165","authenticated-orcid":false,"given":"Sherry G.","family":"Mansour","sequence":"additional","affiliation":[{"name":"Section of Nephrology, Yale School of Medicine, New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,5]]},"reference":[{"key":"B1-20260226","doi-asserted-by":"crossref","first-page":"106572","DOI":"10.1016\/j.cct.2021.106572","article-title":"Biorepository best practices for research and clinical investigations","volume":"116","author":"Sanderson-November","year":"2022","journal-title":"Contemp Clin Trials."},{"issue":"3","key":"B5-20260226","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.kint.2020.08.039","article-title":"Rationale and design of the Kidney Precision Medicine Project","volume":"99","author":"de Boer","year":"2021","journal-title":"Kidney Int."},{"issue":"1","key":"B6-20260226","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physiolgenomics.00104.2020","article-title":"A multimodal and integrated approach to interrogate human kidney biopsies with rigor and reproducibility: guidelines from the Kidney Precision Medicine Project","volume":"53","author":"El-Achkar","year":"2021","journal-title":"Physiol Genomics."},{"issue":"8","key":"B7-20260226","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1038\/s41556-023-01194-w","article-title":"Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)","volume":"25","author":"Jain","year":"2023","journal-title":"Nat Cell Biol."},{"issue":"9","key":"B9-20260226","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1681\/ASN.2010121302","article-title":"Postoperative biomarkers predict acute kidney injury and poor outcomes after adult cardiac surgery","volume":"22","author":"Parikh","year":"2011","journal-title":"J Am Soc Nephrol."},{"issue":"11","key":"B10-20260226","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1001\/jamapediatrics.2016.1532","article-title":"Kidney outcomes 5 years after pediatric cardiac surgery: the TRIBE-AKI study","volume":"170","author":"Greenberg","year":"2016","journal-title":"JAMA Pediatr."},{"issue":"3","key":"B11-20260226","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/ki.2015.104","article-title":"Perioperative heart-type fatty acid binding protein is associated with acute kidney injury after cardiac surgery","volume":"88","author":"Schaub","year":"2015","journal-title":"Kidney Int."},{"issue":"3","key":"B14-20260226","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1001\/jama.2024.8469","article-title":"Kidney transplant outcomes from deceased donors who received dialysis","volume":"332","author":"Wen","year":"2024","journal-title":"JAMA."},{"issue":"1","key":"B15-20260226","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.kint.2018.08.047","article-title":"Deceased-donor acute kidney injury is not associated with kidney allograft failure","volume":"95","author":"Hall","year":"2019","journal-title":"Kidney Int."},{"issue":"8","key":"B16-20260226","doi-asserted-by":"crossref","first-page":"e0161098","DOI":"10.1371\/journal.pone.0161098","article-title":"First post-operative urinary kidney injury biomarkers and association with the duration of AKI in the TRIBE-AKI cohort","volume":"11","author":"Coca","year":"2016","journal-title":"PLoS One."},{"issue":"5","key":"B17-20260226","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1681\/ASN.2011090907","article-title":"Biomarkers predict progression of acute kidney injury after cardiac surgery","volume":"23","author":"Koyner","year":"2012","journal-title":"J Am Soc Nephrol."},{"issue":"8","key":"B18-20260226","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1016\/j.ekir.2024.05.010","article-title":"Derivation and validation of an optimal neutrophil gelatinase-associated lipocalin cutoff to predict stage 2\/3 acute kidney injury (AKI) in critically ill children","volume":"9","author":"Goldstein","year":"2024","journal-title":"Kidney Int Rep."},{"issue":"9","key":"B19-20260226","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1681\/ASN.2010111163","article-title":"Postoperative biomarkers predict acute kidney injury and poor outcomes after pediatric cardiac surgery","volume":"22","author":"Parikh","year":"2011","journal-title":"J Am Soc Nephrol."},{"issue":"6","key":"B21-20260226","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1681\/ASN.2016101127","article-title":"Perspective on clinical application of biomarkers in AKI","volume":"28","author":"Parikh","year":"2017","journal-title":"J Am Soc Nephrol."},{"issue":"2","key":"B22-20260226","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1053\/j.ajkd.2022.08.011","article-title":"Deceased-donor acute kidney injury and acute rejection in kidney transplant recipients: a multicenter cohort","volume":"81","author":"Reese","year":"2023","journal-title":"Am J Kidney Dis."},{"issue":"3","key":"B23-20260226","doi-asserted-by":"crossref","first-page":"e0264329","DOI":"10.1371\/journal.pone.0264329","article-title":"Clinically adjudicated deceased donor acute kidney injury and graft outcomes","volume":"17","author":"Mansour","year":"2022","journal-title":"PLoS One."},{"issue":"1","key":"B24-20260226","doi-asserted-by":"crossref","first-page":"e1918634","DOI":"10.1001\/jamanetworkopen.2019.18634","article-title":"Association of deceased donor acute kidney injury with recipient graft survival","volume":"3","author":"Liu","year":"2020","journal-title":"JAMA Netw Open."},{"issue":"4","key":"B25-20260226","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1097\/TP.0000000000003299","article-title":"Uromodulin to osteopontin ratio in deceased donor urine is associated with kidney graft outcomes","volume":"105","author":"Mansour","year":"2021","journal-title":"Transplantation."},{"issue":"1","key":"B26-20260226","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1186\/s13054-022-04121-x","article-title":"Subphenotypes in acute kidney injury: a narrative review","volume":"26","author":"Vaara","year":"2022","journal-title":"Crit Care."},{"issue":"1","key":"B27-20260226","doi-asserted-by":"crossref","first-page":"7368","DOI":"10.1038\/s41467-024-51304-x","article-title":"Plasma proteomics of acute tubular injury","volume":"15","author":"Schmidt","year":"2024","journal-title":"Nat Commun."},{"issue":"3","key":"B28-20260226","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1053\/j.ajkd.2023.03.010","article-title":"Evaluation of plasma biomarkers to predict major adverse kidney events in hospitalized patients with COVID-19","volume":"82","author":"Menez","year":"2023","journal-title":"Am J Kidney Dis."},{"issue":"6","key":"B29-20260226","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.kint.2022.03.011","article-title":"Integrated single-cell sequencing and histopathological analyses reveal diverse injury and repair responses in a participant with acute kidney injury: a clinical-molecular-pathologic correlation","volume":"101","author":"Menon","year":"2022","journal-title":"Kidney Int."},{"issue":"7970","key":"B30-20260226","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/s41586-023-05769-3","article-title":"An atlas of healthy and injured cell states and niches in the human kidney","volume":"619","author":"Lake","year":"2023","journal-title":"Nature."},{"issue":"3","key":"B31-20260226","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1681\/ASN.2021060757","article-title":"Angiopoietins as prognostic markers for future kidney disease and heart failure events after acute kidney injury","volume":"33","author":"Mansour","year":"2022","journal-title":"J Am Soc Nephrol."},{"issue":"1","key":"B32-20260226","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1186\/s12882-025-04169-1","article-title":"Using vascular biomarkers to assess heart failure event risk in hospitalized patients with and without AKI","volume":"26","author":"Shi","year":"2025","journal-title":"BMC Nephrol."},{"issue":"10","key":"B33-20260226","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.trecan.2021.07.005","article-title":"Overstretched and overlooked: solving challenges faced by early-career investigators after the pandemic","volume":"7","author":"Humphries","year":"2021","journal-title":"Trends Cancer."},{"issue":"1","key":"B34-20260226","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1186\/s13019-022-02066-4","article-title":"Pre-operative kidney biomarkers and risks for death, cardiovascular and chronic kidney disease events after cardiac surgery: the TRIBE-AKI study","volume":"17","author":"Vasquez-Rios","year":"2022","journal-title":"J Cardiothorac Surg."},{"issue":"11","key":"B35-20260226","first-page":"e147464","article-title":"Urinary EGF and MCP-1 and risk of CKD after cardiac surgery","volume":"6","author":"Menez","year":"2021","journal-title":"JCI Insight."},{"issue":"1","key":"B36-20260226","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1053\/j.ajkd.2019.01.028","article-title":"The association of angiogenesis markers with acute kidney injury and mortality after cardiac surgery","volume":"74","author":"Mansour","year":"2019","journal-title":"Am J Kidney Dis."},{"issue":"726","key":"B37-20260226","doi-asserted-by":"crossref","first-page":"eade7287","DOI":"10.1126\/scitranslmed.ade7287","article-title":"Analysis of the human kidney transcriptome and plasma proteome identifies markers of proximal tubule maladaptation to injury","volume":"15","author":"Wen","year":"2023","journal-title":"Sci Transl Med."},{"issue":"1","key":"B38-20260226","doi-asserted-by":"crossref","first-page":"5161","DOI":"10.1038\/s41467-025-60435-8","article-title":"Three dimensional multiscalar neurovascular nephron connectivity map of the human kidney across the lifespan","volume":"16","author":"McLaughlin","year":"2025","journal-title":"Nat Commun."},{"key":"B39-20260226","article-title":"Human BioMolecular Atlas Program (HuBMAP): 3D human reference atlas construction and usage","author":"Borner","year":"2024","journal-title":"bioRxiv."},{"issue":"7777","key":"B40-20260226","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/s41586-019-1629-x","article-title":"The human body at cellular resolution: the NIH Human Biomolecular Atlas Program","volume":"574","year":"2019","journal-title":"Nature."},{"issue":"2","key":"B42-20260226","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1089\/bio.2012.1022","article-title":"2012 best practices for repositories collection, storage, retrieval, and distribution of biological materials for research international society for biological and environmental repositories","volume":"10","year":"2012","journal-title":"Biopreserv Biobank."},{"issue":"4","key":"B43-20260226","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/path.4117","article-title":"Quality really matters: the need to improve specimen quality in biomedical research","volume":"228","author":"Simeon-Dubach","year":"2012","journal-title":"J Pathol."},{"issue":"3","key":"B44-20260226","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1089\/bio.2019.0039","article-title":"The importance of human tissue bioresources in advancing biomedical research","volume":"17","author":"Al Diffalha","year":"2019","journal-title":"Biopreserv Biobank."},{"issue":"11","key":"B45-20260226","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1001\/jama.299.11.1359","article-title":"Centralized biorepositories for genetic and genomic research","volume":"299","author":"Ginsburg","year":"2008","journal-title":"JAMA."},{"issue":"3","key":"B46-20260226","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/QAD.0b013e32835c1244","article-title":"Biobanking past, present and future: responsibilities and benefits","volume":"27","author":"De Souza","year":"2013","journal-title":"AIDS."},{"key":"B47-20260226","doi-asserted-by":"crossref","first-page":"e70463","DOI":"10.2196\/70463","article-title":"Decentralized biobanking apps for patient tracking of biospecimen research: real-world usability and feasibility study","volume":"6","author":"Sanchez","year":"2025","journal-title":"JMIR Bioinform Biotechnol."},{"key":"B48-20260226","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/2043-9113-1-22","article-title":"Leveraging a clinical research information system to assist biospecimen data and workflow management: a hybrid approach","volume":"1","author":"Nadkarni","year":"2011","journal-title":"J Clin Bioinforma."},{"issue":"1","key":"B49-20260226","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1471-2369-11-22","article-title":"The Assessment, Serial Evaluation, and Subsequent Sequelae of Acute Kidney Injury (ASSESS-AKI) study: design and methods","volume":"11","author":"Go","year":"2010","journal-title":"BMC Nephrol."},{"issue":"20","key":"B50-20260226","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1056\/NEJMoa1303154","article-title":"Combined angiotensin inhibition for the treatment of diabetic nephropathy","volume":"369","author":"Fried","year":"2013","journal-title":"New Engl J Med."},{"issue":"3","key":"B51-20260226","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.ekir.2019.11.022","article-title":"APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO): design and rationale","volume":"5","author":"Freedman","year":"2020","journal-title":"Kidney Int Rep."},{"issue":"4","key":"B52-20260226","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1089\/bio.2018.0054","article-title":"Challenges for the sustainability of university-run biobanks","volume":"16","author":"Kongsholm","year":"2018","journal-title":"Biopreserv Biobank."},{"issue":"1","key":"B53-20260226","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13167-016-0053-7","article-title":"Biobanks in the era of personalized medicine: objectives, challenges, and innovation: overview","volume":"7","author":"Kinkorov\u00e1","year":"2015","journal-title":"EPMA J."},{"issue":"1","key":"B54-20260226","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/bfgp\/elx008","article-title":"Legal & ethical compliance when sharing biospecimen","volume":"17","author":"Klingstrom","year":"2018","journal-title":"Brief Funct Genomics."},{"issue":"7","key":"B55-20260226","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1681\/ASN.2022040421","article-title":"Navigating to kidney health equity","volume":"33","author":"Griffith","year":"2022","journal-title":"J Am Soc Nephrol."},{"issue":"4-5","key":"B56-20260226","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.clinbiochem.2014.01.002","article-title":"The procurement, storage, and quality assurance of frozen blood and tissue biospecimens in pathology, biorepository, and biobank settings","volume":"47","author":"Shabihkhani","year":"2014","journal-title":"Clin Biochem."},{"key":"B57-20260226","doi-asserted-by":"crossref","first-page":"106655","DOI":"10.1016\/j.cct.2021.106655","article-title":"Biorepository - a key component of research studies","volume":"112","author":"Sergi","year":"2022","journal-title":"Contemp Clin Trials."},{"issue":"22","key":"B58-20260226","doi-asserted-by":"crossref","first-page":"e123151","DOI":"10.1172\/jci.insight.123151","article-title":"Transcriptional trajectories of human kidney injury progression","volume":"3","author":"Cipp\u00e0","year":"2018","journal-title":"JCI Insight."},{"issue":"1","key":"B59-20260226","doi-asserted-by":"crossref","first-page":"4359","DOI":"10.1038\/s41467-023-39859-7","article-title":"Transcriptional and spatial profiling of the kidney allograft unravels a central role for FcyRIII+ innate immune cells in rejection","volume":"14","author":"Lamarth\u00e9e","year":"2023","journal-title":"Nat Commun."},{"issue":"6685","key":"B60-20260226","doi-asserted-by":"crossref","first-page":"eadd6371","DOI":"10.1126\/science.add6371","article-title":"SOX9 switch links regeneration to fibrosis at the single-cell level in mammalian kidneys","volume":"383","author":"Aggarwal","year":"2024","journal-title":"Science."},{"issue":"3","key":"B61-20260226","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.kint.2020.10.036","article-title":"Patient perspectives and involvement in precision medicine research","volume":"99","author":"Tuttle","year":"2021","journal-title":"Kidney Int."}],"container-title":["Kidney360"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.34067\/KID.0000001085","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T19:58:43Z","timestamp":1786478323000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.34067\/KID.0000001085"}},"subtitle":["Valuable Tools Advancing Acute Kidney Injury Research"],"short-title":[],"issued":{"date-parts":[[2025,12,5]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.34067\/kid.0000001085","relation":{},"ISSN":["2641-7650"],"issn-type":[{"value":"2641-7650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,5]]}}}