{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T16:06:47Z","timestamp":1784736407559,"version":"3.55.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Kidney360"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>CKD is common in patients with pulmonary hypertension and is associated with increased risk of mortality. We hypothesized that worse invasive hemodynamics would be associated with the development of CKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>9,195 patients enrolled in the Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension with incident pulmonary hypertension and at least one creatinine value were included. Logistic regression and Cox proportional hazards models were used to evaluate the association between each hemodynamic parameter, baseline CKD, and incident CKD, respectively. Models were adjusted for age, sex, body mass index, diabetes, and arterial hypertension and longitudinal models were adjusted for baseline eGFR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      At baseline, 4,161 (45.3%) participants had CKD stage 3. Higher right atrial pressure, pulmonary arterial wedge pressure, mean pulmonary artery pressure, pulmonary vascular resistance and lower cardiac index were associated with a higher prevalence of CKD. Over a median follow-up duration of 2.5 [IQR 0.9, 5.2] years among 4,125 participants with eGFR \u226560 ml\/min\/1.73m\n                      <jats:sup>2<\/jats:sup>\n                      at baseline and multiple creatinine measurements, 1,859 (45.1%) developed incident CKD stage 3a. Higher right atrial pressure (HR 1.12 [1.06, 1.18] per 5 mmHg) and higher pulmonary vascular resistance (HR 1.12 [1.05, 1.18] per 1 WU) and lower cardiac index (HR 0.86 [0.80, 0.93] per 1L\/min\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) were associated with the development of CKD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The incidence of CKD is high in patients with pulmonary hypertension. Worse hemodynamic markers are associated with lower eGFR and increased risk of development of CKD in patients with pulmonary hypertension.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.34067\/kid.0000001271","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T16:00:15Z","timestamp":1784736015000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Invasive Cardiac Hemodynamics and Kidney Function in Patients with Pulmonary Hypertension"],"prefix":"10.34067","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1246-8879","authenticated-orcid":false,"given":"Marcelle","family":"Tuttle","sequence":"first","affiliation":[{"name":"Division of Nephrology, Tufts Medical Center, Boston, MA, United States."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1866-9015","authenticated-orcid":false,"given":"Christine","family":"Pausch","sequence":"additional","affiliation":[{"name":"GWT-TUD GmbH, Innovation Center Real World Evidence, Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1136-2616","authenticated-orcid":false,"given":"David","family":"Pittrow","sequence":"additional","affiliation":[{"name":"GWT-TUD GmbH, Innovation Center Real World Evidence, Dresden, Germany"},{"name":"Institute for Clinical Pharmacology, Medical Faculty, Technical University, Dresden, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"McCallum","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Tufts Medical Center, Boston, MA, United States."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1448-327X","authenticated-orcid":false,"given":"Hocine","family":"Tighiouart;","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Tufts Medical Center, Boston, MA, United States."},{"name":"Institute for Clinical Research and Health Policy Studies, Tufts Clinical and Translational Science Institute, Tufts University, Boston, Massachusetts."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9422-6195","authenticated-orcid":false,"given":"Lars","family":"Harbaum","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Internal Medicine II, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7215-0943","authenticated-orcid":false,"given":"Hans","family":"Klose","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Internal Medicine II, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9070-0761","authenticated-orcid":false,"given":"D\u00f6rte","family":"Huscher","sequence":"additional","affiliation":[{"name":"Institute of Biometry and Clinical Epidemiology, and Berlin Institute of Health, Charit\u00e9-Universit\u00e4tsmedizin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9086-2293","authenticated-orcid":false,"given":"Marius M.","family":"Hoeper","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany"},{"name":"German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hanover (BREATH), Hannover, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1860-6302","authenticated-orcid":false,"given":"Mark J.","family":"Sarnak","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Tufts Medical Center, Boston, MA, United States."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,7,22]]},"container-title":["Kidney360"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.34067\/KID.0000001271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T16:00:15Z","timestamp":1784736015000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.34067\/KID.0000001271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,22]]},"references-count":0,"URL":"https:\/\/doi.org\/10.34067\/kid.0000001271","relation":{},"ISSN":["2641-7650"],"issn-type":[{"value":"2641-7650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,22]]},"assertion":[{"value":"2026-01-07","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-16","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}