{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T20:29:44Z","timestamp":1786480184418,"version":"build-2736575974"},"reference-count":85,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["DK128017"],"award-info":[{"award-number":["DK128017"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["DK118391"],"award-info":[{"award-number":["DK118391"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["DK129240"],"award-info":[{"award-number":["DK129240"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"crossref","award":["PR221810"],"award-info":[{"award-number":["PR221810"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["DK128017"],"award-info":[{"award-number":["DK128017"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["DK118391"],"award-info":[{"award-number":["DK118391"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["DK129240"],"award-info":[{"award-number":["DK129240"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"crossref","award":["PR221810"],"award-info":[{"award-number":["PR221810"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Kidney360"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Key Points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Experimental autosomal dominant polycystic kidney disease is associated with longitudinal changes in the kidney micro-RNA and mRNA profiles.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Alterations in cellular transport, a feature of CKD, and a common biological process within polycystic kidney disease models and human autosomal dominant polycystic kidney disease, is present from early stages.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Early versus late micro-RNA expression changes in autosomal dominant polycystic kidney disease could be targeted for a more tailored therapeutic intervention in the disease.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the progressive development and enlargement of bilateral kidney cysts, which often leads to kidney failure. This study comprehensively characterized the expression profile of micro-RNAs (miRNAs) and their target genes in\n                      <jats:italic toggle=\"yes\">Pkd1<\/jats:italic>\n                      <jats:sup>RC\/RC<\/jats:sup>\n                      mice and further compared them with other murine models of polycystic kidney disease (PKD) and a model of CKD and individuals with ADPKD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Pkd1<\/jats:italic>\n                      <jats:sup>RC\/RC<\/jats:sup>\n                      and wild-type (WT) mice (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      =10 each, five males and five females) were studied at 1, 6, and 12 months. At each time point, kidney volume was determined\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      (magnetic resonance imaging), followed by\n                      <jats:italic toggle=\"yes\">ex vivo<\/jats:italic>\n                      histomorphometric analyses. In randomly selected\n                      <jats:italic toggle=\"yes\">Pkd1<\/jats:italic>\n                      <jats:sup>RC\/RC<\/jats:sup>\n                      and WT mouse kidneys (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      =5\/genotype, at 1 and 12 months), miRNA-sequencing (seq) was performed, followed by mRNA-seq, integrated (miRNA-seq\/mRNA-seq analysis), and functional analysis of miRNA target genes. Venn diagrams were constructed to identify overlapping and novel differentially expressed (DE) miRNAs in\n                      <jats:italic toggle=\"yes\">Pkd1<\/jats:italic>\n                      <jats:sup>RC\/RC<\/jats:sup>\n                      and other commonly used murine models of PKD, diabetic kidney disease, and individuals with ADPKD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      miRNA-seq analysis identified 41 and 181 miRNAs DE in\n                      <jats:italic toggle=\"yes\">Pkd1<\/jats:italic>\n                      <jats:sup>RC\/RC<\/jats:sup>\n                      versus WT kidneys at 1 and 12 months, respectively, which were confirmed by quantitative PCR. Target genes of miRNAs DE in\n                      <jats:italic toggle=\"yes\">Pkd1<\/jats:italic>\n                      <jats:sup>RC\/RC<\/jats:sup>\n                      at early stages encoded for proteins mainly implicated in cell proliferation and\n                      <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                      -ketoglutarate (\n                      <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                      -KG) transport, whereas those DE at late stages encoded for transport proteins involved in proinflammatory and metabolic processes. Urine\n                      <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                      -KG concentration (\n                      <jats:sup>1<\/jats:sup>\n                      H nuclear magnetic resonance spectroscopy), its fractional excretion, and tissue levels were higher in\n                      <jats:italic toggle=\"yes\">Pkd1<\/jats:italic>\n                      <jats:sup>RC\/RC<\/jats:sup>\n                      during the entire course of the disease and associated with decreased protein expression of\n                      <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                      -KG transporters sodium-coupled dicarboxylate transporter 3 and organic anion transporter 1. We further identified common DE miRNAs among murine models of PKD, diabetic kidney disease, and previous reports in individuals with ADPKD, as well as several novel miRNAs DE in early and late\n                      <jats:italic toggle=\"yes\">Pkd1<\/jats:italic>\n                      <jats:sup>RC\/RC<\/jats:sup>\n                      kidneys, which have not been previously reported in either other murine models of PKD or patients with ADPKD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our study demonstrates that the renal miRNA expression profile changes longitudinally with the progression of the disease and might suggest that the post-transcriptional regulation of\n                      <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                      -KG transport could represent a novel early feature of the disease.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.34067\/kid.0000001108","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T17:00:27Z","timestamp":1767373227000},"page":"1212-1226","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["The Renal Micro-RNA Expression Profile of Pkd1 RC\/RC Mice Changes Longitudinally with the Progression of the Disease"],"prefix":"10.34067","volume":"7","author":[{"given":"Nalin","family":"Sharma","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota"},{"name":"Mayo Translational PKD Center, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1514-2536","authenticated-orcid":false,"given":"Jamie","family":"Zheng","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota"},{"name":"Mayo Translational PKD Center, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1425-0002","authenticated-orcid":false,"given":"Yahya","family":"Alsawaf","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota"},{"name":"Mayo Translational PKD Center, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santu K.","family":"Singha","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota"},{"name":"Mayo Translational PKD Center, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2370-1714","authenticated-orcid":false,"given":"Xiaohong","family":"Xu","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota"},{"name":"Mayo Translational PKD Center, Mayo Clinic, Rochester, Minnesota"},{"name":"Department of Nephrology, The Affiliated Suqian First People's Hospital of Nanjing Medical University, Suqian, China"},{"name":"Department of Nephrology, Jiangsu Province Suqian Hospital, Suqian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota"},{"name":"Mayo Translational PKD Center, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7806-7238","authenticated-orcid":false,"given":"Ivan","family":"Vuckovic","sequence":"additional","affiliation":[{"name":"Metabolomics Core, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6054-5163","authenticated-orcid":false,"given":"Slobodan","family":"Macura","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9956-8696","authenticated-orcid":false,"given":"Christian","family":"Hanna","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota"},{"name":"Mayo Translational PKD Center, Mayo Clinic, Rochester, Minnesota"},{"name":"Division of Pediatric Nephrology and Hypertension, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3031-8522","authenticated-orcid":false,"given":"Marie C.","family":"Hogan","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota"},{"name":"Mayo Translational PKD Center, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3864-9644","authenticated-orcid":false,"given":"Alfonso","family":"Eirin","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9904-7778","authenticated-orcid":false,"given":"Maria V.","family":"Irazabal","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota"},{"name":"Mayo Translational PKD Center, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,1,2]]},"reference":[{"issue":"1","key":"B1-20260625","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ki.2015.59","article-title":"Autosomal-dominant polycystic kidney disease (ADPKD): executive summary from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference","volume":"88","author":"Chapman","year":"2015","journal-title":"Kidney 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