{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:02:40Z","timestamp":1790103760672,"version":"4.0.1"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007349","name":"Secretaria Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"crossref","award":["1"],"award-info":[{"award-number":["1"]}],"id":[{"id":"10.13039\/501100007349","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007349","name":"Secretaria Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"crossref","award":["1"],"award-info":[{"award-number":["1"]}],"id":[{"id":"10.13039\/501100007349","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Kidney360"],"published-print":{"date-parts":[[2026,7]]},"abstract":"\n Key Points<\/jats:title>\n \n \n \n Iron deficiency is common in patients with AKI.<\/jats:p>\n <\/jats:list-item>\n \n It is unknown whether treating iron deficiency in AKI with intravenous iron reduces the risk of major adverse kidney events.<\/jats:p>\n <\/jats:list-item>\n \n In AKI and iron deficiency, intravenous iron did not reduce the risk of major adverse kidney events at 90 days.<\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>\n \n Background<\/jats:title>\n During AKI, iron deficiency may contribute to worse clinical outcome by interfering cellular repair. Correcting iron deficiency with intravenous (IV) dextran iron may reduce the risk of major adverse kidney events (MAKEs). We aimed to assess whether IV iron was more efficacious than conventional management for reducing MAKE in patients with AKI\u2013iron deficiency.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In a phase 2 randomized controlled trial, from July 2022 to September 2024, patients with AKI and iron deficiency (iron levels <13\n \u03bc<\/jats:italic>\n mol\/L or a transferrin saturation <20%) were eligible. We randomly assigned 120 patients to the control (\n N<\/jats:italic>\n =62) and intervention groups (single 1200 mg IV dextran iron infusion;\n N<\/jats:italic>\n =58). Primary outcome was the risk of MAKE at 90 days (MAKE90). MAKE were defined as death, KRT, or worsening kidney function. Each component of MAKE and hemoglobin were secondary outcomes.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The primary outcome MAKE90 occurred in 48 patients in the IV iron group and 47 in the control group (82% versus 75%;\n P<\/jats:italic>\n = 0.37). Individual components of MAKE were similar in both groups, 36 (62.1%) versus 38 (61.3%) had worsened kidney function, 14 (24.1%) versus 13 (21%) initiated KRT, and mortality was 43.1% and 38.7% in the IV iron and control groups, respectively (\n P<\/jats:italic>\n \u2265 0.05 for all). Hemoglobin values and adverse events did not differ between groups during the study.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n In patients with AKI and iron deficiency, a single dose of IV iron, compared with usual care, did not improve clinical outcomes evaluated by MAKE90, the hemoglobin value, but was safe.<\/jats:p>\n <\/jats:sec>\n \n Clinical Trial registry name and registration number:<\/jats:title>\n ClinicalTrials.gov, ID: NCT05960227 registered September 19, 2022, Institutional Review Board approval 159\/22.<\/jats:p>\n <\/jats:sec>","DOI":"10.34067\/kid.0000001136","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T17:00:43Z","timestamp":1769533243000},"page":"1545-1555","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Intravenous Iron Dextran on Kidney Outcomes in Acute Kidney Injury with Iron Deficiency"],"prefix":"10.34067","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2786-6667","authenticated-orcid":false,"given":"Jonathan S.","family":"Ch\u00e1vez-I\u00f1iguez","sequence":"first","affiliation":[{"name":"Nephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico"},{"name":"University of Guadalajara Health Sciences Center, Guadalajara, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8914-4171","authenticated-orcid":false,"given":"Miguel","family":"Ibarra-Estrada","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2684-7034","authenticated-orcid":false,"given":"Edgar Joel","family":"Carmona-Morales","sequence":"additional","affiliation":[{"name":"Nephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico"},{"name":"University of Guadalajara Health Sciences Center, Guadalajara, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Ron-Maga\u00f1a","sequence":"additional","affiliation":[{"name":"Hematology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8163-3779","authenticated-orcid":false,"given":"Rolando","family":"Claure-Del Granado","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Hospital Obrero No 2 \u2013 Caja Nacional de Salud, Cochabamba, Bolivia"},{"name":"IIBISMED, Facultad de Medicina, Universidad Mayor de San Sim\u00f3n, Cochabamba, Bolivia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9670-1095","authenticated-orcid":false,"given":"Juan Carlos","family":"Velez","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Ochsner Health, New Orleans, Louisiana"},{"name":"Ochsner Clinical School, The University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2612-2615","authenticated-orcid":false,"given":"Gael","family":"Ch\u00e1vez-Alonso","sequence":"additional","affiliation":[{"name":"University of Guadalajara Health Sciences Center, Guadalajara, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9995-0134","authenticated-orcid":false,"given":"Carlos E.","family":"Orozco-Chan","sequence":"additional","affiliation":[{"name":"University of Guadalajara Health Sciences Center, Guadalajara, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estefania","family":"Villalvazo-Maciel","sequence":"additional","affiliation":[{"name":"University of Guadalajara Health Sciences Center, Guadalajara, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania M.","family":"Anaya-Arce","sequence":"additional","affiliation":[{"name":"University of Guadalajara Health Sciences Center, Guadalajara, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9814-5571","authenticated-orcid":false,"given":"Gonz\u00e1lo","family":"Rodr\u00edguez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Nephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0207-7135","authenticated-orcid":false,"given":"Guillermo","family":"Navarro-Blackaller","sequence":"additional","affiliation":[{"name":"Nephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico"},{"name":"University of Guadalajara Health Sciences Center, Guadalajara, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7094-6964","authenticated-orcid":false,"given":"Ram\u00f3n","family":"Medina-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Nephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0960-4447","authenticated-orcid":false,"given":"Alejandro Mart\u00ednez","family":"Gallardo-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Nephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6869-2387","authenticated-orcid":false,"given":"Luz","family":"Alcantar-Vallin","sequence":"additional","affiliation":[{"name":"Nephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico"},{"name":"University of Guadalajara Health Sciences Center, Guadalajara, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4079-6026","authenticated-orcid":false,"given":"Juan A.","family":"G\u00f3mez-Fregoso","sequence":"additional","affiliation":[{"name":"Nephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico"},{"name":"University of Guadalajara Health Sciences Center, Guadalajara, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6067-7799","authenticated-orcid":false,"given":"Gabriela J.","family":"Abundis-Mora","sequence":"additional","affiliation":[{"name":"Nephrology Service, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0558-0035","authenticated-orcid":false,"given":"Guillermo","family":"Garc\u00eda-Garc\u00eda","sequence":"additional","affiliation":[{"name":"University of Guadalajara Health Sciences Center, Guadalajara, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"issue":"4","key":"B1-20260731","doi-asserted-by":"crossref","first-page":"737","DOI":"10.34067\/KID.0006592021","article-title":"Global perspectives in acute kidney injury: Mexico","volume":"3","author":"Ch\u00e1vez-\u00cd\u00f1iguez","year":"2022","journal-title":"Kidney360."},{"issue":"1","key":"B2-20260731","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1186\/s12882-020-01974-8","article-title":"Rates, predictors, and mortality of sepsis-associated acute kidney injury: a systematic review and meta-analysis","volume":"21","author":"Liu","year":"2020","journal-title":"BMC Nephrol."},{"issue":"5","key":"B3-20260731","doi-asserted-by":"crossref","first-page":"717","DOI":"10.2215\/CJN.14181021","article-title":"Overview of diagnostic criteria and epidemiology of acute kidney injury and acute kidney disease in the critically ill patient","volume":"17","author":"Birkelo","year":"2022","journal-title":"Clin J Am Soc Nephrol."},{"issue":"9","key":"B4-20260731","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1007\/s00134-024-07560-y","article-title":"Recommendations for clinical trial design in acute kidney injury from the 31st acute disease quality initiative consensus conference. A consensus statement","volume":"50","author":"Zarbock","year":"2024","journal-title":"Intensive Care Med."},{"issue":"2","key":"B5-20260731","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1053\/j.ajkd.2021.11.010","article-title":"Antifibrotic agents for the management of CKD: a review","volume":"80","author":"Ruiz-Ortega","year":"2022","journal-title":"Am J Kidney Dis."},{"issue":"11","key":"B6-20260731","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1093\/ckj\/sfad107","article-title":"Update on persistent acute kidney injury in critical illnesses","volume":"16","author":"Samoni","year":"2023","journal-title":"Clin Kidney J."},{"issue":"12","key":"B7-20260731","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.2215\/CJN.05920613","article-title":"Distal convoluted tubule","volume":"9","author":"Subramanya","year":"2014","journal-title":"Clin J Am Soc Nephrol."},{"issue":"10","key":"B8-20260731","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nrneph.2017.107","article-title":"Mitochondrial energetics in the kidney","volume":"13","author":"Bhargava","year":"2017","journal-title":"Nat Rev Nephrol."},{"issue":"6","key":"B9-20260731","doi-asserted-by":"crossref","first-page":"F589","DOI":"10.1152\/ajprenal.00372.2021","article-title":"Mitochondria as mediators of systemic inflammation and organ cross talk in acute kidney injury","volume":"322","author":"Hepokoski","year":"2022","journal-title":"Am J Physiol Renal Physiol."},{"issue":"1","key":"B10-20260731","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3390\/jcm11010125","article-title":"Iron deficiency in heart failure: mechanisms and pathophysiology","volume":"11","author":"Alnuwaysir","year":"2021","journal-title":"J Clin Med."},{"issue":"4","key":"B11-20260731","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1073\/pnas.261708798","article-title":"Iron deficiency and iron excess damage mitochondria and mitochondrial DNA in rats","volume":"99","author":"Walter","year":"2002","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"1","key":"B12-20260731","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/cvr\/cvz029","article-title":"Perinatal iron deficiency and a high salt diet cause long-term kidney mitochondrial dysfunction and oxidative stress","volume":"116","author":"Woodman","year":"2020","journal-title":"Cardiovasc Res."},{"issue":"1","key":"B13-20260731","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/cc11454","article-title":"Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (part 1)","volume":"17","author":"Kellum","year":"2013","journal-title":"Crit Care."},{"issue":"2","key":"B14-20260731","doi-asserted-by":"crossref","first-page":"e004519","DOI":"10.1161\/CIRCHEARTFAILURE.117.004519","article-title":"Definition of iron deficiency based on The Gold standard of bone marrow iron staining in heart failure patients","volume":"11","author":"Grote Beverborg","year":"2018","journal-title":"Circ Heart Fail."},{"issue":"1-4","key":"B15-20260731","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1159\/000363725","article-title":"Clinical trial endpoints in acute kidney injury","volume":"127","author":"Billings","year":"2014","journal-title":"Nephron Clin Pract."},{"issue":"1","key":"B16-20260731","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/ejhf.823","article-title":"Effects of ferric carboxymaltose on hospitalisations and mortality rates in iron-deficient heart failure patients: an individual patient data meta-analysis","volume":"20","author":"Anker","year":"2018","journal-title":"Eur J Heart Fail."},{"issue":"31","key":"B17-20260731","first-page":"1","article-title":"Renal replacement therapy for acute kidney injury","volume":"2","author":"Negi","year":"2016","journal-title":"Ren Replace Ther."},{"issue":"6","key":"B18-20260731","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1681\/ASN.2014090922","article-title":"Considerations and challenges in defining optimal iron utilization in hemodialysis","volume":"26","author":"Charytan","year":"2015","journal-title":"J Am Soc Nephrol."},{"issue":"8","key":"B19-20260731","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.2215\/CJN.01180119","article-title":"IDEAL-ICU in context","volume":"14","author":"Leaf","year":"2019","journal-title":"Clin J Am Soc Nephrol."},{"key":"B20-20260731","doi-asserted-by":"crossref","first-page":"c332","DOI":"10.1136\/bmj.c332","article-title":"CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials","volume":"340","author":"Schulz","year":"2010","journal-title":"BMJ."},{"issue":"1","key":"B21-20260731","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1186\/s13054-016-1486-z","article-title":"Iron supplementation to treat anaemia in adult critical care patients: a systematic review and meta-analysis","volume":"20","author":"Shah","year":"2016","journal-title":"Crit Care."},{"issue":"2","key":"B22-20260731","doi-asserted-by":"crossref","first-page":"F426","DOI":"10.1152\/ajprenal.00248.2010","article-title":"Parenteral iron formulations differentially affect MCP-1, HO-1, and NGAL gene expression and renal responses to injury","volume":"299","author":"Johnson","year":"2010","journal-title":"Am J Physiol Renal Physiol."},{"issue":"8","key":"B23-20260731","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1002\/ajh.27352","article-title":"High prevalence of iron deficiency and socioeconomic disparities in laboratory screening of non-pregnant females of reproductive age: a retrospective cohort study","volume":"99","author":"Wen","year":"2024","journal-title":"Am J Hematol."},{"issue":"1","key":"B24-20260731","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/ndt\/gfz192","article-title":"Prevalence, correlates and outcomes of absolute and functional iron deficiency anemia in nondialysis-dependent chronic kidney disease","volume":"36","author":"Awan","year":"2021","journal-title":"Nephrol Dial Transplant."},{"issue":"1","key":"B25-20260731","doi-asserted-by":"crossref","first-page":"e159235","DOI":"10.1172\/jci.insight.159235","article-title":"Iron therapy mitigates chronic kidney disease progression by regulating intracellular iron status of kidney macrophages","volume":"8","author":"Patino","year":"2023","journal-title":"JCI Insight."},{"key":"B26-20260731","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.freeradbiomed.2021.07.025","article-title":"Iron deficiency exacerbates cisplatin- or rhabdomyolysis-induced acute kidney injury through promoting iron-catalyzed oxidative damage","volume":"173","author":"Zhao","year":"2021","journal-title":"Free Radic Biol Med."},{"issue":"19","key":"B27-20260731","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1016\/j.jacc.2018.03.448","article-title":"High-dose ferric carboxymaltose in patients with HFrEF induces significant hypophosphatemia","volume":"71","author":"St\u00f6hr","year":"2018","journal-title":"J Am Coll Cardiol."},{"issue":"17","key":"B28-20260731","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1016\/j.jacc.2007.07.029","article-title":"Intravenous iron reduces NT-pro-brain natriuretic peptide in anemic patients with chronic heart failure and renal insufficiency","volume":"50","author":"Toblli","year":"2007","journal-title":"J Am Coll Cardiol."},{"issue":"3","key":"B29-20260731","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/ejhf.229","article-title":"The impact of intravenous ferric carboxymaltose on renal function: an analysis of the FAIR-HF study","volume":"17","author":"Ponikowski","year":"2015","journal-title":"Eur J Heart Fail."},{"issue":"5","key":"B30-20260731","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1681\/ASN.2019090972","article-title":"Intravenous iron dosing and infection risk in patients on hemodialysis: a prespecified secondary analysis of the PIVOTAL trial","volume":"31","author":"Macdougall","year":"2020","journal-title":"J Am Soc Nephrol."},{"key":"B31-20260731","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.amjcard.2021.04.042","article-title":"Safety and efficacy of intravenous ferric derisomaltose compared to iron sucrose for iron deficiency anemia in patients with chronic kidney disease with and without heart failure","volume":"152","author":"Ambrosy","year":"2021","journal-title":"Am J Cardiol."},{"issue":"4","key":"B32-20260731","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1016\/j.ijcard.2013.04.181","article-title":"IRON-HF study: a randomized trial to assess the effects of iron in heart failure patients with anemia","volume":"168","author":"Beck-da-Silva","year":"2013","journal-title":"Int J Cardiol."},{"issue":"1","key":"B33-20260731","doi-asserted-by":"crossref","first-page":"11072","DOI":"10.1038\/s41598-018-29353-2","article-title":"High serum iron level is associated with increased mortality in patients with sepsis","volume":"8","author":"Lan","year":"2018","journal-title":"Sci Rep."},{"issue":"11","key":"B34-20260731","doi-asserted-by":"crossref","first-page":"e2133935","DOI":"10.1001\/jamanetworkopen.2021.33935","article-title":"Risk of infection associated with administration of intravenous iron: a systematic review and meta-analysis","volume":"4","author":"Shah","year":"2021","journal-title":"JAMA Netw Open."},{"issue":"12","key":"B35-20260731","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1159\/000508857","article-title":"Iron homeostasis and ferritin in sepsis-associated kidney injury","volume":"144","author":"McCullough","year":"2020","journal-title":"Nephron."},{"issue":"10","key":"B36-20260731","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.2215\/CJN.01090115","article-title":"Receipt of intravenous iron and clinical outcomes among hemodialysis patients hospitalized for infection","volume":"10","author":"Ishida","year":"2015","journal-title":"Clin J Am Soc Nephrol."},{"issue":"11","key":"B37-20260731","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1136\/gutjnl-2021-325210","article-title":"British Society of Gastroenterology guidelines for the management of iron deficiency anaemia in adults","volume":"70","author":"Snook","year":"2021","journal-title":"Gut."},{"issue":"6","key":"B38-20260731","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.kint.2022.07.024","article-title":"Hemopexin accumulates in kidneys and worsens acute kidney injury by causing hemoglobin deposition and exacerbation of iron toxicity in proximal tubules","volume":"102","author":"Fan","year":"2022","journal-title":"Kidney Int."},{"issue":"16","key":"B39-20260731","doi-asserted-by":"crossref","first-page":"12928","DOI":"10.3390\/ijms241612928","article-title":"Iron load toxicity in medicine: from molecular and cellular aspects to clinical implications","volume":"24","author":"Kontoghiorghes","year":"2023","journal-title":"Int J Mol Sci."},{"issue":"1","key":"B40-20260731","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1523-1755.2004.00716.x","article-title":"Parenteral iron nephrotoxicity: potential mechanisms and consequences","volume":"66","author":"Zager","year":"2004","journal-title":"Kidney Int."},{"issue":"2","key":"B41-20260731","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3747\/pdi.2018.00125","article-title":"Safety of intravenous iron - cosmofer and monofer therapy in peritoneal dialysis and non-dialysis-dependent chronic kidney disease patients","volume":"39","author":"Sivakumar","year":"2019","journal-title":"Perit Dial Int."},{"issue":"4","key":"B42-20260731","doi-asserted-by":"crossref","first-page":"e342","DOI":"10.1016\/S2352-3026(19)30264-9","article-title":"Intravenous iron: a framework for changing the management of iron deficiency","volume":"7","author":"Auerbach","year":"2020","journal-title":"Lancet Haematol."}],"container-title":["Kidney360"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.34067\/KID.0000001136","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T19:56:27Z","timestamp":1786478187000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.34067\/KID.0000001136"}},"subtitle":["A Randomized Trial"],"short-title":[],"issued":{"date-parts":[[2026,1,27]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.34067\/kid.0000001136","relation":{},"ISSN":["2641-7650"],"issn-type":[{"value":"2641-7650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,27]]},"assertion":[{"value":"2025-11-05","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-21","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}