{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T20:30:16Z","timestamp":1786480216759,"version":"build-2736575974"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["RU5211"],"award-info":[{"award-number":["RU5211"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["RU5211"],"award-info":[{"award-number":["RU5211"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["RU5211"],"award-info":[{"award-number":["RU5211"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["RU5211"],"award-info":[{"award-number":["RU5211"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["RU5211"],"award-info":[{"award-number":["RU5211"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["RU5211"],"award-info":[{"award-number":["RU5211"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Kidney360"],"published-print":{"date-parts":[[2026,5]]},"abstract":"\n Key Points<\/jats:title>\n \n \n \n Kidney function (GFR) correlated with somatic symptom burden bivariately, but not in the multiple regression model.<\/jats:p>\n <\/jats:list-item>\n \n Female sex, coronary heart disease, self-reported general health, proneness to illness, and depressive symptoms correlated with symptom burden.<\/jats:p>\n <\/jats:list-item>\n \n Similar biopsychosocial correlates of symptom burden were observed in individuals with CKD, coronary heart disease, and controls.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Background<\/jats:title>\n Persistent somatic symptoms in individuals with CKD occur across all stages and affect patients' quality of life, morbidity, and mortality. We aimed to unravel associations between biopsychosocial factors and symptom burden in individuals with CKD.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This cross-sectional study analyzed individuals with CKD (eGFR <60 ml\/min per 1.73 m\n 2<\/jats:sup>\n ) from the first 10,000 participants of the population-based Hamburg City Health Study. Somatic symptom burden (Patient Health Questionnaire-15) was the primary outcome. Its association with potential biologic (\n e.g<\/jats:italic>\n ., eGFR), psychologic (\n e.g<\/jats:italic>\n ., depressive symptoms), and sociodemographic correlates was analyzed in a multivariate prediction model. Correlates were compared with healthy controls and individuals with coronary heart disease (CHD).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Somatic symptom burden in patients with non-dialysis CKD (\n n<\/jats:italic>\n =582, mean age: 69.58 years; 44.7% women; mean baseline eGFR: 52 ml\/min per 1.73 m\n 2<\/jats:sup>\n ) increased with lower eGFR (\n r<\/jats:italic>\n =\u22120.161,\n P<\/jats:italic>\n < 0.001). However, in a stepwise multiple linear regression model, eGFR was not correlated with symptom burden. By contrast, female sex, CHD, self-reported general health, proneness to illness, and depressive symptoms were associated with somatic symptom burden. Correlates of somatic symptom burden were compared with those in patients with CHD (\n n<\/jats:italic>\n =618, mean age: 67.13 years; 24.1% women; mean baseline eGFR: 81 ml\/min per 1.73 m\n 2<\/jats:sup>\n ) and matched healthy controls (\n n<\/jats:italic>\n =582, mean age: 69.58 years; 44.7% women; mean baseline eGFR: 81 ml\/min per 1.73 m\n 2<\/jats:sup>\n ). Self-reported general health and depression were associated with somatic symptom burden in all groups, while there were specific correlates in the CHD (\n e.g<\/jats:italic>\n ., age) and the healthy control group (\n e.g<\/jats:italic>\n ., expectancy of deterioration of health status).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Somatic symptom burden in CKD was only marginally related to the eGFR but rather to biopsychosocial factors. Therefore, taking a biopsychosocial perspective on persistent somatic symptom in CKD is important.<\/jats:p>\n <\/jats:sec>\n \n Clinical Trial registry name and registration number:<\/jats:title>\n Biopsychosocial correlates of somatic symptom burden in patients with CKD from the Hamburg City Health Study, 10.17605\/OSF.IO\/58S2R.<\/jats:p>\n <\/jats:sec>","DOI":"10.34067\/kid.0000001130","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T17:00:46Z","timestamp":1769792446000},"page":"1065-1075","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Biopsychosocial Correlates of Somatic Symptom Burden in CKD"],"prefix":"10.34067","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9174-3739","authenticated-orcid":false,"given":"Birte","family":"Jessen","sequence":"first","affiliation":[{"name":"Department of Psychology, Institute for Clinical Psychology and Psychotherapy, Medical School Hamburg, Hamburg, Germany"},{"name":"Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4220-3378","authenticated-orcid":false,"given":"Bernd","family":"L\u00f6we","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3814-6542","authenticated-orcid":false,"given":"Raphael","family":"Twerenbold","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Center of Cardiovascular Science, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Germany and German Center for Cardiovascular Research (DZHK), Partner Site Hamburg-Kiel-L\u00fcbeck, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7443-9890","authenticated-orcid":false,"given":"Martin","family":"H\u00e4rter","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology, Institute for Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4308-223X","authenticated-orcid":false,"given":"Volker","family":"Harth","sequence":"additional","affiliation":[{"name":"Institute for Occupational and Maritime Medicine (ZfAM), University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5416-0179","authenticated-orcid":false,"given":"Hanno","family":"Hoven","sequence":"additional","affiliation":[{"name":"Institute for Occupational and Maritime Medicine (ZfAM), University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7864-0361","authenticated-orcid":false,"given":"Christian","family":"Schmidt-Lauber","sequence":"additional","affiliation":[{"name":"III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"},{"name":"Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7175-5062","authenticated-orcid":false,"given":"Tobias B.","family":"Huber","sequence":"additional","affiliation":[{"name":"III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"},{"name":"Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2023-3824","authenticated-orcid":false,"given":"Meike","family":"Shedden-Mora","sequence":"additional","affiliation":[{"name":"Department of Psychology, Institute for Clinical Psychology and Psychotherapy, Medical School Hamburg, Hamburg, Germany"},{"name":"Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"issue":"1","key":"B1-20260601","doi-asserted-by":"crossref","first-page":"e057596","DOI":"10.1136\/bmjopen-2021-057596","article-title":"Persistent SOMAtic symptoms ACROSS diseases - from risk factors to modification: scientific framework and overarching protocol of the interdisciplinary SOMACROSS research unit (RU 5211)","volume":"12","author":"L\u00f6we","year":"2022","journal-title":"BMJ Open."},{"issue":"10444","key":"B2-20260601","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1016\/S0140-6736(24)00623-8","article-title":"Persistent physical symptoms: definition, genesis, and management","volume":"403","author":"L\u00f6we","year":"2024","journal-title":"Lancet."},{"key":"B3-20260601","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jpsychores.2016.12.017","article-title":"Frequency of somatic symptoms in the general population: normative values for the Patient Health Questionnaire-15 (PHQ-15)","volume":"96","author":"Hinz","year":"2017","journal-title":"J Psychosom Res."},{"issue":"11","key":"B4-20260601","doi-asserted-by":"crossref","first-page":"e067821","DOI":"10.1136\/bmjopen-2022-067821","article-title":"Predictors of somatic symptom persistence in patients with chronic kidney disease (SOMA.CK): study protocol for a mixed-methods cohort study","volume":"12","author":"Shedden-Mora","year":"2022","journal-title":"BMJ Open."},{"issue":"6","key":"B5-20260601","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1093\/ckj\/sfx057","article-title":"Symptom burden in patients with chronic kidney disease not requiring renal replacement therapy","volume":"10","author":"Brown","year":"2017","journal-title":"Clin Kidney J."},{"issue":"4","key":"B6-20260601","doi-asserted-by":"crossref","first-page":"e93069","DOI":"10.1371\/journal.pone.0093069","article-title":"Course of symptoms and health-related quality of life during specialized pre-dialysis care","volume":"9","author":"de Goeij","year":"2014","journal-title":"PLoS One."},{"issue":"6","key":"B7-20260601","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1053\/j.ajkd.2024.06.011","article-title":"Symptom burden and its impact on quality of life in patients with moderate to severe CKD: the international chronic kidney disease outcomes and practice patterns study (CKDopps)","volume":"84","author":"Speyer","year":"2024","journal-title":"Am J Kidney Dis."},{"issue":"4","key":"B8-20260601","doi-asserted-by":"crossref","first-page":"e1003954","DOI":"10.1371\/journal.pmed.1003954","article-title":"Symptom burden and health-related quality of life in chronic kidney disease: a global systematic review and meta-analysis","volume":"19","author":"Fletcher","year":"2022","journal-title":"PLoS Med."},{"issue":"1","key":"B9-20260601","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s12882-021-02355-5","article-title":"Differences in physical symptoms between those with and without kidney disease: a comparative study across disease stages in a UK population","volume":"22","author":"Wilkinson","year":"2021","journal-title":"BMC Nephrol."},{"issue":"15","key":"B10-20260601","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1001\/jamainternmed.2013.6835","article-title":"Somatic symptoms in patients with coronary heart disease: prevalence, risk factors, and quality of life","volume":"173","author":"Kohlmann","year":"2013","journal-title":"JAMA Intern Med."},{"issue":"3","key":"B11-20260601","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.jpainsymman.2018.12.006","article-title":"Comparison of fatigue, pain, and depression in patients with advanced kidney disease and cancer - symptom burden and clusters","volume":"57","author":"Jhamb","year":"2019","journal-title":"J Pain Symptom Manage."},{"issue":"1","key":"B12-20260601","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/s12882-021-02440-9","article-title":"Development of a preliminary conceptual model of the patient experience of chronic kidney disease: a targeted literature review and analysis","volume":"22","author":"Flythe","year":"2021","journal-title":"BMC Nephrol."},{"issue":"2","key":"B13-20260601","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jpsychores.2015.05.004","article-title":"Functional limitations in functional somatic syndromes and well-defined medical diseases. Results from the general population cohort LifeLines","volume":"79","author":"Joustra","year":"2015","journal-title":"J Psychosom Res."},{"issue":"1","key":"B14-20260601","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1159\/000484413","article-title":"Management of functional somatic syndromes and bodily distress","volume":"87","author":"Henningsen","year":"2018","journal-title":"Psychother Psychosom."},{"issue":"6","key":"B15-20260601","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.2215\/CJN.00430109","article-title":"Symptom burden, depression, and quality of life in chronic and end-stage kidney disease","volume":"4","author":"Abdel-Kader","year":"2009","journal-title":"Clin J Am Soc Nephrol."},{"key":"B16-20260601","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.jad.2022.05.104","article-title":"Bidirectional relations between depression symptoms and chronic kidney disease","volume":"311","author":"Liu","year":"2022","journal-title":"J Affect Disord."},{"issue":"1","key":"B17-20260601","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1186\/s12888-023-05249-y","article-title":"Depression among patients with chronic kidney disease, associated factors, and predictors: a cross-sectional study","volume":"23","author":"Bahall","year":"2023","journal-title":"BMC Psychiatry."},{"issue":"2","key":"B18-20260601","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1016\/j.amepre.2020.04.005","article-title":"Adverse childhood experiences and decreased renal function: impact on all-cause mortality in U.S. adults","volume":"59","author":"Ozieh","year":"2020","journal-title":"Am J Prev Med."},{"issue":"3","key":"B19-20260601","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1093\/ckj\/sfw014","article-title":"Patient's perceptions of chronic kidney disease and their association with psychosocial and clinical outcomes: a narrative review","volume":"9","author":"Clarke","year":"2016","journal-title":"Clin Kidney J."},{"issue":"8","key":"B20-20260601","doi-asserted-by":"crossref","first-page":"e356","DOI":"10.1016\/S2468-2667(17)30118-4","article-title":"The effect of multiple adverse childhood experiences on health: a systematic review and meta-analysis","volume":"2","author":"Hughes","year":"2017","journal-title":"Lancet Public Health."},{"issue":"3","key":"B21-20260601","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S2352-4642(21)00339-4","article-title":"Childhood maltreatment and its role in the development of pain and psychopathology","volume":"6","author":"Cay","year":"2022","journal-title":"Lancet Child Adolesc Health."},{"key":"B22-20260601","doi-asserted-by":"crossref","first-page":"116510","DOI":"10.1016\/j.socscimed.2023.116510","article-title":"Self-reported childhood adversity, unhealthy lifestyle and risk of new-onset chronic kidney disease in later life: a prospective cohort study","volume":"341","author":"Zhang","year":"2024","journal-title":"Soc Sci Med."},{"issue":"3","key":"B23-20260601","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/nrneph.2016.187","article-title":"Physical inactivity: a risk factor and target for intervention in renal care","volume":"13","author":"Zelle","year":"2017","journal-title":"Nat Rev Nephrol."},{"issue":"1","key":"B24-20260601","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12882-022-02679-w","article-title":"Patient activation and its association with symptom burden and quality of life across the spectrum of chronic kidney disease stages in England","volume":"23","author":"Magadi","year":"2022","journal-title":"BMC Nephrol."},{"issue":"6","key":"B25-20260601","doi-asserted-by":"crossref","first-page":"e070360","DOI":"10.1136\/bmjopen-2022-070360","article-title":"Assessing physical inactivity as a risk factor for chronic kidney diseases in Iranian population","volume":"13","author":"Moeinzadeh","year":"2023","journal-title":"BMJ Open."},{"issue":"5","key":"B26-20260601","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1097\/PSY.0000000000000588","article-title":"Persistent physical symptoms as perceptual dysregulation: a neuropsychobehavioral model and its clinical implications","volume":"80","author":"Henningsen","year":"2018","journal-title":"Psychosom Med."},{"issue":"6","key":"B27-20260601","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1053\/j.ajkd.2024.07.005","article-title":"Why symptom burden in non-dialysis CKD matters","volume":"84","author":"Shedden-Mora","year":"2024","journal-title":"Am J Kidney Dis."},{"issue":"2","key":"B28-20260601","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s10654-019-00577-4","article-title":"Rationale and design of the Hamburg city health study","volume":"35","author":"Jagodzinski","year":"2020","journal-title":"Eur J Epidemiol."},{"issue":"4","key":"B29-20260601","doi-asserted-by":"crossref","first-page":"S117","DOI":"10.1016\/j.kint.2023.10.018","article-title":"KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease","volume":"105","year":"2024","journal-title":"Kidney Int."},{"issue":"4","key":"B30-20260601","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1053\/j.ajkd.2010.02.337","article-title":"Estimating GFR using the CKD Epidemiology Collaboration (CKD-EPI) creatinine equation: more accurate GFR estimates, lower CKD prevalence estimates, and better risk predictions","volume":"55","author":"Levey","year":"2010","journal-title":"Am J Kidney Dis."},{"issue":"9","key":"B31-20260601","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1093\/ndt\/gfad008","article-title":"Kidney outcome after mild to moderate COVID-19","volume":"38","author":"Schmidt-Lauber","year":"2023","journal-title":"Nephrol Dial Transplant."},{"issue":"2","key":"B32-20260601","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1097\/00006842-200203000-00008","article-title":"The PHQ-15: validity of a new measure for evaluation the severity of somatic symptoms","volume":"64","author":"Kroenke","year":"2002","journal-title":"Psychosom Med."},{"issue":"6","key":"B33-20260601","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.jpsychores.2013.03.093","article-title":"How to assess common somatic symptoms in large-scale studies: a systematic review of questionnaires","volume":"74","author":"Zijlema","year":"2013","journal-title":"J Psychosom Res."},{"issue":"3","key":"B34-20260601","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s11136-020-02688-y","article-title":"Psychometric properties of the EQ-5D-5L: a systematic review of the literature","volume":"30","author":"Feng","year":"2021","journal-title":"Qual Life Res."},{"issue":"11","key":"B36-20260601","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1093\/eurheartj\/ehab914","article-title":"Multi-organ assessment in mainly non-hospitalized individuals after SARS-CoV-2 infection: the Hamburg city health study COVID programme","volume":"43","author":"Petersen","year":"2022","journal-title":"Eur Heart J."},{"key":"B37-20260601","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1186\/1471-2458-12-730","article-title":"German health interview and examination survey for adults (DEGS) - design, objectives and implementation of the first data collection wave","volume":"12","author":"Scheidt-Nave","year":"2012","journal-title":"BMC Public Health."},{"issue":"1","key":"B38-20260601","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1093\/ije\/31.1.168","article-title":"Dity and repeatability of the EPIC-norfolk physical activity questionnaire","volume":"31","author":"Wareham","year":"2002","journal-title":"Int J Epidemiol."},{"issue":"5","key":"B39-20260601","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.genhosppsych.2013.04.006","article-title":"Standardization of the depression screener patient health questionnaire (PHQ-9) in the general population","volume":"35","author":"Kocalevent","year":"2013","journal-title":"Gen Hosp Psychiatry."},{"issue":"8","key":"B40-20260601","doi-asserted-by":"crossref","first-page":"e0182162","DOI":"10.1371\/journal.pone.0182162","article-title":"Psychometric analysis of the generalized anxiety disorder scale (GAD-7) in primary care using modern item response theory","volume":"12","author":"Jordan","year":"2017","journal-title":"PLoS One."},{"issue":"3","key":"B41-20260601","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.paed.2017.12.008","article-title":"Adverse childhood experiences","volume":"28","author":"Boullier","year":"2018","journal-title":"Paediatrics Child Health."},{"key":"B42-20260601","doi-asserted-by":"crossref","first-page":"112968","DOI":"10.1016\/j.socscimed.2020.112968","article-title":"Gender and sex independently associate with common somatic symptoms and lifetime prevalence of chronic disease","volume":"253","author":"Ballering","year":"2020","journal-title":"Soc Sci Med."},{"issue":"11","key":"B43-20260601","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1017\/S0033291720004043","article-title":"Female sex and femininity independently associate with common somatic symptom trajectories","volume":"52","author":"Ballering","year":"2022","journal-title":"Psychol Med."},{"issue":"1","key":"B44-20260601","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00467-006-0359-0","article-title":"Cardiovascular complications of pediatric chronic kidney disease","volume":"23","author":"Mitsnefes","year":"2008","journal-title":"Pediatr Nephrol."},{"issue":"3","key":"B45-20260601","first-page":"335","article-title":"Quality of life, depression and anxiety in children and adolescents with CKD and their primary caregivers","volume":"45","author":"Elorza","year":"2023","journal-title":"J Bras Nefrol."},{"issue":"1","key":"B46-20260601","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1186\/s12888-023-05312-8","article-title":"The impact of anxiety and depression on the quality of life of hemodialysis patients in a sample from Somalia","volume":"23","author":"Mohamed","year":"2023","journal-title":"BMC Psychiatry."},{"issue":"4","key":"B47-20260601","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/jorc.12208","article-title":"Symptom experience in non-dialysis-dependent chronic kidney disease: a qualitative descriptive study","volume":"43","author":"Pugh-Clarke","year":"2017","journal-title":"J Ren Care."},{"issue":"S7","key":"B48-20260601","doi-asserted-by":"crossref","first-page":"S54","DOI":"10.5694\/j.1326-5377.2009.tb02471.x","article-title":"Depression, anxiety and their relationship with chronic diseases: a review of the epidemiology, risk and treatment evidence","volume":"190","author":"Clarke","year":"2009","journal-title":"Med J Aust."},{"issue":"2","key":"B49-20260601","first-page":"202","article-title":"Validation of the kidney disease quality of life short form 36 (KDQOL-36\u2122) US Spanish and English versions in a cohort of Hispanics with chronic kidney disease","volume":"23","author":"Ricardo","year":"2013","journal-title":"Ethn Dis."},{"issue":"6","key":"B50-20260601","doi-asserted-by":"crossref","first-page":"e0179733","DOI":"10.1371\/journal.pone.0179733","article-title":"Measurement properties of patient-reported outcome measures (PROMs) used in adult patients with chronic kidney disease: a systematic review","volume":"12","author":"Aiyegbusi","year":"2017","journal-title":"PLoS One."}],"container-title":["Kidney360"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.34067\/KID.0000001130","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T19:57:47Z","timestamp":1786478267000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.34067\/KID.0000001130"}},"subtitle":["Results of the Hamburg City Health Study"],"short-title":[],"issued":{"date-parts":[[2026,1,30]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.34067\/kid.0000001130","relation":{},"ISSN":["2641-7650"],"issn-type":[{"value":"2641-7650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,30]]},"assertion":[{"value":"2025-09-17","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-13","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}