{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T20:30:21Z","timestamp":1786480221589,"version":"build-2736575974"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Kidney360"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Urolithiasis, a recurrent and increasingly prevalent disease worldwide, has a complex pathophysiology that hinders a comprehensive understanding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We performed a cross-species integrative analysis combining multi-omics profiling of kidneys from a hyperoxaluric mouse model and summary statistics from a large-scale human genome-wide association study (GWAS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In the multi-omics analysis of kidneys from a hyperoxaluric mouse model using RNA-seq, whole-cell proteomics, and phosphoproteomics, we identified 1,173 genes, 342 proteins, and 516 phosphorylated peptides that were differentially expressed compared with control mice. We utilized publicly available large-scale meta-GWAS summary statistics of urolithiasis from BioBank Japan, UK Biobank, and FinnGen (n = 198,769) and prioritized genes using gene enrichment analysis. Through cross-species integration of mouse and human omics, we identified 46 molecules potentially relevant to urolithiasis, hereafter referred to as cross-species urolithiasis-related molecules. We examined the expression and genetic associations of these 46 molecules in human urolithiasis. Among these,\n                      <jats:italic toggle=\"yes\">CRYAB<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">SHROOM3<\/jats:italic>\n                      showed differential expression in human renal papilla tissues with and without stones. Colocalization analysis between urolithiasis GWAS and expression quantitative trait loci (eQTL) data of human renal tubules and glomeruli suggested shared signals at the\n                      <jats:italic toggle=\"yes\">GLUD1<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">UMOD<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">SLC34A1<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">TCEA3<\/jats:italic>\n                      , and\n                      <jats:italic toggle=\"yes\">H1-0<\/jats:italic>\n                      regions. Mendelian randomization analysis using the same renal eQTL datasets further supported these findings, with\n                      <jats:italic toggle=\"yes\">GLUD1<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">UMOD<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">TCEA3<\/jats:italic>\n                      , and\n                      <jats:italic toggle=\"yes\">H1-0<\/jats:italic>\n                      showing statistically significant associations, suggesting a strong genetic link with urolithiasis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The study's findings highlight a set of cross-species urolithiasis-related molecules, supported by both expression and genetic evidence, offering insights for future functional validation and mechanistic investigations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.34067\/kid.0000001211","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T16:02:30Z","timestamp":1781193750000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Cross-Species Comparison between Mouse Kidney Multi-Omics and Human Genome-Wide Association Studies Highlights Molecular Features Associated with Oxalate Nephropathy"],"prefix":"10.34067","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9351-8305","authenticated-orcid":false,"given":"Ryosuke","family":"Chaya","sequence":"first","affiliation":[{"name":"Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601 Japan."},{"name":"Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3092-5114","authenticated-orcid":false,"given":"Kazumi","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Alabama at Birmingham, Birmingham, Alabama, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1380-7597","authenticated-orcid":false,"given":"Yutaka","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuya","family":"Shirai","sequence":"additional","affiliation":[{"name":"Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan."},{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita 565-0871, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5009-6408","authenticated-orcid":false,"given":"Ryuya","family":"Edahiro","sequence":"additional","affiliation":[{"name":"Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan."},{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita 565-0871, Japan."},{"name":"Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Tsurumi 230-0045, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1517-6259","authenticated-orcid":false,"given":"Noah","family":"Sasa","sequence":"additional","affiliation":[{"name":"Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan."},{"name":"Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Tsurumi 230-0045, Japan."},{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Osaka University Graduate School of Medicine, Suita 565-0871, Japan."},{"name":"Department of Genome Informatics, Graduate School of Medicine, the University of Tokyo, Tokyo 113-8654, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9594-7050","authenticated-orcid":false,"given":"Kenichi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan."},{"name":"Laboratory of Children's health and Genetics, Division of Health Sciences, Osaka University Graduate School of Medicine, Suite 565-0871, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1661-0941","authenticated-orcid":false,"given":"Yoshihiro","family":"Tomofuji","sequence":"additional","affiliation":[{"name":"Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan."},{"name":"Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Tsurumi 230-0045, Japan."},{"name":"Department of Genome Informatics, Graduate School of Medicine, the University of Tokyo, Tokyo 113-8654, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7486-3146","authenticated-orcid":false,"given":"Shinichi","family":"Namba","sequence":"additional","affiliation":[{"name":"Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan."},{"name":"Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Tsurumi 230-0045, Japan."},{"name":"Department of Genome Informatics, Graduate School of Medicine, the University of Tokyo, Tokyo 113-8654, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4536-1761","authenticated-orcid":false,"given":"Kyuto","family":"Sonehara","sequence":"additional","affiliation":[{"name":"Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan."},{"name":"Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Tsurumi 230-0045, Japan."},{"name":"Department of Genome Informatics, Graduate School of Medicine, the University of Tokyo, Tokyo 113-8654, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0584-3712","authenticated-orcid":false,"given":"Rei","family":"Unno","sequence":"additional","affiliation":[{"name":"Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601 Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9968-7468","authenticated-orcid":false,"given":"Shuzo","family":"Hamamoto","sequence":"additional","affiliation":[{"name":"Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601 Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2080-3794","authenticated-orcid":false,"given":"Atsushi","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601 Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0838-6767","authenticated-orcid":false,"given":"John","family":"Muroski","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Princeton University, Lewis Thomas Laboratory, Washington Road, Princeton, New Jersey, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2206-7279","authenticated-orcid":false,"given":"Yoichi","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6533-2458","authenticated-orcid":false,"given":"Ileana M.","family":"Cristea","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Princeton University, Lewis Thomas Laboratory, Washington Road, Princeton, New Jersey, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukinori","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan."},{"name":"Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Tsurumi 230-0045, Japan."},{"name":"Department of Genome Informatics, Graduate School of Medicine, the University of Tokyo, Tokyo 113-8654, Japan."},{"name":"Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita 565-0871, Japan."},{"name":"Premium Research Institute for Human Metaverse Medicine (WPI-PRIMe), Osaka University, Suita 565-0871, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2197-2477","authenticated-orcid":false,"given":"Takahiro","family":"Yasui","sequence":"additional","affiliation":[{"name":"Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601 Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,6,11]]},"container-title":["Kidney360"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.34067\/KID.0000001211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T19:58:35Z","timestamp":1786478315000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.34067\/KID.0000001211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.34067\/kid.0000001211","relation":{},"ISSN":["2641-7650"],"issn-type":[{"value":"2641-7650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,11]]},"assertion":[{"value":"2025-06-28","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-29","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}