{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:25:54Z","timestamp":1788326754869,"version":"build-2803163510"},"reference-count":53,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Kidney360"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Key Points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Dapagliflozin reduces proteinuria in patients with Alport syndrome.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Dapagliflozin plays an anti-inflammatory role by inhibiting the stimulator of IFN genes pathway in tubular epithelial cells of Alport syndrome mice.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Alport syndrome (AS) is a hereditary kidney disease caused by\n                      <jats:italic toggle=\"yes\">COL4A3\/4\/5<\/jats:italic>\n                      mutations that lack of effective treatments. Sodium-glucose cotransporter 2 inhibitors have demonstrated renal and cardiovascular protective effects in patients with CKD; however, their long-term effects in patients with AS and the underlying mechanisms remain to be clarified.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a single-arm, prospective study to examine the effect of dapagliflozin in patients with AS. In parallel,\n                      <jats:italic toggle=\"yes\">Col4a3<\/jats:italic>\n                      p.C1615Y-mutant mice (129S2\/Sv background) were used as an AS model to investigate the renoprotective mechanisms of dapagliflozin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of twenty-one patients with AS were enrolled. After approximately 12 months of follow-up (12.6\u00b11.2 months), the mean 24-hour urinary protein decreased by 29% to 1.25\u00b10.73 g from baseline (1.75\u00b10.90;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). The eGFR showed no significant difference compared with baseline (76\u00b128 versus 77\u00b129 ml\/min per 1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      ,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.57). In the animal studies, dapagliflozin significantly reduced macrophage infiltration and the expression of inflammatory cytokines levels in the renal cortex of\n                      <jats:italic toggle=\"yes\">Col4a3<\/jats:italic>\n                      -mutant mice. Mechanistic studies showed that stimulator of IFN genes (STING) pathway was activated in the renal cortex and tubular epithelial cells (TECs) from\n                      <jats:italic toggle=\"yes\">Col4a3<\/jats:italic>\n                      mice, contributing to a proinflammatory phenotype. Dapagliflozin effectively inhibited STING activation and suppressed inflammatory cytokines production in mutant TECs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Dapagliflozin can reduce proteinuria in patients with AS and plays an anti-inflammatory role by inhibiting the STING pathway in TECs of AS mice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.34067\/kid.0000001099","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T17:00:22Z","timestamp":1767805222000},"page":"969-981","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Dapagliflozin Reduces Kidney Inflammation in Alport Syndrome by Inhibiting the Stimulator of IFN Genes Pathway in Renal Tubular Epithelial Cells"],"prefix":"10.34067","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6643-1882","authenticated-orcid":false,"given":"Qimin","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Nephrology, Shanghai Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"},{"name":"Institute of Nephrology, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1571-4498","authenticated-orcid":false,"given":"Yafei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shanghai Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"},{"name":"Institute of Nephrology, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0426-0605","authenticated-orcid":false,"given":"Yuanmeng","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shanghai Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"},{"name":"Institute of Nephrology, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuwen","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shanghai Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"},{"name":"Institute of Nephrology, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2183-8692","authenticated-orcid":false,"given":"Yunzi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shanghai Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"},{"name":"Institute of Nephrology, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanlan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shanghai Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"},{"name":"Institute of Nephrology, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengying","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shanghai Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"},{"name":"Institute of Nephrology, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shanghai Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"},{"name":"Institute of Nephrology, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5104-4586","authenticated-orcid":false,"given":"Qinjie","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shanghai Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"},{"name":"Institute of Nephrology, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8069-6147","authenticated-orcid":false,"given":"Jing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shanghai Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"},{"name":"Institute of Nephrology, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2963-7019","authenticated-orcid":false,"given":"Xiaoxia","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shanghai Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"},{"name":"Institute of Nephrology, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1159-8565","authenticated-orcid":false,"given":"Xiangchen","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shanghai Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"},{"name":"Institute of Nephrology, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"},{"name":"Department of Nephrology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5508-0664","authenticated-orcid":false,"given":"Jingyuan","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shanghai Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China"},{"name":"Institute of Nephrology, 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