{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T14:35:20Z","timestamp":1793284520422,"version":"4.5.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Leverhulme Trust","award":["RPG-2022-299"],"award-info":[{"award-number":["RPG-2022-299"]}],"id":[{"id":"https:\/\/ror.org\/012mzw131","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Wellcome Trust","award":["102532\/Z\/12\/Z, 102531\/Z\/13\/A"],"award-info":[{"award-number":["102532\/Z\/12\/Z, 102531\/Z\/13\/A"]}],"id":[{"id":"https:\/\/ror.org\/029chgv08","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Deutsche Forschungsgemeinschaft","award":["EXC 2030 -390661388"],"award-info":[{"award-number":["EXC 2030 -390661388"]}],"id":[{"id":"https:\/\/ror.org\/018mejw64","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Else Kr\u00f6ner-Fresenius-Stiftung","award":["2020_EKEA.121"],"award-info":[{"award-number":["2020_EKEA.121"]}],"id":[{"id":"https:\/\/ror.org\/03zcxha54","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Deutsche Forschungsgemeinschaft","award":["390661388"],"award-info":[{"award-number":["390661388"]}],"id":[{"id":"https:\/\/ror.org\/018mejw64","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Leverhulme Trust","award":["RPG-2022-299"],"award-info":[{"award-number":["RPG-2022-299"]}],"id":[{"id":"https:\/\/ror.org\/012mzw131","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Wellcome Trust","award":["102532\/Z\/12\/Z, 102531\/Z\/13\/A"],"award-info":[{"award-number":["102532\/Z\/12\/Z, 102531\/Z\/13\/A"]}],"id":[{"id":"https:\/\/ror.org\/029chgv08","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Deutsche Forschungsgemeinschaft","award":["EXC 2030 -390661388"],"award-info":[{"award-number":["EXC 2030 -390661388"]}],"id":[{"id":"https:\/\/ror.org\/018mejw64","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Else Kr\u00f6ner-Fresenius-Stiftung","award":["2020_EKEA.121"],"award-info":[{"award-number":["2020_EKEA.121"]}],"id":[{"id":"https:\/\/ror.org\/03zcxha54","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Deutsche Forschungsgemeinschaft","award":["390661388"],"award-info":[{"award-number":["390661388"]}],"id":[{"id":"https:\/\/ror.org\/018mejw64","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Kidney360"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Key Points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Beneficial diets changed the composition of gut microbiota in an ischemia\u2013reperfusion injury\u2011dependent manner in rodents.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            Taxonomic and functional profiling revealed a central role of\n                            <jats:italic toggle=\"yes\">Lachnospiraceae<\/jats:italic>\n                            , a main producer of microbially derived short-chain fatty acids.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Comparative bulk transcriptomics suggested the metabolic use of these bacterial products as an additional energy source in kidneys of protected mice.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>On one hand, dietary interventions are known for their pivotal role in regulating diversity, composition, and function of the gut microbiome. On the other hand, specific diets show an immense potential in preventing kidney injury from various damaging stimuli in rodents, and recent findings, in turn, highlight a central role of gut microbiota in kidney health and disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Three protective dietary regimens\u2014a fasting-mimicking diet, a diet depleted in sulfur-containing amino acids, and caloric restriction\u2014were examined in parallel in a rodent model of ischemia\u2013reperfusion injury (IRI). To delineate the diet-induced effect on gut microbiota in response to ischemic kidney damage, we used comparative shotgun metagenomics for taxonomic and functional profiling. We further examined the renal metabolic response using comparative transcriptomics to unravel the interplay between gut microbiota and kidney protection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Beneficial dietary preconditioning strategies changed the composition of gut microbiota in an IRI-dependent manner. Using ternary plots to investigate the role of dietary interventions over time before and after ischemic insult, we detected a central role of\n                      <jats:italic toggle=\"yes\">Lachnospiraceae<\/jats:italic>\n                      that commonly expanded in response to renal IRI in dietary preconditioned mice. Further functional profiling of gut microbiota in our model revealed an increase in plasma levels of bacterial-derived short-chain fatty acids in diet-induced kidney protection. Comparative bulk transcriptomics in our model, in turn, pointed toward the metabolic use of these bacterial-derived short-chain fatty acids in kidneys of protected mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Because proximal tubules lack sufficient glycolytic capacity, products of microbial metabolism may serve as an additional energy source to fulfill their high demands when withstanding ischemic damage. Our data shed light on a close interplay between gut microbiota and diet-induced kidney protection calling for further research at the crossroads of microbiology, metabolism, and molecular nephrology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.34067\/kid.0000001219","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T16:00:32Z","timestamp":1779811232000},"page":"1930-1942","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["The Interplay between Gut Microbiota and Diet-Induced Kidney Protection"],"prefix":"10.34067","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2714-4229","authenticated-orcid":false,"given":"Francisco","family":"Lopes","sequence":"first","affiliation":[{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8468-1357","authenticated-orcid":false,"given":"Daniel","family":"Martinez-Martinez","sequence":"additional","affiliation":[{"name":"Institute of Clinical Sciences, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1624-0055","authenticated-orcid":false,"given":"Martin R.","family":"Sp\u00e4th","sequence":"additional","affiliation":[{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"},{"name":"Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Johanna R.","family":"Hoyer-Allo","sequence":"additional","affiliation":[{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"},{"name":"Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0278-4307","authenticated-orcid":false,"given":"Sebastian","family":"Strubl","sequence":"additional","affiliation":[{"name":"Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6427-177X","authenticated-orcid":false,"given":"Sadrija","family":"Cukoski","sequence":"additional","affiliation":[{"name":"Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Knieps","sequence":"additional","affiliation":[{"name":"Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5631-0663","authenticated-orcid":false,"given":"Susanne","family":"Brodesser","sequence":"additional","affiliation":[{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0171-7025","authenticated-orcid":false,"given":"Heike","family":"G\u00f6bel","sequence":"additional","affiliation":[{"name":"Institute for Pathology, Diagnostic and Experimental Nephropathology Unit, Faculty of Medicine and University Hospital Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2118-9338","authenticated-orcid":false,"given":"G\u00fcnter","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Faculty of Mathematics and Natural Sciences, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard M.","family":"van den Berg","sequence":"additional","affiliation":[{"name":"Department of 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